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The map label for this gene is ilvD

Identifier: 50084452

GI number: 50084452

Start: 1265604

End: 1267433

Strand: Direct

Name: ilvD

Synonym: ACIAD1266

Alternate gene names: 50084452

Gene position: 1265604-1267433 (Clockwise)

Preceding gene: 50084451

Following gene: 50084453

Centisome position: 35.17

GC content: 43.66

Gene sequence:

>1830_bases
ATGCCTGATTATCGTTCTAAAACATCGACACACGGAAGAAACATGGCTGGTGCACGTGGATTATGGCGTGCAACAGGAAT
GAAAGATGAAGATTTTGGAAAACCGATTATTGCTGTCGTCAACTCATTTACTCAGTTTGTACCAGGCCATGTTCATTTAA
AAGATCTTGGGCAAATGGTTGCAGAACAAATTCAGGCGGCTGGTGGTGTAGCAAAAGAGTTTAATACCATTGCTGTAGAT
GACGGAATTGCCATGGGACATGATGGCATGTTGTATTCATTGCCGTCACGTGATCTGATTGCAGATTCTGTTGAATACAT
GGTCAATGCGCATTGTGCAGATGCAATGGTATGTATCTCTAACTGTGACAAAATTACACCAGGCATGCTCATGGCTGCAA
TGCGCTTGAATATTCCAGTGGTTTTCGTTTCTGGCGGACCAATGGAAGCGGGTAAAGTCAAATTCCGTGGTAATGAAAAA
GCGATTGATTTAGTCGATGCCATGGTTGTTGCTGCGGATGACAGTTATACCGATGAAGAAGTTCAGGCATTTGAACGCTC
GGCTTGCCCAACATGTGGTTCATGCTCGGGAATGTTTACTGCAAACTCAATGAACTGTTTAACCGAAGCACTTGGATTGT
CTTTGCCAGGAAATGGTTCAATTGTTGCGACACATGCCAACCGTAAAAAGTTATTCTTAAAAGCGGGTGAGTTGATTGTT
AGCTTGGCAAAACGCTACTACGAACAAGATGATAGCAGTATTTTGCCACGTTCAATTGCGACCAAAGCTGCCTATGAAAA
TGCCATGACTTTAGATATCGCGATGGGTGGTTCAACCAATACGGTATTACATTTGCTTGCTGCTGCAAGTGAAGCCGAAG
TGGACTTCACCATGGACGATATTGATCGTTTATCACGTAATGTTCCTGTTCTTTGTAAGGTTGCACCAGCAAAACAAGAT
GTTCACATGGAAGACGTACACCGTGCAGGTGGGATCATGTCAATTCTGGGTGAGCTGGATCGTGCTAAATTGCTGAATAC
AACAGTGAGCACTGTGCATGAAAAGACCTTGCAAGATGCGCTCAATAAATGGGATATTATTCGTACCGAAGACGCAGATG
TCTATGAATTTTTCCGCTCTTCACCAGGTGGTGTGCCAACTCAAGTGGCATTCTCACAAAACCGTTATTATTCGACACTT
GATGGTGACCGTGAAAATGGTGTGATTCGTAATGCCGAACATGCTTTTTCTAAAGACGGTGGTTTGGCTGTACTTTATGG
CAACATCGCGCTAGAGGGTTGTATTGTAAAAACGGCTGGTGTAGACGAATCGATTTTAAAATTTAATGGTACTGCACGCG
TTTTTGAAAGTCAGGATGCTGCGGTAGAAGCAATCTTGGGTAATGAGATTAAAGCGGGCGATGTTGTCGTGATTCGTTAC
GAAGGTCCACGTGGTGGCCCAGGTATGCAAGAAATGTTATACCCAACCAGCTATCTAAAATCTAAAGGTTTAGGTAAGGA
TTGCGCCCTTATTACAGATGGTCGTTTCTCTGGTGGTTCATCGGGCTTATCAATTGGGCATATTTCGCCAGAAGCAGCAG
AAGGCGGTGCTATTGGTTTGGTAGAAGATGGTGATTTGATTGAAATCGATATTCCAAACCGTAGCATGAATCTAAAAGTA
GATGATGAAACGCTGGCTGCTCGCCGTAAAGCTCAAGATGAGAAAGGCTGGAAACCAGTGGAAGAGCGTAAACGTAAGGT
TTCTAAAGCCCTGAAAGTTTATGCTATGCATACAACAAGCGCAGCGAAAGGTGCGGTACGCATATTATAA

Upstream 100 bases:

>100_bases
TGATGTGTCATATTTCGGCTGATCATCTCTTGTGTATCAGTCTCTTTCAGCCAGAGTGAATGTTTATTCATCTCAAGCAC
AACTTGTTGGAAACACCTAC

Downstream 100 bases:

>100_bases
ATGATCATGAATAGATAAAATTAATTTCAATTTTTTCTATTTAACCTGTAATTTCTTTGTAGATATGCATTGAGATTACA
GGTTTTTTTATGACTGATGA

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD 1

Number of amino acids: Translated: 609; Mature: 608

Protein sequence:

>609_residues
MPDYRSKTSTHGRNMAGARGLWRATGMKDEDFGKPIIAVVNSFTQFVPGHVHLKDLGQMVAEQIQAAGGVAKEFNTIAVD
DGIAMGHDGMLYSLPSRDLIADSVEYMVNAHCADAMVCISNCDKITPGMLMAAMRLNIPVVFVSGGPMEAGKVKFRGNEK
AIDLVDAMVVAADDSYTDEEVQAFERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSIVATHANRKKLFLKAGELIV
SLAKRYYEQDDSSILPRSIATKAAYENAMTLDIAMGGSTNTVLHLLAAASEAEVDFTMDDIDRLSRNVPVLCKVAPAKQD
VHMEDVHRAGGIMSILGELDRAKLLNTTVSTVHEKTLQDALNKWDIIRTEDADVYEFFRSSPGGVPTQVAFSQNRYYSTL
DGDRENGVIRNAEHAFSKDGGLAVLYGNIALEGCIVKTAGVDESILKFNGTARVFESQDAAVEAILGNEIKAGDVVVIRY
EGPRGGPGMQEMLYPTSYLKSKGLGKDCALITDGRFSGGSSGLSIGHISPEAAEGGAIGLVEDGDLIEIDIPNRSMNLKV
DDETLAARRKAQDEKGWKPVEERKRKVSKALKVYAMHTTSAAKGAVRIL

Sequences:

>Translated_609_residues
MPDYRSKTSTHGRNMAGARGLWRATGMKDEDFGKPIIAVVNSFTQFVPGHVHLKDLGQMVAEQIQAAGGVAKEFNTIAVD
DGIAMGHDGMLYSLPSRDLIADSVEYMVNAHCADAMVCISNCDKITPGMLMAAMRLNIPVVFVSGGPMEAGKVKFRGNEK
AIDLVDAMVVAADDSYTDEEVQAFERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSIVATHANRKKLFLKAGELIV
SLAKRYYEQDDSSILPRSIATKAAYENAMTLDIAMGGSTNTVLHLLAAASEAEVDFTMDDIDRLSRNVPVLCKVAPAKQD
VHMEDVHRAGGIMSILGELDRAKLLNTTVSTVHEKTLQDALNKWDIIRTEDADVYEFFRSSPGGVPTQVAFSQNRYYSTL
DGDRENGVIRNAEHAFSKDGGLAVLYGNIALEGCIVKTAGVDESILKFNGTARVFESQDAAVEAILGNEIKAGDVVVIRY
EGPRGGPGMQEMLYPTSYLKSKGLGKDCALITDGRFSGGSSGLSIGHISPEAAEGGAIGLVEDGDLIEIDIPNRSMNLKV
DDETLAARRKAQDEKGWKPVEERKRKVSKALKVYAMHTTSAAKGAVRIL
>Mature_608_residues
PDYRSKTSTHGRNMAGARGLWRATGMKDEDFGKPIIAVVNSFTQFVPGHVHLKDLGQMVAEQIQAAGGVAKEFNTIAVDD
GIAMGHDGMLYSLPSRDLIADSVEYMVNAHCADAMVCISNCDKITPGMLMAAMRLNIPVVFVSGGPMEAGKVKFRGNEKA
IDLVDAMVVAADDSYTDEEVQAFERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSIVATHANRKKLFLKAGELIVS
LAKRYYEQDDSSILPRSIATKAAYENAMTLDIAMGGSTNTVLHLLAAASEAEVDFTMDDIDRLSRNVPVLCKVAPAKQDV
HMEDVHRAGGIMSILGELDRAKLLNTTVSTVHEKTLQDALNKWDIIRTEDADVYEFFRSSPGGVPTQVAFSQNRYYSTLD
GDRENGVIRNAEHAFSKDGGLAVLYGNIALEGCIVKTAGVDESILKFNGTARVFESQDAAVEAILGNEIKAGDVVVIRYE
GPRGGPGMQEMLYPTSYLKSKGLGKDCALITDGRFSGGSSGLSIGHISPEAAEGGAIGLVEDGDLIEIDIPNRSMNLKVD
DETLAARRKAQDEKGWKPVEERKRKVSKALKVYAMHTTSAAKGAVRIL

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family

Homologues:

Organism=Escherichia coli, GI48994964, Length=610, Percent_Identity=74.4262295081967, Blast_Score=936, Evalue=0.0,
Organism=Escherichia coli, GI2367371, Length=571, Percent_Identity=30.4728546409807, Blast_Score=194, Evalue=2e-50,
Organism=Escherichia coli, GI1786464, Length=540, Percent_Identity=31.1111111111111, Blast_Score=182, Evalue=6e-47,
Organism=Escherichia coli, GI1788157, Length=549, Percent_Identity=28.9617486338798, Blast_Score=179, Evalue=7e-46,
Organism=Saccharomyces cerevisiae, GI6322476, Length=604, Percent_Identity=39.4039735099338, Blast_Score=362, Evalue=1e-100,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ILVD1_ACIAD (Q6FCR9)

Other databases:

- EMBL:   CR543861
- RefSeq:   YP_045962.1
- STRING:   Q6FCR9
- GeneID:   2877811
- GenomeReviews:   CR543861_GR
- KEGG:   aci:ACIAD1266
- NMPDR:   fig|62977.3.peg.391
- eggNOG:   COG0129
- HOGENOM:   HBG671001
- OMA:   KVPCLSK
- PhylomeDB:   Q6FCR9
- ProtClustDB:   PRK12448
- BioCyc:   ASP62977:ACIAD1266-MONOMER
- HAMAP:   MF_00012
- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558
- PANTHER:   PTHR21000
- TIGRFAMs:   TIGR00110

Pfam domain/function: PF00920 ILVD_EDD; SSF52016 Aconitase/3IPM_dehydase_swvl

EC number: =4.2.1.9

Molecular weight: Translated: 65405; Mature: 65274

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: PS00886 ILVD_EDD_1; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDYRSKTSTHGRNMAGARGLWRATGMKDEDFGKPIIAVVNSFTQFVPGHVHLKDLGQMV
CCCCCCCCCCCCCCCCCCCCHHHHCCCCCHHHCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AEQIQAAGGVAKEFNTIAVDDGIAMGHDGMLYSLPSRDLIADSVEYMVNAHCADAMVCIS
HHHHHHHCCHHHHCCEEEECCCEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMLMAAMRLNIPVVFVSGGPMEAGKVKFRGNEKAIDLVDAMVVAADDSYTDEE
CCCCCCHHHHHHHHHCCCCEEEEECCCCCCCEEEECCCCCHHHHHHEEEEECCCCCCHHH
VQAFERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSIVATHANRKKLFLKAGELIV
HHHHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEEECCCCEEEHHHHHHHH
SLAKRYYEQDDSSILPRSIATKAAYENAMTLDIAMGGSTNTVLHLLAAASEAEVDFTMDD
HHHHHHHHCCCCCCCCHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHCCCCCEEECHHH
IDRLSRNVPVLCKVAPAKQDVHMEDVHRAGGIMSILGELDRAKLLNTTVSTVHEKTLQDA
HHHHHCCCCEEEEECCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LNKWDIIRTEDADVYEFFRSSPGGVPTQVAFSQNRYYSTLDGDRENGVIRNAEHAFSKDG
HHHCCEEECCCCHHHHHHHCCCCCCCEEEEECCCCEEECCCCCCCCCCEECCHHHHCCCC
GLAVLYGNIALEGCIVKTAGVDESILKFNGTARVFESQDAAVEAILGNEIKAGDVVVIRY
CEEEEECCEEEEEEEEEECCCCHHHHEECCCEEEECCCCHHHHHHHCCCCCCCCEEEEEE
EGPRGGPGMQEMLYPTSYLKSKGLGKDCALITDGRFSGGSSGLSIGHISPEAAEGGAIGL
CCCCCCCCHHHHHCCHHHHHHCCCCCCEEEEECCCCCCCCCCEEEECCCCCCCCCCEEEE
VEDGDLIEIDIPNRSMNLKVDDETLAARRKAQDEKGWKPVEERKRKVSKALKVYAMHTTS
EECCCEEEEECCCCCEEEEECHHHHHHHHHHCHHCCCCCHHHHHHHHHHHHEEEEEECCC
AAKGAVRIL
CCCCCEEEC
>Mature Secondary Structure 
PDYRSKTSTHGRNMAGARGLWRATGMKDEDFGKPIIAVVNSFTQFVPGHVHLKDLGQMV
CCCCCCCCCCCCCCCCCCCHHHHCCCCCHHHCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AEQIQAAGGVAKEFNTIAVDDGIAMGHDGMLYSLPSRDLIADSVEYMVNAHCADAMVCIS
HHHHHHHCCHHHHCCEEEECCCEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMLMAAMRLNIPVVFVSGGPMEAGKVKFRGNEKAIDLVDAMVVAADDSYTDEE
CCCCCCHHHHHHHHHCCCCEEEEECCCCCCCEEEECCCCCHHHHHHEEEEECCCCCCHHH
VQAFERSACPTCGSCSGMFTANSMNCLTEALGLSLPGNGSIVATHANRKKLFLKAGELIV
HHHHHHHCCCCCCCCCCCEECCHHHHHHHHHCCCCCCCCCEEEEECCCCEEEHHHHHHHH
SLAKRYYEQDDSSILPRSIATKAAYENAMTLDIAMGGSTNTVLHLLAAASEAEVDFTMDD
HHHHHHHHCCCCCCCCHHHHHHHHHCCCEEEEEEECCCHHHHHHHHHHCCCCCEEECHHH
IDRLSRNVPVLCKVAPAKQDVHMEDVHRAGGIMSILGELDRAKLLNTTVSTVHEKTLQDA
HHHHHCCCCEEEEECCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LNKWDIIRTEDADVYEFFRSSPGGVPTQVAFSQNRYYSTLDGDRENGVIRNAEHAFSKDG
HHHCCEEECCCCHHHHHHHCCCCCCCEEEEECCCCEEECCCCCCCCCCEECCHHHHCCCC
GLAVLYGNIALEGCIVKTAGVDESILKFNGTARVFESQDAAVEAILGNEIKAGDVVVIRY
CEEEEECCEEEEEEEEEECCCCHHHHEECCCEEEECCCCHHHHHHHCCCCCCCCEEEEEE
EGPRGGPGMQEMLYPTSYLKSKGLGKDCALITDGRFSGGSSGLSIGHISPEAAEGGAIGL
CCCCCCCCHHHHHCCHHHHHHCCCCCCEEEEECCCCCCCCCCEEEECCCCCCCCCCEEEE
VEDGDLIEIDIPNRSMNLKVDDETLAARRKAQDEKGWKPVEERKRKVSKALKVYAMHTTS
EECCCEEEEECCCCCEEEEECHHHHHHHHHHCHHCCCCCHHHHHHHHHHHHEEEEEECCC
AAKGAVRIL
CCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA