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The map label for this gene is uvrC

Identifier: 50083605

GI number: 50083605

Start: 335860

End: 337659

Strand: Direct

Name: uvrC

Synonym: ACIAD0340

Alternate gene names: 50083605

Gene position: 335860-337659 (Clockwise)

Preceding gene: 50083604

Following gene: 50083606

Centisome position: 9.33

GC content: 43.94

Gene sequence:

>1800_bases
GTGAATCCAAACGCGCGTCCACATATTGAAAAAATTCTCGCCAACATGACCCAATTACCTGGCGTATATCGTATGCTGGG
TAAAGACGGCGAACTGCTCTACGTTGGTAAAGCCAAAAATTTAAAAAATCGTGTTTCCAGTTATTTTGTCAAAACGATTG
AGCATCCTAAAACACAGGCCTTGGTCGCGCGAATTCATGATATTGAGACACTGGTTACACGCTCTGAAACTGAAGCACTC
TTACTTGAACAGAATCTGATTAAACAGCATCGTCCGCCTTACAATATTATGCTGCGTGACGATAAATCCTATGTCTATAT
TTTTGTGTCCAGTGATAAACCTTATCCACGTATTGCAAGTGGAAGAGGTAAAGGCAAGCATCAGATTGGGAAGTTTTTTG
GGCCGTATCCAAGTGCATATAGTGCCCGAGATACTTTGCTGGTATTACAAAAACTATTTAATGTGCGTCAATGTGAAAAC
AGTTATTTTGCCCAGCGTAAACGGCCGTGTTTGCAATACCAGATTAAACGCTGTTCTGCGCCGTGTGTGGGATTGATTTC
CCCTGAAGATTACAAGCAGGACGTGGACAACTCGATTCGATTTTTGCAAGGTGATACCAAAGAGCTCAATCAGGAATTGA
TTGCCAAGATGGAAGAGGCTGCCGAGCAGCTCGCGTTTGAAAAAGCCATGTTTTATCGTGATCGTTTAGGGCTGTTGCGT
GAAGTACAGGCACAACAGGCAGTTTTCAAAATTAAAGGTGAGGCAGATATTCTGGCAATTGCTTTTCAGGCAGGTGTCAC
CTGTGTACAAATCATGTATGTACGCAATGGACGGATGCTCGGTGGAAAAAGTTATTTCCCAGATATGCTCAGCGATGATT
TGGGGCAAATGCTGAGTGATTTTATTGCCAATTTCTACTTTCAGGTGGCAGATGAAGTTCCTTCAGAGCTCATTGTTAAT
GTTGAGCTGCCCGACCGTAAAGAGCTAGAACAAGCACTACAAACCCAGTTTGACAAGAAAATTCAGATCAAACACAAGGT
ACGAGAAACCCGTGCAGAATGGCAAGAACTGGCCATCATGAATGTTCAGCATGCCATTAAAGGTCAGTTAAGTAATCATT
TGGAACTCAATGAGCGTTTCCATCAGCTTGAACAAGTGGTAGGGCGCCCAGTAGATCGAATTGAATGTTTTGATATCAGT
CATACCATGGGCGAAGCCACAATTGCATCTTGTGTGGTTTTTGATCAGGGAGGTGCGCGTAAACGTGATTATCGTCAGTT
TGGTATTGAGGATATTACCGCAGGAGATGATTATGCAGCGATGCGCCAGGCACTCACCCGACGTTATAAAAAGCACATTG
TACCTGATTTATTACTAATTGATGGTGGCAAGGGGCAGTTACACATGGCCATGGAAGTGATGCAGACACTGGGTCTGGAT
GCATTTATGGTGGGCGTATCTAAAGGTGAAGGTCGTAAGCCAGGGCTTGAAACTTTACATTTTACTGATGGCAGCAAGAT
TCAGTTGCCAGAAGATCACAAGGCATTACATCTGATTCAGCAGGTACGTGATGAAGCGCATCGCTTTGCGATTACCAAAC
ACCGTGCCAAACGTGATAAACGTCGTGCCGGCTCGGTTTTAGAAGTAATTCCAGGATTAGGGCCTAAGCGTCGTCGTGAC
TTATTGACTCATTTTGGTGGTATCCAGGGTGTACTCAAAGCTTCGGAAAAGGAGCTGATGCTGGTTTCTGGTCTGGGGCC
TTCTATGGCAAGAACCATTTATAAAATCTTGCATGAATAA

Upstream 100 bases:

>100_bases
GGAATCTTAAAACTTCAACATTTTGTCATCATGACAACGCTTGAAAAGCATACATGGAAACATCACATTAGTATTCTAGC
CTTTAGCCAAGAATCTAATA

Downstream 100 bases:

>100_bases
ATTGGCAAAAACATCCTGTGACTGGCGCGTCACTGATCATTTTTGTTGTCATAAAATACTGCACAATAGCAATCAGAATG
AAAAATAATGAGTGATGCTA

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C

Number of amino acids: Translated: 599; Mature: 599

Protein sequence:

>599_residues
MNPNARPHIEKILANMTQLPGVYRMLGKDGELLYVGKAKNLKNRVSSYFVKTIEHPKTQALVARIHDIETLVTRSETEAL
LLEQNLIKQHRPPYNIMLRDDKSYVYIFVSSDKPYPRIASGRGKGKHQIGKFFGPYPSAYSARDTLLVLQKLFNVRQCEN
SYFAQRKRPCLQYQIKRCSAPCVGLISPEDYKQDVDNSIRFLQGDTKELNQELIAKMEEAAEQLAFEKAMFYRDRLGLLR
EVQAQQAVFKIKGEADILAIAFQAGVTCVQIMYVRNGRMLGGKSYFPDMLSDDLGQMLSDFIANFYFQVADEVPSELIVN
VELPDRKELEQALQTQFDKKIQIKHKVRETRAEWQELAIMNVQHAIKGQLSNHLELNERFHQLEQVVGRPVDRIECFDIS
HTMGEATIASCVVFDQGGARKRDYRQFGIEDITAGDDYAAMRQALTRRYKKHIVPDLLLIDGGKGQLHMAMEVMQTLGLD
AFMVGVSKGEGRKPGLETLHFTDGSKIQLPEDHKALHLIQQVRDEAHRFAITKHRAKRDKRRAGSVLEVIPGLGPKRRRD
LLTHFGGIQGVLKASEKELMLVSGLGPSMARTIYKILHE

Sequences:

>Translated_599_residues
MNPNARPHIEKILANMTQLPGVYRMLGKDGELLYVGKAKNLKNRVSSYFVKTIEHPKTQALVARIHDIETLVTRSETEAL
LLEQNLIKQHRPPYNIMLRDDKSYVYIFVSSDKPYPRIASGRGKGKHQIGKFFGPYPSAYSARDTLLVLQKLFNVRQCEN
SYFAQRKRPCLQYQIKRCSAPCVGLISPEDYKQDVDNSIRFLQGDTKELNQELIAKMEEAAEQLAFEKAMFYRDRLGLLR
EVQAQQAVFKIKGEADILAIAFQAGVTCVQIMYVRNGRMLGGKSYFPDMLSDDLGQMLSDFIANFYFQVADEVPSELIVN
VELPDRKELEQALQTQFDKKIQIKHKVRETRAEWQELAIMNVQHAIKGQLSNHLELNERFHQLEQVVGRPVDRIECFDIS
HTMGEATIASCVVFDQGGARKRDYRQFGIEDITAGDDYAAMRQALTRRYKKHIVPDLLLIDGGKGQLHMAMEVMQTLGLD
AFMVGVSKGEGRKPGLETLHFTDGSKIQLPEDHKALHLIQQVRDEAHRFAITKHRAKRDKRRAGSVLEVIPGLGPKRRRD
LLTHFGGIQGVLKASEKELMLVSGLGPSMARTIYKILHE
>Mature_599_residues
MNPNARPHIEKILANMTQLPGVYRMLGKDGELLYVGKAKNLKNRVSSYFVKTIEHPKTQALVARIHDIETLVTRSETEAL
LLEQNLIKQHRPPYNIMLRDDKSYVYIFVSSDKPYPRIASGRGKGKHQIGKFFGPYPSAYSARDTLLVLQKLFNVRQCEN
SYFAQRKRPCLQYQIKRCSAPCVGLISPEDYKQDVDNSIRFLQGDTKELNQELIAKMEEAAEQLAFEKAMFYRDRLGLLR
EVQAQQAVFKIKGEADILAIAFQAGVTCVQIMYVRNGRMLGGKSYFPDMLSDDLGQMLSDFIANFYFQVADEVPSELIVN
VELPDRKELEQALQTQFDKKIQIKHKVRETRAEWQELAIMNVQHAIKGQLSNHLELNERFHQLEQVVGRPVDRIECFDIS
HTMGEATIASCVVFDQGGARKRDYRQFGIEDITAGDDYAAMRQALTRRYKKHIVPDLLLIDGGKGQLHMAMEVMQTLGLD
AFMVGVSKGEGRKPGLETLHFTDGSKIQLPEDHKALHLIQQVRDEAHRFAITKHRAKRDKRRAGSVLEVIPGLGPKRRRD
LLTHFGGIQGVLKASEKELMLVSGLGPSMARTIYKILHE

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI87081999, Length=601, Percent_Identity=45.757071547421, Blast_Score=521, Evalue=1e-149,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRC_ACIAD (Q6FF64)

Other databases:

