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The map label for this gene is upp [H]

Identifier: 50083962

GI number: 50083962

Start: 729421

End: 730065

Strand: Direct

Name: upp [H]

Synonym: ACIAD0744

Alternate gene names: 50083962

Gene position: 729421-730065 (Clockwise)

Preceding gene: 50083961

Following gene: 50083963

Centisome position: 20.27

GC content: 43.1

Gene sequence:

>645_bases
GTGTCTCTCGTGCCCATTCAAGAAATTCGTCATCCTTTAATTCGTCATAAACTTGGTTTATTACGTCGTGCGGAGATTAG
TACCAAAAATTTCCGTGAGTTGGCTCAGGAAGTAACCATGCTATTGACCTATGAAGCGACCAAGGATTTACAACTGGTTG
ATCATGAAATTGATGGCTGGGTGGGTAAGGTAAAGACACAACGCATTGCAGGCAAAAAAATTACCATTGTACCAATCTTG
CGTGCAGGTATTGGAATGCTTGAAGGCGTACTCAATCTTATACCAAGTGCGAAAGTAAGTGTGTTGGGATTGGAGCGTGA
TGAAGAAACGCTTGAAGCACGTACCTATTACAAAAAGCTGGTGCCTGATGTTGCGAATCGTATTGCCATGATCATTGATC
CGATGTTGGCAACGGGTAGCTCATTGATTGCGGCAATTGATGTACTGAAAGCCAGTGGTTGTAAAGACATCCGTGTGATG
GTGTTGGTGGCTGCACCAGAAGGTGTAAAGAAAGTGCAGGCTAAGCATCCAGAAGTCGAGATTTATACGGCATCTATTGA
TGATGGTCTAAATGAGCATGGTTATATTGTGCCTGGACTTGGCGATGCTGGTGACAAAATTTTTGGTAGTGTCCAAAAAG
ATTAA

Upstream 100 bases:

>100_bases
TAATGTTTGGTTTTTAACAAAAAGAGCCTCCATTTTTGGAGGCTTTTTTTATTTCATGTTCAAAAACAATTATAATAACC
AAAGTTTATCGTTGTGTTAG

Downstream 100 bases:

>100_bases
TTCCTAAAAATAAAAACAAAAGCCACAATATTGTGGCTTTTGTTTTTTCATTTCTTGATTGTTAAATATTTTTATAAAGA
TCTCTTGATACTTTAGTAAT

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase [H]

Number of amino acids: Translated: 214; Mature: 213

Protein sequence:

>214_residues
MSLVPIQEIRHPLIRHKLGLLRRAEISTKNFRELAQEVTMLLTYEATKDLQLVDHEIDGWVGKVKTQRIAGKKITIVPIL
RAGIGMLEGVLNLIPSAKVSVLGLERDEETLEARTYYKKLVPDVANRIAMIIDPMLATGSSLIAAIDVLKASGCKDIRVM
VLVAAPEGVKKVQAKHPEVEIYTASIDDGLNEHGYIVPGLGDAGDKIFGSVQKD

Sequences:

>Translated_214_residues
MSLVPIQEIRHPLIRHKLGLLRRAEISTKNFRELAQEVTMLLTYEATKDLQLVDHEIDGWVGKVKTQRIAGKKITIVPIL
RAGIGMLEGVLNLIPSAKVSVLGLERDEETLEARTYYKKLVPDVANRIAMIIDPMLATGSSLIAAIDVLKASGCKDIRVM
VLVAAPEGVKKVQAKHPEVEIYTASIDDGLNEHGYIVPGLGDAGDKIFGSVQKD
>Mature_213_residues
SLVPIQEIRHPLIRHKLGLLRRAEISTKNFRELAQEVTMLLTYEATKDLQLVDHEIDGWVGKVKTQRIAGKKITIVPILR
AGIGMLEGVLNLIPSAKVSVLGLERDEETLEARTYYKKLVPDVANRIAMIIDPMLATGSSLIAAIDVLKASGCKDIRVMV
LVAAPEGVKKVQAKHPEVEIYTASIDDGLNEHGYIVPGLGDAGDKIFGSVQKD

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate [H]

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family [H]

Homologues:

Organism=Homo sapiens, GI301129207, Length=202, Percent_Identity=27.2277227722772, Blast_Score=74, Evalue=8e-14,
Organism=Homo sapiens, GI57863312, Length=202, Percent_Identity=26.7326732673267, Blast_Score=74, Evalue=8e-14,
Organism=Homo sapiens, GI21450816, Length=136, Percent_Identity=30.1470588235294, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI87082118, Length=205, Percent_Identity=62.9268292682927, Blast_Score=278, Evalue=3e-76,
Organism=Caenorhabditis elegans, GI17539892, Length=201, Percent_Identity=24.8756218905473, Blast_Score=79, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17539894, Length=201, Percent_Identity=24.8756218905473, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6321920, Length=138, Percent_Identity=42.0289855072464, Blast_Score=112, Evalue=5e-26,
Organism=Drosophila melanogaster, GI45550449, Length=150, Percent_Identity=29.3333333333333, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI28573516, Length=150, Percent_Identity=29.3333333333333, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI28573514, Length=150, Percent_Identity=29.3333333333333, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI28573512, Length=150, Percent_Identity=29.3333333333333, Blast_Score=76, Evalue=1e-14,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000836
- InterPro:   IPR005765 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.9 [H]

Molecular weight: Translated: 23439; Mature: 23308

Theoretical pI: Translated: 7.71; Mature: 7.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLVPIQEIRHPLIRHKLGLLRRAEISTKNFRELAQEVTMLLTYEATKDLQLVDHEIDGW
CCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCH
VGKVKTQRIAGKKITIVPILRAGIGMLEGVLNLIPSAKVSVLGLERDEETLEARTYYKKL
HHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHH
VPDVANRIAMIIDPMLATGSSLIAAIDVLKASGCKDIRVMVLVAAPEGVKKVQAKHPEVE
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCEEEEEEEECCCCHHHHHCCCCCEE
IYTASIDDGLNEHGYIVPGLGDAGDKIFGSVQKD
EEEECCCCCCCCCCEEECCCCCCCHHHHCCCCCC
>Mature Secondary Structure 
SLVPIQEIRHPLIRHKLGLLRRAEISTKNFRELAQEVTMLLTYEATKDLQLVDHEIDGW
CCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCH
VGKVKTQRIAGKKITIVPILRAGIGMLEGVLNLIPSAKVSVLGLERDEETLEARTYYKKL
HHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHH
VPDVANRIAMIIDPMLATGSSLIAAIDVLKASGCKDIRVMVLVAAPEGVKKVQAKHPEVE
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCEEEEEEEECCCCHHHHHCCCCCEE
IYTASIDDGLNEHGYIVPGLGDAGDKIFGSVQKD
EEEECCCCCCCCCCEEECCCCCCCHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA