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The map label for this gene is pyrD

Identifier: 50084503

GI number: 50084503

Start: 1319012

End: 1320016

Strand: Direct

Name: pyrD

Synonym: ACIAD1321

Alternate gene names: 50084503

Gene position: 1319012-1320016 (Clockwise)

Preceding gene: 50084502

Following gene: 50084504

Centisome position: 36.65

GC content: 39.2

Gene sequence:

>1005_bases
ATGTTATATTCGCTTGCTCGCCCTATGTTGTTTTCTTTGGCACCCGAGCGTGCACATGAATTAACTTTGTCTATGTTAAA
AACAGCCCATAAAATGGGAATGTTACGCCAGACTATTCAACCAAAGCCTGTCACTTGTATGGGGATTGAATTCCCAAATC
CAGTAGGTTTAGCAGCGGGTCTAGATAAAAATGGCGCATATATTGACGCTCTAGCTGGATTAGGCTTTGGTTTTATTGAA
ATAGGCACGATTACTCCTCGTCCTCAATCGGGTAATCCAAAACCAAGATTATTTAGAATCCCAGAAGCAAAAGCAATCAT
CAACCGCATGGGGTTTAATAATGAGGGGGTTGATCAGCTGGTTGAAAATGTCAAAGCTGCAAAATTCAGAGGTATTTTAG
GGATCAATATTGGTAAAAATGCCGATACACCTGTCGAAAATGCAGTTGATGATTATCTGATTTGTCTGGAAAAAGTATAT
AACTACGCTTCCTATATCACTGTTAATATTTCATCTCCAAATACCAAAAACCTCCGTAGCTTACAAAGTGGTGATGCTCT
AACGGAGTTACTTGAAACGCTGAAGAAACGTCAGTTAGAACTTGCCGAGCAATATCATCATTATGTGCCTTTAGTTCTCA
AGGTTGCACCAGATTTAACCCATGAAGATATTCAGTTTATCTCTGAGCAGTTACTGACTTTTAAAATTGATGGTCTGATT
GTGACCAATACGACTTTGTCTCGTGAAGGTGTAGAAAATTTGCCTTTTGGTAATGAAGCGGGTGGTTTGTCAGGCGCTCC
TGTTTTTGAAAAAAGTACCGAATGTTTACGTAGCTTTGCAAAAGTTTTAAATGATCAGATTCCATTAATTGGTGTTGGCG
GTATTACTCAAGGTGAGCATGCTGTAGCTAAAAAAGATGCAGGAGCCAGCCTTGTACAAATCTATAGTGGCCTCATATAT
ACTGGACCAGATTTAATCAAAGAATGCGTGAGTGCTATTACTTAA

Upstream 100 bases:

>100_bases
GTACATTAAGTCTTTAAAATAAAGCGTTCACAAGCATGGTGTTTTATGAGACCTGTGCCTATAATAGGTGCACCTCAAAA
GCTAAAGACTTTGATCGACT

Downstream 100 bases:

>100_bases
ACGATGAATACGCTTGATATCATCATTCTGATATTTTTGCTCATTGGAGGGCTCAACGGTTTGCGACAAGGATTTATTAA
AGCCTTTGCGAACTTGATTG

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase

Number of amino acids: Translated: 334; Mature: 334

Protein sequence:

>334_residues
MLYSLARPMLFSLAPERAHELTLSMLKTAHKMGMLRQTIQPKPVTCMGIEFPNPVGLAAGLDKNGAYIDALAGLGFGFIE
IGTITPRPQSGNPKPRLFRIPEAKAIINRMGFNNEGVDQLVENVKAAKFRGILGINIGKNADTPVENAVDDYLICLEKVY
NYASYITVNISSPNTKNLRSLQSGDALTELLETLKKRQLELAEQYHHYVPLVLKVAPDLTHEDIQFISEQLLTFKIDGLI
VTNTTLSREGVENLPFGNEAGGLSGAPVFEKSTECLRSFAKVLNDQIPLIGVGGITQGEHAVAKKDAGASLVQIYSGLIY
TGPDLIKECVSAIT

Sequences:

>Translated_334_residues
MLYSLARPMLFSLAPERAHELTLSMLKTAHKMGMLRQTIQPKPVTCMGIEFPNPVGLAAGLDKNGAYIDALAGLGFGFIE
IGTITPRPQSGNPKPRLFRIPEAKAIINRMGFNNEGVDQLVENVKAAKFRGILGINIGKNADTPVENAVDDYLICLEKVY
NYASYITVNISSPNTKNLRSLQSGDALTELLETLKKRQLELAEQYHHYVPLVLKVAPDLTHEDIQFISEQLLTFKIDGLI
VTNTTLSREGVENLPFGNEAGGLSGAPVFEKSTECLRSFAKVLNDQIPLIGVGGITQGEHAVAKKDAGASLVQIYSGLIY
TGPDLIKECVSAIT
>Mature_334_residues
MLYSLARPMLFSLAPERAHELTLSMLKTAHKMGMLRQTIQPKPVTCMGIEFPNPVGLAAGLDKNGAYIDALAGLGFGFIE
IGTITPRPQSGNPKPRLFRIPEAKAIINRMGFNNEGVDQLVENVKAAKFRGILGINIGKNADTPVENAVDDYLICLEKVY
NYASYITVNISSPNTKNLRSLQSGDALTELLETLKKRQLELAEQYHHYVPLVLKVAPDLTHEDIQFISEQLLTFKIDGLI
VTNTTLSREGVENLPFGNEAGGLSGAPVFEKSTECLRSFAKVLNDQIPLIGVGGITQGEHAVAKKDAGASLVQIYSGLIY
TGPDLIKECVSAIT

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily

Homologues:

Organism=Homo sapiens, GI45006951, Length=330, Percent_Identity=40.3030303030303, Blast_Score=234, Evalue=6e-62,
Organism=Escherichia coli, GI1787177, Length=336, Percent_Identity=55.952380952381, Blast_Score=376, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI17509475, Length=306, Percent_Identity=43.1372549019608, Blast_Score=221, Evalue=3e-58,
Organism=Drosophila melanogaster, GI281361352, Length=342, Percent_Identity=39.4736842105263, Blast_Score=244, Evalue=5e-65,
Organism=Drosophila melanogaster, GI17137316, Length=342, Percent_Identity=39.4736842105263, Blast_Score=244, Evalue=5e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRD_ACIAD (Q6FCL9)

Other databases:

- EMBL:   CR543861
- RefSeq:   YP_046013.1
- ProteinModelPortal:   Q6FCL9
- SMR:   Q6FCL9
- STRING:   Q6FCL9
- GeneID:   2879565
- GenomeReviews:   CR543861_GR
- KEGG:   aci:ACIAD1321
- NMPDR:   fig|62977.3.peg.495
- eggNOG:   COG0167
- HOGENOM:   HBG351027
- OMA:   SYVTVNI
- PhylomeDB:   Q6FCL9
- ProtClustDB:   PRK05286
- BioCyc:   ASP62977:ACIAD1321-MONOMER
- HAMAP:   MF_00225
- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295
- Gene3D:   G3DSA:3.20.20.70
- PIRSF:   PIRSF000164
- TIGRFAMs:   TIGR01036

Pfam domain/function: PF01180 DHO_dh

EC number: =1.3.5.2

Molecular weight: Translated: 36308; Mature: 36308

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00911 DHODEHASE_1; PS00912 DHODEHASE_2

Important sites: ACT_SITE 172-172

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLYSLARPMLFSLAPERAHELTLSMLKTAHKMGMLRQTIQPKPVTCMGIEFPNPVGLAAG
CCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCC
LDKNGAYIDALAGLGFGFIEIGTITPRPQSGNPKPRLFRIPEAKAIINRMGFNNEGVDQL
CCCCCCHHHHHHHCCCCEEEECCCCCCCCCCCCCCCEEECCHHHHHHHHCCCCCCCHHHH
VENVKAAKFRGILGINIGKNADTPVENAVDDYLICLEKVYNYASYITVNISSPNTKNLRS
HHHHHHHHHCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHH
LQSGDALTELLETLKKRQLELAEQYHHYVPLVLKVAPDLTHEDIQFISEQLLTFKIDGLI
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHEEEECCEE
VTNTTLSREGVENLPFGNEAGGLSGAPVFEKSTECLRSFAKVLNDQIPLIGVGGITQGEH
EECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCH
AVAKKDAGASLVQIYSGLIYTGPDLIKECVSAIT
HHHHCCCCHHHHHHHHCHHCCCHHHHHHHHHHCC
>Mature Secondary Structure
MLYSLARPMLFSLAPERAHELTLSMLKTAHKMGMLRQTIQPKPVTCMGIEFPNPVGLAAG
CCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCC
LDKNGAYIDALAGLGFGFIEIGTITPRPQSGNPKPRLFRIPEAKAIINRMGFNNEGVDQL
CCCCCCHHHHHHHCCCCEEEECCCCCCCCCCCCCCCEEECCHHHHHHHHCCCCCCCHHHH
VENVKAAKFRGILGINIGKNADTPVENAVDDYLICLEKVYNYASYITVNISSPNTKNLRS
HHHHHHHHHCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHH
LQSGDALTELLETLKKRQLELAEQYHHYVPLVLKVAPDLTHEDIQFISEQLLTFKIDGLI
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHEEEECCEE
VTNTTLSREGVENLPFGNEAGGLSGAPVFEKSTECLRSFAKVLNDQIPLIGVGGITQGEH
EECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCH
AVAKKDAGASLVQIYSGLIYTGPDLIKECVSAIT
HHHHCCCCHHHHHHHHCHHCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA