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The map label for this gene is lysP [H]

Identifier: 50083923

GI number: 50083923

Start: 686192

End: 687655

Strand: Reverse

Name: lysP [H]

Synonym: ACIAD0700

Alternate gene names: 50083923

Gene position: 687655-686192 (Counterclockwise)

Preceding gene: 50083924

Following gene: 50083921

Centisome position: 19.11

GC content: 43.1

Gene sequence:

>1464_bases
ATGAGCGAAACCACTCAACCTGATCAGCTCCAGCGCAAGCTCGGTGCTCGTCATCTTAATATGATTGCCATTGGCGGCTC
CATTGGCACAGGTTTATTCCTTGCATCTGGCTCAACCATCGCAAATGCGGGACCAGGCGGCGCCCTGCTGGCATACGTAC
TCATCGGCATCATGATTTATTTTCTCATGACCAGTCTCGGTGAACTAGCGACTCATAATCCCACTTCAGGGGCATTTTTT
ACGTATGGCAATCGTTATGTAGAAGAGGGATTCGGGTTCGCATTAGGATGGAACTACTGGTATAACTGGGCCATTACTGT
GGCATTTGAGCTAGTGGCAGTCCAGTTTATTATGAAATTCTGGTTTCCAGATATTCCAGGTTTTTACTGGAGTGCTATTT
TCTTGGTGGTGATTTTTGCCATCAATGCCATGACCGTTAAAGGTTTTGGTGAAAGTGAATTCTGGTTTTCAATGGTCAAG
GTCGTTGCCATCATTGCCTTTATTATTATTGGTATGGCCATGATTATTAAAATCATGATGACCCCAAATATGGCAACCTT
TGGTAACTGGACCTATAAAGATGCACCGTTTGTAGGGGGGTTACAAGCTATGATTGGTGTGGCCATGATTGCAGGATTCT
CATTTCAGGGAACGGAAATGGTCGGTGTTGCGGCAGGTGAGTCTAAAGATCCAAAACGTACAATTCCGCTTGCGATTAAA
CAGATTTTCTGGCGAATTCTGCTATTTTATGTGGTGTGTATTTTCATCATTGGGACCTTGGTCAGCTACGATGACCCGCG
TCTACTTCAAGCTGCACATAGCTCAGATATTGCCTTGTCACCTTTTACCCTGCTGTATGAAAAAGCGGGCTTTGCCTTTG
CTGCAAGCCTGATGAATGCGGTGATTTTAACGGCGATTTTATCGGCTGGAAACTCAGGCATGTACTCTTCTACCCGTATG
CTTTGGGATATGGCAAAAGAAGGACGTGCACCTAAATGGTTTGCAAAGCTTGACCGTCGTGGCGTGCCCATGAACGCCCT
ATATGCAACAACTGCAATTGCAGCACTCTGCTTTTTAACTACATTTATTGGTGAACAGGAAGTCTTTAACTGGCTACTGA
ATATGTCTGGGATGTGTGGTTTTATTGTTTGGCTAGGGATTGCGATTTCACATTATCGCTTCCGCAAAGGTTATATCGCC
CAAGGTTATAAACTTGAAGATCTCGCCTATCGAGCCAAATTTTTTCCTTTTGCACCCTGGTTTGCCTTTATTTTATGTTC
GATTATTATTCTGGGACAAAATTATCAGGCGATATTAGGCGGTAAAATAGACTGGACTGGATTGTTATCCACCTATATCA
GTATTCCACTCTTTTTAATCATTTGGCTTGGTTATAAATGGAAATATAAAACCAAGCTCATTCCTTATCAAGAAATGAAT
GTGAAAGCAGGTAAAGAAGATTGA

Upstream 100 bases:

>100_bases
TTTGATCGAACAAACCTTTGGCCAGTGTCAAGTAAAAACCGATCAACAAGGATTCAAAATTCTCTATGCCAAAGCGACTT
AAGGAATGTAAGGAATTTTC

Downstream 100 bases:

>100_bases
TATTTCATGCTGATTTGACAATTCTGTTGAGTTTATTATGATAACGAGCAAGATTTAACCATTTTCATAATTTTTATTTG
AATTGGCAAACTATAGGAGT

Product: lysine-specific permease

Products: Proton [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 487; Mature: 486

Protein sequence:

>487_residues
MSETTQPDQLQRKLGARHLNMIAIGGSIGTGLFLASGSTIANAGPGGALLAYVLIGIMIYFLMTSLGELATHNPTSGAFF
TYGNRYVEEGFGFALGWNYWYNWAITVAFELVAVQFIMKFWFPDIPGFYWSAIFLVVIFAINAMTVKGFGESEFWFSMVK
VVAIIAFIIIGMAMIIKIMMTPNMATFGNWTYKDAPFVGGLQAMIGVAMIAGFSFQGTEMVGVAAGESKDPKRTIPLAIK
QIFWRILLFYVVCIFIIGTLVSYDDPRLLQAAHSSDIALSPFTLLYEKAGFAFAASLMNAVILTAILSAGNSGMYSSTRM
LWDMAKEGRAPKWFAKLDRRGVPMNALYATTAIAALCFLTTFIGEQEVFNWLLNMSGMCGFIVWLGIAISHYRFRKGYIA
QGYKLEDLAYRAKFFPFAPWFAFILCSIIILGQNYQAILGGKIDWTGLLSTYISIPLFLIIWLGYKWKYKTKLIPYQEMN
VKAGKED

Sequences:

>Translated_487_residues
MSETTQPDQLQRKLGARHLNMIAIGGSIGTGLFLASGSTIANAGPGGALLAYVLIGIMIYFLMTSLGELATHNPTSGAFF
TYGNRYVEEGFGFALGWNYWYNWAITVAFELVAVQFIMKFWFPDIPGFYWSAIFLVVIFAINAMTVKGFGESEFWFSMVK
VVAIIAFIIIGMAMIIKIMMTPNMATFGNWTYKDAPFVGGLQAMIGVAMIAGFSFQGTEMVGVAAGESKDPKRTIPLAIK
QIFWRILLFYVVCIFIIGTLVSYDDPRLLQAAHSSDIALSPFTLLYEKAGFAFAASLMNAVILTAILSAGNSGMYSSTRM
LWDMAKEGRAPKWFAKLDRRGVPMNALYATTAIAALCFLTTFIGEQEVFNWLLNMSGMCGFIVWLGIAISHYRFRKGYIA
QGYKLEDLAYRAKFFPFAPWFAFILCSIIILGQNYQAILGGKIDWTGLLSTYISIPLFLIIWLGYKWKYKTKLIPYQEMN
VKAGKED
>Mature_486_residues
SETTQPDQLQRKLGARHLNMIAIGGSIGTGLFLASGSTIANAGPGGALLAYVLIGIMIYFLMTSLGELATHNPTSGAFFT
YGNRYVEEGFGFALGWNYWYNWAITVAFELVAVQFIMKFWFPDIPGFYWSAIFLVVIFAINAMTVKGFGESEFWFSMVKV
VAIIAFIIIGMAMIIKIMMTPNMATFGNWTYKDAPFVGGLQAMIGVAMIAGFSFQGTEMVGVAAGESKDPKRTIPLAIKQ
IFWRILLFYVVCIFIIGTLVSYDDPRLLQAAHSSDIALSPFTLLYEKAGFAFAASLMNAVILTAILSAGNSGMYSSTRML
WDMAKEGRAPKWFAKLDRRGVPMNALYATTAIAALCFLTTFIGEQEVFNWLLNMSGMCGFIVWLGIAISHYRFRKGYIAQ
GYKLEDLAYRAKFFPFAPWFAFILCSIIILGQNYQAILGGKIDWTGLLSTYISIPLFLIIWLGYKWKYKTKLIPYQEMNV
KAGKED

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of lysine [H]

COG id: COG0833

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Escherichia coli, GI1788480, Length=479, Percent_Identity=63.8830897703549, Blast_Score=634, Evalue=0.0,
Organism=Escherichia coli, GI87081708, Length=439, Percent_Identity=37.129840546697, Blast_Score=318, Evalue=6e-88,
Organism=Escherichia coli, GI1786302, Length=472, Percent_Identity=34.9576271186441, Blast_Score=279, Evalue=2e-76,
Organism=Escherichia coli, GI1786789, Length=434, Percent_Identity=35.2534562211982, Blast_Score=269, Evalue=3e-73,
Organism=Escherichia coli, GI48994972, Length=429, Percent_Identity=36.1305361305361, Blast_Score=259, Evalue=3e-70,
Organism=Escherichia coli, GI1790653, Length=451, Percent_Identity=33.4811529933481, Blast_Score=244, Evalue=1e-65,
Organism=Escherichia coli, GI87081915, Length=420, Percent_Identity=34.0476190476191, Blast_Score=239, Evalue=3e-64,
Organism=Escherichia coli, GI1789017, Length=487, Percent_Identity=29.5687885010267, Blast_Score=238, Evalue=9e-64,
Organism=Escherichia coli, GI1786602, Length=391, Percent_Identity=36.8286445012788, Blast_Score=217, Evalue=1e-57,
Organism=Escherichia coli, GI87082250, Length=341, Percent_Identity=24.3401759530792, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17531343, Length=398, Percent_Identity=22.6130653266332, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320772, Length=495, Percent_Identity=36.969696969697, Blast_Score=334, Evalue=2e-92,
Organism=Saccharomyces cerevisiae, GI6324061, Length=495, Percent_Identity=34.3434343434343, Blast_Score=318, Evalue=1e-87,
Organism=Saccharomyces cerevisiae, GI6322892, Length=494, Percent_Identity=36.6396761133603, Blast_Score=310, Evalue=3e-85,
Organism=Saccharomyces cerevisiae, GI6324990, Length=496, Percent_Identity=35.4838709677419, Blast_Score=309, Evalue=5e-85,
Organism=Saccharomyces cerevisiae, GI6321629, Length=498, Percent_Identity=33.7349397590361, Blast_Score=307, Evalue=2e-84,
Organism=Saccharomyces cerevisiae, GI6324059, Length=503, Percent_Identity=34.1948310139165, Blast_Score=293, Evalue=4e-80,
Organism=Saccharomyces cerevisiae, GI6324553, Length=496, Percent_Identity=33.8709677419355, Blast_Score=272, Evalue=7e-74,
Organism=Saccharomyces cerevisiae, GI6324924, Length=498, Percent_Identity=32.3293172690763, Blast_Score=270, Evalue=3e-73,
Organism=Saccharomyces cerevisiae, GI6319824, Length=479, Percent_Identity=30.6889352818372, Blast_Score=254, Evalue=2e-68,
Organism=Saccharomyces cerevisiae, GI6320717, Length=499, Percent_Identity=29.8597194388778, Blast_Score=251, Evalue=1e-67,
Organism=Saccharomyces cerevisiae, GI6322967, Length=481, Percent_Identity=32.4324324324324, Blast_Score=247, Evalue=2e-66,
Organism=Saccharomyces cerevisiae, GI6321053, Length=484, Percent_Identity=31.198347107438, Blast_Score=245, Evalue=1e-65,
Organism=Saccharomyces cerevisiae, GI6319543, Length=492, Percent_Identity=28.8617886178862, Blast_Score=236, Evalue=7e-63,
Organism=Saccharomyces cerevisiae, GI6320251, Length=469, Percent_Identity=28.3582089552239, Blast_Score=234, Evalue=2e-62,
Organism=Saccharomyces cerevisiae, GI6324981, Length=502, Percent_Identity=32.8685258964143, Blast_Score=234, Evalue=2e-62,
Organism=Saccharomyces cerevisiae, GI6319542, Length=478, Percent_Identity=28.8702928870293, Blast_Score=233, Evalue=4e-62,
Organism=Saccharomyces cerevisiae, GI6319608, Length=477, Percent_Identity=28.0922431865828, Blast_Score=213, Evalue=6e-56,
Organism=Saccharomyces cerevisiae, GI6320364, Length=566, Percent_Identity=25.6183745583039, Blast_Score=172, Evalue=9e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 54215; Mature: 54083

Theoretical pI: Translated: 9.30; Mature: 9.30

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSETTQPDQLQRKLGARHLNMIAIGGSIGTGLFLASGSTIANAGPGGALLAYVLIGIMIY
CCCCCCHHHHHHHHCCCCEEEEEECCCCCCCEEEECCCEECCCCCHHHHHHHHHHHHHHH
FLMTSLGELATHNPTSGAFFTYGNRYVEEGFGFALGWNYWYNWAITVAFELVAVQFIMKF
HHHHHHHHHHCCCCCCCCEEECCCHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHH
WFPDIPGFYWSAIFLVVIFAINAMTVKGFGESEFWFSMVKVVAIIAFIIIGMAMIIKIMM
HCCCCCHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TPNMATFGNWTYKDAPFVGGLQAMIGVAMIAGFSFQGTEMVGVAAGESKDPKRTIPLAIK
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCHHHHHHH
QIFWRILLFYVVCIFIIGTLVSYDDPRLLQAAHSSDIALSPFTLLYEKAGFAFAASLMNA
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
VILTAILSAGNSGMYSSTRMLWDMAKEGRAPKWFAKLDRRGVPMNALYATTAIAALCFLT
HHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
TFIGEQEVFNWLLNMSGMCGFIVWLGIAISHYRFRKGYIAQGYKLEDLAYRAKFFPFAPW
HHHCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHCCCEEEHHHHHHHHCCCCHHH
FAFILCSIIILGQNYQAILGGKIDWTGLLSTYISIPLFLIIWLGYKWKYKTKLIPYQEMN
HHHHHHHHHHHCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCHHHCC
VKAGKED
CCCCCCC
>Mature Secondary Structure 
SETTQPDQLQRKLGARHLNMIAIGGSIGTGLFLASGSTIANAGPGGALLAYVLIGIMIY
CCCCCHHHHHHHHCCCCEEEEEECCCCCCCEEEECCCEECCCCCHHHHHHHHHHHHHHH
FLMTSLGELATHNPTSGAFFTYGNRYVEEGFGFALGWNYWYNWAITVAFELVAVQFIMKF
HHHHHHHHHHCCCCCCCCEEECCCHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHH
WFPDIPGFYWSAIFLVVIFAINAMTVKGFGESEFWFSMVKVVAIIAFIIIGMAMIIKIMM
HCCCCCHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TPNMATFGNWTYKDAPFVGGLQAMIGVAMIAGFSFQGTEMVGVAAGESKDPKRTIPLAIK
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCHHHHHHH
QIFWRILLFYVVCIFIIGTLVSYDDPRLLQAAHSSDIALSPFTLLYEKAGFAFAASLMNA
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHH
VILTAILSAGNSGMYSSTRMLWDMAKEGRAPKWFAKLDRRGVPMNALYATTAIAALCFLT
HHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
TFIGEQEVFNWLLNMSGMCGFIVWLGIAISHYRFRKGYIAQGYKLEDLAYRAKFFPFAPW
HHHCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHCCCEEEHHHHHHHHCCCCHHH
FAFILCSIIILGQNYQAILGGKIDWTGLLSTYISIPLFLIIWLGYKWKYKTKLIPYQEMN
HHHHHHHHHHHCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCHHHCC
VKAGKED
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-lysine [Periplasm] = Proton [Cytoplasm] + L-lysine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1315732; 9278503; 7551055 [H]