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Identifier: 50084431

GI number: 50084431

Start: 1245224

End: 1246222

Strand: Direct

Name: add

Synonym: ACIAD1245

Alternate gene names: 50084431

Gene position: 1245224-1246222 (Clockwise)

Preceding gene: 50084430

Following gene: 50084433

Centisome position: 34.6

GC content: 37.64

Gene sequence:

>999_bases
ATGAATCAATCAGAACTTATTCGTGCCTTGCCTAAAGCTGAATTGCACGTACATATCGAAGGTACATTTGAGCCTGAACT
TATGTTTGAGATTGCGCAGCGTAATCATATCGATATTCCTTATAAATCTGTAGAGGAAATTAAAAAAGCTTATAATTTTC
ATAATTTACAGTCATTTTTAGATATCTATTATGCAGGGGCTAATGTTCTGATCAATGAGCAGGATTTTTATGATCTTGCG
TGGGCTTACTTTAAAAAATGTGCCGAAGATCGTGTGGTACATACAGAGATGTTCTTTGATCCACAAACCCATACCGAGCG
CGGTGTTTCATTTGAAATTGTGCTTAATGGTTTGAAGCGAGCATGTAAAGATGCAAAGGAGCATTTAGGCATTAGCTCAC
ATTTGATCATGTGCTTTTTGCGTCATTTAAGCGAAGAAGATGCATTTAAAACGCTTGAACAGGCGTTACCTTACAAAGCT
GATATTATTGCAGTTGGACTTGATTCCAGCGAAGTTGGTCATCCGCCTTCAAAGTTTGCTCGGGTATTTGAAAAAGCACG
TGAAGAAGGCTTTTTGGTTGTGGCACACGCTGGTGAAGAAGGGCCGCCTGAATACGTATGGGAAGCATTAGATTTACTGA
AGGTGAATCGTATTGATCATGGGGTACGTTCAGAAGAAGATCCTGCTTTAATGCAAAGATTGATTCAGGAAAAAATGCCT
CTAACCGTGTGTCCTTTAAGCAATTTGAAACTTTGTGTTGTAAACGATATGAAAGAACACAATATTCGTCGTTTGCTTAA
TCAGGGGGTACATGTGACAGTAAATTCTGATGATCCTTCTTACTTTGGGGGATATATGAACGATAACTTTGTGGCAATTC
AAGCTGCTTTAGATTTATCAAATGAAGAGTTGAAAAAACTGGCCATTAATTCTTTTGAAGCTTCATTTATTGATGAAGAA
GAGAAACAAAACTGGATTGAAGAAATCAACCAGATTTAA

Upstream 100 bases:

>100_bases
TACTTTGGGCTTTTAAATTTGCAGCATTTGGCGGTTAATTTTTCTTATTCAACTAAAGGGTGTAGAGTAATACACCCTTT
TTCTTTTTTCTGGAGTCTGG

Downstream 100 bases:

>100_bases
ATAAAAAAATGCATCTTAAAAGATGCATTTTTTATGTCTATAAATACCCGATGTTCAACGAGATTGTTTGATCATGCTCT
TAAGAACATTATCTTTATCA

Product: adenosine deaminase

Products: NA

Alternate protein names: Adenosine aminohydrolase

Number of amino acids: Translated: 332; Mature: 332

Protein sequence:

>332_residues
MNQSELIRALPKAELHVHIEGTFEPELMFEIAQRNHIDIPYKSVEEIKKAYNFHNLQSFLDIYYAGANVLINEQDFYDLA
WAYFKKCAEDRVVHTEMFFDPQTHTERGVSFEIVLNGLKRACKDAKEHLGISSHLIMCFLRHLSEEDAFKTLEQALPYKA
DIIAVGLDSSEVGHPPSKFARVFEKAREEGFLVVAHAGEEGPPEYVWEALDLLKVNRIDHGVRSEEDPALMQRLIQEKMP
LTVCPLSNLKLCVVNDMKEHNIRRLLNQGVHVTVNSDDPSYFGGYMNDNFVAIQAALDLSNEELKKLAINSFEASFIDEE
EKQNWIEEINQI

Sequences:

>Translated_332_residues
MNQSELIRALPKAELHVHIEGTFEPELMFEIAQRNHIDIPYKSVEEIKKAYNFHNLQSFLDIYYAGANVLINEQDFYDLA
WAYFKKCAEDRVVHTEMFFDPQTHTERGVSFEIVLNGLKRACKDAKEHLGISSHLIMCFLRHLSEEDAFKTLEQALPYKA
DIIAVGLDSSEVGHPPSKFARVFEKAREEGFLVVAHAGEEGPPEYVWEALDLLKVNRIDHGVRSEEDPALMQRLIQEKMP
LTVCPLSNLKLCVVNDMKEHNIRRLLNQGVHVTVNSDDPSYFGGYMNDNFVAIQAALDLSNEELKKLAINSFEASFIDEE
EKQNWIEEINQI
>Mature_332_residues
MNQSELIRALPKAELHVHIEGTFEPELMFEIAQRNHIDIPYKSVEEIKKAYNFHNLQSFLDIYYAGANVLINEQDFYDLA
WAYFKKCAEDRVVHTEMFFDPQTHTERGVSFEIVLNGLKRACKDAKEHLGISSHLIMCFLRHLSEEDAFKTLEQALPYKA
DIIAVGLDSSEVGHPPSKFARVFEKAREEGFLVVAHAGEEGPPEYVWEALDLLKVNRIDHGVRSEEDPALMQRLIQEKMP
LTVCPLSNLKLCVVNDMKEHNIRRLLNQGVHVTVNSDDPSYFGGYMNDNFVAIQAALDLSNEELKKLAINSFEASFIDEE
EKQNWIEEINQI

Specific function: Unknown

COG id: COG1816

COG function: function code F; Adenosine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosine and AMP deaminases family

Homologues:

Organism=Homo sapiens, GI47078295, Length=339, Percent_Identity=26.5486725663717, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI29029552, Length=121, Percent_Identity=33.0578512396694, Blast_Score=68, Evalue=9e-12,
Organism=Homo sapiens, GI29029550, Length=121, Percent_Identity=31.404958677686, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1787910, Length=330, Percent_Identity=28.4848484848485, Blast_Score=155, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI32565969, Length=338, Percent_Identity=25.4437869822485, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17538512, Length=338, Percent_Identity=25.4437869822485, Blast_Score=91, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6324188, Length=341, Percent_Identity=45.7478005865103, Blast_Score=311, Evalue=9e-86,
Organism=Drosophila melanogaster, GI24645260, Length=336, Percent_Identity=22.0238095238095, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ADD_ACIAD (Q6FCU0)

Other databases:

- EMBL:   CR543861
- RefSeq:   YP_045941.1
- HSSP:   Q7RMV2
- ProteinModelPortal:   Q6FCU0
- SMR:   Q6FCU0
- STRING:   Q6FCU0
- GeneID:   2879613
- GenomeReviews:   CR543861_GR
- KEGG:   aci:ACIAD1245
- NMPDR:   fig|62977.3.peg.314
- eggNOG:   COG1816
- HOGENOM:   HBG630382
- OMA:   YFGGYLN
- PhylomeDB:   Q6FCU0
- ProtClustDB:   PRK09358
- BioCyc:   ASP62977:ACIAD1245-MONOMER
- HAMAP:   MF_00540
- InterPro:   IPR001365
- InterPro:   IPR006330
- PANTHER:   PTHR11409
- TIGRFAMs:   TIGR01430

Pfam domain/function: PF00962 A_deaminase

EC number: =3.5.4.4

Molecular weight: Translated: 38109; Mature: 38109

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: PS00485 A_DEAMINASE

Important sites: ACT_SITE 199-199 BINDING 18-18 BINDING 20-20 BINDING 278-278

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQSELIRALPKAELHVHIEGTFEPELMFEIAQRNHIDIPYKSVEEIKKAYNFHNLQSFL
CCHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHCHHHHHHHH
DIYYAGANVLINEQDFYDLAWAYFKKCAEDRVVHTEMFFDPQTHTERGVSFEIVLNGLKR
HHHHCCCCEEECCCHHHHHHHHHHHHHHHCCEEEHHEEECCCCCHHCCCCHHHHHHHHHH
ACKDAKEHLGISSHLIMCFLRHLSEEDAFKTLEQALPYKADIIAVGLDSSEVGHPPSKFA
HHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCHHHHH
RVFEKAREEGFLVVAHAGEEGPPEYVWEALDLLKVNRIDHGVRSEEDPALMQRLIQEKMP
HHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCC
LTVCPLSNLKLCVVNDMKEHNIRRLLNQGVHVTVNSDDPSYFGGYMNDNFVAIQAALDLS
EEEECCCCCEEEEECCHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCEEEEEEECCCC
NEELKKLAINSFEASFIDEEEKQNWIEEINQI
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MNQSELIRALPKAELHVHIEGTFEPELMFEIAQRNHIDIPYKSVEEIKKAYNFHNLQSFL
CCHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHCHHHHHHHH
DIYYAGANVLINEQDFYDLAWAYFKKCAEDRVVHTEMFFDPQTHTERGVSFEIVLNGLKR
HHHHCCCCEEECCCHHHHHHHHHHHHHHHCCEEEHHEEECCCCCHHCCCCHHHHHHHHHH
ACKDAKEHLGISSHLIMCFLRHLSEEDAFKTLEQALPYKADIIAVGLDSSEVGHPPSKFA
HHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCHHHHH
RVFEKAREEGFLVVAHAGEEGPPEYVWEALDLLKVNRIDHGVRSEEDPALMQRLIQEKMP
HHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCC
LTVCPLSNLKLCVVNDMKEHNIRRLLNQGVHVTVNSDDPSYFGGYMNDNFVAIQAALDLS
EEEECCCCCEEEEECCHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCEEEEEEECCCC
NEELKKLAINSFEASFIDEEEKQNWIEEINQI
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA