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The map label for this gene is msrA [H]

Identifier: 50083748

GI number: 50083748

Start: 500029

End: 500562

Strand: Reverse

Name: msrA [H]

Synonym: ACIAD0510

Alternate gene names: 50083748

Gene position: 500562-500029 (Counterclockwise)

Preceding gene: 50083749

Following gene: 50083742

Centisome position: 13.91

GC content: 38.2

Gene sequence:

>534_bases
TTGAGGACCATCATGCAACAGGCATTATTTGGCGGTGGATGTTTCTGGTGTACCGAAGCCGTATTTCAACAAATCCGTGG
CGTTGAAAAAATCGTAAGTGGTTATGCTGGCGGTGTAAATGAAAATCCTACATACGAAGCCGTGTGTACAGGTGAAACCA
ATCATGCTGAAGTAATTCTGATTGACTTTGATGAATCACAAGTCAGTTATGATGATTTATTACATGTATTTTTCGCTATT
CATGATCCAACGACGCTGAACCGTCAAGGCAATGATATTGGTACTCAATATCGCTCAGTCATTTATTATTTTGATGAACA
TCAAAAACAAGATGCTGAAAAACTGATTGCCGAGTTAAAAGCTGAAGGCATGAGTGTAGTGACTGAACTGAGTCCAATGC
CCACTTTTTATCCAGCCGAAGATTATCATCAGGATTTTTATACAAAGAATCCATCACAAGGTTTTTGTAATTTTGCAATT
CCTCCAAAAATTGCCAAATTACGTAGCAAATTTCAGTCTTTACTCAAAGCCTGA

Upstream 100 bases:

>100_bases
AATCCGTAAATTAAATGTTCAAGGGCTTTTTATTGAGCAGATCGTCACGATATAGATTGTAGGTTCATAAAAAACCTTTA
TAGTAAATTCATTTGTTATT

Downstream 100 bases:

>100_bases
ACAAAAAAAAGCAACTCGATCGAGTTGCTTTTTTTATTGCGCTGAATCAAGCGCGTTTAATTTTCACTGACAAAAGCAAT
ATCGCTGAGTCCGGCTCCAC

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 177; Mature: 177

Protein sequence:

>177_residues
MRTIMQQALFGGGCFWCTEAVFQQIRGVEKIVSGYAGGVNENPTYEAVCTGETNHAEVILIDFDESQVSYDDLLHVFFAI
HDPTTLNRQGNDIGTQYRSVIYYFDEHQKQDAEKLIAELKAEGMSVVTELSPMPTFYPAEDYHQDFYTKNPSQGFCNFAI
PPKIAKLRSKFQSLLKA

Sequences:

>Translated_177_residues
MRTIMQQALFGGGCFWCTEAVFQQIRGVEKIVSGYAGGVNENPTYEAVCTGETNHAEVILIDFDESQVSYDDLLHVFFAI
HDPTTLNRQGNDIGTQYRSVIYYFDEHQKQDAEKLIAELKAEGMSVVTELSPMPTFYPAEDYHQDFYTKNPSQGFCNFAI
PPKIAKLRSKFQSLLKA
>Mature_177_residues
MRTIMQQALFGGGCFWCTEAVFQQIRGVEKIVSGYAGGVNENPTYEAVCTGETNHAEVILIDFDESQVSYDDLLHVFFAI
HDPTTLNRQGNDIGTQYRSVIYYFDEHQKQDAEKLIAELKAEGMSVVTELSPMPTFYPAEDYHQDFYTKNPSQGFCNFAI
PPKIAKLRSKFQSLLKA

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=162, Percent_Identity=42.5925925925926, Blast_Score=130, Evalue=5e-31,
Organism=Homo sapiens, GI208609995, Length=162, Percent_Identity=42.5925925925926, Blast_Score=129, Evalue=1e-30,
Organism=Homo sapiens, GI208609993, Length=136, Percent_Identity=38.9705882352941, Blast_Score=86, Evalue=2e-17,
Organism=Escherichia coli, GI1790665, Length=153, Percent_Identity=43.7908496732026, Blast_Score=132, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17533973, Length=143, Percent_Identity=33.5664335664336, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6320881, Length=153, Percent_Identity=37.2549019607843, Blast_Score=98, Evalue=7e-22,
Organism=Drosophila melanogaster, GI24664627, Length=162, Percent_Identity=35.1851851851852, Blast_Score=97, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24664631, Length=162, Percent_Identity=34.5679012345679, Blast_Score=94, Evalue=7e-20,
Organism=Drosophila melanogaster, GI45553131, Length=154, Percent_Identity=34.4155844155844, Blast_Score=93, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 20024; Mature: 20024

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTIMQQALFGGGCFWCTEAVFQQIRGVEKIVSGYAGGVNENPTYEAVCTGETNHAEVIL
CHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCEEEEE
IDFDESQVSYDDLLHVFFAIHDPTTLNRQGNDIGTQYRSVIYYFDEHQKQDAEKLIAELK
EECCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AEGMSVVTELSPMPTFYPAEDYHQDFYTKNPSQGFCNFAIPPKIAKLRSKFQSLLKA
HCHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRTIMQQALFGGGCFWCTEAVFQQIRGVEKIVSGYAGGVNENPTYEAVCTGETNHAEVIL
CHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCEEEEE
IDFDESQVSYDDLLHVFFAIHDPTTLNRQGNDIGTQYRSVIYYFDEHQKQDAEKLIAELK
EECCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AEGMSVVTELSPMPTFYPAEDYHQDFYTKNPSQGFCNFAIPPKIAKLRSKFQSLLKA
HCHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA