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The map label for this gene is dctA [H]

Identifier: 50083590

GI number: 50083590

Start: 320208

End: 321506

Strand: Direct

Name: dctA [H]

Synonym: ACIAD0319

Alternate gene names: 50083590

Gene position: 320208-321506 (Clockwise)

Preceding gene: 50083589

Following gene: 50083591

Centisome position: 8.9

GC content: 37.26

Gene sequence:

>1299_bases
ATGAAAAAGGAAACCACAGTACGCTATGTACTTATTGCCATATTTTTGGGTGCCATAATTGGGTTGTTATGTCACTATCT
GGCATCTACAGCAGAGCAGGCAAAAGAAATTTCATCTTATTTTAATCTATTAACCGCTATCTTTCTTAGATTAATTAAAA
TGATTATTGCCCCATTAATCTTCTCAACGATTGTCGTTGGTATTGTATCTATGGGTAACTCATCATCAATAGGTAAAATT
ACCTTTAAGGCCATGGGATGGTTTATTAGCGCCTCAATTATTTCGCTAGGGCTTGGAATGTTATTTGCAAATGTCTTCCA
TCCTGGTGTTGGCTTGAACCTCACTCCTGATCATGCAACCAATGCATTACCTTCTTCTATTAATACAGATGGGTTTTCAT
TAAATGGATTTATTACTCATCTATTTCCGCGCAGCTTTGCTGAAGCCATGGCGAACAATGAAATTCTGCAAATCCTCATT
TTCTCGATTTTCTTTGGGAAAGCGCTCAGTTTTATTAATCATCAATACACGTCAGTTATTTTTAAGATGGTTGAAGAACT
TAGCCATATCATGTTTAAAATTACAGAATATGTCATGAAATTTGCACCTGTTGCTGCATTTTCAGCGATTGCTTCTGCAA
TTACAGTACAAGGTGTTGGTGTATTTGTAAATTATGCAACTTTTCTCGGTTCATTCTTTTTAGCTTTAGCTGTTTTACTT
GTTATTCTATTTTCTGTGGCTTACATTTTCCTTAGAACGGATACATTTAAGTTGGCTAAACTTATACGTGAACCTGTCAT
GTTAGCTTTTGTAACGACCAGTAGTGAATCTGCTTATCCTAAAACCATGGATGCATTGAATAAATTTGGTGTACCTAAGC
AAGTGACGAGCTTTGTATTGCCTTTAGGCTACTCATTCAACTTAGATGGTTCAATGATGTATGCAGCGTTTGCAATTCTT
TTTATTGCACAAGCTTACAATATAGATTTGAGTATTACACAACAAATCCTCATCTTATTGACGTTGATGATTACCAGTAA
AGGGATTGCAGGGGTATCAAAGGCATCGATTGTGGTGGTTGCTGCAACGCTCAGTTTGTTTAAGCTCCCTGAAGCTGGAT
TACTCCTGATACTCGCAATTGATCAATTTTTAGATATGGGACGTACCGCGACGAATGTTGTCGGTAATAGTATTGCAACA
GCAGTGATTGCGAGAACGACACCAATGGAAGAGTTAAAGCCAGAAACGAATATGGAAGACGTTCAACAGATGGTGAACAC
TTCGCAACAAAGTGCCTAA

Upstream 100 bases:

>100_bases
TTTTGTGCATGAGCTTTTTTATTTATGCATTAAGCAACAAGAAAAAGCTGCCATAACTAAAAAGGGACACTGAGTTCTTC
GGTAATCTAGTGAGTGTAGT

Downstream 100 bases:

>100_bases
CTCAGTTTTTAACTAGGACAAAAGAAAGTAGCTTAGTTGGAGTTACTTTCATTTTTATGCAATTGTTGATCCTAGCCAAA
ATAATGGACAGTACTTCCCT

Product: proton/sodium-glutamate symport protein

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 432; Mature: 432

Protein sequence:

>432_residues
MKKETTVRYVLIAIFLGAIIGLLCHYLASTAEQAKEISSYFNLLTAIFLRLIKMIIAPLIFSTIVVGIVSMGNSSSIGKI
TFKAMGWFISASIISLGLGMLFANVFHPGVGLNLTPDHATNALPSSINTDGFSLNGFITHLFPRSFAEAMANNEILQILI
FSIFFGKALSFINHQYTSVIFKMVEELSHIMFKITEYVMKFAPVAAFSAIASAITVQGVGVFVNYATFLGSFFLALAVLL
VILFSVAYIFLRTDTFKLAKLIREPVMLAFVTTSSESAYPKTMDALNKFGVPKQVTSFVLPLGYSFNLDGSMMYAAFAIL
FIAQAYNIDLSITQQILILLTLMITSKGIAGVSKASIVVVAATLSLFKLPEAGLLLILAIDQFLDMGRTATNVVGNSIAT
AVIARTTPMEELKPETNMEDVQQMVNTSQQSA

Sequences:

>Translated_432_residues
MKKETTVRYVLIAIFLGAIIGLLCHYLASTAEQAKEISSYFNLLTAIFLRLIKMIIAPLIFSTIVVGIVSMGNSSSIGKI
TFKAMGWFISASIISLGLGMLFANVFHPGVGLNLTPDHATNALPSSINTDGFSLNGFITHLFPRSFAEAMANNEILQILI
FSIFFGKALSFINHQYTSVIFKMVEELSHIMFKITEYVMKFAPVAAFSAIASAITVQGVGVFVNYATFLGSFFLALAVLL
VILFSVAYIFLRTDTFKLAKLIREPVMLAFVTTSSESAYPKTMDALNKFGVPKQVTSFVLPLGYSFNLDGSMMYAAFAIL
FIAQAYNIDLSITQQILILLTLMITSKGIAGVSKASIVVVAATLSLFKLPEAGLLLILAIDQFLDMGRTATNVVGNSIAT
AVIARTTPMEELKPETNMEDVQQMVNTSQQSA
>Mature_432_residues
MKKETTVRYVLIAIFLGAIIGLLCHYLASTAEQAKEISSYFNLLTAIFLRLIKMIIAPLIFSTIVVGIVSMGNSSSIGKI
TFKAMGWFISASIISLGLGMLFANVFHPGVGLNLTPDHATNALPSSINTDGFSLNGFITHLFPRSFAEAMANNEILQILI
FSIFFGKALSFINHQYTSVIFKMVEELSHIMFKITEYVMKFAPVAAFSAIASAITVQGVGVFVNYATFLGSFFLALAVLL
VILFSVAYIFLRTDTFKLAKLIREPVMLAFVTTSSESAYPKTMDALNKFGVPKQVTSFVLPLGYSFNLDGSMMYAAFAIL
FIAQAYNIDLSITQQILILLTLMITSKGIAGVSKASIVVVAATLSLFKLPEAGLLLILAIDQFLDMGRTATNVVGNSIAT
AVIARTTPMEELKPETNMEDVQQMVNTSQQSA

Specific function: Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI169790839, Length=453, Percent_Identity=25.8278145695364, Blast_Score=129, Evalue=7e-30,
Organism=Homo sapiens, GI66773030, Length=468, Percent_Identity=26.2820512820513, Blast_Score=128, Evalue=8e-30,
Organism=Homo sapiens, GI21314632, Length=429, Percent_Identity=25.8741258741259, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI40254478, Length=476, Percent_Identity=25.6302521008403, Blast_Score=115, Evalue=8e-26,
Organism=Homo sapiens, GI4827012, Length=262, Percent_Identity=30.1526717557252, Blast_Score=113, Evalue=4e-25,
Organism=Homo sapiens, GI223468564, Length=253, Percent_Identity=27.6679841897233, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI223468566, Length=253, Percent_Identity=27.6679841897233, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI5032093, Length=253, Percent_Identity=27.6679841897233, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI194239697, Length=181, Percent_Identity=33.7016574585635, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI262359914, Length=401, Percent_Identity=24.1895261845387, Blast_Score=89, Evalue=8e-18,
Organism=Homo sapiens, GI301601644, Length=158, Percent_Identity=30.379746835443, Blast_Score=83, Evalue=6e-16,
Organism=Escherichia coli, GI1790514, Length=404, Percent_Identity=36.1386138613861, Blast_Score=253, Evalue=1e-68,
Organism=Escherichia coli, GI1789947, Length=416, Percent_Identity=37.2596153846154, Blast_Score=251, Evalue=7e-68,
Organism=Escherichia coli, GI1788024, Length=425, Percent_Identity=24.7058823529412, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1789473, Length=227, Percent_Identity=23.3480176211454, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17537407, Length=434, Percent_Identity=26.036866359447, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI193206654, Length=448, Percent_Identity=26.1160714285714, Blast_Score=125, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI71996953, Length=489, Percent_Identity=26.1758691206544, Blast_Score=121, Evalue=7e-28,
Organism=Caenorhabditis elegans, GI193206505, Length=441, Percent_Identity=24.4897959183673, Blast_Score=114, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI71983099, Length=456, Percent_Identity=24.3421052631579, Blast_Score=113, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI71983106, Length=433, Percent_Identity=24.7113163972286, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17541374, Length=442, Percent_Identity=24.6606334841629, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24583025, Length=442, Percent_Identity=26.2443438914027, Blast_Score=125, Evalue=4e-29,
Organism=Drosophila melanogaster, GI17137668, Length=442, Percent_Identity=26.2443438914027, Blast_Score=125, Evalue=4e-29,
Organism=Drosophila melanogaster, GI24583023, Length=442, Percent_Identity=26.2443438914027, Blast_Score=125, Evalue=4e-29,
Organism=Drosophila melanogaster, GI281360481, Length=462, Percent_Identity=25.7575757575758, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI281360483, Length=462, Percent_Identity=25.7575757575758, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI17137666, Length=462, Percent_Identity=25.7575757575758, Blast_Score=96, Evalue=4e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 46952; Mature: 46952

Theoretical pI: Translated: 8.81; Mature: 8.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKETTVRYVLIAIFLGAIIGLLCHYLASTAEQAKEISSYFNLLTAIFLRLIKMIIAPLI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FSTIVVGIVSMGNSSSIGKITFKAMGWFISASIISLGLGMLFANVFHPGVGLNLTPDHAT
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHC
NALPSSINTDGFSLNGFITHLFPRSFAEAMANNEILQILIFSIFFGKALSFINHQYTSVI
CCCCCCCCCCCEEHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
FKMVEELSHIMFKITEYVMKFAPVAAFSAIASAITVQGVGVFVNYATFLGSFFLALAVLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VILFSVAYIFLRTDTFKLAKLIREPVMLAFVTTSSESAYPKTMDALNKFGVPKQVTSFVL
HHHHHHHHHHHHCCHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHCCCCHHHHHHHH
PLGYSFNLDGSMMYAAFAILFIAQAYNIDLSITQQILILLTLMITSKGIAGVSKASIVVV
HCCCEECCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
AATLSLFKLPEAGLLLILAIDQFLDMGRTATNVVGNSIATAVIARTTPMEELKPETNMED
HHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHCCCCCCHHH
VQQMVNTSQQSA
HHHHHHCCCCCC
>Mature Secondary Structure
MKKETTVRYVLIAIFLGAIIGLLCHYLASTAEQAKEISSYFNLLTAIFLRLIKMIIAPLI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FSTIVVGIVSMGNSSSIGKITFKAMGWFISASIISLGLGMLFANVFHPGVGLNLTPDHAT
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHC
NALPSSINTDGFSLNGFITHLFPRSFAEAMANNEILQILIFSIFFGKALSFINHQYTSVI
CCCCCCCCCCCEEHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
FKMVEELSHIMFKITEYVMKFAPVAAFSAIASAITVQGVGVFVNYATFLGSFFLALAVLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VILFSVAYIFLRTDTFKLAKLIREPVMLAFVTTSSESAYPKTMDALNKFGVPKQVTSFVL
HHHHHHHHHHHHCCHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHCCCCHHHHHHHH
PLGYSFNLDGSMMYAAFAILFIAQAYNIDLSITQQILILLTLMITSKGIAGVSKASIVVV
HCCCEECCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHH
AATLSLFKLPEAGLLLILAIDQFLDMGRTATNVVGNSIATAVIARTTPMEELKPETNMED
HHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHCCCCCCHHH
VQQMVNTSQQSA
HHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA