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The map label for this gene is asd [H]

Identifier: 50083721

GI number: 50083721

Start: 471037

End: 472155

Strand: Reverse

Name: asd [H]

Synonym: ACIAD0479

Alternate gene names: 50083721

Gene position: 472155-471037 (Counterclockwise)

Preceding gene: 50083724

Following gene: 50083720

Centisome position: 13.12

GC content: 43.34

Gene sequence:

>1119_bases
ATGAAAGTAGGTCTGGTCGGTTGGCGCGGGATGGTTGGTTCCGTCCTTATGCAACGTATGGTTGAAGAAAATGATTTTGC
TCACTTTGAGCCATTTTACTTTTCTACCAGTAATGCAGGTGGTGAAGCTCCTTCATTTGGTGGTAAAACTGCCCCAGCAC
TTATGGATGCAACAGACATTAAGAGTCTGAAGCAAATGGACGTCATTATTACCTGCCAAGGTGGTGACTATACTTCTGAA
GTTTTTCCAAAACTCAAAGCCGAAGGCTGGAATGGTTACTGGATTGATGCTGCATCGACGTTACGCATGGTGGATGATGC
CATTATCGTACTAGATCCAGTGAATGCACATGTGATTAAAGATGGTTTAGCTAAAGGCACTAAAACATTTGTAGGCGGTA
ACTGTACAGTTTCCTTGATGCTCATGGGTCTTGGTTCACTCTTCCAAAATAATTTGGTTGAATGGATGAGTGCCATGACC
TATCAGGCTGCATCTGGTGCAGGTGCGCAAAACATGCGTGAGCTTTTATCTGGCATGGGGTATTTGTATAACAATACCAA
AGAATTGCTAGATGACCCACGTTCTGCAATTTTGGATATCGACAGTCGCGTTGCAGAATTACAACGTGGTGAAGGTTTTC
CAAAAGCAAACTTTGGTGTGCCATTAGCAGGCTCATTGATTCCTTATATCGATAAACAGCTTGAAAGTGGTCAGTCTAAA
GAAGAGTGGAAAGGCCAAGCAGAAACCAACAAAATCTTGGGGAATGCTCAAATTGTCCCAATTGATGGTCACTGTGTACG
TATTGGTGCAATGCGTTGCCACTCACAAGCACTCACCATTAAGCTCAGAAAAGATGTTCCACTGGATGAAATCGAAGATA
TGATTCGTCAGTCAAATGAATGGGCAAAGGTGGTTCCAAATACTCGTGAAGCGTCTATGACTGATCTCACTCCTGTTGCC
GTGACTGGCACATTGACTGTACCAGTTGGACGTTTACGCAAATTAAATATGGGTAAAGAATACCTTGGTGCGTTCACTGT
AGGTGATCAGTTGCTTTGGGGTGCTGCTGAGCCGTTACGTCGTATGTTACGTATTCTGATCGAATACAAAAATGCTTAA

Upstream 100 bases:

>100_bases
TAAACGTCATGTTTTAATTGGATAATACTTGCAGTTGTGATCGCTTTTGATACACTCAAGCCCCCTTTTTACATTTTTTA
ACGCACCGAGGCAAAATGAC

Downstream 100 bases:

>100_bases
ACTTGATTGTTAATGATGTCATGAAGCCGATCTTGATGATCGGCTTTTTTGTGCATCGACATTTTAAAGACTGATCATGC
GATGTATTTGTCGGTGTTGC

Product: aspartate-semialdehyde dehydrogenase

Products: NA

Alternate protein names: ASA dehydrogenase; ASADH [H]

Number of amino acids: Translated: 372; Mature: 372

Protein sequence:

>372_residues
MKVGLVGWRGMVGSVLMQRMVEENDFAHFEPFYFSTSNAGGEAPSFGGKTAPALMDATDIKSLKQMDVIITCQGGDYTSE
VFPKLKAEGWNGYWIDAASTLRMVDDAIIVLDPVNAHVIKDGLAKGTKTFVGGNCTVSLMLMGLGSLFQNNLVEWMSAMT
YQAASGAGAQNMRELLSGMGYLYNNTKELLDDPRSAILDIDSRVAELQRGEGFPKANFGVPLAGSLIPYIDKQLESGQSK
EEWKGQAETNKILGNAQIVPIDGHCVRIGAMRCHSQALTIKLRKDVPLDEIEDMIRQSNEWAKVVPNTREASMTDLTPVA
VTGTLTVPVGRLRKLNMGKEYLGAFTVGDQLLWGAAEPLRRMLRILIEYKNA

Sequences:

>Translated_372_residues
MKVGLVGWRGMVGSVLMQRMVEENDFAHFEPFYFSTSNAGGEAPSFGGKTAPALMDATDIKSLKQMDVIITCQGGDYTSE
VFPKLKAEGWNGYWIDAASTLRMVDDAIIVLDPVNAHVIKDGLAKGTKTFVGGNCTVSLMLMGLGSLFQNNLVEWMSAMT
YQAASGAGAQNMRELLSGMGYLYNNTKELLDDPRSAILDIDSRVAELQRGEGFPKANFGVPLAGSLIPYIDKQLESGQSK
EEWKGQAETNKILGNAQIVPIDGHCVRIGAMRCHSQALTIKLRKDVPLDEIEDMIRQSNEWAKVVPNTREASMTDLTPVA
VTGTLTVPVGRLRKLNMGKEYLGAFTVGDQLLWGAAEPLRRMLRILIEYKNA
>Mature_372_residues
MKVGLVGWRGMVGSVLMQRMVEENDFAHFEPFYFSTSNAGGEAPSFGGKTAPALMDATDIKSLKQMDVIITCQGGDYTSE
VFPKLKAEGWNGYWIDAASTLRMVDDAIIVLDPVNAHVIKDGLAKGTKTFVGGNCTVSLMLMGLGSLFQNNLVEWMSAMT
YQAASGAGAQNMRELLSGMGYLYNNTKELLDDPRSAILDIDSRVAELQRGEGFPKANFGVPLAGSLIPYIDKQLESGQSK
EEWKGQAETNKILGNAQIVPIDGHCVRIGAMRCHSQALTIKLRKDVPLDEIEDMIRQSNEWAKVVPNTREASMTDLTPVA
VTGTLTVPVGRLRKLNMGKEYLGAFTVGDQLLWGAAEPLRRMLRILIEYKNA

Specific function: Second step in the common biosynthetic pathway leading from Asp to the cell wall precursor meso-diaminopimelate, to Lys, to Met, to Ile and to Thr. [C]

COG id: COG0136

COG function: function code E; Aspartate-semialdehyde dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aspartate-semialdehyde dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1789841, Length=365, Percent_Identity=67.6712328767123, Blast_Score=523, Evalue=1e-150,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000319
- InterPro:   IPR011534
- InterPro:   IPR012080
- InterPro:   IPR016040
- InterPro:   IPR000534
- InterPro:   IPR012280 [H]

Pfam domain/function: PF01118 Semialdhyde_dh; PF02774 Semialdhyde_dhC [H]

EC number: =1.2.1.11 [H]

Molecular weight: Translated: 40703; Mature: 40703

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: PS01103 ASD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVGLVGWRGMVGSVLMQRMVEENDFAHFEPFYFSTSNAGGEAPSFGGKTAPALMDATDI
CCEECCCHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCCCCCCCHHHCHHHH
KSLKQMDVIITCQGGDYTSEVFPKLKAEGWNGYWIDAASTLRMVDDAIIVLDPVNAHVIK
HHHHHCCEEEEECCCCCHHHHHHHHHCCCCCEEEECHHHHHHHHCCEEEEECCCCHHHHH
DGLAKGTKTFVGGNCTVSLMLMGLGSLFQNNLVEWMSAMTYQAASGAGAQNMRELLSGMG
HHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCH
YLYNNTKELLDDPRSAILDIDSRVAELQRGEGFPKANFGVPLAGSLIPYIDKQLESGQSK
HHHCCCHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCH
EEWKGQAETNKILGNAQIVPIDGHCVRIGAMRCHSQALTIKLRKDVPLDEIEDMIRQSNE
HHHCCCCHHHHHCCCCEEEEECCCEEEEEHHHHCCCEEEEEEECCCCHHHHHHHHHCCCC
WAKVVPNTREASMTDLTPVAVTGTLTVPVGRLRKLNMGKEYLGAFTVGDQLLWGAAEPLR
CEECCCCCCCCCCCCCCCEEEEEEEECCHHHHHHCCCCHHHHHHHHHCCHHHHCCHHHHH
RMLRILIEYKNA
HHHHHHHHHCCC
>Mature Secondary Structure
MKVGLVGWRGMVGSVLMQRMVEENDFAHFEPFYFSTSNAGGEAPSFGGKTAPALMDATDI
CCEECCCHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCCCCCCCHHHCHHHH
KSLKQMDVIITCQGGDYTSEVFPKLKAEGWNGYWIDAASTLRMVDDAIIVLDPVNAHVIK
HHHHHCCEEEEECCCCCHHHHHHHHHCCCCCEEEECHHHHHHHHCCEEEEECCCCHHHHH
DGLAKGTKTFVGGNCTVSLMLMGLGSLFQNNLVEWMSAMTYQAASGAGAQNMRELLSGMG
HHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCH
YLYNNTKELLDDPRSAILDIDSRVAELQRGEGFPKANFGVPLAGSLIPYIDKQLESGQSK
HHHCCCHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCH
EEWKGQAETNKILGNAQIVPIDGHCVRIGAMRCHSQALTIKLRKDVPLDEIEDMIRQSNE
HHHCCCCHHHHHCCCCEEEEECCCEEEEEHHHHCCCEEEEEEECCCCHHHHHHHHHCCCC
WAKVVPNTREASMTDLTPVAVTGTLTVPVGRLRKLNMGKEYLGAFTVGDQLLWGAAEPLR
CEECCCCCCCCCCCCCCCEEEEEEEECCHHHHHHCCCCHHHHHHHHHCCHHHHCCHHHHH
RMLRILIEYKNA
HHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9084174; 10984043 [H]