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The map label for this gene is hutH [H]

Identifier: 50083810

GI number: 50083810

Start: 563940

End: 565523

Strand: Direct

Name: hutH [H]

Synonym: ACIAD0574

Alternate gene names: 50083810

Gene position: 563940-565523 (Clockwise)

Preceding gene: 50083809

Following gene: 50083811

Centisome position: 15.67

GC content: 46.97

Gene sequence:

>1584_bases
GTGAATACGACTTTGAATATCACCCAGCCGCAGACACTGACGGTTGGCTTAGAGCCTTTGAGTATTGAAGATGTTGTTCG
TGTGGCTCAGGCAAAGTGCCGTGTTGCATTACCTGAACAACAAGACTGGCGCGATTTGATTCAGAAAGGTGCAGATTTTC
TGGATACTTTGCTTCAAGAAGAAGGCGTCATTTATGGGGTGACCACAGGTTATGGAGATTCTTGTCTGGTCGAAGTGCCG
ACTCATCAAGTGCATGAACTGCCGCTACAGCTTTCACGCTTTCATGGTTGTGGACTTGGGCAAAATCTGGATCTGGTGAC
TGCACGCGCTGTGGTCATTACACGACTCTGTTCGCTGGCACGTGGTTATTCTGGTGTTTCATTGGCATTGCTGGAACGTC
TAGTGTGGTTGCTCAATGAAAATGTGATTCCTGTAATTCCTTCCGAGGGCTCGGTAGGGGCAAGTGGTGATCTGACACCG
TTATCTTATATCGCTGGAGTATTGGTCGGTGAGCGAGAGGTGTATTACCAAGGCAAGATTATTCCTGTGCAACAGGTGTA
TCAGCAAAAAGCTATCCAGCCTTTAACCTTGCGTCCTAAAGAAGGTTTGGCCTTGATGAATGGCACTGCGGTGATGACCG
CAATCGCTTGTTTAAATTATAAGCGGGCTGAACAGATTGCACAGACAGCCACATTAGTCACAGCAATCAATGTACTGGCA
CTCGAAGGTAATCCGACACATTTTGATGAGGTGTTGTTTGCTCAGAAGCCGCATACAGGTCAGCAAAAAATTGCAGCCCA
ATTGCGTGACTGGCTTAACAGCGAGGTACAAACCGCACATCAAAGCCCACGATTACAAGATCGTTATTCGCTGCGCTGTG
CGCCGCATGTGATTGGTGTATTTGAAGATTCAAAAGTCTGGCTACGTCAGTTTATCGAAAATGAATTGAATTCTAGCAAT
GACAACCCGCTGATTGATCCTGTGAATTTGAGAGTGCTGCATGGTGGACATTTCTATGGCGGGCATATTGCACAGGCGAT
GGACAGTTTGAAAATCATGATCGCAAATATTGCAGACCTGATGGATCGTCAGTTGGCACAATTGGTCGATCACAAAATGA
ATCATGGTCTGCCGCGCAACCTGACAGGTGCAACCGCGGAACGTTTACCGCTGAATCATGGATTCAAGGCGGTACAGATT
GGCGTATCTGCATGGACGGCTGAGGCATTAAAACAGACTTTGTCGGCATCGATCTTCTCACGATCTACCGAGTGTCATAA
TCAGGATAAAGTCAGTATGGGCACCATTGCTGCGCGTGATGCGACACGAATTATTGTATTGACTGAACAAGTGATGGCTG
CACTGTGCTGTGCCAGTATACAGGCAATACATTTGAAGCAGTTGGCACAACAATTAAGTCCAACCCTCCGTGCATTTAGT
GCATGGACCTTACACAGTCTTGCACTGGTGATCGAAGACCGACCATTACAAACCGAATTGCAACAGATTGTTGATCGTTT
TGCCCATTTTGAGCTGTCTAATGCAGATTGGATGCAGCAACAGGAGCAGCTTTATGCAGGCTGA

Upstream 100 bases:

>100_bases
ATGCAAGAGATCACCAAACGATATGTGCATTTATTAGAACAACATTGCCTGCGTGCGCCTTATCAGTGGTTTAACTTTTA
TCATTTTTGGACGAAGTAGC

Downstream 100 bases:

>100_bases
AGTCGTTATTGAAGTTCCGTTTCATGATGTGGATACCATGAATGTGGTCTGGCATGGACATTATTTAAAATATTTTGAAA
TTGCGCGCTGTAAGCTGCTG

Product: histidine ammonia-lyase protein (Histidase)

Products: NA

Alternate protein names: Histidase [H]

Number of amino acids: Translated: 527; Mature: 527

Protein sequence:

>527_residues
MNTTLNITQPQTLTVGLEPLSIEDVVRVAQAKCRVALPEQQDWRDLIQKGADFLDTLLQEEGVIYGVTTGYGDSCLVEVP
THQVHELPLQLSRFHGCGLGQNLDLVTARAVVITRLCSLARGYSGVSLALLERLVWLLNENVIPVIPSEGSVGASGDLTP
LSYIAGVLVGEREVYYQGKIIPVQQVYQQKAIQPLTLRPKEGLALMNGTAVMTAIACLNYKRAEQIAQTATLVTAINVLA
LEGNPTHFDEVLFAQKPHTGQQKIAAQLRDWLNSEVQTAHQSPRLQDRYSLRCAPHVIGVFEDSKVWLRQFIENELNSSN
DNPLIDPVNLRVLHGGHFYGGHIAQAMDSLKIMIANIADLMDRQLAQLVDHKMNHGLPRNLTGATAERLPLNHGFKAVQI
GVSAWTAEALKQTLSASIFSRSTECHNQDKVSMGTIAARDATRIIVLTEQVMAALCCASIQAIHLKQLAQQLSPTLRAFS
AWTLHSLALVIEDRPLQTELQQIVDRFAHFELSNADWMQQQEQLYAG

Sequences:

>Translated_527_residues
MNTTLNITQPQTLTVGLEPLSIEDVVRVAQAKCRVALPEQQDWRDLIQKGADFLDTLLQEEGVIYGVTTGYGDSCLVEVP
THQVHELPLQLSRFHGCGLGQNLDLVTARAVVITRLCSLARGYSGVSLALLERLVWLLNENVIPVIPSEGSVGASGDLTP
LSYIAGVLVGEREVYYQGKIIPVQQVYQQKAIQPLTLRPKEGLALMNGTAVMTAIACLNYKRAEQIAQTATLVTAINVLA
LEGNPTHFDEVLFAQKPHTGQQKIAAQLRDWLNSEVQTAHQSPRLQDRYSLRCAPHVIGVFEDSKVWLRQFIENELNSSN
DNPLIDPVNLRVLHGGHFYGGHIAQAMDSLKIMIANIADLMDRQLAQLVDHKMNHGLPRNLTGATAERLPLNHGFKAVQI
GVSAWTAEALKQTLSASIFSRSTECHNQDKVSMGTIAARDATRIIVLTEQVMAALCCASIQAIHLKQLAQQLSPTLRAFS
AWTLHSLALVIEDRPLQTELQQIVDRFAHFELSNADWMQQQEQLYAG
>Mature_527_residues
MNTTLNITQPQTLTVGLEPLSIEDVVRVAQAKCRVALPEQQDWRDLIQKGADFLDTLLQEEGVIYGVTTGYGDSCLVEVP
THQVHELPLQLSRFHGCGLGQNLDLVTARAVVITRLCSLARGYSGVSLALLERLVWLLNENVIPVIPSEGSVGASGDLTP
LSYIAGVLVGEREVYYQGKIIPVQQVYQQKAIQPLTLRPKEGLALMNGTAVMTAIACLNYKRAEQIAQTATLVTAINVLA
LEGNPTHFDEVLFAQKPHTGQQKIAAQLRDWLNSEVQTAHQSPRLQDRYSLRCAPHVIGVFEDSKVWLRQFIENELNSSN
DNPLIDPVNLRVLHGGHFYGGHIAQAMDSLKIMIANIADLMDRQLAQLVDHKMNHGLPRNLTGATAERLPLNHGFKAVQI
GVSAWTAEALKQTLSASIFSRSTECHNQDKVSMGTIAARDATRIIVLTEQVMAALCCASIQAIHLKQLAQQLSPTLRAFS
AWTLHSLALVIEDRPLQTELQQIVDRFAHFELSNADWMQQQEQLYAG

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family [H]

Homologues:

Organism=Homo sapiens, GI4504333, Length=467, Percent_Identity=33.8329764453961, Blast_Score=276, Evalue=5e-74,
Organism=Caenorhabditis elegans, GI17567831, Length=495, Percent_Identity=33.1313131313131, Blast_Score=248, Evalue=4e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313 [H]

Pfam domain/function: PF00221 PAL [H]

EC number: =4.3.1.3 [H]

Molecular weight: Translated: 58166; Mature: 58166

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: PS00488 PAL_HISTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTTLNITQPQTLTVGLEPLSIEDVVRVAQAKCRVALPEQQDWRDLIQKGADFLDTLLQE
CCCCEECCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
EGVIYGVTTGYGDSCLVEVPTHQVHELPLQLSRFHGCGLGQNLDLVTARAVVITRLCSLA
CCEEEEEECCCCCCEEEECCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHH
RGYSGVSLALLERLVWLLNENVIPVIPSEGSVGASGDLTPLSYIAGVLVGEREVYYQGKI
CCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHCCCEEEECCCE
IPVQQVYQQKAIQPLTLRPKEGLALMNGTAVMTAIACLNYKRAEQIAQTATLVTAINVLA
EEHHHHHHHHCCCCCEECCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEE
LEGNPTHFDEVLFAQKPHTGQQKIAAQLRDWLNSEVQTAHQSPRLQDRYSLRCAPHVIGV
ECCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEECCCEEEE
FEDSKVWLRQFIENELNSSNDNPLIDPVNLRVLHGGHFYGGHIAQAMDSLKIMIANIADL
ECCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
MDRQLAQLVDHKMNHGLPRNLTGATAERLPLNHGFKAVQIGVSAWTAEALKQTLSASIFS
HHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHH
RSTECHNQDKVSMGTIAARDATRIIVLTEQVMAALCCASIQAIHLKQLAQQLSPTLRAFS
CCHHCCCCCCCCCCEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AWTLHSLALVIEDRPLQTELQQIVDRFAHFELSNADWMQQQEQLYAG
HHHHHHEEHEECCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MNTTLNITQPQTLTVGLEPLSIEDVVRVAQAKCRVALPEQQDWRDLIQKGADFLDTLLQE
CCCCEECCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
EGVIYGVTTGYGDSCLVEVPTHQVHELPLQLSRFHGCGLGQNLDLVTARAVVITRLCSLA
CCEEEEEECCCCCCEEEECCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHH
RGYSGVSLALLERLVWLLNENVIPVIPSEGSVGASGDLTPLSYIAGVLVGEREVYYQGKI
CCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCHHHHHHHHHHCCCEEEECCCE
IPVQQVYQQKAIQPLTLRPKEGLALMNGTAVMTAIACLNYKRAEQIAQTATLVTAINVLA
EEHHHHHHHHCCCCCEECCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEE
LEGNPTHFDEVLFAQKPHTGQQKIAAQLRDWLNSEVQTAHQSPRLQDRYSLRCAPHVIGV
ECCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEECCCEEEE
FEDSKVWLRQFIENELNSSNDNPLIDPVNLRVLHGGHFYGGHIAQAMDSLKIMIANIADL
ECCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHH
MDRQLAQLVDHKMNHGLPRNLTGATAERLPLNHGFKAVQIGVSAWTAEALKQTLSASIFS
HHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHH
RSTECHNQDKVSMGTIAARDATRIIVLTEQVMAALCCASIQAIHLKQLAQQLSPTLRAFS
CCHHCCCCCCCCCCEEEECCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AWTLHSLALVIEDRPLQTELQQIVDRFAHFELSNADWMQQQEQLYAG
HHHHHHEEHEECCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]