- EMBL:   CR543861
- RefSeq:   YP_045115.1
- ProteinModelPortal:   Q6FF64
- STRING:   Q6FF64
- GeneID:   2879211
- GenomeReviews:   CR543861_GR
- KEGG:   aci:ACIAD0340
- NMPDR:   fig|62977.3.peg.816
- eggNOG:   COG0322
- HOGENOM:   HBG566029
- OMA:   DVLYVGK
- PhylomeDB:   Q6FF64
- ProtClustDB:   PRK00558
- BioCyc:   ASP62977:ACIAD0340-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00203
- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305
- SMART:   SM00465
- SMART:   SM00278
- TIGRFAMs:   TIGR00194

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N; SSF47781 RuvA_2_like; SSF46600 UvrB_C; SSF82771 UvrC_N

EC number: NA

Molecular weight: Translated: 68207; Mature: 68207

Theoretical pI: Translated: 9.47; Mature: 9.47

Prosite motif: PS50151 UVR; PS50164 UVRC_1; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNPNARPHIEKILANMTQLPGVYRMLGKDGELLYVGKAKNLKNRVSSYFVKTIEHPKTQA
CCCCCCHHHHHHHHHHHHCCHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHCCCHHHH
LVARIHDIETLVTRSETEALLLEQNLIKQHRPPYNIMLRDDKSYVYIFVSSDKPYPRIAS
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEECCCCEEEEEEECCCCCCCCCC
GRGKGKHQIGKFFGPYPSAYSARDTLLVLQKLFNVRQCENSYFAQRKRPCLQYQIKRCSA
CCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCC
PCVGLISPEDYKQDVDNSIRFLQGDTKELNQELIAKMEEAAEQLAFEKAMFYRDRLGLLR
CEEECCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EVQAQQAVFKIKGEADILAIAFQAGVTCVQIMYVRNGRMLGGKSYFPDMLSDDLGQMLSD
HHHHHHHHHEECCCCCEEEEEHHHCCHHEEEEEEECCEEECCCCCCCHHHHHHHHHHHHH
FIANFYFQVADEVPSELIVNVELPDRKELEQALQTQFDKKIQIKHKVRETRAEWQELAIM
HHHHHHHHHHHHCCHHEEEEECCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
NVQHAIKGQLSNHLELNERFHQLEQVVGRPVDRIECFDISHTMGEATIASCVVFDQGGAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECHHHHCHHHHHHEEEECCCCCC
KRDYRQFGIEDITAGDDYAAMRQALTRRYKKHIVPDLLLIDGGKGQLHMAMEVMQTLGLD
CHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHCCH
AFMVGVSKGEGRKPGLETLHFTDGSKIQLPEDHKALHLIQQVRDEAHRFAITKHRAKRDK
HEEEECCCCCCCCCCCCEEEECCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RRAGSVLEVIPGLGPKRRRDLLTHFGGIQGVLKASEKELMLVSGLGPSMARTIYKILHE
HHHCCHHHHHCCCCCHHHHHHHHHHCCHHHHHHCCCCCEEEEECCCHHHHHHHHHHHCC
>Mature Secondary Structure
MNPNARPHIEKILANMTQLPGVYRMLGKDGELLYVGKAKNLKNRVSSYFVKTIEHPKTQA
CCCCCCHHHHHHHHHHHHCCHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHCCCHHHH
LVARIHDIETLVTRSETEALLLEQNLIKQHRPPYNIMLRDDKSYVYIFVSSDKPYPRIAS
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEECCCCEEEEEEECCCCCCCCCC
GRGKGKHQIGKFFGPYPSAYSARDTLLVLQKLFNVRQCENSYFAQRKRPCLQYQIKRCSA
CCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCC
PCVGLISPEDYKQDVDNSIRFLQGDTKELNQELIAKMEEAAEQLAFEKAMFYRDRLGLLR
CEEECCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EVQAQQAVFKIKGEADILAIAFQAGVTCVQIMYVRNGRMLGGKSYFPDMLSDDLGQMLSD
HHHHHHHHHEECCCCCEEEEEHHHCCHHEEEEEEECCEEECCCCCCCHHHHHHHHHHHHH
FIANFYFQVADEVPSELIVNVELPDRKELEQALQTQFDKKIQIKHKVRETRAEWQELAIM
HHHHHHHHHHHHCCHHEEEEECCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
NVQHAIKGQLSNHLELNERFHQLEQVVGRPVDRIECFDISHTMGEATIASCVVFDQGGAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECHHHHCHHHHHHEEEECCCCCC
KRDYRQFGIEDITAGDDYAAMRQALTRRYKKHIVPDLLLIDGGKGQLHMAMEVMQTLGLD
CHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHCCH
AFMVGVSKGEGRKPGLETLHFTDGSKIQLPEDHKALHLIQQVRDEAHRFAITKHRAKRDK
HEEEECCCCCCCCCCCCEEEECCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RRAGSVLEVIPGLGPKRRRDLLTHFGGIQGVLKASEKELMLVSGLGPSMARTIYKILHE
HHHCCHHHHHCCCCCHHHHHHHHHHCCHHHHHHCCCCCEEEEECCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA