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The map label for this gene is adk

Identifier: 50084300

GI number: 50084300

Start: 1094957

End: 1095616

Strand: Direct

Name: adk

Synonym: ACIAD1105

Alternate gene names: 50084300

Gene position: 1094957-1095616 (Clockwise)

Preceding gene: 50084299

Following gene: 50084301

Centisome position: 30.43

GC content: 43.33

Gene sequence:

>660_bases
ATGCGCATTATTTTACTCGGACCACCTGGAGCAGGTAAAGGTACTCAGGCTCAGTTGATCTGTAAGCGCTATGATATCCC
ACAAATTTCAACCGGTGATATGCTCCGAGCTGCGATTCGTGAAGGAACTGAACTTGGCTTAAAAGCTAAAAGTGTGATGG
AGTCTGGTGGACTGGTATCAGATGAGCTAATTATTGGTCTGGTAAAAGAGCGTATTGCTCAACCCGATTGCGAAAACGGC
TGCATTTTCGATGGTTTCCCGCGTACGATTCCACAAGCTGAAGCTTTGGAAAATGCAGGAATTACAATTGATCACGTGAT
TGAGATCGCTGTACCAGACGAAGAAATTGTAAAGCGTCTCTCTGGTCGACGTCAGCATCCAGCTTCTGGTCGTGTCTATC
ACATTGAGTACAATCCACCTAAAGTGGAAGGTAAAGATGATGTGACAGGTGAAGAACTTGTTCAGCGTCCAGATGATTTA
GAAGAAACCATTCGTAAGCGTCTTGGGTCTTACCACAGTGAAACTGAACAATTGGTTGGTTTCTATCAAGGTCGTGCAGC
GTCTGGTGAAAATGCACCGACATATAACAAATTAGATGGCTTACGTACCATTGATGTGGTTCAAAAAGATCTATTTGCTA
TTTTAGACGAGACTAAATAA

Upstream 100 bases:

>100_bases
TGTTTGTCGCTTTCTTATAATTTAGATGCTGTAGACATGACATATCAATGGTCATATTCCAAGGCATCGTGATGATTGTT
TTTAATGAGGATGCTTTCTT

Downstream 100 bases:

>100_bases
TTTATTTGGTTTTTTGCTAATATAAAAGAGTCCTGATTATTGCAGGACTCTTTTATATTTTGAGGATATCCTGTTTGCTA
AAAATTGCTCTAATTATTCT

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 219; Mature: 219

Protein sequence:

>219_residues
MRIILLGPPGAGKGTQAQLICKRYDIPQISTGDMLRAAIREGTELGLKAKSVMESGGLVSDELIIGLVKERIAQPDCENG
CIFDGFPRTIPQAEALENAGITIDHVIEIAVPDEEIVKRLSGRRQHPASGRVYHIEYNPPKVEGKDDVTGEELVQRPDDL
EETIRKRLGSYHSETEQLVGFYQGRAASGENAPTYNKLDGLRTIDVVQKDLFAILDETK

Sequences:

>Translated_219_residues
MRIILLGPPGAGKGTQAQLICKRYDIPQISTGDMLRAAIREGTELGLKAKSVMESGGLVSDELIIGLVKERIAQPDCENG
CIFDGFPRTIPQAEALENAGITIDHVIEIAVPDEEIVKRLSGRRQHPASGRVYHIEYNPPKVEGKDDVTGEELVQRPDDL
EETIRKRLGSYHSETEQLVGFYQGRAASGENAPTYNKLDGLRTIDVVQKDLFAILDETK
>Mature_219_residues
MRIILLGPPGAGKGTQAQLICKRYDIPQISTGDMLRAAIREGTELGLKAKSVMESGGLVSDELIIGLVKERIAQPDCENG
CIFDGFPRTIPQAEALENAGITIDHVIEIAVPDEEIVKRLSGRRQHPASGRVYHIEYNPPKVEGKDDVTGEELVQRPDDL
EETIRKRLGSYHSETEQLVGFYQGRAASGENAPTYNKLDGLRTIDVVQKDLFAILDETK

Specific function: This small ubiquitous enzyme is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI7524346, Length=221, Percent_Identity=43.4389140271493, Blast_Score=198, Evalue=3e-51,
Organism=Homo sapiens, GI4502013, Length=221, Percent_Identity=43.4389140271493, Blast_Score=198, Evalue=3e-51,
Organism=Homo sapiens, GI19923437, Length=185, Percent_Identity=44.3243243243243, Blast_Score=167, Evalue=9e-42,
Organism=Homo sapiens, GI310110345, Length=185, Percent_Identity=41.6216216216216, Blast_Score=144, Evalue=6e-35,
Organism=Homo sapiens, GI53832003, Length=185, Percent_Identity=41.6216216216216, Blast_Score=144, Evalue=6e-35,
Organism=Homo sapiens, GI8051579, Length=185, Percent_Identity=41.6216216216216, Blast_Score=144, Evalue=6e-35,
Organism=Homo sapiens, GI53832001, Length=185, Percent_Identity=41.6216216216216, Blast_Score=144, Evalue=6e-35,
Organism=Homo sapiens, GI22749187, Length=183, Percent_Identity=31.6939890710383, Blast_Score=105, Evalue=2e-23,
Organism=Homo sapiens, GI4502011, Length=185, Percent_Identity=31.3513513513514, Blast_Score=93, Evalue=1e-19,
Organism=Homo sapiens, GI21450759, Length=148, Percent_Identity=31.0810810810811, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI237858799, Length=148, Percent_Identity=31.0810810810811, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI28144897, Length=184, Percent_Identity=28.804347826087, Blast_Score=77, Evalue=9e-15,
Organism=Homo sapiens, GI28144899, Length=184, Percent_Identity=28.804347826087, Blast_Score=77, Evalue=1e-14,
Organism=Escherichia coli, GI1786680, Length=215, Percent_Identity=62.7906976744186, Blast_Score=277, Evalue=3e-76,
Organism=Caenorhabditis elegans, GI17552384, Length=187, Percent_Identity=47.5935828877005, Blast_Score=186, Evalue=9e-48,
Organism=Caenorhabditis elegans, GI17537943, Length=185, Percent_Identity=34.5945945945946, Blast_Score=124, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI17567503, Length=185, Percent_Identity=31.3513513513514, Blast_Score=91, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6320432, Length=188, Percent_Identity=52.1276595744681, Blast_Score=209, Evalue=3e-55,
Organism=Saccharomyces cerevisiae, GI6321018, Length=189, Percent_Identity=40.7407407407407, Blast_Score=135, Evalue=6e-33,
Organism=Saccharomyces cerevisiae, GI6322828, Length=187, Percent_Identity=27.2727272727273, Blast_Score=71, Evalue=1e-13,
Organism=Drosophila melanogaster, GI22026816, Length=208, Percent_Identity=45.6730769230769, Blast_Score=190, Evalue=5e-49,
Organism=Drosophila melanogaster, GI17737899, Length=185, Percent_Identity=44.8648648648649, Blast_Score=147, Evalue=5e-36,
Organism=Drosophila melanogaster, GI24645822, Length=185, Percent_Identity=44.8648648648649, Blast_Score=147, Evalue=5e-36,
Organism=Drosophila melanogaster, GI17647141, Length=182, Percent_Identity=29.1208791208791, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24663208, Length=182, Percent_Identity=29.1208791208791, Blast_Score=85, Evalue=3e-17,
Organism=Drosophila melanogaster, GI221459597, Length=186, Percent_Identity=26.3440860215054, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21356893, Length=186, Percent_Identity=26.3440860215054, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_ACIAD (Q6FD71)

Other databases:

- EMBL:   CR543861
- RefSeq:   YP_045810.1
- ProteinModelPortal:   Q6FD71
- SMR:   Q6FD71
- STRING:   Q6FD71
- GeneID:   2878206
- GenomeReviews:   CR543861_GR
- KEGG:   aci:ACIAD1105
- NMPDR:   fig|62977.3.peg.1303
- eggNOG:   COG0563
- HOGENOM:   HBG630208
- OMA:   RTYHVKY
- PhylomeDB:   Q6FD71
- ProtClustDB:   PRK00279
- BioCyc:   ASP62977:ACIAD1105-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid

EC number: =2.7.4.3

Molecular weight: Translated: 24093; Mature: 24093

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIILLGPPGAGKGTQAQLICKRYDIPQISTGDMLRAAIREGTELGLKAKSVMESGGLVS
CEEEEECCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHCCHHCCHHHHHHHHCCCCCH
DELIIGLVKERIAQPDCENGCIFDGFPRTIPQAEALENAGITIDHVIEIAVPDEEIVKRL
HHHHHHHHHHHHCCCCCCCCCEECCCCCCCCHHHHHHHCCCCHHHEEEEECCCHHHHHHH
SGRRQHPASGRVYHIEYNPPKVEGKDDVTGEELVQRPDDLEETIRKRLGSYHSETEQLVG
HCCCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHH
FYQGRAASGENAPTYNKLDGLRTIDVVQKDLFAILDETK
HHHCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRIILLGPPGAGKGTQAQLICKRYDIPQISTGDMLRAAIREGTELGLKAKSVMESGGLVS
CEEEEECCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHCCHHCCHHHHHHHHCCCCCH
DELIIGLVKERIAQPDCENGCIFDGFPRTIPQAEALENAGITIDHVIEIAVPDEEIVKRL
HHHHHHHHHHHHCCCCCCCCCEECCCCCCCCHHHHHHHCCCCHHHEEEEECCCHHHHHHH
SGRRQHPASGRVYHIEYNPPKVEGKDDVTGEELVQRPDDLEETIRKRLGSYHSETEQLVG
HCCCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHH
FYQGRAASGENAPTYNKLDGLRTIDVVQKDLFAILDETK
HHHCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA