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The map label for this gene is proY [H]

Identifier: 50084359

GI number: 50084359

Start: 1165244

End: 1166626

Strand: Direct

Name: proY [H]

Synonym: ACIAD1168

Alternate gene names: 50084359

Gene position: 1165244-1166626 (Clockwise)

Preceding gene: 50084358

Following gene: 50084360

Centisome position: 32.38

GC content: 42.52

Gene sequence:

>1383_bases
ATGTCACAACACTCCACTTTACAGCGGGGATTAAATACCCGTCATATCCGTTTTTTGGCATTAGGTTCAGCTATTGGAAC
AGGACTGTTTTATGGCTCGGCAACGGCAATAAAAATGGCGGGGCCTTCGGTATTATTAGCCTATATGGTAGCTGGGATTG
CGATTTATATCGTGATGCGTGCACTCGGTGAAATGGCTGTTCATAATCCTGTATCTGGTTCGTTTAGTCATTATGCTTCC
CAATACATCGGTCTTCTTGCGGGCTTCACAACAGGATGGACTTACGTCTTTGAAATGATCATTGTGGCACTTGCAGACGT
GACGGCATTTGGTATCTATATGGGGTTTTGGTATCCCGATGTACCGCGCTGGATCTGGATATTATCACTCATCATGTTTT
TGGGCGCGATCAATCTGATTCATGTCAAAGTCTTTGGTGAATTAGAGTTTTGGTTATCGATGGTCAAAGTGACTGCAATT
GTTGCCATGATTCTGGGTGGCTTAGGTCTGATGTTCTATGGTTTTCATACAGATCATGCCTCCTTTACGCCAGGTATTCA
AAATTTGTGGATCCATGATGGCTTCATGCCAAACGGCATTGCAGGATTAGTTGCATGTTTGTCTGTAGTTGTGTTTGCAT
TTGGTGGCATTGAAATTATTGGAATCACTGCGGGTGAGTCACAAGATCCAAAGACAACATTACCGAAGGCAATCAATGCG
GTACCTGTACGTATCTTACTATTTTATGTATTAACCATTTTTGTCCTTATGTCGATTTTTCCATGGAACCAGATTGGAAG
TCAGGGTAGTCCGTTTGTACAAATTTTCGAAAATCTGGGCATTGGTTCTGCTGCAACGGTATTAAATATTGTGGTCATTA
CCGCTGCAATTTCGGCAATTAACAGTGACGTATTTGGTGCAGGTCGTATGCTGTATGGCATGTCGAATCGTGGTCAGGCA
CCACAAATTTTTCAGAAACTTTCTAAAAATGGCGTGCCATGGATGACCATTGTAGTCATGGCTGGTGTGTTACTGGTTGG
GGTCGTGCTTAATTACCTGATTCCAGAAAACGTATTCATCATCATTGCATCTATCGCGACATTTGCAACCGTTTGGGTCT
GGTTAATGATCTTGGTTTCTCAAGTTGCCATGCGTCGAAAGTTGTCAAAAGCAGAAATTAAGGCGCTTGATTTTCCTGTG
GTTGGTTGGCCCTATGCACCTGCGTTTGCCATTGTATTTATGTTGTTTATTTTAGCGATGATGGGGTATTTCCCAGATTC
AAGACCTGCCATATATGTAGGCGCTATCTGGTTAATCCTACTCTGGATTGCTTACATGGTTTGGGTAAAGCCAAATACAA
TTAAGACAGACATGGAGCTTTAA

Upstream 100 bases:

>100_bases
TCCTTAAAGCTATTACCGAGTTTATCTGAAGTGTGATCTATAAAATGGTCACATACAGTGGTCGAATCTAACTAAATTTC
CTCAAAGATTGGAGATTAAA

Downstream 100 bases:

>100_bases
TATAATACTAAAATAGAAAGCTGATTTTATCCAATTTAAAACTGCTCAAGCCTAAACAAGCCTTGAGCAGATCAAGGATA
TAATAATGAAAATTTTATGG

Product: amino acid APC transporter

Products: Proton [Cytoplasm]; L-proline [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 460; Mature: 459

Protein sequence:

>460_residues
MSQHSTLQRGLNTRHIRFLALGSAIGTGLFYGSATAIKMAGPSVLLAYMVAGIAIYIVMRALGEMAVHNPVSGSFSHYAS
QYIGLLAGFTTGWTYVFEMIIVALADVTAFGIYMGFWYPDVPRWIWILSLIMFLGAINLIHVKVFGELEFWLSMVKVTAI
VAMILGGLGLMFYGFHTDHASFTPGIQNLWIHDGFMPNGIAGLVACLSVVVFAFGGIEIIGITAGESQDPKTTLPKAINA
VPVRILLFYVLTIFVLMSIFPWNQIGSQGSPFVQIFENLGIGSAATVLNIVVITAAISAINSDVFGAGRMLYGMSNRGQA
PQIFQKLSKNGVPWMTIVVMAGVLLVGVVLNYLIPENVFIIIASIATFATVWVWLMILVSQVAMRRKLSKAEIKALDFPV
VGWPYAPAFAIVFMLFILAMMGYFPDSRPAIYVGAIWLILLWIAYMVWVKPNTIKTDMEL

Sequences:

>Translated_460_residues
MSQHSTLQRGLNTRHIRFLALGSAIGTGLFYGSATAIKMAGPSVLLAYMVAGIAIYIVMRALGEMAVHNPVSGSFSHYAS
QYIGLLAGFTTGWTYVFEMIIVALADVTAFGIYMGFWYPDVPRWIWILSLIMFLGAINLIHVKVFGELEFWLSMVKVTAI
VAMILGGLGLMFYGFHTDHASFTPGIQNLWIHDGFMPNGIAGLVACLSVVVFAFGGIEIIGITAGESQDPKTTLPKAINA
VPVRILLFYVLTIFVLMSIFPWNQIGSQGSPFVQIFENLGIGSAATVLNIVVITAAISAINSDVFGAGRMLYGMSNRGQA
PQIFQKLSKNGVPWMTIVVMAGVLLVGVVLNYLIPENVFIIIASIATFATVWVWLMILVSQVAMRRKLSKAEIKALDFPV
VGWPYAPAFAIVFMLFILAMMGYFPDSRPAIYVGAIWLILLWIAYMVWVKPNTIKTDMEL
>Mature_459_residues
SQHSTLQRGLNTRHIRFLALGSAIGTGLFYGSATAIKMAGPSVLLAYMVAGIAIYIVMRALGEMAVHNPVSGSFSHYASQ
YIGLLAGFTTGWTYVFEMIIVALADVTAFGIYMGFWYPDVPRWIWILSLIMFLGAINLIHVKVFGELEFWLSMVKVTAIV
AMILGGLGLMFYGFHTDHASFTPGIQNLWIHDGFMPNGIAGLVACLSVVVFAFGGIEIIGITAGESQDPKTTLPKAINAV
PVRILLFYVLTIFVLMSIFPWNQIGSQGSPFVQIFENLGIGSAATVLNIVVITAAISAINSDVFGAGRMLYGMSNRGQAP
QIFQKLSKNGVPWMTIVVMAGVLLVGVVLNYLIPENVFIIIASIATFATVWVWLMILVSQVAMRRKLSKAEIKALDFPVV
GWPYAPAFAIVFMLFILAMMGYFPDSRPAIYVGAIWLILLWIAYMVWVKPNTIKTDMEL

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of proline [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI181337167, Length=327, Percent_Identity=26.2996941896024, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI71999149, Length=342, Percent_Identity=22.8070175438596, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI110347453, Length=372, Percent_Identity=25, Blast_Score=73, Evalue=4e-13,
Organism=Escherichia coli, GI1786602, Length=446, Percent_Identity=59.8654708520179, Blast_Score=526, Evalue=1e-151,
Organism=Escherichia coli, GI1786789, Length=448, Percent_Identity=42.6339285714286, Blast_Score=378, Evalue=1e-106,
Organism=Escherichia coli, GI1786302, Length=455, Percent_Identity=43.0769230769231, Blast_Score=370, Evalue=1e-103,
Organism=Escherichia coli, GI48994972, Length=449, Percent_Identity=42.0935412026726, Blast_Score=352, Evalue=4e-98,
Organism=Escherichia coli, GI1790653, Length=452, Percent_Identity=39.1592920353982, Blast_Score=332, Evalue=4e-92,
Organism=Escherichia coli, GI87081915, Length=417, Percent_Identity=36.9304556354916, Blast_Score=294, Evalue=7e-81,
Organism=Escherichia coli, GI87081708, Length=463, Percent_Identity=34.5572354211663, Blast_Score=290, Evalue=1e-79,
Organism=Escherichia coli, GI1789017, Length=428, Percent_Identity=36.214953271028, Blast_Score=269, Evalue=4e-73,
Organism=Escherichia coli, GI1788480, Length=470, Percent_Identity=35.1063829787234, Blast_Score=249, Evalue=2e-67,
Organism=Escherichia coli, GI87081869, Length=217, Percent_Identity=22.5806451612903, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI87082023, Length=351, Percent_Identity=21.9373219373219, Blast_Score=69, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17540018, Length=416, Percent_Identity=25.9615384615385, Blast_Score=75, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17531343, Length=369, Percent_Identity=25.7452574525745, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17532491, Length=408, Percent_Identity=22.7941176470588, Blast_Score=72, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6324061, Length=466, Percent_Identity=30.9012875536481, Blast_Score=212, Evalue=1e-55,
Organism=Saccharomyces cerevisiae, GI6324990, Length=500, Percent_Identity=30.2, Blast_Score=196, Evalue=5e-51,
Organism=Saccharomyces cerevisiae, GI6320772, Length=440, Percent_Identity=30.6818181818182, Blast_Score=196, Evalue=8e-51,
Organism=Saccharomyces cerevisiae, GI6324924, Length=474, Percent_Identity=29.1139240506329, Blast_Score=180, Evalue=4e-46,
Organism=Saccharomyces cerevisiae, GI6324059, Length=476, Percent_Identity=29.2016806722689, Blast_Score=177, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6322892, Length=414, Percent_Identity=28.743961352657, Blast_Score=169, Evalue=7e-43,
Organism=Saccharomyces cerevisiae, GI6324553, Length=400, Percent_Identity=30.5, Blast_Score=161, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6319824, Length=477, Percent_Identity=26.2054507337526, Blast_Score=161, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6321629, Length=411, Percent_Identity=25.5474452554745, Blast_Score=154, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6320251, Length=417, Percent_Identity=26.8585131894484, Blast_Score=153, Evalue=5e-38,
Organism=Saccharomyces cerevisiae, GI6319542, Length=416, Percent_Identity=25.4807692307692, Blast_Score=143, Evalue=5e-35,
Organism=Saccharomyces cerevisiae, GI6320717, Length=439, Percent_Identity=22.3234624145786, Blast_Score=137, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6319543, Length=407, Percent_Identity=24.3243243243243, Blast_Score=134, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6321053, Length=476, Percent_Identity=25.2100840336134, Blast_Score=134, Evalue=4e-32,
Organism=Saccharomyces cerevisiae, GI6319608, Length=454, Percent_Identity=24.8898678414097, Blast_Score=134, Evalue=4e-32,
Organism=Saccharomyces cerevisiae, GI6322967, Length=403, Percent_Identity=24.8138957816377, Blast_Score=134, Evalue=4e-32,
Organism=Saccharomyces cerevisiae, GI6324981, Length=403, Percent_Identity=26.5508684863524, Blast_Score=129, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6320364, Length=528, Percent_Identity=23.6742424242424, Blast_Score=118, Evalue=2e-27,
Organism=Drosophila melanogaster, GI161077963, Length=352, Percent_Identity=26.1363636363636, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24667468, Length=403, Percent_Identity=23.3250620347395, Blast_Score=78, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 50367; Mature: 50236

Theoretical pI: Translated: 9.26; Mature: 9.26

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQHSTLQRGLNTRHIRFLALGSAIGTGLFYGSATAIKMAGPSVLLAYMVAGIAIYIVMR
CCCHHHHHHCCCCCCEEEEEEHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHH
ALGEMAVHNPVSGSFSHYASQYIGLLAGFTTGWTYVFEMIIVALADVTAFGIYMGFWYPD
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
VPRWIWILSLIMFLGAINLIHVKVFGELEFWLSMVKVTAIVAMILGGLGLMFYGFHTDHA
HHHHHHHHHHHHHHHHHHHEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCC
SFTPGIQNLWIHDGFMPNGIAGLVACLSVVVFAFGGIEIIGITAGESQDPKTTLPKAINA
CCCCCHHHHCEECCCCCCCHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCHHHHHHHHH
VPVRILLFYVLTIFVLMSIFPWNQIGSQGSPFVQIFENLGIGSAATVLNIVVITAAISAI
HHHHHHHHHHHHHHHHHHHCCCHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
NSDVFGAGRMLYGMSNRGQAPQIFQKLSKNGVPWMTIVVMAGVLLVGVVLNYLIPENVFI
CCCHHCCCHHEECCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHH
IIASIATFATVWVWLMILVSQVAMRRKLSKAEIKALDFPVVGWPYAPAFAIVFMLFILAM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
MGYFPDSRPAIYVGAIWLILLWIAYMVWVKPNTIKTDMEL
HCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
SQHSTLQRGLNTRHIRFLALGSAIGTGLFYGSATAIKMAGPSVLLAYMVAGIAIYIVMR
CCHHHHHHCCCCCCEEEEEEHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHH
ALGEMAVHNPVSGSFSHYASQYIGLLAGFTTGWTYVFEMIIVALADVTAFGIYMGFWYPD
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
VPRWIWILSLIMFLGAINLIHVKVFGELEFWLSMVKVTAIVAMILGGLGLMFYGFHTDHA
HHHHHHHHHHHHHHHHHHHEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCC
SFTPGIQNLWIHDGFMPNGIAGLVACLSVVVFAFGGIEIIGITAGESQDPKTTLPKAINA
CCCCCHHHHCEECCCCCCCHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCHHHHHHHHH
VPVRILLFYVLTIFVLMSIFPWNQIGSQGSPFVQIFENLGIGSAATVLNIVVITAAISAI
HHHHHHHHHHHHHHHHHHHCCCHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
NSDVFGAGRMLYGMSNRGQAPQIFQKLSKNGVPWMTIVVMAGVLLVGVVLNYLIPENVFI
CCCHHCCCHHEECCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHH
IIASIATFATVWVWLMILVSQVAMRRKLSKAEIKALDFPVVGWPYAPAFAIVFMLFILAM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
MGYFPDSRPAIYVGAIWLILLWIAYMVWVKPNTIKTDMEL
HCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-proline [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-proline [Periplasm] = Proton [Cytoplasm] + L-proline [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]