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The map label for this gene is cyaA [H]

Identifier: 50084575

GI number: 50084575

Start: 1392866

End: 1394323

Strand: Direct

Name: cyaA [H]

Synonym: ACIAD1397

Alternate gene names: 50084575

Gene position: 1392866-1394323 (Clockwise)

Preceding gene: 50084574

Following gene: 50084584

Centisome position: 38.71

GC content: 34.5

Gene sequence:

>1458_bases
GTGCTCACGAGATTTATTGAAAGAGGGCCTCAGCAGTTTATTTATTTCCATCGAATGATGGGATATTTTATTCTGTCCTT
GCTTATTGTGATTTATTCCTTTACTTCTGCACATAGTCAATATCAAATTTATGTTCCAATTTTCATTGTTATACTTGTTC
TTTTAATACCCAGATTAAATCGTGTATTCGAAGCAAAATTTGATAAAAAGATAACACGTAGTATTTTTTTCTTAATCGAT
ACCTTTGTGGTATCAATTGTTCTTGCGGGTGTCCACCTCAGTCTGGTACTTACATTTATTATTCTTTTTGCATGGATTTA
TAGTGCAATTAATAGTCGGATTCCATTTGTTGTTATGTCACTGGCTGTATTATCAGGCATAGCATGCTTTTATTTTCATA
CTTTTTTCGTATTTGGTTTTCAAGGTTATTTAGCCAATACCAGCCAAGAATTAACCGTAATTAGCTTAATTTGTCTGATT
ATTTTTATTAGTATGGGTAATTACTATCAACATATTTATATAGAAAGAATAAAACAGTTGCGTCAAGATTATTATAATCA
GATGACACGTTATATGACTTTTGCTAATCAATTGAGCCGCTATGCACCATTGCAGTTATGGCAGTCGATCATGCGTGGTG
AAGCAGAAGCAAAAATTGAATACAAACGTAAAAAACTCACGGTATTTTTTTCTGATATACAAGGCTTTACAGAGCTTTCG
GAGTCTTTAATTCCCGATGATTTAGCGTTCTTGTTAAATGATTATTTAAGTCATATGACTGAAATTGCAAATCAATATGA
AGCAACCATTGATAAATTCATGGGCGATGCGATTCTAATTTTCTTTGGTGATCCAAATTCTCAGGGTGTACAGCAGGATG
CTGCATCATGTGTAGAAATGGCAATAGCTATGCGCCAACAAATGAAGTTATTACGCGAACGATGGAAAAAAATGGGTTAT
CCTGCATTAAATATTCGTATGGGCGTAAGTACAGGATATTGTCACGTTGGAAACTATGGTGCGACTTATCGTATGGCTTA
TACCATTGTTGGGCGTGATGTAAATTTGGCTGCCAGATTACAATATGCAGCAGAGGTCGATGAGATTCTTATTTCTGATG
AAACGTATCAATTGATTAAAGATCAATTTCTGTGTGCACCCAAAGCACCTATTTATCTTAAGGGGATTCAAGGTGCTGTA
AAAACATGGCAGGTTTTGGAAAAATATACAGGAAATCAGGAAGATTTACAGCAGTGGTTTGACTACGAATATAAAGGTTT
CCACCTTTTACTTAATCTTGAAGAAGTACAGCGTTTTGAATACTCGGAATTGGTTGAAGTCATGGAAAAGATGATACATC
GTATTCAGGCGCAACAAGCAATGACCAATGATAAAGGAATTGTAAAATTATCTATGAAAGATGAAGTCAAGCTTGCACAG
GGTAATTTAAAATCATAA

Upstream 100 bases:

>100_bases
GCGTGGACAAGGTGATATGCCATTCGATTGGCGTATGGACTAAGTTCATCTGTGCTGCATATGGAATTATGCAGCTTAAA
ACTGTGTTGCGGAGGATAGG

Downstream 100 bases:

>100_bases
AAAAGCCTTCTATAAATAGAAGGCCTGATAAGATGAGACAATTAAAAGTTAATGATTTTCAGATGCATGATTAATCGTAT
ACTTTGGAATCTCAACTTCA

Product: adenylate or guanylate cyclase

Products: NA

Alternate protein names: ATP pyrophosphate-lyase 1; Adenylyl cyclase 1; AC 1 [H]

Number of amino acids: Translated: 485; Mature: 485

Protein sequence:

>485_residues
MLTRFIERGPQQFIYFHRMMGYFILSLLIVIYSFTSAHSQYQIYVPIFIVILVLLIPRLNRVFEAKFDKKITRSIFFLID
TFVVSIVLAGVHLSLVLTFIILFAWIYSAINSRIPFVVMSLAVLSGIACFYFHTFFVFGFQGYLANTSQELTVISLICLI
IFISMGNYYQHIYIERIKQLRQDYYNQMTRYMTFANQLSRYAPLQLWQSIMRGEAEAKIEYKRKKLTVFFSDIQGFTELS
ESLIPDDLAFLLNDYLSHMTEIANQYEATIDKFMGDAILIFFGDPNSQGVQQDAASCVEMAIAMRQQMKLLRERWKKMGY
PALNIRMGVSTGYCHVGNYGATYRMAYTIVGRDVNLAARLQYAAEVDEILISDETYQLIKDQFLCAPKAPIYLKGIQGAV
KTWQVLEKYTGNQEDLQQWFDYEYKGFHLLLNLEEVQRFEYSELVEVMEKMIHRIQAQQAMTNDKGIVKLSMKDEVKLAQ
GNLKS

Sequences:

>Translated_485_residues
MLTRFIERGPQQFIYFHRMMGYFILSLLIVIYSFTSAHSQYQIYVPIFIVILVLLIPRLNRVFEAKFDKKITRSIFFLID
TFVVSIVLAGVHLSLVLTFIILFAWIYSAINSRIPFVVMSLAVLSGIACFYFHTFFVFGFQGYLANTSQELTVISLICLI
IFISMGNYYQHIYIERIKQLRQDYYNQMTRYMTFANQLSRYAPLQLWQSIMRGEAEAKIEYKRKKLTVFFSDIQGFTELS
ESLIPDDLAFLLNDYLSHMTEIANQYEATIDKFMGDAILIFFGDPNSQGVQQDAASCVEMAIAMRQQMKLLRERWKKMGY
PALNIRMGVSTGYCHVGNYGATYRMAYTIVGRDVNLAARLQYAAEVDEILISDETYQLIKDQFLCAPKAPIYLKGIQGAV
KTWQVLEKYTGNQEDLQQWFDYEYKGFHLLLNLEEVQRFEYSELVEVMEKMIHRIQAQQAMTNDKGIVKLSMKDEVKLAQ
GNLKS
>Mature_485_residues
MLTRFIERGPQQFIYFHRMMGYFILSLLIVIYSFTSAHSQYQIYVPIFIVILVLLIPRLNRVFEAKFDKKITRSIFFLID
TFVVSIVLAGVHLSLVLTFIILFAWIYSAINSRIPFVVMSLAVLSGIACFYFHTFFVFGFQGYLANTSQELTVISLICLI
IFISMGNYYQHIYIERIKQLRQDYYNQMTRYMTFANQLSRYAPLQLWQSIMRGEAEAKIEYKRKKLTVFFSDIQGFTELS
ESLIPDDLAFLLNDYLSHMTEIANQYEATIDKFMGDAILIFFGDPNSQGVQQDAASCVEMAIAMRQQMKLLRERWKKMGY
PALNIRMGVSTGYCHVGNYGATYRMAYTIVGRDVNLAARLQYAAEVDEILISDETYQLIKDQFLCAPKAPIYLKGIQGAV
KTWQVLEKYTGNQEDLQQWFDYEYKGFHLLLNLEEVQRFEYSELVEVMEKMIHRIQAQQAMTNDKGIVKLSMKDEVKLAQ
GNLKS

Specific function: Unknown

COG id: COG2114

COG function: function code T; Adenylate cyclase, family 3 (some proteins contain HAMP domain)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate cyclase domain [H]

Homologues:

Organism=Homo sapiens, GI148536830, Length=168, Percent_Identity=27.9761904761905, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI4580422, Length=213, Percent_Identity=27.6995305164319, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI167830411, Length=207, Percent_Identity=27.536231884058, Blast_Score=67, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI193208534, Length=196, Percent_Identity=26.530612244898, Blast_Score=76, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17534655, Length=218, Percent_Identity=26.1467889908257, Blast_Score=70, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17561804, Length=180, Percent_Identity=27.7777777777778, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI161076872, Length=185, Percent_Identity=28.1081081081081, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI28574512, Length=185, Percent_Identity=28.1081081081081, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24585694, Length=189, Percent_Identity=24.3386243386243, Blast_Score=69, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054 [H]

Pfam domain/function: PF00211 Guanylate_cyc [H]

EC number: =4.6.1.1 [H]

Molecular weight: Translated: 56410; Mature: 56410

Theoretical pI: Translated: 7.89; Mature: 7.89

Prosite motif: PS50125 GUANYLATE_CYCLASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCC
>Mature Secondary Structure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CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9523018; 8418825 [H]