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The map label for this gene is aldH [H]

Identifier: 50083419

GI number: 50083419

Start: 135198

End: 136778

Strand: Direct

Name: aldH [H]

Synonym: ACIAD0131

Alternate gene names: 50083419

Gene position: 135198-136778 (Clockwise)

Preceding gene: 50083418

Following gene: 50083420

Centisome position: 3.76

GC content: 45.48

Gene sequence:

>1581_bases
ATGAGCGAGAATAACGGTAAACAGTTTATCAATGGTCAGCGTGTAGCAGCCAATGCTCCTACCATTGAAAGTATCAATGC
GACAGATTATCAGCCTACAGGTTATTTGTTTAGTCAGGCTACGCTTGATGAAGTTGATCAGGCGGCACAGGCAGCGTATC
AGGCCTTTTTAAAATATCAGCATACGACACAACAACAACGTGCTGACTTTTTAGATGAAATTGCAATTCAAATTGAGAAT
CTGGGTTCCAAGTTGCAAGAAGTAGCAGCACAGGAAACAGGTTTGCCACTGGTCCGTCTTCAGGGTGAAACTGGACGTGT
GACAGGACAACTTCGTTTGTTTGCAGAACTCTTGCGTCGTGGTGATTTTTATGGTGCCCGAATCGATACGGCATTGCCAG
AACGTAAGCCTTTGCCTCGCGTTGATTTACGCCAGTATAAAATAGGTGTAGGGCCTGTCGCGGTATTTGGTGCAAGTAAT
TTCCCACTGGCATTCTCTACAGCGGGTGGGGATACGGTCGCTGCTCTTGCCGCAGGCTGTTCAGTGGTGTTTAAGGCACA
CTCAGGACATATGGCTACAGCTGAATTAGTTGCGCAAGCGATTGAAAAAGCGATTCTGAATAGCGGTATCCCAAGTGGAA
CATTCAATATGATTTTCGGTTCACGTGTGGGCGCAAATCTGGTTGAACATCCGTTGATTCAGGCGGCAGGTTTTACAGGT
TCACTCGAAGGTGGAATGGCCTTGTTTAATCTGGCACAAAATCGTCCACAACCCATTCCTTTTTTTGCAGAGATGTCGAG
CGTTAACCCTGTCATCGTTATGCCTGAGGCTTTAAATGCCCGCGGCGAGAAAGTTGCTCAGGATACGGTTGCCTCTTTTA
ATATGGGGTGTGGTCAGTTTTGTACTAAACCTGGATTAATCATTGGAATTAAGAGTCCTGCATTTGATCAATTCGTTACA
GCTCTCATCGATACGACTCGTACTGCTGTTCCACAGATCATGCTCAATCAAGGCACATTGAAAAGCTATCAGCAGGGTAT
TGATGCTTTACTCAATGAACAAGGGTTTAAATGCATTGCCTCTGGTCAGGCCCCTGAGTTGATTTCCCAAGCACAGCCAC
ACTTGTTTCAGGCAGATCAGTCGGTATTGTTATCAGGAAATCCAAAATTACAGCATGAAGTATTTGGGCCAATGTCGATC
GTGATTGCTGTGGATGATGAAGCAACGCTTTTGAATGGACTTGAAAAGTTGGCTGGTCAGCTGACGGCAACCATAATTGC
TGATGAAAGTGATCTGCCACAGGCAAAAGAGTTACTTAATCTTCTGACGCGTAAAGCTGGGCGAGTATTATTCAATGGGT
TTCCAACGGGTGTTGAAGTCTCTGATGCCATGGTACATGGAGGCCCATTTCCAGCAACAAGTGATTCCCGCGGTACTTCA
GTGGGAACGGGGGCGATTGAGCGTTTCTTGCGTCCCGTCTGTTATCAAAACACCTCTCAGGTATTATTACCTGATGTCTT
AAAAGACGGTAATCCTTTACACATTACCCGCTTGGTCAATGGTGTATTAACACAAAATTAA

Upstream 100 bases:

>100_bases
TAAGCGATCTAACTCCTCAGGATTATGAAGATTTAGCGGCATTAATTGCAACGCTTGGACCACAGTAAACTCAAACTTCA
TACAGGTTAGGAAGGCAAAG

Downstream 100 bases:

>100_bases
TTCGCTTTGAATGATTCACCGCTCTTCTTCAATGAAGGGGGGTGAATGCAATCAATTGGAGTCTAAGTTTCTGCTATCGA
ATTTGAGAGTAGTGAAAATT

Product: 2-ketoglutarate semialdehyde dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 526; Mature: 525

Protein sequence:

>526_residues
MSENNGKQFINGQRVAANAPTIESINATDYQPTGYLFSQATLDEVDQAAQAAYQAFLKYQHTTQQQRADFLDEIAIQIEN
LGSKLQEVAAQETGLPLVRLQGETGRVTGQLRLFAELLRRGDFYGARIDTALPERKPLPRVDLRQYKIGVGPVAVFGASN
FPLAFSTAGGDTVAALAAGCSVVFKAHSGHMATAELVAQAIEKAILNSGIPSGTFNMIFGSRVGANLVEHPLIQAAGFTG
SLEGGMALFNLAQNRPQPIPFFAEMSSVNPVIVMPEALNARGEKVAQDTVASFNMGCGQFCTKPGLIIGIKSPAFDQFVT
ALIDTTRTAVPQIMLNQGTLKSYQQGIDALLNEQGFKCIASGQAPELISQAQPHLFQADQSVLLSGNPKLQHEVFGPMSI
VIAVDDEATLLNGLEKLAGQLTATIIADESDLPQAKELLNLLTRKAGRVLFNGFPTGVEVSDAMVHGGPFPATSDSRGTS
VGTGAIERFLRPVCYQNTSQVLLPDVLKDGNPLHITRLVNGVLTQN

Sequences:

>Translated_526_residues
MSENNGKQFINGQRVAANAPTIESINATDYQPTGYLFSQATLDEVDQAAQAAYQAFLKYQHTTQQQRADFLDEIAIQIEN
LGSKLQEVAAQETGLPLVRLQGETGRVTGQLRLFAELLRRGDFYGARIDTALPERKPLPRVDLRQYKIGVGPVAVFGASN
FPLAFSTAGGDTVAALAAGCSVVFKAHSGHMATAELVAQAIEKAILNSGIPSGTFNMIFGSRVGANLVEHPLIQAAGFTG
SLEGGMALFNLAQNRPQPIPFFAEMSSVNPVIVMPEALNARGEKVAQDTVASFNMGCGQFCTKPGLIIGIKSPAFDQFVT
ALIDTTRTAVPQIMLNQGTLKSYQQGIDALLNEQGFKCIASGQAPELISQAQPHLFQADQSVLLSGNPKLQHEVFGPMSI
VIAVDDEATLLNGLEKLAGQLTATIIADESDLPQAKELLNLLTRKAGRVLFNGFPTGVEVSDAMVHGGPFPATSDSRGTS
VGTGAIERFLRPVCYQNTSQVLLPDVLKDGNPLHITRLVNGVLTQN
>Mature_525_residues
SENNGKQFINGQRVAANAPTIESINATDYQPTGYLFSQATLDEVDQAAQAAYQAFLKYQHTTQQQRADFLDEIAIQIENL
GSKLQEVAAQETGLPLVRLQGETGRVTGQLRLFAELLRRGDFYGARIDTALPERKPLPRVDLRQYKIGVGPVAVFGASNF
PLAFSTAGGDTVAALAAGCSVVFKAHSGHMATAELVAQAIEKAILNSGIPSGTFNMIFGSRVGANLVEHPLIQAAGFTGS
LEGGMALFNLAQNRPQPIPFFAEMSSVNPVIVMPEALNARGEKVAQDTVASFNMGCGQFCTKPGLIIGIKSPAFDQFVTA
LIDTTRTAVPQIMLNQGTLKSYQQGIDALLNEQGFKCIASGQAPELISQAQPHLFQADQSVLLSGNPKLQHEVFGPMSIV
IAVDDEATLLNGLEKLAGQLTATIIADESDLPQAKELLNLLTRKAGRVLFNGFPTGVEVSDAMVHGGPFPATSDSRGTSV
GTGAIERFLRPVCYQNTSQVLLPDVLKDGNPLHITRLVNGVLTQN

Specific function: Catalyzes the oxidation of long-chain aliphatic aldehydes to acids. May be implicated in controlling luminescence as it catalyzes the oxidation of the fatty aldehyde substrate for the light-emitting reaction [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldehyde dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507229, Length=377, Percent_Identity=26.790450928382, Blast_Score=80, Evalue=6e-15,
Organism=Homo sapiens, GI12007648, Length=445, Percent_Identity=22.4719101123595, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI25777721, Length=384, Percent_Identity=25.78125, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1789015, Length=421, Percent_Identity=27.0783847980998, Blast_Score=89, Evalue=1e-18,
Organism=Escherichia coli, GI87081896, Length=429, Percent_Identity=25.8741258741259, Blast_Score=79, Evalue=9e-16,
Organism=Escherichia coli, GI1788042, Length=385, Percent_Identity=27.7922077922078, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI1787250, Length=278, Percent_Identity=31.6546762589928, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17534119, Length=398, Percent_Identity=26.8844221105528, Blast_Score=77, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI133930964, Length=413, Percent_Identity=25.4237288135593, Blast_Score=76, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI25143874, Length=296, Percent_Identity=24.3243243243243, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI25143876, Length=296, Percent_Identity=24.3243243243243, Blast_Score=69, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI71995613, Length=312, Percent_Identity=27.2435897435897, Blast_Score=67, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71995606, Length=312, Percent_Identity=27.2435897435897, Blast_Score=67, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6319478, Length=417, Percent_Identity=25.4196642685851, Blast_Score=88, Evalue=3e-18,
Organism=Drosophila melanogaster, GI281362580, Length=390, Percent_Identity=27.6923076923077, Blast_Score=98, Evalue=2e-20,
Organism=Drosophila melanogaster, GI62472918, Length=390, Percent_Identity=27.6923076923077, Blast_Score=98, Evalue=2e-20,
Organism=Drosophila melanogaster, GI62472926, Length=390, Percent_Identity=27.6923076923077, Blast_Score=98, Evalue=2e-20,
Organism=Drosophila melanogaster, GI62472936, Length=390, Percent_Identity=27.6923076923077, Blast_Score=98, Evalue=2e-20,
Organism=Drosophila melanogaster, GI21356737, Length=390, Percent_Identity=27.6923076923077, Blast_Score=98, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590 [H]

Pfam domain/function: PF00171 Aldedh [H]

EC number: =1.2.1.4 [H]

Molecular weight: Translated: 56146; Mature: 56014

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSENNGKQFINGQRVAANAPTIESINATDYQPTGYLFSQATLDEVDQAAQAAYQAFLKYQ
CCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCEECHHHHHHHHHHHHHHHHHHHHHH
HTTQQQRADFLDEIAIQIENLGSKLQEVAAQETGLPLVRLQGETGRVTGQLRLFAELLRR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHC
GDFYGARIDTALPERKPLPRVDLRQYKIGVGPVAVFGASNFPLAFSTAGGDTVAALAAGC
CCCCCCEECCCCCCCCCCCCCCHHHEEECCCCEEEECCCCCCEEEECCCCHHHHHHHHCC
SVVFKAHSGHMATAELVAQAIEKAILNSGIPSGTFNMIFGSRVGANLVEHPLIQAAGFTG
CEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHEECCHHCCHHHHHHHHHHCCCCC
SLEGGMALFNLAQNRPQPIPFFAEMSSVNPVIVMPEALNARGEKVAQDTVASFNMGCGQF
CCCCCHHHHHHHHCCCCCCCHHHHHCCCCCEEEECHHHCCCCHHHHHHHHHHHCCCCHHH
CTKPGLIIGIKSPAFDQFVTALIDTTRTAVPQIMLNQGTLKSYQQGIDALLNEQGFKCIA
HCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEE
SGQAPELISQAQPHLFQADQSVLLSGNPKLQHEVFGPMSIVIAVDDEATLLNGLEKLAGQ
CCCCHHHHHHCCCCHHHCCCCEEECCCCCCHHHHCCCEEEEEEECCCHHHHHHHHHHHHH
LTATIIADESDLPQAKELLNLLTRKAGRVLFNGFPTGVEVSDAMVHGGPFPATSDSRGTS
EEEEEEECCCCCHHHHHHHHHHHHHCCCEEECCCCCCCCCCHHEECCCCCCCCCCCCCCC
VGTGAIERFLRPVCYQNTSQVLLPDVLKDGNPLHITRLVNGVLTQN
CCHHHHHHHHHHHHHCCCCCEECHHHHCCCCCEEHHHHHHHHHCCC
>Mature Secondary Structure 
SENNGKQFINGQRVAANAPTIESINATDYQPTGYLFSQATLDEVDQAAQAAYQAFLKYQ
CCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCEECHHHHHHHHHHHHHHHHHHHHHH
HTTQQQRADFLDEIAIQIENLGSKLQEVAAQETGLPLVRLQGETGRVTGQLRLFAELLRR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHC
GDFYGARIDTALPERKPLPRVDLRQYKIGVGPVAVFGASNFPLAFSTAGGDTVAALAAGC
CCCCCCEECCCCCCCCCCCCCCHHHEEECCCCEEEECCCCCCEEEECCCCHHHHHHHHCC
SVVFKAHSGHMATAELVAQAIEKAILNSGIPSGTFNMIFGSRVGANLVEHPLIQAAGFTG
CEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHEECCHHCCHHHHHHHHHHCCCCC
SLEGGMALFNLAQNRPQPIPFFAEMSSVNPVIVMPEALNARGEKVAQDTVASFNMGCGQF
CCCCCHHHHHHHHCCCCCCCHHHHHCCCCCEEEECHHHCCCCHHHHHHHHHHHCCCCHHH
CTKPGLIIGIKSPAFDQFVTALIDTTRTAVPQIMLNQGTLKSYQQGIDALLNEQGFKCIA
HCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEE
SGQAPELISQAQPHLFQADQSVLLSGNPKLQHEVFGPMSIVIAVDDEATLLNGLEKLAGQ
CCCCHHHHHHCCCCHHHCCCCEEECCCCCCHHHHCCCEEEEEEECCCHHHHHHHHHHHHH
LTATIIADESDLPQAKELLNLLTRKAGRVLFNGFPTGVEVSDAMVHGGPFPATSDSRGTS
EEEEEEECCCCCHHHHHHHHHHHHHCCCEEECCCCCCCCCCHHEECCCCCCCCCCCCCCC
VGTGAIERFLRPVCYQNTSQVLLPDVLKDGNPLHITRLVNGVLTQN
CCHHHHHHHHHHHHHCCCCCEECHHHHCCCCCEEHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8527447; 10903148 [H]