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The map label for this gene is fabF [H]

Identifier: 50083819

GI number: 50083819

Start: 573200

End: 574423

Strand: Direct

Name: fabF [H]

Synonym: ACIAD0583

Alternate gene names: 50083819

Gene position: 573200-574423 (Clockwise)

Preceding gene: 50083818

Following gene: 50083820

Centisome position: 15.93

GC content: 46.16

Gene sequence:

>1224_bases
ATGAAACGCGTAGTGGTTACAGGAATGTCGGGGATTACCTCACTGGGTGAAACTGCAGATGCAATTTTTGAAAAGTTTGC
TCAGGGCAAAAGTGGCATTCGCTACATGGCCGATTGGGAACAATATACGGACTTACGTACCAAACTGGGTGGGCCTGTTG
AAAGTTTTAGTATTCCTAAGCATTTTAACCGTAAAGTAACACGTGGCATGGGACGTGTGGCGCTGATGTCGGTCATTGCT
GCCGAGGCTGCGCTTAAAGATGCAAAACTGTTCGATGATCCGATATTGAAAAGTGGTGATACAGGTGTTGCATTCGGTTC
ATCTGCGGGGAGTGTTGATGCGGTACGAGAGTTTGGTTGTATGCTCATTGACAACGATATGACCAAAATGAATGCCACCA
CGTATATCCGTATGATGTCACACACCAGTGCAGTCAATATGACCGTATATTTTGGTTTAAAAGGCCTCACCTTACCAACC
TCAAGTGCTTGCACATCGGGTTCGATGGCAATCGGACAGGCTTATGAGGCGATTAAATATGGCAAGCAAACTGTAATGCT
GGCAGGTGGAGCTGAAGAAATTAGTGCGGCTGGCGCAGCGGTATTTGATGTGTTACTTGCAACCAGTGGTATGAATGACC
ATCCTGAGCAGTCACCGCGTCCTTTTGATGCAAAGCGCGATGGCTTGGTTATTGGTGAAGGCGCAGGATGTTTAGTTTTA
GAAGAATATGAGCATGCGCAAGCACGTGGTGCCACCATTTATGCCGAAATTGTTGGCTATGGTAGCAATACCGATGGACA
GCATGTCACCCGTCCTGATCAAGCCATGATGGCGCGCTGTATGCAACTCTCGTTAAAAGATGCAGGCTTGAGCGCAGAGC
AGATAGGATATGTCAACGCACATGGCACTTCTACCGATCAGGGTGATATTGCCGAAACTCAGGCCACTGCTCAAGTACTT
GGTAAGAAACCGATTAGCTCATTAAAAAGCTATTTTGGACATACCTTAGGTGCTTGTGGTGCCATTGAGGCTTGGCTTAG
CATTGAGATGATGCAGCGTAACCAGTATATTCCAACCTTGAATCTGGATGACGTAGATCCATTATGTGGGGATTTGGATT
ACATTACAGGGCAGTCGCGTGCGTTGGGTGCCGATATCGTAATGAGTAATAATTTTGCTTTTGGAGGGATTAATACCTCC
CTGATTTTTAAACGTGTTGAATAA

Upstream 100 bases:

>100_bases
GACACGTAGATGAAGTTGCCAGTGTGGTGAAATTTTTGTGTTCAGATGAAGCCTCGTACATTACCCGTCAGGTCATCTCC
GTCAATGGAGGACTGATTTA

Downstream 100 bases:

>100_bases
GAGGAAAACAACAATGTTATTGAAACAACAACTCACGATCGCTGTACTTTGCCTTGGGGCAATGGGTGCGGCACAAGCAG
CAGACAATGTCCATAACCTT

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 407; Mature: 407

Protein sequence:

>407_residues
MKRVVVTGMSGITSLGETADAIFEKFAQGKSGIRYMADWEQYTDLRTKLGGPVESFSIPKHFNRKVTRGMGRVALMSVIA
AEAALKDAKLFDDPILKSGDTGVAFGSSAGSVDAVREFGCMLIDNDMTKMNATTYIRMMSHTSAVNMTVYFGLKGLTLPT
SSACTSGSMAIGQAYEAIKYGKQTVMLAGGAEEISAAGAAVFDVLLATSGMNDHPEQSPRPFDAKRDGLVIGEGAGCLVL
EEYEHAQARGATIYAEIVGYGSNTDGQHVTRPDQAMMARCMQLSLKDAGLSAEQIGYVNAHGTSTDQGDIAETQATAQVL
GKKPISSLKSYFGHTLGACGAIEAWLSIEMMQRNQYIPTLNLDDVDPLCGDLDYITGQSRALGADIVMSNNFAFGGINTS
LIFKRVE

Sequences:

>Translated_407_residues
MKRVVVTGMSGITSLGETADAIFEKFAQGKSGIRYMADWEQYTDLRTKLGGPVESFSIPKHFNRKVTRGMGRVALMSVIA
AEAALKDAKLFDDPILKSGDTGVAFGSSAGSVDAVREFGCMLIDNDMTKMNATTYIRMMSHTSAVNMTVYFGLKGLTLPT
SSACTSGSMAIGQAYEAIKYGKQTVMLAGGAEEISAAGAAVFDVLLATSGMNDHPEQSPRPFDAKRDGLVIGEGAGCLVL
EEYEHAQARGATIYAEIVGYGSNTDGQHVTRPDQAMMARCMQLSLKDAGLSAEQIGYVNAHGTSTDQGDIAETQATAQVL
GKKPISSLKSYFGHTLGACGAIEAWLSIEMMQRNQYIPTLNLDDVDPLCGDLDYITGQSRALGADIVMSNNFAFGGINTS
LIFKRVE
>Mature_407_residues
MKRVVVTGMSGITSLGETADAIFEKFAQGKSGIRYMADWEQYTDLRTKLGGPVESFSIPKHFNRKVTRGMGRVALMSVIA
AEAALKDAKLFDDPILKSGDTGVAFGSSAGSVDAVREFGCMLIDNDMTKMNATTYIRMMSHTSAVNMTVYFGLKGLTLPT
SSACTSGSMAIGQAYEAIKYGKQTVMLAGGAEEISAAGAAVFDVLLATSGMNDHPEQSPRPFDAKRDGLVIGEGAGCLVL
EEYEHAQARGATIYAEIVGYGSNTDGQHVTRPDQAMMARCMQLSLKDAGLSAEQIGYVNAHGTSTDQGDIAETQATAQVL
GKKPISSLKSYFGHTLGACGAIEAWLSIEMMQRNQYIPTLNLDDVDPLCGDLDYITGQSRALGADIVMSNNFAFGGINTS
LIFKRVE

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=416, Percent_Identity=35.3365384615385, Blast_Score=219, Evalue=3e-57,
Organism=Homo sapiens, GI223972627, Length=175, Percent_Identity=36.5714285714286, Blast_Score=96, Evalue=8e-20,
Organism=Homo sapiens, GI41872631, Length=274, Percent_Identity=27.7372262773723, Blast_Score=87, Evalue=3e-17,
Organism=Escherichia coli, GI1787337, Length=415, Percent_Identity=39.5180722891566, Blast_Score=250, Evalue=1e-67,
Organism=Escherichia coli, GI1788663, Length=413, Percent_Identity=34.3825665859564, Blast_Score=224, Evalue=1e-59,
Organism=Caenorhabditis elegans, GI71983541, Length=415, Percent_Identity=32.0481927710843, Blast_Score=192, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI71983535, Length=263, Percent_Identity=37.6425855513308, Blast_Score=155, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI212642053, Length=330, Percent_Identity=30.3030303030303, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17550940, Length=265, Percent_Identity=27.1698113207547, Blast_Score=84, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6320904, Length=448, Percent_Identity=31.6964285714286, Blast_Score=191, Evalue=2e-49,
Organism=Drosophila melanogaster, GI24644341, Length=419, Percent_Identity=32.9355608591885, Blast_Score=202, Evalue=3e-52,
Organism=Drosophila melanogaster, GI19920632, Length=274, Percent_Identity=28.1021897810219, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI221330659, Length=274, Percent_Identity=28.1021897810219, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24581345, Length=276, Percent_Identity=25.7246376811594, Blast_Score=75, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 43370; Mature: 43370

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRVVVTGMSGITSLGETADAIFEKFAQGKSGIRYMADWEQYTDLRTKLGGPVESFSIPK
CCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHCCCCHHHCCCCH
HFNRKVTRGMGRVALMSVIAAEAALKDAKLFDDPILKSGDTGVAFGSSAGSVDAVREFGC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCHHHHHHCCC
MLIDNDMTKMNATTYIRMMSHTSAVNMTVYFGLKGLTLPTSSACTSGSMAIGQAYEAIKY
EEEECCCHHHCHHHEEEEHHCCCEEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHC
GKQTVMLAGGAEEISAAGAAVFDVLLATSGMNDHPEQSPRPFDAKRDGLVIGEGAGCLVL
CCEEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEECCCCEEEE
EEYEHAQARGATIYAEIVGYGSNTDGQHVTRPDQAMMARCMQLSLKDAGLSAEQIGYVNA
ECCHHHHHCCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHCCEEEC
HGTSTDQGDIAETQATAQVLGKKPISSLKSYFGHTLGACGAIEAWLSIEMMQRNQYIPTL
CCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
NLDDVDPLCGDLDYITGQSRALGADIVMSNNFAFGGINTSLIFKRVE
CCCCCCCCCCCCHHHCCCCCCCCEEEEEECCEEECCCCCEEEEEECC
>Mature Secondary Structure
MKRVVVTGMSGITSLGETADAIFEKFAQGKSGIRYMADWEQYTDLRTKLGGPVESFSIPK
CCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHCCCCHHHCCCCH
HFNRKVTRGMGRVALMSVIAAEAALKDAKLFDDPILKSGDTGVAFGSSAGSVDAVREFGC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCHHHHHHCCC
MLIDNDMTKMNATTYIRMMSHTSAVNMTVYFGLKGLTLPTSSACTSGSMAIGQAYEAIKY
EEEECCCHHHCHHHEEEEHHCCCEEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHC
GKQTVMLAGGAEEISAAGAAVFDVLLATSGMNDHPEQSPRPFDAKRDGLVIGEGAGCLVL
CCEEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEECCCCEEEE
EEYEHAQARGATIYAEIVGYGSNTDGQHVTRPDQAMMARCMQLSLKDAGLSAEQIGYVNA
ECCHHHHHCCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHCCEEEC
HGTSTDQGDIAETQATAQVLGKKPISSLKSYFGHTLGACGAIEAWLSIEMMQRNQYIPTL
CCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
NLDDVDPLCGDLDYITGQSRALGADIVMSNNFAFGGINTSLIFKRVE
CCCCCCCCCCCCHHHCCCCCCCCEEEEEECCEEECCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231; 11152607 [H]