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The map label for this gene is pbp

Identifier: 49481675

GI number: 49481675

Start: 4173125

End: 4174879

Strand: Reverse

Name: pbp

Synonym: BT9727_4111

Alternate gene names: 49481675

Gene position: 4174879-4173125 (Counterclockwise)

Preceding gene: 49481456

Following gene: 49478826

Centisome position: 79.71

GC content: 35.84

Gene sequence:

>1755_bases
ATGAAAATAAAACGGAGAATTACAATTGTTTTAATTTGTTTTATATGTGTCATGTTTATATTACTTTGTCGTTTAATTCA
AATACAAATTATCGATACGGAATCATTTACGGATCGTAAGATTAATTTAATTGAAAAAAGTGTTACACAGCGGACGCAAT
CCATTACGTTAGATGATGGACGAGGCCATTTTATAGATCGTAATGGTCAGGAAATAGGTGAGAAAAAGTATCCTGTTTTA
ATTATTTTTCCCTTTCTACAAATAAAAAATGACATGTTAGAGAAAATTGCGCATATCATTGGTATGTCGAGACAAGAGAT
TGAAAGTCAAATGAAAGATAAGAAAAGTGCATTTATTATGCAAAGAGGAAATGGACCATTTCGCTTGGCACGAGAGCAGA
TGGAGAAGGTGAATCAATTAAATGTATTAGGCATTGTAGCAGCTGAAGTTCGTTTGCGGCAAACTAGCGTGATGAATCAT
TTAATTGGCAATGTGGGTGAGAATGAACGAGAATTTCAAAAACGGTACGGAGAAGTAAGAAAAATTTCAAAACAAACGCC
GATTGGCATTTCAGGATTACAGCAAGCATTTGATGAATTTCTTTTGACTGATGGAGAGGCAAAAGTATTGTATCAAGTGG
ACCGGCAAGGAGAACCGATTTTTGGCAAACAAGCGAAATATACATCACCTGGAAATCCATTTTATCCAGTGACGATTCAA
ACTACTTTACATAACGAGTTACAGAAGAAAGCAGAAGAAGTAGTTGAAGCAAGTGAAATAAAGAAGGGAGGATTAGTGCT
ACTTGATGTAAAGAAAAATGAAATTTTAGCGATGGTCAGCAAACCATCTGTACAGGTGAAAGATGAGAGTTTATATAAAA
CTACACTTGAAAATCAAATGTTAACACCACATTTTCCCGGTTCTGTTTTTAAAACAATAGTTGCAGCGGCAGCGATTGAT
CAAAATGAAAATGTTTTTAATCGCACATTTAATTGTAATAAAGATTTATATGGTGAAGACCACCCAAAAGTTATGATGGG
GACACTTAGTTTTAAAGAGAGCTTTGCTAGAAGCTGTAACAGGACATTTTCAGAGTTAGGAAACGAGTTAATACAAAAGG
ATAAGATGGTGTTAGAAACTTATGTAGCGGCTTTAGGAGGCGCTGATAAGGTTGGATGGAGAGGTTCTGTATTTCATACA
ACTCATTTTGAACAAATGCCAGAGGAGAAGAGTGTTACGATTTGGGGGAATGGAGGAAATAAGAATAGTAAAAAGGCGGT
AGCGCAAACAGCAATTGGACAGAAAGATGTACGTATGTCACCTCTAGCGATTGCAAATATGATGGCGACGATTGCTAGAG
GTGGAGAAAAGATGGAAGTGAAAGCTGTGGAAAAAATAATGTATAAAAATGGAACAGACTTTTATACATTTGAAGACCAT
ACATTAGGTGGGAAACAGCTTTCGTATGAAACAGTGAAAACATTACAACAGTTATTAAGGAGCGTTGTGACAACGGAGAA
AGGCACAGGAGCAGCATTCAGTTCATTACCATTAAGTGTCGCTGGAAAATCTGGGACAGCACAAACAGGAAAAGGAACGA
AAGAGAATCGTTGGTTTGCAGGTTATTTTCCATATGAAAATCCAAGATATGCTTTAGTTGTCGTGGATATAGAAACGAAT
AGCGGTGTAAATAAAGTTACACCTATTTTCAAATCTATCGTAGAATCAATCTATCGATTAGAGAATGAAAAGTAA

Upstream 100 bases:

>100_bases
TAAAATAATTAAAAATCACTCGTGTAAAAGCGAGTGATTTTTTTATTTGTATAAAAGATGAAACACTCCGTCCAAACTAT
AATAGACGAGGTGTTTTTTT

Downstream 100 bases:

>100_bases
TCTTGCAATTTATAGTAAAATGTTTTCATTTCATGAAAATATTATTGTAAATGTTCAACCTTTCTAGATTTAATGTTACA
ATAGCAAGTATGAAAAACTG

Product: penicillin-binding protein

Products: NA

Alternate protein names: PBP-4B; PBP4b; Penicillin-binding protein I [H]

Number of amino acids: Translated: 584; Mature: 584

Protein sequence:

>584_residues
MKIKRRITIVLICFICVMFILLCRLIQIQIIDTESFTDRKINLIEKSVTQRTQSITLDDGRGHFIDRNGQEIGEKKYPVL
IIFPFLQIKNDMLEKIAHIIGMSRQEIESQMKDKKSAFIMQRGNGPFRLAREQMEKVNQLNVLGIVAAEVRLRQTSVMNH
LIGNVGENEREFQKRYGEVRKISKQTPIGISGLQQAFDEFLLTDGEAKVLYQVDRQGEPIFGKQAKYTSPGNPFYPVTIQ
TTLHNELQKKAEEVVEASEIKKGGLVLLDVKKNEILAMVSKPSVQVKDESLYKTTLENQMLTPHFPGSVFKTIVAAAAID
QNENVFNRTFNCNKDLYGEDHPKVMMGTLSFKESFARSCNRTFSELGNELIQKDKMVLETYVAALGGADKVGWRGSVFHT
THFEQMPEEKSVTIWGNGGNKNSKKAVAQTAIGQKDVRMSPLAIANMMATIARGGEKMEVKAVEKIMYKNGTDFYTFEDH
TLGGKQLSYETVKTLQQLLRSVVTTEKGTGAAFSSLPLSVAGKSGTAQTGKGTKENRWFAGYFPYENPRYALVVVDIETN
SGVNKVTPIFKSIVESIYRLENEK

Sequences:

>Translated_584_residues
MKIKRRITIVLICFICVMFILLCRLIQIQIIDTESFTDRKINLIEKSVTQRTQSITLDDGRGHFIDRNGQEIGEKKYPVL
IIFPFLQIKNDMLEKIAHIIGMSRQEIESQMKDKKSAFIMQRGNGPFRLAREQMEKVNQLNVLGIVAAEVRLRQTSVMNH
LIGNVGENEREFQKRYGEVRKISKQTPIGISGLQQAFDEFLLTDGEAKVLYQVDRQGEPIFGKQAKYTSPGNPFYPVTIQ
TTLHNELQKKAEEVVEASEIKKGGLVLLDVKKNEILAMVSKPSVQVKDESLYKTTLENQMLTPHFPGSVFKTIVAAAAID
QNENVFNRTFNCNKDLYGEDHPKVMMGTLSFKESFARSCNRTFSELGNELIQKDKMVLETYVAALGGADKVGWRGSVFHT
THFEQMPEEKSVTIWGNGGNKNSKKAVAQTAIGQKDVRMSPLAIANMMATIARGGEKMEVKAVEKIMYKNGTDFYTFEDH
TLGGKQLSYETVKTLQQLLRSVVTTEKGTGAAFSSLPLSVAGKSGTAQTGKGTKENRWFAGYFPYENPRYALVVVDIETN
SGVNKVTPIFKSIVESIYRLENEK
>Mature_584_residues
MKIKRRITIVLICFICVMFILLCRLIQIQIIDTESFTDRKINLIEKSVTQRTQSITLDDGRGHFIDRNGQEIGEKKYPVL
IIFPFLQIKNDMLEKIAHIIGMSRQEIESQMKDKKSAFIMQRGNGPFRLAREQMEKVNQLNVLGIVAAEVRLRQTSVMNH
LIGNVGENEREFQKRYGEVRKISKQTPIGISGLQQAFDEFLLTDGEAKVLYQVDRQGEPIFGKQAKYTSPGNPFYPVTIQ
TTLHNELQKKAEEVVEASEIKKGGLVLLDVKKNEILAMVSKPSVQVKDESLYKTTLENQMLTPHFPGSVFKTIVAAAAID
QNENVFNRTFNCNKDLYGEDHPKVMMGTLSFKESFARSCNRTFSELGNELIQKDKMVLETYVAALGGADKVGWRGSVFHT
THFEQMPEEKSVTIWGNGGNKNSKKAVAQTAIGQKDVRMSPLAIANMMATIARGGEKMEVKAVEKIMYKNGTDFYTFEDH
TLGGKQLSYETVKTLQQLLRSVVTTEKGTGAAFSSLPLSVAGKSGTAQTGKGTKENRWFAGYFPYENPRYALVVVDIETN
SGVNKVTPIFKSIVESIYRLENEK

Specific function: Penicillin-binding protein with an unknown catalytic activity. Penicillin-binding proteins (PBPs) function in the late steps of murein biosynthesis. Beta-lactamase inactivates the PBPs by acylating an essential serine residue in the active site of these p

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell membrane; Single-pass type II membrane protein (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 65691; Mature: 65691

Theoretical pI: Translated: 9.58; Mature: 9.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIKRRITIVLICFICVMFILLCRLIQIQIIDTESFTDRKINLIEKSVTQRTQSITLDDG
CCCHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHHHHHHHHEEEEECC
RGHFIDRNGQEIGEKKYPVLIIFPFLQIKNDMLEKIAHIIGMSRQEIESQMKDKKSAFIM
CCCEECCCCHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHEEEE
QRGNGPFRLAREQMEKVNQLNVLGIVAAEVRLRQTSVMNHLIGNVGENEREFQKRYGEVR
ECCCCCHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
KISKQTPIGISGLQQAFDEFLLTDGEAKVLYQVDRQGEPIFGKQAKYTSPGNPFYPVTIQ
HHHCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCEEEEEEE
TTLHNELQKKAEEVVEASEIKKGGLVLLDVKKNEILAMVSKPSVQVKDESLYKTTLENQM
HHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEECCCCEEECCHHHHHHHHHCCC
LTPHFPGSVFKTIVAAAAIDQNENVFNRTFNCNKDLYGEDHPKVMMGTLSFKESFARSCN
CCCCCCHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHH
RTFSELGNELIQKDKMVLETYVAALGGADKVGWRGSVFHTTHFEQMPEEKSVTIWGNGGN
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECHHHHCCCCCCEEEEECCCC
KNSKKAVAQTAIGQKDVRMSPLAIANMMATIARGGEKMEVKAVEKIMYKNGTDFYTFEDH
CCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCEEEECCC
TLGGKQLSYETVKTLQQLLRSVVTTEKGTGAAFSSLPLSVAGKSGTAQTGKGTKENRWFA
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHCCCEEECCCCCCCCCCCCCCCCCEEE
GYFPYENPRYALVVVDIETNSGVNKVTPIFKSIVESIYRLENEK
EECCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKIKRRITIVLICFICVMFILLCRLIQIQIIDTESFTDRKINLIEKSVTQRTQSITLDDG
CCCHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHHHHHHHHEEEEECC
RGHFIDRNGQEIGEKKYPVLIIFPFLQIKNDMLEKIAHIIGMSRQEIESQMKDKKSAFIM
CCCEECCCCHHCCCCCCCEEEEEHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHEEEE
QRGNGPFRLAREQMEKVNQLNVLGIVAAEVRLRQTSVMNHLIGNVGENEREFQKRYGEVR
ECCCCCHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
KISKQTPIGISGLQQAFDEFLLTDGEAKVLYQVDRQGEPIFGKQAKYTSPGNPFYPVTIQ
HHHCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCEEEEEEE
TTLHNELQKKAEEVVEASEIKKGGLVLLDVKKNEILAMVSKPSVQVKDESLYKTTLENQM
HHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEECCCCEEECCHHHHHHHHHCCC
LTPHFPGSVFKTIVAAAAIDQNENVFNRTFNCNKDLYGEDHPKVMMGTLSFKESFARSCN
CCCCCCHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHH
RTFSELGNELIQKDKMVLETYVAALGGADKVGWRGSVFHTTHFEQMPEEKSVTIWGNGGN
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECHHHHCCCCCCEEEEECCCC
KNSKKAVAQTAIGQKDVRMSPLAIANMMATIARGGEKMEVKAVEKIMYKNGTDFYTFEDH
CCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCEEEECCC
TLGGKQLSYETVKTLQQLLRSVVTTEKGTGAAFSSLPLSVAGKSGTAQTGKGTKENRWFA
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHCCCEEECCCCCCCCCCCCCCCCCEEE
GYFPYENPRYALVVVDIETNSGVNKVTPIFKSIVESIYRLENEK
EECCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]