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The map label for this gene is dctA [H]

Identifier: 50084519

GI number: 50084519

Start: 1335452

End: 1336750

Strand: Direct

Name: dctA [H]

Synonym: ACIAD1339

Alternate gene names: 50084519

Gene position: 1335452-1336750 (Clockwise)

Preceding gene: 50084518

Following gene: 50084520

Centisome position: 37.11

GC content: 39.57

Gene sequence:

>1299_bases
ATGAATCAGAAAAAATTGCTCAAATATATTTTGATTGCAATGGTCTCAGGGATTCTTGTTGGGTGGGCATGTCACAGTGC
ATTAAATGAAACTCAAACTGCAGAAATCGCATCGTACTTTAAAATTGTGACAGATGTATTTTTAAGATTAATTAAAATGA
TCATCGGTCCATTGGTTTTTGCAACCATTGTATCTGGTCTGATTTCAATGGGTAAATCTTCATCTTTAGGCTCAGTGACA
TTAAAAGCCATGAGCTGGTTCATCGGTGCTTCTCTTATTTCCTTGTTGCTGGGTATGGGCTTGGCAAACTTCTTTCAGCC
AGGCGCAGGGATGAATCTTGCCATTCCTGTTGAGCATGTGGATATTGGTGTAACCACAGCCAATTTGACATTACAGAATT
TCATTACGCATATTTTCCCGCGTAGTTTTGCAGAAGCTATGGCAAACAATGAAATTTTGCAGATTCTCGTATTTTCTATT
TTCTTTGGTGCAGCATTGGCTTATGTCAACCATCAAACCAAAGAAGGTACGGTGATTGCGCGCCTGATTGATGAGCTCGC
CAGAATTATGTTCAAGATTACTGACTATGTCATGGCTTTTGCTCCAGTGGCTGTGTTTGCTGCAATTGCTGCTGCAATCG
CGGTTAAAGGTCCAATGTTAATTATTGATTACAGTGTATTTATTGGTCAGTTTTATACGGGTCTGGCATTGTTGTGGTTG
GTTTTGATTTCAGTGGGTTATATTTTCCTGAAAAAAGATGTATTTCGTTTATTGGGAATTATGCGTGAACCCGCTGCTCT
TGCTTTTGCGACATCAAGCAGCGAATCTGCTTATCCAAAAATAATTGCAGGTTTAAACAAGTTTGGTGTACCTAAACGAA
TCTCGAGCTTTGTGCTTCCTTTAGGATATTCGTTCAATCTTGATGGGTCGATGATGTATATGTCCTTTGCAGTATTATTT
ATTGCACAGGCCTACAATATTGATTTGAGTTTTACACAGCAAATTATGATCCTACTGACTTTAATGATTACCAGTAAAGG
AATTGCAGGTGTATCTCGTGCTTCGATTGTTGTCATCGCAGCGACCTTGACTATGTTTAAGCTACCAGAAGCTGGTATTT
TATTGATCTTGGCAATTGATCAGTTCTTGGATATGGGCCGCTCTGCAACCAATGTGATTGGAAACAGTATTGCGACAGCA
GTAGTTGCTAAAACTGAAGCACATGAGCATGATGAAGTGATTGAAGATGCGCATATCGTAGATGACATCGTGCCTGTGAG
TACGACAGGTCATTCATAA

Upstream 100 bases:

>100_bases
GTGATTACGTGGTTTGATAAACATGGAATGTTCATCGAAGAAAGTTATGCAATATCTTTAGATTCTTCGATGAAAAGTGA
TTGCTAAAAGGAAATAATGT

Downstream 100 bases:

>100_bases
ATTGAAATTATCGTTGTGTGATTAAGTCACGATAATAGAGAGCCTGCATAAGCAGGCTTTTTTGTATTTGATATCAGCCT
TTTTTGGGCAGGATAGCTTC

Product: glutamate symport transmembrane protein

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 432; Mature: 432

Protein sequence:

>432_residues
MNQKKLLKYILIAMVSGILVGWACHSALNETQTAEIASYFKIVTDVFLRLIKMIIGPLVFATIVSGLISMGKSSSLGSVT
LKAMSWFIGASLISLLLGMGLANFFQPGAGMNLAIPVEHVDIGVTTANLTLQNFITHIFPRSFAEAMANNEILQILVFSI
FFGAALAYVNHQTKEGTVIARLIDELARIMFKITDYVMAFAPVAVFAAIAAAIAVKGPMLIIDYSVFIGQFYTGLALLWL
VLISVGYIFLKKDVFRLLGIMREPAALAFATSSSESAYPKIIAGLNKFGVPKRISSFVLPLGYSFNLDGSMMYMSFAVLF
IAQAYNIDLSFTQQIMILLTLMITSKGIAGVSRASIVVIAATLTMFKLPEAGILLILAIDQFLDMGRSATNVIGNSIATA
VVAKTEAHEHDEVIEDAHIVDDIVPVSTTGHS

Sequences:

>Translated_432_residues
MNQKKLLKYILIAMVSGILVGWACHSALNETQTAEIASYFKIVTDVFLRLIKMIIGPLVFATIVSGLISMGKSSSLGSVT
LKAMSWFIGASLISLLLGMGLANFFQPGAGMNLAIPVEHVDIGVTTANLTLQNFITHIFPRSFAEAMANNEILQILVFSI
FFGAALAYVNHQTKEGTVIARLIDELARIMFKITDYVMAFAPVAVFAAIAAAIAVKGPMLIIDYSVFIGQFYTGLALLWL
VLISVGYIFLKKDVFRLLGIMREPAALAFATSSSESAYPKIIAGLNKFGVPKRISSFVLPLGYSFNLDGSMMYMSFAVLF
IAQAYNIDLSFTQQIMILLTLMITSKGIAGVSRASIVVIAATLTMFKLPEAGILLILAIDQFLDMGRSATNVIGNSIATA
VVAKTEAHEHDEVIEDAHIVDDIVPVSTTGHS
>Mature_432_residues
MNQKKLLKYILIAMVSGILVGWACHSALNETQTAEIASYFKIVTDVFLRLIKMIIGPLVFATIVSGLISMGKSSSLGSVT
LKAMSWFIGASLISLLLGMGLANFFQPGAGMNLAIPVEHVDIGVTTANLTLQNFITHIFPRSFAEAMANNEILQILVFSI
FFGAALAYVNHQTKEGTVIARLIDELARIMFKITDYVMAFAPVAVFAAIAAAIAVKGPMLIIDYSVFIGQFYTGLALLWL
VLISVGYIFLKKDVFRLLGIMREPAALAFATSSSESAYPKIIAGLNKFGVPKRISSFVLPLGYSFNLDGSMMYMSFAVLF
IAQAYNIDLSFTQQIMILLTLMITSKGIAGVSRASIVVIAATLTMFKLPEAGILLILAIDQFLDMGRSATNVIGNSIATA
VVAKTEAHEHDEVIEDAHIVDDIVPVSTTGHS

Specific function: Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI169790839, Length=433, Percent_Identity=26.7898383371824, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI4827012, Length=321, Percent_Identity=32.7102803738318, Blast_Score=126, Evalue=4e-29,
Organism=Homo sapiens, GI21314632, Length=422, Percent_Identity=27.4881516587678, Blast_Score=122, Evalue=6e-28,
Organism=Homo sapiens, GI66773030, Length=472, Percent_Identity=24.7881355932203, Blast_Score=119, Evalue=6e-27,
Organism=Homo sapiens, GI223468564, Length=295, Percent_Identity=30.1694915254237, Blast_Score=113, Evalue=4e-25,
Organism=Homo sapiens, GI223468566, Length=294, Percent_Identity=30.2721088435374, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI5032093, Length=421, Percent_Identity=28.0285035629454, Blast_Score=112, Evalue=9e-25,
Organism=Homo sapiens, GI40254478, Length=487, Percent_Identity=23.6139630390144, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI194239697, Length=473, Percent_Identity=26.8498942917548, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI262359914, Length=369, Percent_Identity=24.390243902439, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI301601644, Length=176, Percent_Identity=31.8181818181818, Blast_Score=82, Evalue=1e-15,
Organism=Escherichia coli, GI1790514, Length=415, Percent_Identity=38.3132530120482, Blast_Score=252, Evalue=4e-68,
Organism=Escherichia coli, GI1789947, Length=423, Percent_Identity=34.9881796690307, Blast_Score=223, Evalue=1e-59,
Organism=Escherichia coli, GI1788024, Length=404, Percent_Identity=25.4950495049505, Blast_Score=95, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI71996953, Length=474, Percent_Identity=26.1603375527426, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI193206654, Length=462, Percent_Identity=24.025974025974, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17537407, Length=463, Percent_Identity=24.622030237581, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI71983099, Length=491, Percent_Identity=25.2545824847251, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI71983106, Length=491, Percent_Identity=25.2545824847251, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI193206505, Length=459, Percent_Identity=23.3115468409586, Blast_Score=111, Evalue=8e-25,
Organism=Caenorhabditis elegans, GI17541374, Length=191, Percent_Identity=31.9371727748691, Blast_Score=88, Evalue=9e-18,
Organism=Drosophila melanogaster, GI24583025, Length=478, Percent_Identity=24.2677824267782, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI17137668, Length=478, Percent_Identity=24.2677824267782, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24583023, Length=478, Percent_Identity=24.2677824267782, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI281360483, Length=429, Percent_Identity=24.009324009324, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI17137666, Length=429, Percent_Identity=24.009324009324, Blast_Score=88, Evalue=1e-17,
Organism=Drosophila melanogaster, GI281360481, Length=429, Percent_Identity=24.009324009324, Blast_Score=88, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 46643; Mature: 46643

Theoretical pI: Translated: 7.29; Mature: 7.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQKKLLKYILIAMVSGILVGWACHSALNETQTAEIASYFKIVTDVFLRLIKMIIGPLVF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ATIVSGLISMGKSSSLGSVTLKAMSWFIGASLISLLLGMGLANFFQPGAGMNLAIPVEHV
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEE
DIGVTTANLTLQNFITHIFPRSFAEAMANNEILQILVFSIFFGAALAYVNHQTKEGTVIA
EEEEEEHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
RLIDELARIMFKITDYVMAFAPVAVFAAIAAAIAVKGPMLIIDYSVFIGQFYTGLALLWL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHH
VLISVGYIFLKKDVFRLLGIMREPAALAFATSSSESAYPKIIAGLNKFGVPKRISSFVLP
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHCCCHHHHHHHHHC
LGYSFNLDGSMMYMSFAVLFIAQAYNIDLSFTQQIMILLTLMITSKGIAGVSRASIVVIA
CCCEECCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
ATLTMFKLPEAGILLILAIDQFLDMGRSATNVIGNSIATAVVAKTEAHEHDEVIEDAHIV
HHHHHHHCCCCCEEHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
DDIVPVSTTGHS
HHCCCCCCCCCC
>Mature Secondary Structure
MNQKKLLKYILIAMVSGILVGWACHSALNETQTAEIASYFKIVTDVFLRLIKMIIGPLVF
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ATIVSGLISMGKSSSLGSVTLKAMSWFIGASLISLLLGMGLANFFQPGAGMNLAIPVEHV
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEE
DIGVTTANLTLQNFITHIFPRSFAEAMANNEILQILVFSIFFGAALAYVNHQTKEGTVIA
EEEEEEHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
RLIDELARIMFKITDYVMAFAPVAVFAAIAAAIAVKGPMLIIDYSVFIGQFYTGLALLWL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHH
VLISVGYIFLKKDVFRLLGIMREPAALAFATSSSESAYPKIIAGLNKFGVPKRISSFVLP
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHCCCHHHHHHHHHC
LGYSFNLDGSMMYMSFAVLFIAQAYNIDLSFTQQIMILLTLMITSKGIAGVSRASIVVIA
CCCEECCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
ATLTMFKLPEAGILLILAIDQFLDMGRSATNVIGNSIATAVVAKTEAHEHDEVIEDAHIV
HHHHHHHCCCCCEEHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
DDIVPVSTTGHS
HHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA