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The map label for this gene is xylB [H]

Identifier: 50084740

GI number: 50084740

Start: 1569992

End: 1571107

Strand: Direct

Name: xylB [H]

Synonym: ACIAD1578

Alternate gene names: 50084740

Gene position: 1569992-1571107 (Clockwise)

Preceding gene: 50084739

Following gene: 50084741

Centisome position: 43.63

GC content: 45.97

Gene sequence:

>1116_bases
ATGAAAATTACAGCAGCAGTGGCGCGTCAGGCGCATCAGGATTTTAGTATTGAACAGGTTGAACTTGATGAGCCAAAAGA
TCATGAAGTCTTGGTCCGTATTGAAGGTGTGGGGTTGTGTCATACCGACTTGGTCGCTCGCGATCGTTTAATTCCAATTC
CACTTCCCGCAGTTCTTGGACATGAAGGAGCAGGTGTGGTTGAAAAAATTGGTAAAGCAGTGACCAAAGTGGCCGTGGGT
GATCATGTCTTAATGAGTTTTAACAGTTGTGGTGAATGCCCACGCTGTAAAGAACATTTACCACCTTATTGTACTCAGTT
TCCGCAGCTCAACTATGTCGGTGCGCGCCCAGATGGAAGCTCTACGCTAAAACAAAATGATCAGGCGGTATCGGGTTATT
TCTTCGGACAATCTTCCTTTGCCAGTCATGCGCTTGCCAATGAACGTAACATTGTTAAGGTTGCTCAGGATTTACCGATC
GAAATTTTAGGACCACTTGGTTGTGGTTTACAAACAGGTGCAGGAGGGGTGATGCGTTCACTGGCTTGTCCTCAAGGTTC
GACTATTGCGATTTTTGGCGGGGGGCCTGTTGGTTTGGCAGCGGTAATGGGAGCCGTCATTCAACAGTGCGCAACCATTA
TTTTAGTTGAACCAATGGCTTCACGTCGTGAACTGGCCCTTGAGTTGGGTGCGCATCATGTAATTGATCCAGCACAGGGT
AATATTACCGAACACATCCGCAATATCTTACCGCAAGGTGTCGATTTTGCATTTGAATCGAGTGGACGAGGTGAAGTGGT
TGAAGCGGCACTGGCATCATTGGGCAGTCATGGTTTACTTGGATTAGTCGGAGTTCCGCCCAGTGTAGAAACCACACTCA
ATGTCAATCTGGTGTCACTCATTACTTTTGGTCACCGTATTCACGGCATTATCGAAGGCGATAGTGATCTGGATACCTTC
TTGCCAGAATTGATTCAACATTATCAAGCAGGCAAATTTCCTTTCGACAAACTTATCAAAAAGTATGCACTAAGTGAAAT
TAATCAGGCCATACAAGATCAGGCACAAGGCCGCTGTATAAAAGCGGTTCTCATTCCTGAACATGCCCATCATTAG

Upstream 100 bases:

>100_bases
GTCGTGAAAATGGACAGGAAGTTTTAGATGCATATCTGGAGTCTAAGTCTGTGATTATGGCTTTAAGTTAAAAAATTAAA
TGGATTAAGGGAATAATGCA

Downstream 100 bases:

>100_bases
AAAAAAAAAGGAGAGTTTTATGCCAACGATTGCCATTGTCACTCGTGAAGGTGAACGCACCTCGGTTACCGTTGAAAATC
AACTTTCACTCATGGAGAAC

Product: aryl-alcohol dehydrogenase

Products: NA

Alternate protein names: Benzyl alcohol dehydrogenase; BADH [H]

Number of amino acids: Translated: 371; Mature: 371

Protein sequence:

>371_residues
MKITAAVARQAHQDFSIEQVELDEPKDHEVLVRIEGVGLCHTDLVARDRLIPIPLPAVLGHEGAGVVEKIGKAVTKVAVG
DHVLMSFNSCGECPRCKEHLPPYCTQFPQLNYVGARPDGSSTLKQNDQAVSGYFFGQSSFASHALANERNIVKVAQDLPI
EILGPLGCGLQTGAGGVMRSLACPQGSTIAIFGGGPVGLAAVMGAVIQQCATIILVEPMASRRELALELGAHHVIDPAQG
NITEHIRNILPQGVDFAFESSGRGEVVEAALASLGSHGLLGLVGVPPSVETTLNVNLVSLITFGHRIHGIIEGDSDLDTF
LPELIQHYQAGKFPFDKLIKKYALSEINQAIQDQAQGRCIKAVLIPEHAHH

Sequences:

>Translated_371_residues
MKITAAVARQAHQDFSIEQVELDEPKDHEVLVRIEGVGLCHTDLVARDRLIPIPLPAVLGHEGAGVVEKIGKAVTKVAVG
DHVLMSFNSCGECPRCKEHLPPYCTQFPQLNYVGARPDGSSTLKQNDQAVSGYFFGQSSFASHALANERNIVKVAQDLPI
EILGPLGCGLQTGAGGVMRSLACPQGSTIAIFGGGPVGLAAVMGAVIQQCATIILVEPMASRRELALELGAHHVIDPAQG
NITEHIRNILPQGVDFAFESSGRGEVVEAALASLGSHGLLGLVGVPPSVETTLNVNLVSLITFGHRIHGIIEGDSDLDTF
LPELIQHYQAGKFPFDKLIKKYALSEINQAIQDQAQGRCIKAVLIPEHAHH
>Mature_371_residues
MKITAAVARQAHQDFSIEQVELDEPKDHEVLVRIEGVGLCHTDLVARDRLIPIPLPAVLGHEGAGVVEKIGKAVTKVAVG
DHVLMSFNSCGECPRCKEHLPPYCTQFPQLNYVGARPDGSSTLKQNDQAVSGYFFGQSSFASHALANERNIVKVAQDLPI
EILGPLGCGLQTGAGGVMRSLACPQGSTIAIFGGGPVGLAAVMGAVIQQCATIILVEPMASRRELALELGAHHVIDPAQG
NITEHIRNILPQGVDFAFESSGRGEVVEAALASLGSHGLLGLVGVPPSVETTLNVNLVSLITFGHRIHGIIEGDSDLDTF
LPELIQHYQAGKFPFDKLIKKYALSEINQAIQDQAQGRCIKAVLIPEHAHH

Specific function: Oxidizes primary alcohols with an aromatic or cyclohex- 1-ene ring. It is highly specific for benzyl alcohol [H]

COG id: COG1062

COG function: function code C; Zn-dependent alcohol dehydrogenases, class III

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI34577061, Length=371, Percent_Identity=35.0404312668464, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI4501929, Length=372, Percent_Identity=34.6774193548387, Blast_Score=189, Evalue=3e-48,
Organism=Homo sapiens, GI4501933, Length=371, Percent_Identity=34.5013477088949, Blast_Score=186, Evalue=2e-47,
Organism=Homo sapiens, GI156523966, Length=373, Percent_Identity=33.7801608579088, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI4501939, Length=366, Percent_Identity=33.6065573770492, Blast_Score=175, Evalue=6e-44,
Organism=Homo sapiens, GI71565152, Length=375, Percent_Identity=31.7333333333333, Blast_Score=165, Evalue=7e-41,
Organism=Homo sapiens, GI71565154, Length=369, Percent_Identity=30.3523035230352, Blast_Score=163, Evalue=2e-40,
Organism=Homo sapiens, GI262073058, Length=369, Percent_Identity=30.6233062330623, Blast_Score=155, Evalue=5e-38,
Organism=Homo sapiens, GI71743840, Length=369, Percent_Identity=30.6233062330623, Blast_Score=155, Evalue=5e-38,
Organism=Homo sapiens, GI156627571, Length=291, Percent_Identity=24.0549828178694, Blast_Score=66, Evalue=5e-11,
Organism=Escherichia coli, GI1786552, Length=373, Percent_Identity=30.8310991957105, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI87082125, Length=382, Percent_Identity=24.3455497382199, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1788073, Length=372, Percent_Identity=22.8494623655914, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1788407, Length=263, Percent_Identity=24.7148288973384, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI226510992, Length=244, Percent_Identity=26.2295081967213, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI25146526, Length=376, Percent_Identity=32.1808510638298, Blast_Score=169, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI71997431, Length=382, Percent_Identity=31.413612565445, Blast_Score=164, Evalue=8e-41,
Organism=Caenorhabditis elegans, GI17565904, Length=339, Percent_Identity=30.9734513274336, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17562876, Length=365, Percent_Identity=22.7397260273973, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17562878, Length=244, Percent_Identity=25.4098360655738, Blast_Score=65, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17562582, Length=295, Percent_Identity=27.4576271186441, Blast_Score=65, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17562584, Length=311, Percent_Identity=24.7588424437299, Blast_Score=65, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6320033, Length=375, Percent_Identity=30.6666666666667, Blast_Score=179, Evalue=5e-46,
Organism=Saccharomyces cerevisiae, GI6323980, Length=242, Percent_Identity=28.9256198347107, Blast_Score=82, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6319257, Length=272, Percent_Identity=27.9411764705882, Blast_Score=80, Evalue=7e-16,
Organism=Saccharomyces cerevisiae, GI6319258, Length=278, Percent_Identity=25.5395683453237, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6319949, Length=234, Percent_Identity=31.6239316239316, Blast_Score=76, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6323729, Length=228, Percent_Identity=27.6315789473684, Blast_Score=67, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6324486, Length=330, Percent_Identity=23.3333333333333, Blast_Score=66, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6319621, Length=294, Percent_Identity=25.8503401360544, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17737895, Length=371, Percent_Identity=30.4582210242588, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI17137530, Length=231, Percent_Identity=28.1385281385281, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.90 [H]

Molecular weight: Translated: 39509; Mature: 39509

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKITAAVARQAHQDFSIEQVELDEPKDHEVLVRIEGVGLCHTDLVARDRLIPIPLPAVLG
CCCHHHHHHHHHCCCCCEEEECCCCCCCEEEEEEECCCEEHHHHHHCCCCCCCCCHHHHC
HEGAGVVEKIGKAVTKVAVGDHVLMSFNSCGECPRCKEHLPPYCTQFPQLNYVGARPDGS
CCCCCHHHHHHHHHHHHHCCCHHEEECCCCCCCCCHHHCCCCHHHCCCCCCEECCCCCCC
STLKQNDQAVSGYFFGQSSFASHALANERNIVKVAQDLPIEILGPLGCGLQTGAGGVMRS
CHHHCCCCEEEEEEECCHHHHHHHHHCCCCCEEHHHCCCEEEECCCCCCCCCCCCHHHHH
LACPQGSTIAIFGGGPVGLAAVMGAVIQQCATIILVEPMASRRELALELGAHHVIDPAQG
HCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHEEEECCCHHHHHHHHHHCCCCCCCCCCC
NITEHIRNILPQGVDFAFESSGRGEVVEAALASLGSHGLLGLVGVPPSVETTLNVNLVSL
CHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHCCCCCCEEEECCCCCCCEEECCHHHHH
ITFGHRIHGIIEGDSDLDTFLPELIQHYQAGKFPFDKLIKKYALSEINQAIQDQAQGRCI
HHHHHHEEEEEECCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEE
KAVLIPEHAHH
EEEECCCCCCC
>Mature Secondary Structure
MKITAAVARQAHQDFSIEQVELDEPKDHEVLVRIEGVGLCHTDLVARDRLIPIPLPAVLG
CCCHHHHHHHHHCCCCCEEEECCCCCCCEEEEEEECCCEEHHHHHHCCCCCCCCCHHHHC
HEGAGVVEKIGKAVTKVAVGDHVLMSFNSCGECPRCKEHLPPYCTQFPQLNYVGARPDGS
CCCCCHHHHHHHHHHHHHCCCHHEEECCCCCCCCCHHHCCCCHHHCCCCCCEECCCCCCC
STLKQNDQAVSGYFFGQSSFASHALANERNIVKVAQDLPIEILGPLGCGLQTGAGGVMRS
CHHHCCCCEEEEEEECCHHHHHHHHHCCCCCEEHHHCCCEEEECCCCCCCCCCCCHHHHH
LACPQGSTIAIFGGGPVGLAAVMGAVIQQCATIILVEPMASRRELALELGAHHVIDPAQG
HCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHEEEECCCHHHHHHHHHHCCCCCCCCCCC
NITEHIRNILPQGVDFAFESSGRGEVVEAALASLGSHGLLGLVGVPPSVETTLNVNLVSL
CHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHCCCCCCEEEECCCCCCCEEECCHHHHH
ITFGHRIHGIIEGDSDLDTFLPELIQHYQAGKFPFDKLIKKYALSEINQAIQDQAQGRCI
HHHHHHEEEEEECCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEE
KAVLIPEHAHH
EEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8496150; 1989592 [H]