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The map label for this gene is coaE

Identifier: 49481340

GI number: 49481340

Start: 4380954

End: 4381556

Strand: Reverse

Name: coaE

Synonym: BT9727_4314

Alternate gene names: 49481340

Gene position: 4381556-4380954 (Counterclockwise)

Preceding gene: 49478693

Following gene: 49478813

Centisome position: 83.65

GC content: 35.82

Gene sequence:

>603_bases
ATGACGGTAGTAATTGGATTAACGGGAGGTATTGCAAGCGGAAAAAGTACAGTATCTCAAATGTTTCGCGAGCTCAGTAT
ACCAGTTATTGATGCAGATATTATTGCAAGAGAAGTTGTAGAAAAAGGAAAACCAGCATATAACAAAATTGTAGAAGTGT
TTGGAACGGAAGTACTACAAGAAGATGGAGAACTGGATCGACCGAAATTAGGAAGTGTCGTTTTCTATAATGAAGAGAAA
CGATTGCAGTTAAACAAAATTGTTCATCCTGCAGTGCGTGAGGAAATGAATAGGCGAAAGGAAATGTACATAAAAGAAGG
TATGCAAGCGGTTGTGTTAGATATTCCTCTCTTATTTGAAAGTAAATTAACAAGTCTCGTTGACCGCGTTTTAGTTGTAG
CAGTTAAGCCACATACGCAATTAGAACGTTTAATGAAGCGAAATAATTTTTCAGAAGAAGAAGCAACAGCTCGTATTCAA
TCTCAAATGCCGTTAGAAGAAAAAGTGAAAAATGCAGATGAAGTGATAAATAATGATGGCACAATTATGGGAACGAAAAC
ACAATTACAGGCGATTTTAAAGAAATGGAACATTATTGACTAA

Upstream 100 bases:

>100_bases
ATTCCTGCCTGGGGTATTACTCATTATTATTGGAATTTGGAAAATGTAAGTACGGGCGTGGAACATTAGTTTCGCGCCTT
TTATTATGAGGAGGGTTATG

Downstream 100 bases:

>100_bases
AAAATTGTGAAATTAATGAAAATGCTTAGTGACATATCCCCTTTTTGTGTTATACTATTATTGGGATTGGAGATAAATAG
TATAACGCATTCAAGGGGGA

Product: dephospho-CoA kinase

Products: NA

Alternate protein names: Dephosphocoenzyme A kinase [H]

Number of amino acids: Translated: 200; Mature: 199

Protein sequence:

>200_residues
MTVVIGLTGGIASGKSTVSQMFRELSIPVIDADIIAREVVEKGKPAYNKIVEVFGTEVLQEDGELDRPKLGSVVFYNEEK
RLQLNKIVHPAVREEMNRRKEMYIKEGMQAVVLDIPLLFESKLTSLVDRVLVVAVKPHTQLERLMKRNNFSEEEATARIQ
SQMPLEEKVKNADEVINNDGTIMGTKTQLQAILKKWNIID

Sequences:

>Translated_200_residues
MTVVIGLTGGIASGKSTVSQMFRELSIPVIDADIIAREVVEKGKPAYNKIVEVFGTEVLQEDGELDRPKLGSVVFYNEEK
RLQLNKIVHPAVREEMNRRKEMYIKEGMQAVVLDIPLLFESKLTSLVDRVLVVAVKPHTQLERLMKRNNFSEEEATARIQ
SQMPLEEKVKNADEVINNDGTIMGTKTQLQAILKKWNIID
>Mature_199_residues
TVVIGLTGGIASGKSTVSQMFRELSIPVIDADIIAREVVEKGKPAYNKIVEVFGTEVLQEDGELDRPKLGSVVFYNEEKR
LQLNKIVHPAVREEMNRRKEMYIKEGMQAVVLDIPLLFESKLTSLVDRVLVVAVKPHTQLERLMKRNNFSEEEATARIQS
QMPLEEKVKNADEVINNDGTIMGTKTQLQAILKKWNIID

Specific function: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A [H]

COG id: COG0237

COG function: function code H; Dephospho-CoA kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DPCK (dephospho-CoA kinase) domain [H]

Homologues:

Organism=Homo sapiens, GI191252797, Length=187, Percent_Identity=47.5935828877005, Blast_Score=178, Evalue=3e-45,
Organism=Homo sapiens, GI191252795, Length=187, Percent_Identity=47.5935828877005, Blast_Score=178, Evalue=3e-45,
Organism=Homo sapiens, GI110227607, Length=201, Percent_Identity=35.8208955223881, Blast_Score=110, Evalue=6e-25,
Organism=Homo sapiens, GI110227605, Length=201, Percent_Identity=35.8208955223881, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI110227603, Length=201, Percent_Identity=35.8208955223881, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI110227601, Length=201, Percent_Identity=35.8208955223881, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI205277394, Length=201, Percent_Identity=35.8208955223881, Blast_Score=109, Evalue=1e-24,
Organism=Escherichia coli, GI1786292, Length=181, Percent_Identity=41.4364640883978, Blast_Score=132, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17554944, Length=182, Percent_Identity=43.956043956044, Blast_Score=156, Evalue=6e-39,
Organism=Caenorhabditis elegans, GI25143409, Length=171, Percent_Identity=33.3333333333333, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6320402, Length=198, Percent_Identity=43.9393939393939, Blast_Score=159, Evalue=3e-40,
Organism=Drosophila melanogaster, GI24644728, Length=180, Percent_Identity=44.4444444444444, Blast_Score=163, Evalue=7e-41,
Organism=Drosophila melanogaster, GI24658602, Length=198, Percent_Identity=33.3333333333333, Blast_Score=111, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001977 [H]

Pfam domain/function: PF01121 CoaE [H]

EC number: =2.7.1.24 [H]

Molecular weight: Translated: 22605; Mature: 22473

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: PS01294 COAE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVVIGLTGGIASGKSTVSQMFRELSIPVIDADIIAREVVEKGKPAYNKIVEVFGTEVLQ
CEEEEEECCCCCCCHHHHHHHHHHHCCCEECHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
EDGELDRPKLGSVVFYNEEKRLQLNKIVHPAVREEMNRRKEMYIKEGMQAVVLDIPLLFE
CCCCCCCCCCCCEEEECCCHHHHHHHHHCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHH
SKLTSLVDRVLVVAVKPHTQLERLMKRNNFSEEEATARIQSQMPLEEKVKNADEVINNDG
HHHHHHHHHHHHHEECCHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHCCHHHHHCCCC
TIMGTKTQLQAILKKWNIID
CEEECHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TVVIGLTGGIASGKSTVSQMFRELSIPVIDADIIAREVVEKGKPAYNKIVEVFGTEVLQ
EEEEEECCCCCCCHHHHHHHHHHHCCCEECHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
EDGELDRPKLGSVVFYNEEKRLQLNKIVHPAVREEMNRRKEMYIKEGMQAVVLDIPLLFE
CCCCCCCCCCCCEEEECCCHHHHHHHHHCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHH
SKLTSLVDRVLVVAVKPHTQLERLMKRNNFSEEEATARIQSQMPLEEKVKNADEVINNDG
HHHHHHHHHHHHHEECCHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHCCHHHHHCCCC
TIMGTKTQLQAILKKWNIID
CEEECHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12721629 [H]