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The map label for this gene is fur [H]

Identifier: 50084118

GI number: 50084118

Start: 891728

End: 892168

Strand: Direct

Name: fur [H]

Synonym: ACIAD0910

Alternate gene names: 50084118

Gene position: 891728-892168 (Clockwise)

Preceding gene: 50084116

Following gene: 50084121

Centisome position: 24.78

GC content: 34.92

Gene sequence:

>441_bases
ATGCCGATTTCCAATCAAGATTTACGAAAAGCTGGACTGAAAGTCACCCTTCCTCGAATTAAGATTTTGGAATTATTAGA
AAATTCAAAACAACATCATTTGAGTGCTGAAGATATTTATAAAACTTTGCTTGAACAAGGCGAAGATGTGGGTTTAGCAA
CAGTTTACCGTGTATTAACTCAGTTTGAAGCAGCAGGAATTATTCAGCGTCATCATTTTGAAAACAATCATTCTGTTTTT
GAAATTATGCAAGAAGACCACCACGATCATTTAGTATGTTTAAATTGTGGGAAAGTTGTTGAATTTACAAATGAAGTTAT
TGAACATGAGCAACATACAGTAGCTGAAAAGCATGGCTTTACGCTGACTGGCCATTCTTTAAATTTATATGGTTATTGCG
ATGCGACTGAGTGTCAGGAAGCATATCGTAAAAAGCAGTAA

Upstream 100 bases:

>100_bases
ATCCCGATAAATTATGATGCATTTGATCCAAGGATAGATCATACTGCATCTAAACACGATTGCCTATTCCAACTTGAGAT
TTGTTGAGAGACCTTTTTTT

Downstream 100 bases:

>100_bases
AATCACATAAATACAACAATTAAAAGAGGGCAAAATTGCCCTCTTTTATTTGAGATTACGGCGTTGACCATCAAAAGTCA
TTTTCCGTTCCATTTCGGAC

Product: negative regulator of ferric iron uptake

Products: NA

Alternate protein names: Ferric uptake regulator [H]

Number of amino acids: Translated: 146; Mature: 145

Protein sequence:

>146_residues
MPISNQDLRKAGLKVTLPRIKILELLENSKQHHLSAEDIYKTLLEQGEDVGLATVYRVLTQFEAAGIIQRHHFENNHSVF
EIMQEDHHDHLVCLNCGKVVEFTNEVIEHEQHTVAEKHGFTLTGHSLNLYGYCDATECQEAYRKKQ

Sequences:

>Translated_146_residues
MPISNQDLRKAGLKVTLPRIKILELLENSKQHHLSAEDIYKTLLEQGEDVGLATVYRVLTQFEAAGIIQRHHFENNHSVF
EIMQEDHHDHLVCLNCGKVVEFTNEVIEHEQHTVAEKHGFTLTGHSLNLYGYCDATECQEAYRKKQ
>Mature_145_residues
PISNQDLRKAGLKVTLPRIKILELLENSKQHHLSAEDIYKTLLEQGEDVGLATVYRVLTQFEAAGIIQRHHFENNHSVFE
IMQEDHHDHLVCLNCGKVVEFTNEVIEHEQHTVAEKHGFTLTGHSLNLYGYCDATECQEAYRKKQ

Specific function: Acts as a global negative controlling element, employing Fe(2+) as a cofactor to bind the operator of the repressed genes [H]

COG id: COG0735

COG function: function code P; Fe2+/Zn2+ uptake regulation proteins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Fur family [H]

Homologues:

Organism=Escherichia coli, GI1786899, Length=140, Percent_Identity=59.2857142857143, Blast_Score=181, Evalue=2e-47,

Paralogues:

None

Copy number: 3432 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002481
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01475 FUR [H]

EC number: NA

Molecular weight: Translated: 16805; Mature: 16674

Theoretical pI: Translated: 6.22; Mature: 6.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPISNQDLRKAGLKVTLPRIKILELLENSKQHHLSAEDIYKTLLEQGEDVGLATVYRVLT
CCCCCHHHHHCCCEEECHHHHHHHHHHCCHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHH
QFEAAGIIQRHHFENNHSVFEIMQEDHHDHLVCLNCGKVVEFTNEVIEHEQHTVAEKHGF
HHHHHHHHHHHHCCCCCHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCC
TLTGHSLNLYGYCDATECQEAYRKKQ
EEECCCEEEEEECCHHHHHHHHHCCC
>Mature Secondary Structure 
PISNQDLRKAGLKVTLPRIKILELLENSKQHHLSAEDIYKTLLEQGEDVGLATVYRVLT
CCCCHHHHHCCCEEECHHHHHHHHHHCCHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHH
QFEAAGIIQRHHFENNHSVFEIMQEDHHDHLVCLNCGKVVEFTNEVIEHEQHTVAEKHGF
HHHHHHHHHHHHCCCCCHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHCCC
TLTGHSLNLYGYCDATECQEAYRKKQ
EEECCCEEEEEECCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8200525 [H]