Click here to switch to the map view.

The map label for this gene is tlyC

Identifier: 49481309

GI number: 49481309

Start: 4100827

End: 4101459

Strand: Reverse

Name: tlyC

Synonym: BT9727_4035

Alternate gene names: 49481309

Gene position: 4101459-4100827 (Counterclockwise)

Preceding gene: 49481310

Following gene: 49478603

Centisome position: 78.31

GC content: 35.55

Gene sequence:

>633_bases
GTGATTATCATAGAGCTGAATAAAAGACAAGAACATATCATTCAGATTGTAAAAGATCACGGTCCTATTACAGGGGAGTC
AATTGCTGCGCAATTGGGGTTAACACGTGCAACGTTAAGACCAGACTTAGCAATTTTAACGATGGCTGGTTATTTAGAAG
CACGTCCACGCGTAGGTTATTTTTATACGGGTAAAACTGGGGGGCAGTTATTATCTGAAGCTGTTAAGAAGATTAAAGTA
CAAGATTATCAATCTAGACCAGTTGTAATTGATAAAAATGTATCAGTATACGATGCGATTTGTACTATGTTTTTAGAGGA
TGTAGGTACATTATTTGTTGTAGATCAATCGACTCTATTAGTAGGCGTTGTATCTCGTAAAGATTTATTACGAGCTAGCT
TAGGAAAGCAGGATTTAACCTCACTTCCGGTTAATATTATCATGACAAGGATGCCAAACATTGCGATGTGTCGTAAAGAA
GATTCTTTATATGATATTGCGATGGAATTAATAGAAAGACAGATTGATGCGATGCCAGTTGTAAAAGATACGAAACAAGG
TTTAGAAGTGGTTGGACGAATTACAAAAACAAATATTACACGTGCGTTTGTAAACTTAGTAAATAACGAATAA

Upstream 100 bases:

>100_bases
CCGTATACGGTCCTTTTTACATCCTTTCTTTTTCGAATAGCATATTTAGTATATAATATTTAAGAGATAGTATAACTTTT
TTCGTTGTGCATTAAAGGTG

Downstream 100 bases:

>100_bases
GTGTAATTTGTTTAAAGTGAGGTAATGTAATGGATAATAAAATCGTATATGTCGTATCTGACTCTGTAGGAGAAACGGCT
GATTTGGTTGTTCGAGCAGC

Product: CBS domain-containing protein

Products: NA

Alternate protein names: Catabolite control protein N; Control catabolite protein of gluconeogenesis [H]

Number of amino acids: Translated: 210; Mature: 210

Protein sequence:

>210_residues
MIIIELNKRQEHIIQIVKDHGPITGESIAAQLGLTRATLRPDLAILTMAGYLEARPRVGYFYTGKTGGQLLSEAVKKIKV
QDYQSRPVVIDKNVSVYDAICTMFLEDVGTLFVVDQSTLLVGVVSRKDLLRASLGKQDLTSLPVNIIMTRMPNIAMCRKE
DSLYDIAMELIERQIDAMPVVKDTKQGLEVVGRITKTNITRAFVNLVNNE

Sequences:

>Translated_210_residues
MIIIELNKRQEHIIQIVKDHGPITGESIAAQLGLTRATLRPDLAILTMAGYLEARPRVGYFYTGKTGGQLLSEAVKKIKV
QDYQSRPVVIDKNVSVYDAICTMFLEDVGTLFVVDQSTLLVGVVSRKDLLRASLGKQDLTSLPVNIIMTRMPNIAMCRKE
DSLYDIAMELIERQIDAMPVVKDTKQGLEVVGRITKTNITRAFVNLVNNE
>Mature_210_residues
MIIIELNKRQEHIIQIVKDHGPITGESIAAQLGLTRATLRPDLAILTMAGYLEARPRVGYFYTGKTGGQLLSEAVKKIKV
QDYQSRPVVIDKNVSVYDAICTMFLEDVGTLFVVDQSTLLVGVVSRKDLLRASLGKQDLTSLPVNIIMTRMPNIAMCRKE
DSLYDIAMELIERQIDAMPVVKDTKQGLEVVGRITKTNITRAFVNLVNNE

Specific function: Transcription repressor that binds to the promoter of gapB and pckA genes, preventing their expression. Acts as a regulator for catabolite repression of gluconeogenic genes [H]

COG id: COG0517

COG function: function code R; FOG: CBS domain

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH deoR-type DNA-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR013196
- InterPro:   IPR001034
- InterPro:   IPR016842
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00571 CBS; PF08279 HTH_11 [H]

EC number: NA

Molecular weight: Translated: 23404; Mature: 23404

Theoretical pI: Translated: 8.66; Mature: 8.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIIELNKRQEHIIQIVKDHGPITGESIAAQLGLTRATLRPDLAILTMAGYLEARPRVGY
CEEEEECCHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHCCCCHHEEEHHHHHCCCCCCCE
FYTGKTGGQLLSEAVKKIKVQDYQSRPVVIDKNVSVYDAICTMFLEDVGTLFVVDQSTLL
EEECCCHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHCCEEEEEECCEEE
VGVVSRKDLLRASLGKQDLTSLPVNIIMTRMPNIAMCRKEDSLYDIAMELIERQIDAMPV
EEEHHHHHHHHHHCCHHHHHHCCHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHCCCC
VKDTKQGLEVVGRITKTNITRAFVNLVNNE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIIIELNKRQEHIIQIVKDHGPITGESIAAQLGLTRATLRPDLAILTMAGYLEARPRVGY
CEEEEECCHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHCCCCHHEEEHHHHHCCCCCCCE
FYTGKTGGQLLSEAVKKIKVQDYQSRPVVIDKNVSVYDAICTMFLEDVGTLFVVDQSTLL
EEECCCHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHCCEEEEEECCEEE
VGVVSRKDLLRASLGKQDLTSLPVNIIMTRMPNIAMCRKEDSLYDIAMELIERQIDAMPV
EEEHHHHHHHHHHCCHHHHHHCCHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHCCCC
VKDTKQGLEVVGRITKTNITRAFVNLVNNE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]