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The map label for this gene is ndk

Identifier: 50083793

GI number: 50083793

Start: 548655

End: 549086

Strand: Direct

Name: ndk

Synonym: ACIAD0556

Alternate gene names: 50083793

Gene position: 548655-549086 (Clockwise)

Preceding gene: 50083792

Following gene: 50083794

Centisome position: 15.25

GC content: 45.14

Gene sequence:

>432_bases
ATGGCAGTTGAACGTACTTTGTCTATCATCAAGCCAGATGCTGTAGGTAAAAATCACATTGGTGAAATCATTGCTCGCTT
TGAAAAAGCAGGTTTAAAACCAGTTGCGATGAAATATAAACACCTTTCTCAAGCTGAAGCTGAAGGCTTTTATGCAGAGC
ACAAAGAACGCGGTTTCTTTGCTGACCTTGTTGCATTCATGACTTCTGGTCCAGTGGTTGTATCTGCACTTGAAGGTGAA
AATGCAGTACTTGCTCACCGTGAAATCCTTGGTGCAACCAATCCAAAAGAAGCTGCGCCTGGTACAATCCGCGCTGACTT
TGCAACAAGCATTGACGAAAATGCTGCGCACGGTTCTGACTCTGTAGCATCTGCTGAGCGTGAAATCGCTTACTTCTTTG
CTGCGGACGAAATCTTCCCGCGCACTCGTTAA

Upstream 100 bases:

>100_bases
AAAATCGTAACTTTTACATATTCAAAGCTGATTATTACCAGTGACATCGGTATAATGCGGCAAATTTTTTTCACGTTTGA
AAGAGTTATAGGAGCCAATC

Downstream 100 bases:

>100_bases
TTAAAAGCATTTAAACCAGATAAGTGTTATTATACTTATCTGGTTTTTTTATTCTCTCTTGATGTGATTGCTTGTTTTTT
AGGCAGTCTGATTTCATCTC

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase

Number of amino acids: Translated: 143; Mature: 142

Protein sequence:

>143_residues
MAVERTLSIIKPDAVGKNHIGEIIARFEKAGLKPVAMKYKHLSQAEAEGFYAEHKERGFFADLVAFMTSGPVVVSALEGE
NAVLAHREILGATNPKEAAPGTIRADFATSIDENAAHGSDSVASAEREIAYFFAADEIFPRTR

Sequences:

>Translated_143_residues
MAVERTLSIIKPDAVGKNHIGEIIARFEKAGLKPVAMKYKHLSQAEAEGFYAEHKERGFFADLVAFMTSGPVVVSALEGE
NAVLAHREILGATNPKEAAPGTIRADFATSIDENAAHGSDSVASAEREIAYFFAADEIFPRTR
>Mature_142_residues
AVERTLSIIKPDAVGKNHIGEIIARFEKAGLKPVAMKYKHLSQAEAEGFYAEHKERGFFADLVAFMTSGPVVVSALEGEN
AVLAHREILGATNPKEAAPGTIRADFATSIDENAAHGSDSVASAEREIAYFFAADEIFPRTR

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI37693993, Length=136, Percent_Identity=48.5294117647059, Blast_Score=135, Evalue=8e-33,
Organism=Homo sapiens, GI66392203, Length=136, Percent_Identity=47.7941176470588, Blast_Score=134, Evalue=2e-32,
Organism=Homo sapiens, GI66392227, Length=136, Percent_Identity=47.7941176470588, Blast_Score=134, Evalue=3e-32,
Organism=Homo sapiens, GI66392205, Length=136, Percent_Identity=47.7941176470588, Blast_Score=134, Evalue=3e-32,
Organism=Homo sapiens, GI4505409, Length=136, Percent_Identity=47.7941176470588, Blast_Score=134, Evalue=3e-32,
Organism=Homo sapiens, GI66392192, Length=136, Percent_Identity=47.7941176470588, Blast_Score=134, Evalue=3e-32,
Organism=Homo sapiens, GI38045913, Length=140, Percent_Identity=46.4285714285714, Blast_Score=131, Evalue=2e-31,
Organism=Homo sapiens, GI4557797, Length=140, Percent_Identity=46.4285714285714, Blast_Score=131, Evalue=2e-31,
Organism=Homo sapiens, GI4826862, Length=135, Percent_Identity=42.2222222222222, Blast_Score=118, Evalue=2e-27,
Organism=Homo sapiens, GI37574614, Length=135, Percent_Identity=40.7407407407407, Blast_Score=99, Evalue=9e-22,
Organism=Homo sapiens, GI7019465, Length=135, Percent_Identity=40.7407407407407, Blast_Score=99, Evalue=1e-21,
Organism=Homo sapiens, GI4505413, Length=135, Percent_Identity=40.7407407407407, Blast_Score=90, Evalue=6e-19,
Organism=Homo sapiens, GI5031951, Length=136, Percent_Identity=37.5, Blast_Score=85, Evalue=2e-17,
Organism=Homo sapiens, GI30023828, Length=137, Percent_Identity=33.5766423357664, Blast_Score=78, Evalue=3e-15,
Organism=Homo sapiens, GI148839372, Length=138, Percent_Identity=29.7101449275362, Blast_Score=65, Evalue=2e-11,
Organism=Escherichia coli, GI1788866, Length=143, Percent_Identity=65.034965034965, Blast_Score=187, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI17506807, Length=135, Percent_Identity=48.8888888888889, Blast_Score=131, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6322783, Length=135, Percent_Identity=47.4074074074074, Blast_Score=132, Evalue=3e-32,
Organism=Drosophila melanogaster, GI45549037, Length=139, Percent_Identity=47.4820143884892, Blast_Score=134, Evalue=2e-32,
Organism=Drosophila melanogaster, GI18860097, Length=134, Percent_Identity=35.8208955223881, Blast_Score=80, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK_ACIAD (Q6FEM7)

Other databases:

- EMBL:   CR543861
- RefSeq:   YP_045303.1
- ProteinModelPortal:   Q6FEM7
- SMR:   Q6FEM7
- STRING:   Q6FEM7
- GeneID:   2879456
- GenomeReviews:   CR543861_GR
- KEGG:   aci:ACIAD0556
- NMPDR:   fig|62977.3.peg.42
- eggNOG:   COG0105
- HOGENOM:   HBG445152
- OMA:   ERPFFGA
- PhylomeDB:   Q6FEM7
- ProtClustDB:   PRK00668
- BioCyc:   ASP62977:ACIAD0556-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- InterPro:   IPR023005
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 15448; Mature: 15316

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 117-117 BINDING 11-11 BINDING 59-59 BINDING 87-87 BINDING 93-93 BINDING 104-104 BINDING 114-114

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVERTLSIIKPDAVGKNHIGEIIARFEKAGLKPVAMKYKHLSQAEAEGFYAEHKERGFF
CCCHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHCCCHH
ADLVAFMTSGPVVVSALEGENAVLAHREILGATNPKEAAPGTIRADFATSIDENAAHGSD
HHHHHHHCCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCCCCEEEHHHHCCCCCCCCCCC
SVASAEREIAYFFAADEIFPRTR
HHHHHHHHHHEEEECCCCCCCCC
>Mature Secondary Structure 
AVERTLSIIKPDAVGKNHIGEIIARFEKAGLKPVAMKYKHLSQAEAEGFYAEHKERGFF
CCHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHCCCHH
ADLVAFMTSGPVVVSALEGENAVLAHREILGATNPKEAAPGTIRADFATSIDENAAHGSD
HHHHHHHCCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCCCCEEEHHHHCCCCCCCCCCC
SVASAEREIAYFFAADEIFPRTR
HHHHHHHHHHEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA