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The map label for this gene is ffh [H]

Identifier: 50084052

GI number: 50084052

Start: 826408

End: 827820

Strand: Direct

Name: ffh [H]

Synonym: ACIAD0839

Alternate gene names: 50084052

Gene position: 826408-827820 (Clockwise)

Preceding gene: 50084047

Following gene: 50084055

Centisome position: 22.96

GC content: 45.36

Gene sequence:

>1413_bases
ATGTTTGATACCTTAACAGAACGACTCACGCAGAGTTTAAGAAATGTTACTGGCTCAGGGCAGCTAACCGAAGACAATAT
TAAAGATACCTTACGTGAAGTACGTATGGCACTTCTTGAAGCTGATGTTGCGTTACCTGTAACTCGTGAATTTATCGCGA
AAGTTAAGGAACAGGCATTGGGTCAGGAAGTCATGACTCAGCTTTCCCCTGGGCAGGCATTCGTCAAAATTGTGCATGAC
GAATTGACCAAAATGATGGGTGAGGCCAATGAAAGCCTTGATCTCGCGGCAAAGCCACCTGTAGTGGTCTTGCTTGCAGG
TTTGCAAGGTGCAGGTAAAACCACCACAGCTGCAAAGCTTGCACGATTTTTACAAGAACGACAAAAGAAAAAAGTCGCGA
TGGTCTCTGCCGACGTTTATCGTCCTGCAGCGATTAAACAGTTACAAACTGTTGCGGCAGAAGTTGGCGCGATGTTCTTT
GAATCGAATGCCAATGAAAAGCCGATTGATATTGCCAACCGTGCCATTGAGCAAGCCAAAATCCAGTTTGCCGATGTGCT
GATTGTCGATACCGCAGGCCGTCTACATGTCGATGAAGACATGATGGGCGAAATTAAAGAATTACATGCCTCAATCAAAC
CGACAGAAACCTTGTTTGTGGTTGATGCCATGACGGGGCAGGATGCTGCCAATACCGCGAAAGCATTTAACGATGCCTTA
CCATTGACGGGTGTGATTCTGACCAAAACTGATGGTGATGCACGCGGTGGTGCAGCACTTTCTGTTCGTGCAATTACTGG
TAAACCGATTAAGTTCTTGGGGATGGGCGAGAAGCTGGATGCTCTTGAGCCGTTCCATCCCGAACGTATCGCACAGCGTA
TTCTTGGTATGGGTGACGTATTGTCACTTGTGGAAGAAGTCGAGCGCAAAATCGACAAAGAAAAAGCCGAAAAAATGGCG
AAAAAATTGCAAAAAGGCGGTACTTTCAACTTGGAAGACATGCTGATGCAATTTGAGCAAATGAAAAAAATGGGCGGCAT
GATGGGCTTTCTGGATAAACTTCCAGGCATGAGCAACTCAGGGATCCAGCAGGCACTTGAACAGGCGAATCCTGAAAAAC
AAGTCAAGAAAATGGAAGCCATTATTCAGTCGATGACGCCGAAAGAGCGTAAGAATCCAGATATTATCAATCCAAGCCGT
AAAAAGCGTATTGCTGCGGGTTGCGGTATGGATGTTTCTGAAATCAATAAATTGCTTAAACAGCACAGTCAGATGGCAAA
AATGATGAAGAAATTTGCCAATCCATCTGGTATGAGCAAAATGATGCGTTCATTTGGCAATCTGCAAAAACAGTTTGGCG
GTGGTGGTGGCGTTGGTCCATTGTTTGGCGGTGGTAAAGACGACAAAAAGTAA

Upstream 100 bases:

>100_bases
AAATTCGCGGCGAACTACAGTATCCTATAGCATCTTATGCATAAATTTTCTATTTTGAGAAAGATTTTTTTGCAACTGGC
CATTTTTAGCGGATTTTGCA

Downstream 100 bases:

>100_bases
GCTGAACTCATCAGTTAAACTCAAAAAGGCGCTTGATGCGCCTTTTTCGTGGATATTAGAATCTTTACTAGGGTAATTGA
TGCCTTACATAATGCTGCAA

Product: GTP-binding signal recognition particle protein

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 470; Mature: 470

Protein sequence:

>470_residues
MFDTLTERLTQSLRNVTGSGQLTEDNIKDTLREVRMALLEADVALPVTREFIAKVKEQALGQEVMTQLSPGQAFVKIVHD
ELTKMMGEANESLDLAAKPPVVVLLAGLQGAGKTTTAAKLARFLQERQKKKVAMVSADVYRPAAIKQLQTVAAEVGAMFF
ESNANEKPIDIANRAIEQAKIQFADVLIVDTAGRLHVDEDMMGEIKELHASIKPTETLFVVDAMTGQDAANTAKAFNDAL
PLTGVILTKTDGDARGGAALSVRAITGKPIKFLGMGEKLDALEPFHPERIAQRILGMGDVLSLVEEVERKIDKEKAEKMA
KKLQKGGTFNLEDMLMQFEQMKKMGGMMGFLDKLPGMSNSGIQQALEQANPEKQVKKMEAIIQSMTPKERKNPDIINPSR
KKRIAAGCGMDVSEINKLLKQHSQMAKMMKKFANPSGMSKMMRSFGNLQKQFGGGGGVGPLFGGGKDDKK

Sequences:

>Translated_470_residues
MFDTLTERLTQSLRNVTGSGQLTEDNIKDTLREVRMALLEADVALPVTREFIAKVKEQALGQEVMTQLSPGQAFVKIVHD
ELTKMMGEANESLDLAAKPPVVVLLAGLQGAGKTTTAAKLARFLQERQKKKVAMVSADVYRPAAIKQLQTVAAEVGAMFF
ESNANEKPIDIANRAIEQAKIQFADVLIVDTAGRLHVDEDMMGEIKELHASIKPTETLFVVDAMTGQDAANTAKAFNDAL
PLTGVILTKTDGDARGGAALSVRAITGKPIKFLGMGEKLDALEPFHPERIAQRILGMGDVLSLVEEVERKIDKEKAEKMA
KKLQKGGTFNLEDMLMQFEQMKKMGGMMGFLDKLPGMSNSGIQQALEQANPEKQVKKMEAIIQSMTPKERKNPDIINPSR
KKRIAAGCGMDVSEINKLLKQHSQMAKMMKKFANPSGMSKMMRSFGNLQKQFGGGGGVGPLFGGGKDDKK
>Mature_470_residues
MFDTLTERLTQSLRNVTGSGQLTEDNIKDTLREVRMALLEADVALPVTREFIAKVKEQALGQEVMTQLSPGQAFVKIVHD
ELTKMMGEANESLDLAAKPPVVVLLAGLQGAGKTTTAAKLARFLQERQKKKVAMVSADVYRPAAIKQLQTVAAEVGAMFF
ESNANEKPIDIANRAIEQAKIQFADVLIVDTAGRLHVDEDMMGEIKELHASIKPTETLFVVDAMTGQDAANTAKAFNDAL
PLTGVILTKTDGDARGGAALSVRAITGKPIKFLGMGEKLDALEPFHPERIAQRILGMGDVLSLVEEVERKIDKEKAEKMA
KKLQKGGTFNLEDMLMQFEQMKKMGGMMGFLDKLPGMSNSGIQQALEQANPEKQVKKMEAIIQSMTPKERKNPDIINPSR
KKRIAAGCGMDVSEINKLLKQHSQMAKMMKKFANPSGMSKMMRSFGNLQKQFGGGGGVGPLFGGGKDDKK

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=442, Percent_Identity=33.2579185520362, Blast_Score=234, Evalue=9e-62,
Organism=Homo sapiens, GI226371618, Length=369, Percent_Identity=34.6883468834688, Blast_Score=209, Evalue=4e-54,
Organism=Homo sapiens, GI89061728, Length=160, Percent_Identity=38.75, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI23308697, Length=315, Percent_Identity=27.3015873015873, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI295424842, Length=315, Percent_Identity=27.3015873015873, Blast_Score=100, Evalue=3e-21,
Organism=Escherichia coli, GI1788963, Length=427, Percent_Identity=66.9789227166276, Blast_Score=586, Evalue=1e-168,
Organism=Escherichia coli, GI1789874, Length=265, Percent_Identity=35.0943396226415, Blast_Score=152, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI17539958, Length=439, Percent_Identity=30.751708428246, Blast_Score=211, Evalue=6e-55,
Organism=Caenorhabditis elegans, GI193206261, Length=215, Percent_Identity=32.5581395348837, Blast_Score=100, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6325345, Length=438, Percent_Identity=33.3333333333333, Blast_Score=221, Evalue=2e-58,
Organism=Saccharomyces cerevisiae, GI6320498, Length=317, Percent_Identity=25.2365930599369, Blast_Score=87, Evalue=6e-18,
Organism=Drosophila melanogaster, GI17647949, Length=487, Percent_Identity=31.4168377823409, Blast_Score=210, Evalue=2e-54,
Organism=Drosophila melanogaster, GI24641198, Length=273, Percent_Identity=28.2051282051282, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 51233; Mature: 51233

Theoretical pI: Translated: 9.84; Mature: 9.84

Prosite motif: PS50191 CRAL_TRIO ; PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
6.2 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
6.2 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDTLTERLTQSLRNVTGSGQLTEDNIKDTLREVRMALLEADVALPVTREFIAKVKEQAL
CCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
GQEVMTQLSPGQAFVKIVHDELTKMMGEANESLDLAAKPPVVVLLAGLQGAGKTTTAAKL
HHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHH
ARFLQERQKKKVAMVSADVYRPAAIKQLQTVAAEVGAMFFESNANEKPIDIANRAIEQAK
HHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
IQFADVLIVDTAGRLHVDEDMMGEIKELHASIKPTETLFVVDAMTGQDAANTAKAFNDAL
HHHHHEEEEECCCCEECCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHCCC
PLTGVILTKTDGDARGGAALSVRAITGKPIKFLGMGEKLDALEPFHPERIAQRILGMGDV
CCCEEEEEECCCCCCCCCEEEEEEECCCCEEEEECCCHHCCCCCCCHHHHHHHHHCHHHH
LSLVEEVERKIDKEKAEKMAKKLQKGGTFNLEDMLMQFEQMKKMGGMMGFLDKLPGMSNS
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
GIQQALEQANPEKQVKKMEAIIQSMTPKERKNPDIINPSRKKRIAAGCGMDVSEINKLLK
HHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHH
QHSQMAKMMKKFANPSGMSKMMRSFGNLQKQFGGGGGVGPLFGGGKDDKK
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MFDTLTERLTQSLRNVTGSGQLTEDNIKDTLREVRMALLEADVALPVTREFIAKVKEQAL
CCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
GQEVMTQLSPGQAFVKIVHDELTKMMGEANESLDLAAKPPVVVLLAGLQGAGKTTTAAKL
HHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHH
ARFLQERQKKKVAMVSADVYRPAAIKQLQTVAAEVGAMFFESNANEKPIDIANRAIEQAK
HHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
IQFADVLIVDTAGRLHVDEDMMGEIKELHASIKPTETLFVVDAMTGQDAANTAKAFNDAL
HHHHHEEEEECCCCEECCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHCCC
PLTGVILTKTDGDARGGAALSVRAITGKPIKFLGMGEKLDALEPFHPERIAQRILGMGDV
CCCEEEEEECCCCCCCCCEEEEEEECCCCEEEEECCCHHCCCCCCCHHHHHHHHHCHHHH
LSLVEEVERKIDKEKAEKMAKKLQKGGTFNLEDMLMQFEQMKKMGGMMGFLDKLPGMSNS
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
GIQQALEQANPEKQVKKMEAIIQSMTPKERKNPDIINPSRKKRIAAGCGMDVSEINKLLK
HHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHH
QHSQMAKMMKKFANPSGMSKMMRSFGNLQKQFGGGGGVGPLFGGGKDDKK
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]