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The map label for this gene is ubiB [H]

Identifier: 50083641

GI number: 50083641

Start: 375764

End: 377383

Strand: Reverse

Name: ubiB [H]

Synonym: ACIAD0382

Alternate gene names: 50083641

Gene position: 377383-375764 (Counterclockwise)

Preceding gene: 50083642

Following gene: 50083640

Centisome position: 10.49

GC content: 43.7

Gene sequence:

>1620_bases
ATGGTTCCGCACGTTTCACGGTTACTCGAACTCTGGCGTATTGCTGCACATTATCGGCTCGACACCCTGTTTCCTGCGGA
AGAATTGCCTGCCAAAGCCCGCCATGCGATTAATCTAATCAAGCTACATCCCGCAGCATGGTCCAGTCGTGAACGAAAAA
ACCCGCTTAAACTCAAAGAAGCACTTGAGGATATGGGGCCGTTGGCAATTAAATTAGGACAATTGCTTTCCACCCGACGC
GATCTTATTCCGCCAGAAATCTTGTCTCAACTGGTTTTACTTCAAGATCAAGTGAAACCTTTTGATCCCCAAATTGCAAA
ACAGCGGATTCAAGATTCTTTAAAAGCAGAGGTCAATACTCTCTTTGCTCGCTTTGATGAGCAACCACTTGCAGCCGCAT
CGATTGCTCAGGTTCATACCGCAGCACTATTCGATGGCCGAGAAGTGATTGTTAAAGTCACGCGTCCCAATATACGCACA
CAAATTCTGCAAGATTTTGAAATTATTTCATGGCTAGGTCAATCACTAGAAAGTCGACTTGAAGCAGCTCGTGCGCTGCA
CCTGAGTGAAATTATTCAAGACTATCGTCAGATTATTCTCAATGAGCTTGATCTTACGTTAGAGGCAGATAATACGCGGC
GCATGCGACATTACTTTACTGGCTCCAGTATGATGTATGTGCCTGAAGTGTATATGGACAGTAAAGATGTCATGGTCGCC
GAACGAATCACTGGCGTGCCTATTTCGGATACAGCCACATTTGATCGTTTGGGAATGAATCGCGCGGATCTAGCAGAAAA
AGGATTAACTATCTTTTTCACTCAGGTTTTCCGAGATAACTTTTTCCATGCCGATATGCACCCTGGCAATGTGTTTGTTG
AGACCATTAATCCCGCCAACCCACGCTTTATTGCACTGGATTGTGCAATTATGGGGGAACTCTCCAAGCACGACCAGATG
ACCGTTGCTCGCATGCTATTGGCGGTCATGAACAACAACTTTATGCAGTTAATCCAGATTGTACATCAAGCTGGATGGAT
TCCACCTGGCACAGATCAAGATGCTTTAGCCCGTGAAATGCGTCGTACTGTTGGACCGATGGTTTCCAAACCAATGGATC
AACTGGATTTTGCTGGAATTTTACTGCAAGTGATGGATATTGCACGCCGCTTTCATCTGGAAATTCCACCACAATTGATG
TTATTGCTGAAAACACTGGTACATGTTGAAGGACTCGGAACAGATCTTTATCCTCAACTGGATATCTGGAAACTGGCCAA
ACCCATTTTGACCGAATGGGTCAAATCTAATATGAACCCAGTCAAGAATATCAAGGAAATTGGACAACAAATTCCTGATT
TATTGTTAGGTGCACAGGATTTACCTACCTTACTGATTGACAGTTTAAATGGTTTAAAAAATCAGTCTGCCTGGCAGGAT
CGTCAAGTTCGGGAATTACAGCAATTACGTTTGCAAATGGAACATCAGCAAAAGCGTAGCTGGATTTTTGGCAGTATCAT
TGCCATCCTATTGAGTATTGCCATCATTGCACCATGGTATATTTCGATTGTCTTGATTACGCTCACTATCTTGCTATCGA
TCTGGCGAATCGTTAAATAA

Upstream 100 bases:

>100_bases
CATGCCACTCGCCAGCTCAATCAAGAGCTTGATCGTGTTGAAGCCAGACTGCAACAGCTCAACCTGCAATTACAATCAGA
CAACTAGGTGATATTTTATT

Downstream 100 bases:

>100_bases
TGGATCATGAGGTGAAGCGCTGATTCAAACTTCACCTCAAATATTAAATACCCCTACAATGAAAAAAATAAATAAGATTG
CCATTATCGGTGCTGGTACA

Product: 2-octaprenylphenol hydroxylase of ubiquinone biosynthetic pathway

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 539; Mature: 539

Protein sequence:

>539_residues
MVPHVSRLLELWRIAAHYRLDTLFPAEELPAKARHAINLIKLHPAAWSSRERKNPLKLKEALEDMGPLAIKLGQLLSTRR
DLIPPEILSQLVLLQDQVKPFDPQIAKQRIQDSLKAEVNTLFARFDEQPLAAASIAQVHTAALFDGREVIVKVTRPNIRT
QILQDFEIISWLGQSLESRLEAARALHLSEIIQDYRQIILNELDLTLEADNTRRMRHYFTGSSMMYVPEVYMDSKDVMVA
ERITGVPISDTATFDRLGMNRADLAEKGLTIFFTQVFRDNFFHADMHPGNVFVETINPANPRFIALDCAIMGELSKHDQM
TVARMLLAVMNNNFMQLIQIVHQAGWIPPGTDQDALAREMRRTVGPMVSKPMDQLDFAGILLQVMDIARRFHLEIPPQLM
LLLKTLVHVEGLGTDLYPQLDIWKLAKPILTEWVKSNMNPVKNIKEIGQQIPDLLLGAQDLPTLLIDSLNGLKNQSAWQD
RQVRELQQLRLQMEHQQKRSWIFGSIIAILLSIAIIAPWYISIVLITLTILLSIWRIVK

Sequences:

>Translated_539_residues
MVPHVSRLLELWRIAAHYRLDTLFPAEELPAKARHAINLIKLHPAAWSSRERKNPLKLKEALEDMGPLAIKLGQLLSTRR
DLIPPEILSQLVLLQDQVKPFDPQIAKQRIQDSLKAEVNTLFARFDEQPLAAASIAQVHTAALFDGREVIVKVTRPNIRT
QILQDFEIISWLGQSLESRLEAARALHLSEIIQDYRQIILNELDLTLEADNTRRMRHYFTGSSMMYVPEVYMDSKDVMVA
ERITGVPISDTATFDRLGMNRADLAEKGLTIFFTQVFRDNFFHADMHPGNVFVETINPANPRFIALDCAIMGELSKHDQM
TVARMLLAVMNNNFMQLIQIVHQAGWIPPGTDQDALAREMRRTVGPMVSKPMDQLDFAGILLQVMDIARRFHLEIPPQLM
LLLKTLVHVEGLGTDLYPQLDIWKLAKPILTEWVKSNMNPVKNIKEIGQQIPDLLLGAQDLPTLLIDSLNGLKNQSAWQD
RQVRELQQLRLQMEHQQKRSWIFGSIIAILLSIAIIAPWYISIVLITLTILLSIWRIVK
>Mature_539_residues
MVPHVSRLLELWRIAAHYRLDTLFPAEELPAKARHAINLIKLHPAAWSSRERKNPLKLKEALEDMGPLAIKLGQLLSTRR
DLIPPEILSQLVLLQDQVKPFDPQIAKQRIQDSLKAEVNTLFARFDEQPLAAASIAQVHTAALFDGREVIVKVTRPNIRT
QILQDFEIISWLGQSLESRLEAARALHLSEIIQDYRQIILNELDLTLEADNTRRMRHYFTGSSMMYVPEVYMDSKDVMVA
ERITGVPISDTATFDRLGMNRADLAEKGLTIFFTQVFRDNFFHADMHPGNVFVETINPANPRFIALDCAIMGELSKHDQM
TVARMLLAVMNNNFMQLIQIVHQAGWIPPGTDQDALAREMRRTVGPMVSKPMDQLDFAGILLQVMDIARRFHLEIPPQLM
LLLKTLVHVEGLGTDLYPQLDIWKLAKPILTEWVKSNMNPVKNIKEIGQQIPDLLLGAQDLPTLLIDSLNGLKNQSAWQD
RQVRELQQLRLQMEHQQKRSWIFGSIIAILLSIAIIAPWYISIVLITLTILLSIWRIVK

Specific function: Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis [H]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC1 family. UbiB subfamily [H]

Homologues:

Organism=Homo sapiens, GI41393593, Length=267, Percent_Identity=30.7116104868914, Blast_Score=122, Evalue=6e-28,
Organism=Homo sapiens, GI40254938, Length=226, Percent_Identity=29.646017699115, Blast_Score=102, Evalue=9e-22,
Organism=Homo sapiens, GI217035081, Length=193, Percent_Identity=27.4611398963731, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI32261307, Length=335, Percent_Identity=22.3880597014925, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI34147522, Length=230, Percent_Identity=27.3913043478261, Blast_Score=67, Evalue=5e-11,
Organism=Escherichia coli, GI2367309, Length=495, Percent_Identity=41.010101010101, Blast_Score=379, Evalue=1e-106,
Organism=Caenorhabditis elegans, GI17559152, Length=287, Percent_Identity=26.1324041811847, Blast_Score=105, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI32565180, Length=288, Percent_Identity=26.0416666666667, Blast_Score=80, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6325148, Length=447, Percent_Identity=21.0290827740492, Blast_Score=100, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6323282, Length=263, Percent_Identity=26.9961977186312, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6321319, Length=241, Percent_Identity=25.3112033195021, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24662575, Length=309, Percent_Identity=30.42071197411, Blast_Score=112, Evalue=1e-24,
Organism=Drosophila melanogaster, GI22024280, Length=279, Percent_Identity=24.7311827956989, Blast_Score=91, Evalue=3e-18,
Organism=Drosophila melanogaster, GI18859849, Length=298, Percent_Identity=22.1476510067114, Blast_Score=66, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR010232 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 61544; Mature: 61544

Theoretical pI: Translated: 7.26; Mature: 7.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVPHVSRLLELWRIAAHYRLDTLFPAEELPAKARHAINLIKLHPAAWSSRERKNPLKLKE
CCCHHHHHHHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHHEECCCCCCCCCCCCCHHHHH
ALEDMGPLAIKLGQLLSTRRDLIPPEILSQLVLLQDQVKPFDPQIAKQRIQDSLKAEVNT
HHHHHCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
LFARFDEQPLAAASIAQVHTAALFDGREVIVKVTRPNIRTQILQDFEIISWLGQSLESRL
HHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
EAARALHLSEIIQDYRQIILNELDLTLEADNTRRMRHYFTGSSMMYVPEVYMDSKDVMVA
HHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCHHHHHHCCCCCEEEECHHHCCCCCHHHH
ERITGVPISDTATFDRLGMNRADLAEKGLTIFFTQVFRDNFFHADMHPGNVFVETINPAN
HHHCCCCCCCCCHHHHHCCCHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCC
PRFIALDCAIMGELSKHDQMTVARMLLAVMNNNFMQLIQIVHQAGWIPPGTDQDALAREM
CCEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCHHHHHHHH
RRTVGPMVSKPMDQLDFAGILLQVMDIARRFHLEIPPQLMLLLKTLVHVEGLGTDLYPQL
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCC
DIWKLAKPILTEWVKSNMNPVKNIKEIGQQIPDLLLGAQDLPTLLIDSLNGLKNQSAWQD
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHH
RQVRELQQLRLQMEHQQKRSWIFGSIIAILLSIAIIAPWYISIVLITLTILLSIWRIVK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVPHVSRLLELWRIAAHYRLDTLFPAEELPAKARHAINLIKLHPAAWSSRERKNPLKLKE
CCCHHHHHHHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHHEECCCCCCCCCCCCCHHHHH
ALEDMGPLAIKLGQLLSTRRDLIPPEILSQLVLLQDQVKPFDPQIAKQRIQDSLKAEVNT
HHHHHCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
LFARFDEQPLAAASIAQVHTAALFDGREVIVKVTRPNIRTQILQDFEIISWLGQSLESRL
HHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
EAARALHLSEIIQDYRQIILNELDLTLEADNTRRMRHYFTGSSMMYVPEVYMDSKDVMVA
HHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCHHHHHHCCCCCEEEECHHHCCCCCHHHH
ERITGVPISDTATFDRLGMNRADLAEKGLTIFFTQVFRDNFFHADMHPGNVFVETINPAN
HHHCCCCCCCCCHHHHHCCCHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCC
PRFIALDCAIMGELSKHDQMTVARMLLAVMNNNFMQLIQIVHQAGWIPPGTDQDALAREM
CCEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCHHHHHHHH
RRTVGPMVSKPMDQLDFAGILLQVMDIARRFHLEIPPQLMLLLKTLVHVEGLGTDLYPQL
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCC
DIWKLAKPILTEWVKSNMNPVKNIKEIGQQIPDLLLGAQDLPTLLIDSLNGLKNQSAWQD
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHHH
RQVRELQQLRLQMEHQQKRSWIFGSIIAILLSIAIIAPWYISIVLITLTILLSIWRIVK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA