| Definition | Acinetobacter sp. ADP1 chromosome, complete genome. |
|---|---|
| Accession | NC_005966 |
| Length | 3,598,621 |
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The map label for this gene is fabG2 [H]
Identifier: 50084727
GI number: 50084727
Start: 1556547
End: 1557311
Strand: Direct
Name: fabG2 [H]
Synonym: ACIAD1565
Alternate gene names: 50084727
Gene position: 1556547-1557311 (Clockwise)
Preceding gene: 50084726
Following gene: 50084728
Centisome position: 43.25
GC content: 44.84
Gene sequence:
>765_bases ATGAGGCTAAAGGGAAATGTTGTACTCGTGACAGGTGGTGCTTCTGGTTTAGGAGGTGCAGTTGTACAGCGCCTTGCTGA GCAAGGAGCAAGGTTAGTGATTATCGATTTAAATCAATCATTAGGTGAACAACTTGCACGTCAGGTCAGTGGACTATTTG TGCAGGCCGATGTGACCAATGAAGAACAGATTGATCAGGCTTTTCAACAGGCAGAAGAATTTTATAAGAAGAAAGTACGC GTTGTGGTGAATTGCGCAGGTATTGGTCCTCCTGGTAAAGCCATTGATCGTGAAGGTAATCCACTTGCGTTATCCACCTT CAGCAAGATTATTAATATTAATTTAAACGGTACATTTAATGTTTTATCGAAATTTGCTGCACGGCTGCATAGAGAAGCCG TTGAAGGTGAAGAACGCGGTGTAATTATTAATACGGCCAGTGTAGCTGCGTTTGATGGGCAAATAGGTCAGCCTGCTTAT GCAGCCTCCAAAGCAGGCGTGGTTGGCATGACCTTGCCTTTGGCACGTGAGTTTGCACGTTACGGCATTCGGGTCATGAC CATCGCACCAGGGATTTTTCTCACACCTTTATTAGCCACGTTACCGCAAGATGTTCAAGACTCATTAGGTGCTCAAGTGC CATTTCCAAGCCGTTTGGGGCAGCCTGATGAATTTGCCCAATTAGTCGAAAGTATCATCCTCAATCCAATGTTAAATGGC GAAGTGATCCGATTAGATGGTGCAATACGGATGACAGCAAAATGA
Upstream 100 bases:
>100_bases CTTTTTGATCATTCTTTTCATTGCGTTGACTTTAGCAAATGGTGCTTCTAATTTTACTCTTAAGAATAATACTTACTTAT GAGTTTTAATGGAGTAAAAA
Downstream 100 bases:
>100_bases TCAATAATGATTTAAATCTGGCACATGACATCGCCATTAAGGTTGAAAAGTTTGTACGTGAGGTGGTAATTCCGTATGAG CGTGACCCACGGCGTGATCA
Product: 3-hydroxyacyl-CoA dehydrogenase (short-chain)
Products: 3-oxoacyl-CoA; NADH; H+
Alternate protein names: NA
Number of amino acids: Translated: 254; Mature: 254
Protein sequence:
>254_residues MRLKGNVVLVTGGASGLGGAVVQRLAEQGARLVIIDLNQSLGEQLARQVSGLFVQADVTNEEQIDQAFQQAEEFYKKKVR VVVNCAGIGPPGKAIDREGNPLALSTFSKIININLNGTFNVLSKFAARLHREAVEGEERGVIINTASVAAFDGQIGQPAY AASKAGVVGMTLPLAREFARYGIRVMTIAPGIFLTPLLATLPQDVQDSLGAQVPFPSRLGQPDEFAQLVESIILNPMLNG EVIRLDGAIRMTAK
Sequences:
>Translated_254_residues MRLKGNVVLVTGGASGLGGAVVQRLAEQGARLVIIDLNQSLGEQLARQVSGLFVQADVTNEEQIDQAFQQAEEFYKKKVR VVVNCAGIGPPGKAIDREGNPLALSTFSKIININLNGTFNVLSKFAARLHREAVEGEERGVIINTASVAAFDGQIGQPAY AASKAGVVGMTLPLAREFARYGIRVMTIAPGIFLTPLLATLPQDVQDSLGAQVPFPSRLGQPDEFAQLVESIILNPMLNG EVIRLDGAIRMTAK >Mature_254_residues MRLKGNVVLVTGGASGLGGAVVQRLAEQGARLVIIDLNQSLGEQLARQVSGLFVQADVTNEEQIDQAFQQAEEFYKKKVR VVVNCAGIGPPGKAIDREGNPLALSTFSKIININLNGTFNVLSKFAARLHREAVEGEERGVIINTASVAAFDGQIGQPAY AASKAGVVGMTLPLAREFARYGIRVMTIAPGIFLTPLLATLPQDVQDSLGAQVPFPSRLGQPDEFAQLVESIILNPMLNG EVIRLDGAIRMTAK
Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]
COG id: NA
COG function: NA
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI4758504, Length=253, Percent_Identity=54.1501976284585, Blast_Score=251, Evalue=5e-67, Organism=Homo sapiens, GI83715985, Length=253, Percent_Identity=50.5928853754941, Blast_Score=226, Evalue=2e-59, Organism=Homo sapiens, GI15277342, Length=240, Percent_Identity=35, Blast_Score=126, Evalue=2e-29, Organism=Homo sapiens, GI40254992, Length=247, Percent_Identity=30.7692307692308, Blast_Score=100, Evalue=1e-21, Organism=Homo sapiens, GI31542939, Length=268, Percent_Identity=26.865671641791, Blast_Score=90, Evalue=2e-18, Organism=Homo sapiens, GI59889578, Length=211, Percent_Identity=32.2274881516588, Blast_Score=80, Evalue=2e-15, Organism=Homo sapiens, GI66933014, Length=198, Percent_Identity=29.7979797979798, Blast_Score=77, Evalue=2e-14, Organism=Homo sapiens, GI19923817, Length=266, Percent_Identity=25.9398496240602, Blast_Score=75, Evalue=5e-14, Organism=Homo sapiens, GI224922801, Length=183, Percent_Identity=31.6939890710383, Blast_Score=75, Evalue=8e-14, Organism=Homo sapiens, GI4504503, Length=223, Percent_Identity=29.1479820627803, Blast_Score=74, Evalue=2e-13, Organism=Homo sapiens, GI4504505, Length=229, Percent_Identity=28.82096069869, Blast_Score=72, Evalue=5e-13, Organism=Homo sapiens, GI22507405, Length=224, Percent_Identity=27.6785714285714, Blast_Score=70, Evalue=2e-12, Organism=Homo sapiens, GI150247226, Length=197, Percent_Identity=30.4568527918782, Blast_Score=69, Evalue=5e-12, Organism=Homo sapiens, GI10190704, Length=265, Percent_Identity=29.0566037735849, Blast_Score=68, Evalue=9e-12, Organism=Homo sapiens, GI5031737, Length=261, Percent_Identity=28.735632183908, Blast_Score=66, Evalue=4e-11, Organism=Homo sapiens, GI4503817, Length=209, Percent_Identity=28.2296650717703, Blast_Score=65, Evalue=5e-11, Organism=Escherichia coli, GI1787335, Length=261, Percent_Identity=32.183908045977, Blast_Score=92, Evalue=2e-20, Organism=Escherichia coli, GI87082100, Length=240, Percent_Identity=27.5, Blast_Score=89, Evalue=3e-19, Organism=Escherichia coli, GI87082160, Length=205, Percent_Identity=32.6829268292683, Blast_Score=77, Evalue=1e-15, Organism=Escherichia coli, GI1789208, Length=257, Percent_Identity=31.5175097276265, Blast_Score=76, Evalue=2e-15, Organism=Escherichia coli, GI1790717, Length=259, Percent_Identity=28.957528957529, Blast_Score=73, Evalue=2e-14, Organism=Escherichia coli, GI2367175, Length=253, Percent_Identity=28.8537549407115, Blast_Score=70, Evalue=1e-13, Organism=Escherichia coli, GI1789057, Length=234, Percent_Identity=26.9230769230769, Blast_Score=69, Evalue=4e-13, Organism=Escherichia coli, GI1788459, Length=228, Percent_Identity=28.0701754385965, Blast_Score=66, Evalue=2e-12, Organism=Escherichia coli, GI1786812, Length=206, Percent_Identity=28.6407766990291, Blast_Score=64, Evalue=1e-11, Organism=Escherichia coli, GI1787905, Length=233, Percent_Identity=27.4678111587983, Blast_Score=63, Evalue=1e-11, Organism=Caenorhabditis elegans, GI17538182, Length=253, Percent_Identity=49.4071146245059, Blast_Score=226, Evalue=9e-60, Organism=Caenorhabditis elegans, GI17555706, Length=233, Percent_Identity=34.3347639484979, Blast_Score=118, Evalue=3e-27, Organism=Caenorhabditis elegans, GI25147288, Length=257, Percent_Identity=30.3501945525292, Blast_Score=107, Evalue=6e-24, Organism=Caenorhabditis elegans, GI17536651, Length=260, Percent_Identity=31.1538461538462, Blast_Score=86, Evalue=2e-17, Organism=Caenorhabditis elegans, GI17536025, Length=261, Percent_Identity=29.5019157088123, Blast_Score=81, Evalue=5e-16, Organism=Caenorhabditis elegans, GI17561402, Length=267, Percent_Identity=27.7153558052434, Blast_Score=74, Evalue=6e-14, Organism=Caenorhabditis elegans, GI17561272, Length=261, Percent_Identity=32.183908045977, Blast_Score=74, Evalue=9e-14, Organism=Caenorhabditis elegans, GI17568967, Length=226, Percent_Identity=27.8761061946903, Blast_Score=71, Evalue=5e-13, Organism=Caenorhabditis elegans, GI17562906, Length=268, Percent_Identity=26.4925373134328, Blast_Score=67, Evalue=1e-11, Organism=Caenorhabditis elegans, GI17560676, Length=264, Percent_Identity=25.3787878787879, Blast_Score=65, Evalue=4e-11, Organism=Caenorhabditis elegans, GI17562904, Length=238, Percent_Identity=27.3109243697479, Blast_Score=64, Evalue=6e-11, Organism=Saccharomyces cerevisiae, GI6322861, Length=246, Percent_Identity=29.6747967479675, Blast_Score=77, Evalue=2e-15, Organism=Saccharomyces cerevisiae, GI6320089, Length=239, Percent_Identity=26.3598326359833, Blast_Score=62, Evalue=7e-11, Organism=Drosophila melanogaster, GI17737361, Length=253, Percent_Identity=50.9881422924901, Blast_Score=241, Evalue=4e-64, Organism=Drosophila melanogaster, GI24639444, Length=257, Percent_Identity=31.9066147859922, Blast_Score=124, Evalue=7e-29, Organism=Drosophila melanogaster, GI24665243, Length=212, Percent_Identity=27.8301886792453, Blast_Score=81, Evalue=7e-16, Organism=Drosophila melanogaster, GI221331218, Length=212, Percent_Identity=27.8301886792453, Blast_Score=81, Evalue=7e-16, Organism=Drosophila melanogaster, GI24665247, Length=213, Percent_Identity=27.6995305164319, Blast_Score=78, Evalue=5e-15, Organism=Drosophila melanogaster, GI221331216, Length=213, Percent_Identity=27.6995305164319, Blast_Score=78, Evalue=6e-15, Organism=Drosophila melanogaster, GI21355319, Length=241, Percent_Identity=28.6307053941909, Blast_Score=77, Evalue=8e-15, Organism=Drosophila melanogaster, GI23397609, Length=200, Percent_Identity=31.5, Blast_Score=75, Evalue=6e-14, Organism=Drosophila melanogaster, GI28571526, Length=238, Percent_Identity=26.0504201680672, Blast_Score=70, Evalue=2e-12, Organism=Drosophila melanogaster, GI24644339, Length=240, Percent_Identity=26.25, Blast_Score=68, Evalue=7e-12, Organism=Drosophila melanogaster, GI21357041, Length=238, Percent_Identity=27.3109243697479, Blast_Score=67, Evalue=1e-11, Organism=Drosophila melanogaster, GI24643142, Length=232, Percent_Identity=29.7413793103448, Blast_Score=64, Evalue=7e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 - InterPro: IPR020904 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: 1.1.1.35
Molecular weight: Translated: 27077; Mature: 27077
Theoretical pI: Translated: 7.37; Mature: 7.37
Prosite motif: PS00061 ADH_SHORT
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.4 %Cys (Translated Protein) 2.0 %Met (Translated Protein) 2.4 %Cys+Met (Translated Protein) 0.4 %Cys (Mature Protein) 2.0 %Met (Mature Protein) 2.4 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MRLKGNVVLVTGGASGLGGAVVQRLAEQGARLVIIDLNQSLGEQLARQVSGLFVQADVTN CCCCCCEEEEECCCCCCCHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHCEEEEECCCC EEQIDQAFQQAEEFYKKKVRVVVNCAGIGPPGKAIDREGNPLALSTFSKIININLNGTFN HHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCCCCEEHEEHHEEEEEECCCHHH VLSKFAARLHREAVEGEERGVIINTASVAAFDGQIGQPAYAASKAGVVGMTLPLAREFAR HHHHHHHHHHHHHHCCCCCCEEEEECEEEEECCCCCCCCHHHCCCCEEEEHHHHHHHHHH YGIRVMTIAPGIFLTPLLATLPQDVQDSLGAQVPFPSRLGQPDEFAQLVESIILNPMLNG CCEEEEEECCCHHHHHHHHHCCHHHHHHCCCCCCCHHHCCCCHHHHHHHHHHHHCCCCCC EVIRLDGAIRMTAK EEEEECCEEEECCC >Mature Secondary Structure MRLKGNVVLVTGGASGLGGAVVQRLAEQGARLVIIDLNQSLGEQLARQVSGLFVQADVTN CCCCCCEEEEECCCCCCCHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHCEEEEECCCC EEQIDQAFQQAEEFYKKKVRVVVNCAGIGPPGKAIDREGNPLALSTFSKIININLNGTFN HHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCCCCEEHEEHHEEEEEECCCHHH VLSKFAARLHREAVEGEERGVIINTASVAAFDGQIGQPAYAASKAGVVGMTLPLAREFAR HHHHHHHHHHHHHHCCCCCCEEEEECEEEEECCCCCCCCHHHCCCCEEEEHHHHHHHHHH YGIRVMTIAPGIFLTPLLATLPQDVQDSLGAQVPFPSRLGQPDEFAQLVESIILNPMLNG CCEEEEEECCCHHHHHHHHHCCHHHHHHCCCCCCCHHHCCCCHHHHHHHHHHHHCCCCCC EVIRLDGAIRMTAK EEEEECCEEEECCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: (S)-3-hydroxyacyl-CoA; NAD+
Specific reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H+
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 9634230; 12218036 [H]