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The map label for this gene is rcsC [C]

Identifier: 50083830

GI number: 50083830

Start: 583098

End: 584363

Strand: Direct

Name: rcsC [C]

Synonym: ACIAD0595

Alternate gene names: 50083830

Gene position: 583098-584363 (Clockwise)

Preceding gene: 50083829

Following gene: 50083831

Centisome position: 16.2

GC content: 37.28

Gene sequence:

>1266_bases
ATGGAAATGCAAGTGTTACGACTTGATCAAGTTGATCAACTGAGTGCGTGTCGTTTATCCCTCATGCTTGGCCTAAATAG
CGATAATGATTTGATAAAACGCTATCTTGATTTTACAACAAAGTTGTTAAAATCTGGAAAAGCCTTATTAAGTTTTCATG
AAGAACCTTATTTCTGGTATAGCGATACTCAAAGTATTTGTGCAATTCCCAAAGTAGAAGGTATTGATATTGCTGCTTTT
CATCATTGCGATCATATCAATTTGAATGAACACGCTTTTAATTCTTTATCTGGCTTGCCAGGATTTATCAATACAGCCCA
TAAGCGTATTTTAGCAATCAATCTACAAAAAACGGATCAAGAGTCAATCGGCTTTGCCTTGTTTTTTGATGATGAAATCA
ATGCATTTGATTCGAATTTAATTGATCTGGTTAAGGACTATACTGCTGGTTTTGTTCGACATATTGAACTGAAATTTAAC
TTTGAAGAGCTAAACGAGCTATATGAGCAACAAGCCGCATTAAATTTTAGTAAAACCAAGTTTTTCTCCATTATTTCACA
TGATTTGCGCGCACCTTTTCACGGTTTGCTCGGCTTTTCTGAGGTTTTGGCAAAAGAACGAGAAACACTTGATGATTCAA
GTATTCAAAATATTGCCGATTACCTATATGAGACGTCTCAATCGACCTATAATTTGCTGGAAAGCTTGCTGAATTGGGCA
ATGGCTGAGGGTGGTCGCTTTGTATATCATCCAATCAGTTTTAATTTGAAACAAGTCACGACCATCGTAAAAAATATTCT
AAATACCTTTGCCCTGAAAAAAAATATTGAGTTGATTGATCACGTAGCTGATGACATCAAGATCTACGCTGATATCAATA
TGATTACTTCCTTGATTCAGAACCTAGTATCCAATGCCTTAAAGTTTACTCAGACAGATGGCACGGGTAAGGTGATTATT
GATGCGATAAAGGTTGCTGATCATGTTGAAATTACGATACGTGATACAGGTATGGGAATGTCCGAGTCTAAAATACGGGA
TATTTTTCAACCAAGAATCACAGTGAGTTTTCGAGGGACAAGTGGTGAGAAAGGGGCTGGTCTTGGTCTTGTCCTGTGTA
AGCGTTTTGTCGATCTTAATCTCGGTGCAATTTCAGTCACCTCCAAAGAAGGTGAAGGTACTGTATTTACGGTGACCTTA
CCTATTGCCCAGAATGTTGCAGAGATTTATGCGGAAAAGCAGGTGAGTGAAGAAAAATTGGTTTAA

Upstream 100 bases:

>100_bases
AAAATTTGCTAAATGTATTAAATAAATTCTTGTTTTGTTGTTCTGTTGTTTCCATTTATTAATTTTTCTTAATAATAATC
AAAATCACTGCGAGGCGAGC

Downstream 100 bases:

>100_bases
ATAGAACTCCCTAAACATGCCTGCAACTGCTATAACTATGCAAACAAAAGGTTGCAGGTTTTTTATGAATACTGAGCAGT
TGCAAAAAACATTAAGATCA

Product: sensory transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 421; Mature: 421

Protein sequence:

>421_residues
MEMQVLRLDQVDQLSACRLSLMLGLNSDNDLIKRYLDFTTKLLKSGKALLSFHEEPYFWYSDTQSICAIPKVEGIDIAAF
HHCDHINLNEHAFNSLSGLPGFINTAHKRILAINLQKTDQESIGFALFFDDEINAFDSNLIDLVKDYTAGFVRHIELKFN
FEELNELYEQQAALNFSKTKFFSIISHDLRAPFHGLLGFSEVLAKERETLDDSSIQNIADYLYETSQSTYNLLESLLNWA
MAEGGRFVYHPISFNLKQVTTIVKNILNTFALKKNIELIDHVADDIKIYADINMITSLIQNLVSNALKFTQTDGTGKVII
DAIKVADHVEITIRDTGMGMSESKIRDIFQPRITVSFRGTSGEKGAGLGLVLCKRFVDLNLGAISVTSKEGEGTVFTVTL
PIAQNVAEIYAEKQVSEEKLV

Sequences:

>Translated_421_residues
MEMQVLRLDQVDQLSACRLSLMLGLNSDNDLIKRYLDFTTKLLKSGKALLSFHEEPYFWYSDTQSICAIPKVEGIDIAAF
HHCDHINLNEHAFNSLSGLPGFINTAHKRILAINLQKTDQESIGFALFFDDEINAFDSNLIDLVKDYTAGFVRHIELKFN
FEELNELYEQQAALNFSKTKFFSIISHDLRAPFHGLLGFSEVLAKERETLDDSSIQNIADYLYETSQSTYNLLESLLNWA
MAEGGRFVYHPISFNLKQVTTIVKNILNTFALKKNIELIDHVADDIKIYADINMITSLIQNLVSNALKFTQTDGTGKVII
DAIKVADHVEITIRDTGMGMSESKIRDIFQPRITVSFRGTSGEKGAGLGLVLCKRFVDLNLGAISVTSKEGEGTVFTVTL
PIAQNVAEIYAEKQVSEEKLV
>Mature_421_residues
MEMQVLRLDQVDQLSACRLSLMLGLNSDNDLIKRYLDFTTKLLKSGKALLSFHEEPYFWYSDTQSICAIPKVEGIDIAAF
HHCDHINLNEHAFNSLSGLPGFINTAHKRILAINLQKTDQESIGFALFFDDEINAFDSNLIDLVKDYTAGFVRHIELKFN
FEELNELYEQQAALNFSKTKFFSIISHDLRAPFHGLLGFSEVLAKERETLDDSSIQNIADYLYETSQSTYNLLESLLNWA
MAEGGRFVYHPISFNLKQVTTIVKNILNTFALKKNIELIDHVADDIKIYADINMITSLIQNLVSNALKFTQTDGTGKVII
DAIKVADHVEITIRDTGMGMSESKIRDIFQPRITVSFRGTSGEKGAGLGLVLCKRFVDLNLGAISVTSKEGEGTVFTVTL
PIAQNVAEIYAEKQVSEEKLV

Specific function: Member Of The Two-Component Regulatory System rcsC/rcsB Involved In The Regulation Of The Expression Of Genes Involved In Colanic Acid Capsule Synthesis. rcsC Probably Functions As A Membrane-Associated Protein Kinase That Phosphorylates rcsB In Response

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAC (PAS-associated C-terminal) domain [H]

Homologues:

Organism=Escherichia coli, GI145693157, Length=244, Percent_Identity=26.6393442622951, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1788713, Length=248, Percent_Identity=29.4354838709677, Blast_Score=98, Evalue=8e-22,
Organism=Escherichia coli, GI87081816, Length=300, Percent_Identity=27.6666666666667, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI1789149, Length=283, Percent_Identity=26.5017667844523, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI1786783, Length=254, Percent_Identity=27.5590551181102, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI48994928, Length=245, Percent_Identity=27.3469387755102, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1788393, Length=260, Percent_Identity=23.8461538461538, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1786600, Length=244, Percent_Identity=24.5901639344262, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1788549, Length=225, Percent_Identity=24.8888888888889, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1786912, Length=228, Percent_Identity=25.8771929824561, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790436, Length=224, Percent_Identity=25.4464285714286, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR001610
- InterPro:   IPR000700
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 47297; Mature: 47297

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEMQVLRLDQVDQLSACRLSLMLGLNSDNDLIKRYLDFTTKLLKSGKALLSFHEEPYFWY
CCCEEEECCCCCHHHHHHEEEEEECCCCHHHHHHHHHHHHHHHHCCHHHEEECCCCEEEE
SDTQSICAIPKVEGIDIAAFHHCDHINLNEHAFNSLSGLPGFINTAHKRILAINLQKTDQ
CCCCCEECCCCCCCCEEEEEECCCCCCCCHHHHHHHCCCCHHHHHHCCEEEEEEECCCCC
ESIGFALFFDDEINAFDSNLIDLVKDYTAGFVRHIELKFNFEELNELYEQQAALNFSKTK
CCCCEEEEECCCCCHHHHHHHHHHHHHHHHHEEEEEEEECHHHHHHHHHHHHHCCCHHHH
FFSIISHDLRAPFHGLLGFSEVLAKERETLDDSSIQNIADYLYETSQSTYNLLESLLNWA
HHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
MAEGGRFVYHPISFNLKQVTTIVKNILNTFALKKNIELIDHVADDIKIYADINMITSLIQ
HHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHEEEEEEHHHHHHHHH
NLVSNALKFTQTDGTGKVIIDAIKVADHVEITIRDTGMGMSESKIRDIFQPRITVSFRGT
HHHHHHHEEECCCCCCCEEEEEEECCCEEEEEEEECCCCCCHHHHHHHHCCCEEEEEECC
SGEKGAGLGLVLCKRFVDLNLGAISVTSKEGEGTVFTVTLPIAQNVAEIYAEKQVSEEKL
CCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCEEEEEEECHHHHHHHHHHHHHCHHHCC
V
C
>Mature Secondary Structure
MEMQVLRLDQVDQLSACRLSLMLGLNSDNDLIKRYLDFTTKLLKSGKALLSFHEEPYFWY
CCCEEEECCCCCHHHHHHEEEEEECCCCHHHHHHHHHHHHHHHHCCHHHEEECCCCEEEE
SDTQSICAIPKVEGIDIAAFHHCDHINLNEHAFNSLSGLPGFINTAHKRILAINLQKTDQ
CCCCCEECCCCCCCCEEEEEECCCCCCCCHHHHHHHCCCCHHHHHHCCEEEEEEECCCCC
ESIGFALFFDDEINAFDSNLIDLVKDYTAGFVRHIELKFNFEELNELYEQQAALNFSKTK
CCCCEEEEECCCCCHHHHHHHHHHHHHHHHHEEEEEEEECHHHHHHHHHHHHHCCCHHHH
FFSIISHDLRAPFHGLLGFSEVLAKERETLDDSSIQNIADYLYETSQSTYNLLESLLNWA
HHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
MAEGGRFVYHPISFNLKQVTTIVKNILNTFALKKNIELIDHVADDIKIYADINMITSLIQ
HHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHEEEEEEHHHHHHHHH
NLVSNALKFTQTDGTGKVIIDAIKVADHVEITIRDTGMGMSESKIRDIFQPRITVSFRGT
HHHHHHHEEECCCCCCCEEEEEEECCCEEEEEEEECCCCCCHHHHHHHHCCCEEEEEECC
SGEKGAGLGLVLCKRFVDLNLGAISVTSKEGEGTVFTVTLPIAQNVAEIYAEKQVSEEKL
CCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCEEEEEEECHHHHHHHHHHHHHCHHHCC
V
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11481430; 7756693 [H]