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The map label for this gene is nuoH [H]

Identifier: 50083955

GI number: 50083955

Start: 721943

End: 722944

Strand: Direct

Name: nuoH [H]

Synonym: ACIAD0737

Alternate gene names: 50083955

Gene position: 721943-722944 (Clockwise)

Preceding gene: 50083954

Following gene: 50083956

Centisome position: 20.06

GC content: 45.71

Gene sequence:

>1002_bases
ATGCGTCAAACACCGCTCTGGGCAGAGAACTGGCCAATTGCATATTCAGTCATTCAGGCGATTGTGATTTTACTGGTCGT
TGTTCTGGTTGCTGCATTAATGTCATTTATTGAACGTCGTCTACTTGCATGGTGGCAAGACCGTTATGGTCCGAACCGTG
TAGGTCCTGGCGGTATGTTTCAGATTGTGGCAGACATGCTCAAGATCATGTTCAAAGAAGACTGGACACCAAAATTTGCA
GATAAACTCACGTTTCGTATGGCACCAGCAGTGGCAATGGCAACTGCGGTACTGTCATTTATCGTGATTCCAGTCAGCCC
AACACTGGGTGTGGCGGATATGAGTATTGGTCTGTTGTTCTTTATGGCAATGGCTGGTATTGCAGTGTATGCGGTTTTAT
TTGGTGGTTGGGCTTCAAACAACAAATATTCATTACTTGGTGGTTTACGTTCGGCTGCTCAGACCATTTCTTATGAGGTC
TTTTTAGGGATTTCCCTAATGGGCGTTGTTGCAATTGCGGGTTCATTTAATCTACGTGAAATTGTAGAAGCGCAACGCGA
CATGTGGTTTATCGTACCGCAGTTCCTTGGTTTCATGATCTTTGTGGTTGCTGGTGTTGCGGTGACTCACCGTCATCCAT
TTGACCAACCAGAAGCCGAGCAAGAGCTGGCAGAGGGTTATCACGTCGAGTATGGCGGTATGAAATGGGGCATGTTCTTC
GTCGCTGAATATGTCAACATCGTACTGATTTCTGCACTGATCGTGACGTTGTTCTTTGGTGGTTGGCTTGCACCGTTTAA
CCTTGAGATACCGTTTATTCCACCCGTATTTTGGTTCATTGTAAAAACAGCATTCTTTGTCATGATGTTTGTTTTGGCAC
GTGGTGCGTTAATGCGTCCACGTTATGACCAAGTGATGAATTTTGGTTGGAAAGTTTGTTTGCCGCTGGCGTTGGTCAAC
CTGATGGTGACTGGTGCTGTGATTCTGATGAATCAGGCCTAA

Upstream 100 bases:

>100_bases
AGCGGGTTATATTGGTTATCCAATTGGGTTGGCACCAACAATCTCAATGGCCGAACCTGTGTCTGTTGCGGTAGGAGTAT
AATTCATGAATCAAGAAATT

Downstream 100 bases:

>100_bases
GACAGCAGGGAGTACAAAATGTATAAAGTTCTAGCTGGAGTTGGGTCAATCGTTCGTACATTGTGGATGGTTTTCACTCA
CATTACACGTAAACGTGACA

Product: NADH dehydrogenase subunit H

Products: NA

Alternate protein names: NADH dehydrogenase I subunit H; NDH-1 subunit H [H]

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MRQTPLWAENWPIAYSVIQAIVILLVVVLVAALMSFIERRLLAWWQDRYGPNRVGPGGMFQIVADMLKIMFKEDWTPKFA
DKLTFRMAPAVAMATAVLSFIVIPVSPTLGVADMSIGLLFFMAMAGIAVYAVLFGGWASNNKYSLLGGLRSAAQTISYEV
FLGISLMGVVAIAGSFNLREIVEAQRDMWFIVPQFLGFMIFVVAGVAVTHRHPFDQPEAEQELAEGYHVEYGGMKWGMFF
VAEYVNIVLISALIVTLFFGGWLAPFNLEIPFIPPVFWFIVKTAFFVMMFVLARGALMRPRYDQVMNFGWKVCLPLALVN
LMVTGAVILMNQA

Sequences:

>Translated_333_residues
MRQTPLWAENWPIAYSVIQAIVILLVVVLVAALMSFIERRLLAWWQDRYGPNRVGPGGMFQIVADMLKIMFKEDWTPKFA
DKLTFRMAPAVAMATAVLSFIVIPVSPTLGVADMSIGLLFFMAMAGIAVYAVLFGGWASNNKYSLLGGLRSAAQTISYEV
FLGISLMGVVAIAGSFNLREIVEAQRDMWFIVPQFLGFMIFVVAGVAVTHRHPFDQPEAEQELAEGYHVEYGGMKWGMFF
VAEYVNIVLISALIVTLFFGGWLAPFNLEIPFIPPVFWFIVKTAFFVMMFVLARGALMRPRYDQVMNFGWKVCLPLALVN
LMVTGAVILMNQA
>Mature_333_residues
MRQTPLWAENWPIAYSVIQAIVILLVVVLVAALMSFIERRLLAWWQDRYGPNRVGPGGMFQIVADMLKIMFKEDWTPKFA
DKLTFRMAPAVAMATAVLSFIVIPVSPTLGVADMSIGLLFFMAMAGIAVYAVLFGGWASNNKYSLLGGLRSAAQTISYEV
FLGISLMGVVAIAGSFNLREIVEAQRDMWFIVPQFLGFMIFVVAGVAVTHRHPFDQPEAEQELAEGYHVEYGGMKWGMFF
VAEYVNIVLISALIVTLFFGGWLAPFNLEIPFIPPVFWFIVKTAFFVMMFVLARGALMRPRYDQVMNFGWKVCLPLALVN
LMVTGAVILMNQA

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1005

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 1 (chain H)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 1 family [H]

Homologues:

Organism=Homo sapiens, GI251831107, Length=291, Percent_Identity=38.1443298969072, Blast_Score=197, Evalue=2e-50,
Organism=Escherichia coli, GI1788618, Length=317, Percent_Identity=64.6687697160883, Blast_Score=433, Evalue=1e-123,
Organism=Escherichia coli, GI1789077, Length=237, Percent_Identity=29.535864978903, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023020
- InterPro:   IPR001694
- InterPro:   IPR018086 [H]

Pfam domain/function: PF00146 NADHdh [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 37225; Mature: 37225

Theoretical pI: Translated: 7.59; Mature: 7.59

Prosite motif: PS00667 COMPLEX1_ND1_1 ; PS00668 COMPLEX1_ND1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
6.3 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
6.3 %Met     (Mature Protein)
6.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRQTPLWAENWPIAYSVIQAIVILLVVVLVAALMSFIERRLLAWWQDRYGPNRVGPGGMF
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHH
QIVADMLKIMFKEDWTPKFADKLTFRMAPAVAMATAVLSFIVIPVSPTLGVADMSIGLLF
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
FMAMAGIAVYAVLFGGWASNNKYSLLGGLRSAAQTISYEVFLGISLMGVVAIAGSFNLRE
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
IVEAQRDMWFIVPQFLGFMIFVVAGVAVTHRHPFDQPEAEQELAEGYHVEYGGMKWGMFF
HHHHHHHHEEHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCEEEECCCHHHHHH
VAEYVNIVLISALIVTLFFGGWLAPFNLEIPFIPPVFWFIVKTAFFVMMFVLARGALMRP
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
RYDQVMNFGWKVCLPLALVNLMVTGAVILMNQA
CHHHHHHCCHHHHHHHHHHHHHHHHHHHEEECC
>Mature Secondary Structure
MRQTPLWAENWPIAYSVIQAIVILLVVVLVAALMSFIERRLLAWWQDRYGPNRVGPGGMF
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHH
QIVADMLKIMFKEDWTPKFADKLTFRMAPAVAMATAVLSFIVIPVSPTLGVADMSIGLLF
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
FMAMAGIAVYAVLFGGWASNNKYSLLGGLRSAAQTISYEVFLGISLMGVVAIAGSFNLRE
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
IVEAQRDMWFIVPQFLGFMIFVVAGVAVTHRHPFDQPEAEQELAEGYHVEYGGMKWGMFF
HHHHHHHHEEHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCCCEEEECCCHHHHHH
VAEYVNIVLISALIVTLFFGGWLAPFNLEIPFIPPVFWFIVKTAFFVMMFVLARGALMRP
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
RYDQVMNFGWKVCLPLALVNLMVTGAVILMNQA
CHHHHHHCCHHHHHHHHHHHHHHHHHHHEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA