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The map label for this gene is clpP

Identifier: 50083772

GI number: 50083772

Start: 521583

End: 522188

Strand: Direct

Name: clpP

Synonym: ACIAD0534

Alternate gene names: 50083772

Gene position: 521583-522188 (Clockwise)

Preceding gene: 50083771

Following gene: 50083773

Centisome position: 14.49

GC content: 41.75

Gene sequence:

>606_bases
ATGTATGTTCCAACGATTGAAAATGCTTTAGTTCCTGTTGTGGTTGAACAATCTTCGCGTGGCGAACGTTCTTTTGATAT
TTTTTCACGCCTTTTGCGTGAGCGTGTCATTTTCCTCACAGGTGAAGTGGAAGATAACATGGCCAATTTAATTGTGGCTC
AGATGTTGTTTTTAGAAGCTGAGAACCCAGATAAAGATATTCATCTTTATATTAATTCACCAGGCGGTTCTGTAACTGCT
GGTATGGCAATTTATGACACCATGCAGTTTATTAAACCTGATGTGGTGACTTACTGTATGGGACAAGCGGCTTCAATGGG
AGCCTTCTTACTCAATGCAGGCGCAAAAGGTAAACGTTATTGCCTTGAAAATGCCCGTGTCATGATTCATCAGCCACTGG
GTGGTTTTCGTGGTCAGGCATCAGATATTGAAATTCATGCGCGCGAGATTCTGTTTATCAAAGAACGTTTAAACCGTTTG
ATGGCAGAACACAGCGGTCAAGATTATGAGAGAGTTGCTCGTGATACAGATCGTGATAACTTCATGACCGCACAAGCCGC
AAAAGAATATGGTTTAGTGGATGAAGTTTTATCTAAGCGTCCCTAA

Upstream 100 bases:

>100_bases
TAATCTGATATTTCGTTTGGAATGTTTTTGCAATTTTAGTCATTATCCCTCATATTGTCGTTATGGGTTAAGTTACAAAA
ATTTAGGAATAAATAAACGT

Downstream 100 bases:

>100_bases
TAATTAAGATTTAAGTTGTGGAGTAGATATGTCCGAACATCCTCAAGGACAAAAACACTGTTCATTTTGCGGTAAATCTC
AGGCTGAAGTCGGAAAACTG

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp

Number of amino acids: Translated: 201; Mature: 201

Protein sequence:

>201_residues
MYVPTIENALVPVVVEQSSRGERSFDIFSRLLRERVIFLTGEVEDNMANLIVAQMLFLEAENPDKDIHLYINSPGGSVTA
GMAIYDTMQFIKPDVVTYCMGQAASMGAFLLNAGAKGKRYCLENARVMIHQPLGGFRGQASDIEIHAREILFIKERLNRL
MAEHSGQDYERVARDTDRDNFMTAQAAKEYGLVDEVLSKRP

Sequences:

>Translated_201_residues
MYVPTIENALVPVVVEQSSRGERSFDIFSRLLRERVIFLTGEVEDNMANLIVAQMLFLEAENPDKDIHLYINSPGGSVTA
GMAIYDTMQFIKPDVVTYCMGQAASMGAFLLNAGAKGKRYCLENARVMIHQPLGGFRGQASDIEIHAREILFIKERLNRL
MAEHSGQDYERVARDTDRDNFMTAQAAKEYGLVDEVLSKRP
>Mature_201_residues
MYVPTIENALVPVVVEQSSRGERSFDIFSRLLRERVIFLTGEVEDNMANLIVAQMLFLEAENPDKDIHLYINSPGGSVTA
GMAIYDTMQFIKPDVVTYCMGQAASMGAFLLNAGAKGKRYCLENARVMIHQPLGGFRGQASDIEIHAREILFIKERLNRL
MAEHSGQDYERVARDTDRDNFMTAQAAKEYGLVDEVLSKRP

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=192, Percent_Identity=52.6041666666667, Blast_Score=231, Evalue=4e-61,
Organism=Escherichia coli, GI1786641, Length=192, Percent_Identity=77.0833333333333, Blast_Score=319, Evalue=7e-89,
Organism=Caenorhabditis elegans, GI17538017, Length=186, Percent_Identity=51.0752688172043, Blast_Score=211, Evalue=1e-55,
Organism=Drosophila melanogaster, GI20129427, Length=192, Percent_Identity=57.2916666666667, Blast_Score=246, Evalue=1e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP_ACIAD (Q6FEP8)

Other databases:

- EMBL:   CR543861
- RefSeq:   YP_045282.1
- ProteinModelPortal:   Q6FEP8
- SMR:   Q6FEP8
- STRING:   Q6FEP8
- MEROPS:   S14.001
- GeneID:   2877930
- GenomeReviews:   CR543861_GR
- KEGG:   aci:ACIAD0534
- NMPDR:   fig|62977.3.peg.1297
- eggNOG:   COG0740
- HOGENOM:   HBG558421
- OMA:   CQRMERD
- PhylomeDB:   Q6FEP8
- ProtClustDB:   PRK00277
- BioCyc:   ASP62977:ACIAD0534-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- InterPro:   IPR018215
- PANTHER:   PTHR10381
- PRINTS:   PR00127
- TIGRFAMs:   TIGR00493

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 22580; Mature: 22580

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: ACT_SITE 105-105 ACT_SITE 130-130

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYVPTIENALVPVVVEQSSRGERSFDIFSRLLRERVIFLTGEVEDNMANLIVAQMLFLEA
CCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHC
ENPDKDIHLYINSPGGSVTAGMAIYDTMQFIKPDVVTYCMGQAASMGAFLLNAGAKGKRY
CCCCCEEEEEEECCCCCEEHHHHHHHHHHHHCHHHHHHHHCCHHHHHHHEECCCCCCHHH
CLENARVMIHQPLGGFRGQASDIEIHAREILFIKERLNRLMAEHSGQDYERVARDTDRDN
HHCCCEEEEECCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCH
FMTAQAAKEYGLVDEVLSKRP
HHHHHHHHHCCHHHHHHCCCC
>Mature Secondary Structure
MYVPTIENALVPVVVEQSSRGERSFDIFSRLLRERVIFLTGEVEDNMANLIVAQMLFLEA
CCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHC
ENPDKDIHLYINSPGGSVTAGMAIYDTMQFIKPDVVTYCMGQAASMGAFLLNAGAKGKRY
CCCCCEEEEEEECCCCCEEHHHHHHHHHHHHCHHHHHHHHCCHHHHHHHEECCCCCCHHH
CLENARVMIHQPLGGFRGQASDIEIHAREILFIKERLNRLMAEHSGQDYERVARDTDRDN
HHCCCEEEEECCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCH
FMTAQAAKEYGLVDEVLSKRP
HHHHHHHHHCCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA