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The map label for this gene is fabF [H]

Identifier: 50083816

GI number: 50083816

Start: 570788

End: 572038

Strand: Direct

Name: fabF [H]

Synonym: ACIAD0580

Alternate gene names: 50083816

Gene position: 570788-572038 (Clockwise)

Preceding gene: 50083815

Following gene: 50083817

Centisome position: 15.86

GC content: 47.4

Gene sequence:

>1251_bases
CTGGTGAGAAAAACCGTGACGCATCAACAACAACATTCTGCCGCAGTGGGTATTCAGTTAAGTGCAAGTCTTTCTGCTTT
GGGCAGTTCATCTCAGCAAGTGCGCCAGAATTTAACCCAGCCCAACTCGACTCAACAAACTACATTATCATTACAACAGC
ATTGGCTTTCAGAGCACGCAGTCTGGGTGGGGGCCTATCAAGAGAACTTCATTGAACAATTGCCTGAGCGCTGTGCGCCG
TGGCAATCCCGTAATTTACGCTTTGCTGTCACTGCACTTTCGCAAATCGAAACAGAGCTAAGACAACGTACAGCCCATAT
AAATCCATCACGCTTAGCGATTGTGGTGGGGACATCGACATCAGGCATTGCTGATAATGAGTCATTATTGGCAGAATATT
TTCAAGGTAAAACTGAGGTGGTGATTGATCATCACAAACAGGAAATGAATGCGCTGGCCAAAGGCTTGCAAGCGTATTTG
GGCTGGTGTGGCGCTGCATATACGATTTCAACAGCCTGCTCATCCAGTGCCAAAGCGTTTATCGCGGGACAGCGTTTACT
CAATGCGGGTTTAGCAGATGCCGTACTGGTCGGTGGTGTCGATACACTTTGCCGCTTAACCTTAAATGGATTTAACAGTC
TGGAGAGCTTATCGGCGAGTATCTGTCAGCCTTGTGGTGCAGAACGTGATGGAATTAATATTGGTGAAGCTGCCAGTTTG
TTTTTATTGACCCGTGATATCGCACCTGTCATGTTTTTGGGTGGGGGGGAGGCCATGGATGCATGGCATATTTCGGCACC
TCATCCTGATGGGCTGGGTGCTGCACAAGCCATGCAGCGCGCATTAAAGGCTGCAAATCTTGAAGCTGCACAGATTGATT
ATTTAAATTTGCACGGTACTGCCACACCGCAAAATGATGCCATGGAAATTAAGGCCGTACGACAAGTGTTTGCAGGTCAT
CCGATCAAACTCAGTAGTACCAAGCATCAAACTGGGCATTGTCTGGGAGCAGCAGGCGCGGTTGAAGCATTTATCTGTCA
GCAGGCTTTACTCGATCAGAGCTGGTTACCCTGGCATCAACAGGGACAACTGGATCATGAGCTTGCGGATCAGACCTATG
TCAATGCCAGTACCAAAATCGAATCACTTCATTATATGATGAGCAATTCATTTGCGTTTGGTGGTAGCAATGTGAGTCTG
ATTTTTGGCCGAAACTTTGAACAAAACCTCTTGGGGACAGCATCGACATGA

Upstream 100 bases:

>100_bases
AAGCGCATTAGAACAACACATTGAGTTGGATAATGTACAAGTGCCGTATCAAATGACGTTTTCACCGATTGAAAATACAT
TGCAACCTAATTAAAAAAAT

Downstream 100 bases:

>100_bases
ACATCAATGAAAATGCCAGCCAATATATTCCACATGAAGCACCCATGGTGTTTGTGGATGATCTCATTGAAATCTTTGAT
CAAGGGGCTTTGGCCAGTTT

Product: 3-oxoacyl-(acyl carrier protein) synthase I

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 416; Mature: 416

Protein sequence:

>416_residues
MVRKTVTHQQQHSAAVGIQLSASLSALGSSSQQVRQNLTQPNSTQQTTLSLQQHWLSEHAVWVGAYQENFIEQLPERCAP
WQSRNLRFAVTALSQIETELRQRTAHINPSRLAIVVGTSTSGIADNESLLAEYFQGKTEVVIDHHKQEMNALAKGLQAYL
GWCGAAYTISTACSSSAKAFIAGQRLLNAGLADAVLVGGVDTLCRLTLNGFNSLESLSASICQPCGAERDGINIGEAASL
FLLTRDIAPVMFLGGGEAMDAWHISAPHPDGLGAAQAMQRALKAANLEAAQIDYLNLHGTATPQNDAMEIKAVRQVFAGH
PIKLSSTKHQTGHCLGAAGAVEAFICQQALLDQSWLPWHQQGQLDHELADQTYVNASTKIESLHYMMSNSFAFGGSNVSL
IFGRNFEQNLLGTAST

Sequences:

>Translated_416_residues
MVRKTVTHQQQHSAAVGIQLSASLSALGSSSQQVRQNLTQPNSTQQTTLSLQQHWLSEHAVWVGAYQENFIEQLPERCAP
WQSRNLRFAVTALSQIETELRQRTAHINPSRLAIVVGTSTSGIADNESLLAEYFQGKTEVVIDHHKQEMNALAKGLQAYL
GWCGAAYTISTACSSSAKAFIAGQRLLNAGLADAVLVGGVDTLCRLTLNGFNSLESLSASICQPCGAERDGINIGEAASL
FLLTRDIAPVMFLGGGEAMDAWHISAPHPDGLGAAQAMQRALKAANLEAAQIDYLNLHGTATPQNDAMEIKAVRQVFAGH
PIKLSSTKHQTGHCLGAAGAVEAFICQQALLDQSWLPWHQQGQLDHELADQTYVNASTKIESLHYMMSNSFAFGGSNVSL
IFGRNFEQNLLGTAST
>Mature_416_residues
MVRKTVTHQQQHSAAVGIQLSASLSALGSSSQQVRQNLTQPNSTQQTTLSLQQHWLSEHAVWVGAYQENFIEQLPERCAP
WQSRNLRFAVTALSQIETELRQRTAHINPSRLAIVVGTSTSGIADNESLLAEYFQGKTEVVIDHHKQEMNALAKGLQAYL
GWCGAAYTISTACSSSAKAFIAGQRLLNAGLADAVLVGGVDTLCRLTLNGFNSLESLSASICQPCGAERDGINIGEAASL
FLLTRDIAPVMFLGGGEAMDAWHISAPHPDGLGAAQAMQRALKAANLEAAQIDYLNLHGTATPQNDAMEIKAVRQVFAGH
PIKLSSTKHQTGHCLGAAGAVEAFICQQALLDQSWLPWHQQGQLDHELADQTYVNASTKIESLHYMMSNSFAFGGSNVSL
IFGRNFEQNLLGTAST

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=258, Percent_Identity=37.984496124031, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI223972627, Length=146, Percent_Identity=43.1506849315069, Blast_Score=100, Evalue=3e-21,
Organism=Escherichia coli, GI1787337, Length=274, Percent_Identity=35.7664233576642, Blast_Score=128, Evalue=8e-31,
Organism=Escherichia coli, GI1788663, Length=400, Percent_Identity=28, Blast_Score=108, Evalue=8e-25,
Organism=Caenorhabditis elegans, GI71983541, Length=357, Percent_Identity=28.8515406162465, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI71983535, Length=261, Percent_Identity=32.5670498084291, Blast_Score=111, Evalue=6e-25,
Organism=Saccharomyces cerevisiae, GI6320904, Length=266, Percent_Identity=30.8270676691729, Blast_Score=111, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24644341, Length=258, Percent_Identity=33.3333333333333, Blast_Score=128, Evalue=8e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 44776; Mature: 44776

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVRKTVTHQQQHSAAVGIQLSASLSALGSSSQQVRQNLTQPNSTQQTTLSLQQHWLSEHA
CCCCCCCHHHHCCCEEEEEEECHHHHHCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHCC
VWVGAYQENFIEQLPERCAPWQSRNLRFAVTALSQIETELRQRTAHINPSRLAIVVGTST
EEEEHHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCCCEEEEEEECCC
SGIADNESLLAEYFQGKTEVVIDHHKQEMNALAKGLQAYLGWCGAAYTISTACSSSAKAF
CCCCCCHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
IAGQRLLNAGLADAVLVGGVDTLCRLTLNGFNSLESLSASICQPCGAERDGINIGEAASL
HHHHHHHHCCHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHH
FLLTRDIAPVMFLGGGEAMDAWHISAPHPDGLGAAQAMQRALKAANLEAAQIDYLNLHGT
HHHHHCCCCEEEECCCCCCCEEECCCCCCCCCCHHHHHHHHHHHCCCCHHEEEEEEECCC
ATPQNDAMEIKAVRQVFAGHPIKLSSTKHQTGHCLGAAGAVEAFICQQALLDQSWLPWHQ
CCCCCCHHHHHHHHHHHCCCCEEECCCCCCCCCEECHHHHHHHHHHHHHHHCCCCCCCCC
QGQLDHELADQTYVNASTKIESLHYMMSNSFAFGGSNVSLIFGRNFEQNLLGTAST
CCCCCHHHHHHHHCCCHHHHHHHHHHHHCCEEECCCCEEEEECCCCCHHCCCCCCC
>Mature Secondary Structure
MVRKTVTHQQQHSAAVGIQLSASLSALGSSSQQVRQNLTQPNSTQQTTLSLQQHWLSEHA
CCCCCCCHHHHCCCEEEEEEECHHHHHCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHCC
VWVGAYQENFIEQLPERCAPWQSRNLRFAVTALSQIETELRQRTAHINPSRLAIVVGTST
EEEEHHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCCCEEEEEEECCC
SGIADNESLLAEYFQGKTEVVIDHHKQEMNALAKGLQAYLGWCGAAYTISTACSSSAKAF
CCCCCCHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
IAGQRLLNAGLADAVLVGGVDTLCRLTLNGFNSLESLSASICQPCGAERDGINIGEAASL
HHHHHHHHCCHHHHHHHCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHH
FLLTRDIAPVMFLGGGEAMDAWHISAPHPDGLGAAQAMQRALKAANLEAAQIDYLNLHGT
HHHHHCCCCEEEECCCCCCCEEECCCCCCCCCCHHHHHHHHHHHCCCCHHEEEEEEECCC
ATPQNDAMEIKAVRQVFAGHPIKLSSTKHQTGHCLGAAGAVEAFICQQALLDQSWLPWHQ
CCCCCCHHHHHHHHHHHCCCCEEECCCCCCCCCEECHHHHHHHHHHHHHHHCCCCCCCCC
QGQLDHELADQTYVNASTKIESLHYMMSNSFAFGGSNVSLIFGRNFEQNLLGTAST
CCCCCHHHHHHHHCCCHHHHHHHHHHHHCCEEECCCCEEEEECCCCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]