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The map label for this gene is algC [H]

Identifier: 50084111

GI number: 50084111

Start: 885462

End: 886886

Strand: Direct

Name: algC [H]

Synonym: ACIAD0902

Alternate gene names: 50084111

Gene position: 885462-886886 (Clockwise)

Preceding gene: 50084110

Following gene: 50084112

Centisome position: 24.61

GC content: 42.04

Gene sequence:

>1425_bases
ATGGATATCAAGCAGGCTTTTCCGTTTCAGATTTTTCGTGCATACGATATTCGTGGAAAACTGAATATATTGACACCTGA
ACGGATCGTTGCAATTGCTCATGGATTGGCATCTCAATATTTGGATGCAGAGCAAACATGTGTCGTTATTGGATATGATG
CCCGTTTAACCAGTCCCTCTTATGCACAGTTAATTCAGTCTGTATTTGAGCAACGTGGTCTAACGGTGATCAACATGGGG
TGTTGTTCTACGCCCCTAATGTACTTCACGGCACGCCACTACGAAGGAAATGGAGTGATGATCACGGCCAGCCATAACCC
AAAATCAGACAATGGCATTAAGTGGCTCATTGATAACGAACCACCATCACCAGAGATGATTCAGCAAGTAGGGTGGTCAG
CTTCCCAGATTCGGGTGGATGCGTCAGATTTTCAATCTTGTACTGCAATACCACATCAAATCAAAACCGAGTTTTTTAAT
GTTTATCAAGATACGATCCTTCAAGATATTCATTTAAACCGATCCTTTAAAGTGGTATTGGATGGTTTACATGGTTCCGC
AGGTCAATGTGCAAAAATTTTACTCGAAAAACTCGGATGTGACGTGATTGCACTGCGCTGCGAGGCAAATGGTGAATTTC
CAGATCATGCACCTGATCCTTCTCAGGCAAAGCATCTTGAGTCTTTGCGCCAGCAGATCATATTGCAGCGGGCTGACATC
GGAATTGCACTTGATGGAGACGGAGACCGTTTGGTGGTGATTGATGAACACACCAACATCATTAGTGCAGATCGGCTCAT
TTCATTGTTTAGTCATTTATGCTTGCAAACATTACCCGCACGTGAAATTGTATTTGACGTAAAATGTTCAACGATGGTCC
GAAATACCGTATTGAACTGTTCTGGCACACCTAAGATGATTCGTACTGGCAGCAGCTTTTTACGCAAGTATCTGGCTCAA
TCACAAGGACATGCGATTTTTGGTGGCGAATATGCAGGTCATTATGTGTTTAATGACGGGCGTGGTTTTGGTTTTGATGA
TGGCATTTATGCAGCTTTGCGCTTGCTCGAATATTTAAGCCAATCTCCACAGCAAACCATTTTTCAATTATTACAAGCCT
ATCCTGAGCGTTGTTCTACTGAAGATCTGTATATTAGTACGCATCATGCGAACCCAGAAGTCGTTTTAAAATATATAGAG
CAGTTTGCACAACATATACCTGCACAGTTAAGTAAAATTGATGGTATCCGTCTTGATTTTGAAGACGGTTTTGGCATTAT
TCGAGCATCCAACACGGGTGAATATTTTACTGTGCGTTTTGATGCGGATACGCCCCAGCGTTTAGCTGAAATCAGACAAA
TATTTATCGTCATGCTGCAAAAGCAATACCCTAACATTGCACATGATCTTTCACAGGCTTATTAA

Upstream 100 bases:

>100_bases
GTGTTTTGCAATATTTCCCTTCCACTTTACCTCAAGCGTTTTCATGTACTTATTTCAATTTTTATTATTTTGCTAATATA
GGCATAAGAAGAATTTACTT

Downstream 100 bases:

>100_bases
GGAGAGGCGAATGCCACATCAGCATAAAGGTATCGATAAGGCAAAAATTTTGACTGAAGCTTTACCTTATATTCAACGTT
TTTCTGGTAAAACGCTGGTG

Product: phosphomannomutase

Products: NA

Alternate protein names: PMM / PGM [H]

Number of amino acids: Translated: 474; Mature: 474

Protein sequence:

>474_residues
MDIKQAFPFQIFRAYDIRGKLNILTPERIVAIAHGLASQYLDAEQTCVVIGYDARLTSPSYAQLIQSVFEQRGLTVINMG
CCSTPLMYFTARHYEGNGVMITASHNPKSDNGIKWLIDNEPPSPEMIQQVGWSASQIRVDASDFQSCTAIPHQIKTEFFN
VYQDTILQDIHLNRSFKVVLDGLHGSAGQCAKILLEKLGCDVIALRCEANGEFPDHAPDPSQAKHLESLRQQIILQRADI
GIALDGDGDRLVVIDEHTNIISADRLISLFSHLCLQTLPAREIVFDVKCSTMVRNTVLNCSGTPKMIRTGSSFLRKYLAQ
SQGHAIFGGEYAGHYVFNDGRGFGFDDGIYAALRLLEYLSQSPQQTIFQLLQAYPERCSTEDLYISTHHANPEVVLKYIE
QFAQHIPAQLSKIDGIRLDFEDGFGIIRASNTGEYFTVRFDADTPQRLAEIRQIFIVMLQKQYPNIAHDLSQAY

Sequences:

>Translated_474_residues
MDIKQAFPFQIFRAYDIRGKLNILTPERIVAIAHGLASQYLDAEQTCVVIGYDARLTSPSYAQLIQSVFEQRGLTVINMG
CCSTPLMYFTARHYEGNGVMITASHNPKSDNGIKWLIDNEPPSPEMIQQVGWSASQIRVDASDFQSCTAIPHQIKTEFFN
VYQDTILQDIHLNRSFKVVLDGLHGSAGQCAKILLEKLGCDVIALRCEANGEFPDHAPDPSQAKHLESLRQQIILQRADI
GIALDGDGDRLVVIDEHTNIISADRLISLFSHLCLQTLPAREIVFDVKCSTMVRNTVLNCSGTPKMIRTGSSFLRKYLAQ
SQGHAIFGGEYAGHYVFNDGRGFGFDDGIYAALRLLEYLSQSPQQTIFQLLQAYPERCSTEDLYISTHHANPEVVLKYIE
QFAQHIPAQLSKIDGIRLDFEDGFGIIRASNTGEYFTVRFDADTPQRLAEIRQIFIVMLQKQYPNIAHDLSQAY
>Mature_474_residues
MDIKQAFPFQIFRAYDIRGKLNILTPERIVAIAHGLASQYLDAEQTCVVIGYDARLTSPSYAQLIQSVFEQRGLTVINMG
CCSTPLMYFTARHYEGNGVMITASHNPKSDNGIKWLIDNEPPSPEMIQQVGWSASQIRVDASDFQSCTAIPHQIKTEFFN
VYQDTILQDIHLNRSFKVVLDGLHGSAGQCAKILLEKLGCDVIALRCEANGEFPDHAPDPSQAKHLESLRQQIILQRADI
GIALDGDGDRLVVIDEHTNIISADRLISLFSHLCLQTLPAREIVFDVKCSTMVRNTVLNCSGTPKMIRTGSSFLRKYLAQ
SQGHAIFGGEYAGHYVFNDGRGFGFDDGIYAALRLLEYLSQSPQQTIFQLLQAYPERCSTEDLYISTHHANPEVVLKYIE
QFAQHIPAQLSKIDGIRLDFEDGFGIIRASNTGEYFTVRFDADTPQRLAEIRQIFIVMLQKQYPNIAHDLSQAY

Specific function: The phosphomannomutase activity produces a precursor for alginate polymerization. The alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics. Also involved in core-LPS biosynthesis due to it

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Escherichia coli, GI1788361, Length=463, Percent_Identity=27.2138228941685, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI1789566, Length=358, Percent_Identity=24.5810055865922, Blast_Score=100, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2; =5.4.2.8 [H]

Molecular weight: Translated: 53174; Mature: 53174

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIKQAFPFQIFRAYDIRGKLNILTPERIVAIAHGLASQYLDAEQTCVVIGYDARLTSPS
CCCCCCCCHHHEEEEECCCEEEEECHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCH
YAQLIQSVFEQRGLTVINMGCCSTPLMYFTARHYEGNGVMITASHNPKSDNGIKWLIDNE
HHHHHHHHHHHCCCEEEECCCCCCCHHHHEEEEEECCEEEEEECCCCCCCCCEEEEECCC
PPSPEMIQQVGWSASQIRVDASDFQSCTAIPHQIKTEFFNVYQDTILQDIHLNRSFKVVL
CCCHHHHHHHCCCHHEEEECHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEE
DGLHGSAGQCAKILLEKLGCDVIALRCEANGEFPDHAPDPSQAKHLESLRQQIILQRADI
ECCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
GIALDGDGDRLVVIDEHTNIISADRLISLFSHLCLQTLPAREIVFDVKCSTMVRNTVLNC
CEEEECCCCEEEEEECCCCEEHHHHHHHHHHHHHHHHCCCHHEEEEEHHHHHHHHHHCCC
SGTPKMIRTGSSFLRKYLAQSQGHAIFGGEYAGHYVFNDGRGFGFDDGIYAALRLLEYLS
CCCHHHHHCCHHHHHHHHHHCCCCEEECCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHH
QSPQQTIFQLLQAYPERCSTEDLYISTHHANPEVVLKYIEQFAQHIPAQLSKIDGIRLDF
CCHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHCCHHHHHCCCEEEEE
EDGFGIIRASNTGEYFTVRFDADTPQRLAEIRQIFIVMLQKQYPNIAHDLSQAY
CCCCEEEEECCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHCC
>Mature Secondary Structure
MDIKQAFPFQIFRAYDIRGKLNILTPERIVAIAHGLASQYLDAEQTCVVIGYDARLTSPS
CCCCCCCCHHHEEEEECCCEEEEECHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCH
YAQLIQSVFEQRGLTVINMGCCSTPLMYFTARHYEGNGVMITASHNPKSDNGIKWLIDNE
HHHHHHHHHHHCCCEEEECCCCCCCHHHHEEEEEECCEEEEEECCCCCCCCCEEEEECCC
PPSPEMIQQVGWSASQIRVDASDFQSCTAIPHQIKTEFFNVYQDTILQDIHLNRSFKVVL
CCCHHHHHHHCCCHHEEEECHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEE
DGLHGSAGQCAKILLEKLGCDVIALRCEANGEFPDHAPDPSQAKHLESLRQQIILQRADI
ECCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCC
GIALDGDGDRLVVIDEHTNIISADRLISLFSHLCLQTLPAREIVFDVKCSTMVRNTVLNC
CEEEECCCCEEEEEECCCCEEHHHHHHHHHHHHHHHHCCCHHEEEEEHHHHHHHHHHCCC
SGTPKMIRTGSSFLRKYLAQSQGHAIFGGEYAGHYVFNDGRGFGFDDGIYAALRLLEYLS
CCCHHHHHCCHHHHHHHHHHCCCCEEECCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHH
QSPQQTIFQLLQAYPERCSTEDLYISTHHANPEVVLKYIEQFAQHIPAQLSKIDGIRLDF
CCHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHCCHHHHHCCCEEEEE
EDGFGIIRASNTGEYFTVRFDADTPQRLAEIRQIFIVMLQKQYPNIAHDLSQAY
CCCCEEEEECCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1903398; 10984043; 7515870; 10481091; 8050998; 11716469; 11839312 [H]