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The map label for this gene is pbpA

Identifier: 49481285

GI number: 49481285

Start: 4078099

End: 4080225

Strand: Reverse

Name: pbpA

Synonym: BT9727_4013

Alternate gene names: 49481285

Gene position: 4080225-4078099 (Counterclockwise)

Preceding gene: 49480651

Following gene: 49481283

Centisome position: 77.9

GC content: 37.28

Gene sequence:

>2127_bases
ATGAGCAAGAAGCAGAAACAACAAAAGAAAAAGACTCACGTTCCTTTTCGGTTAAACGTGCTGTTTTTCTGCGTGTTTTT
AATGTTCTCCGCGGTTATTGTAAGGCTTGGATATGTACAAATTGTTCGCGGTGAGGAATATAAAAATGAAGTGGAGAGGA
AAGAGAACTCGACGATTAGTAATCCTGTACCACGTGGGAAAATATTTGACCGTTATGGGCGAGCTGTAGTAGATAATGCA
GCTGTACGTACGATTACATTTACAAAAATGAAAGGATCAACTGCAGAGGCTCGCTTAGAAACAGCGAAAAAGCTAGCAGA
TTTGATTGAAGTACCGACAGATAAATTAACAGATCGCGATAAGAAAGATTATTGGCTTGCTATTCATAAAGAGGAAGCTA
AAGAAAAAATTACGAATAAAGATCGTCAAGAGTTTAAAGATAAAAAAATTGACGATAAAGAATTAGATGAGCGTCAACGA
AATCGCGTGACAGAAGAAGAAGTGAATCAATTATCCGCAAAAGATTTAGAAGTACTAGCGATTAAAAGCAAAATGGACGG
CGGATATGCGATGACGCCACAAGTTATTAAAAAGGATGCTACAGATGAAGAGTATGCGATTATTAGTGAAAATTTAGCGC
AATTGCCGGGAGTAGATACAAGTGTCGATTGGGAACGAAAATATGCATATGATGGCGATTTGTTCCGAAGTGTACTTGGA
GGTGTAACAACTTCTGACGAAGGTTTACCGAGAGAAAGACTAGATTACTATCTTGTTCGTGATTATAATCGAAATGACCG
CGTAGGGAAAAGTTATCTTGAGCAGCAATATGAAGATAGTTTGCACGGTAATAAAGCAGAAGTGAGAAATGTTACAGATA
AAAACGGTAATATTTTAGAAACGATTAACGTATCAAAAGGACAAAGTGGTAATGATCTGAATTTAACAATTGATATGGAA
TTACAAAAGCGTGTAGAAGAAATTATCACGAAAAGTTTATTGAAATATAAAGGTGGGCAACCACTTTTAGATCGTGCATT
CGTTGTAATGATGAATCCGAAGAATGGTGAAGTTTTATCTATGGCAGGAAAACAATTAGTGAATGAAAATGGCGAAACGA
AAGTGCAAGATTTCGCATTAGGAACGATGACAAGTTCTTATCCGATGGGATCGACTGTAAAAGGTGCGACGATACTTACT
GGATATCAAACAGGCGCGATTCAGCCAGGTTCCGTTCAACTCGATGAACCAATTGTATTAAAAGGACCGCTAAAAAAATC
TTCTTGGAAGACAATGGGCTATATTAATGATCTTACAGCGTTAAAAATGTCTTCTAACGTATATATGTTTAAAACAGCGA
TGAATATCGCTGGTGTTCCTTATGTACGAGGCGGTACGTTAGATATAAAACAAAAATCATATGATACGATGCGTTACTAT
TTCGGTCAATTTGGGCTTGGTGTAAAAACTGGTATTGATTTACCGAATGAAACGGCTGGACAAAGAGGTAGAACAGATCA
TATGCCAGGTTTCCTATTAGATTTATCAATTGGACAGTATGATACGTATACACCACTTCAATTAGCACAATATGTTTCAA
CAATTGCAAATGGTGGTTACCGTATGCAGCCGCAAGTTGTAAAAGAAATTCGTCAACCAGCAGCGAAACAAGATGAAGTT
GGAAAAGTTGTTCATTCAATGGAACCGAAAGTACTAAACCGTGTAGATATGCCTGAATCACAAATTAAACGTGTTCAGGA
AGGATTTAAACAAGTGTTTAACAGTCCGGGTGGTACGGCTTTAAGCTATTTTTCAACTGCAAAATATACAGCTGCTGGTA
AAACAGGTACAGCTCAAACTGTGTATGGCGGAGATAAAGAGATTGGTAGAAATGCAAAAGGTGAGCGCAAAGAGACATAT
AACTTAACGTTAGTAGGTTATGCGCCGGCTGAAGACCCTGAAGTAGCATTTTCTGTTGTTGTACCTTGGGTAGATGATAA
ATCAGGTATTAACGGTTATATTAGTCGTGACATTTTGGATGCGTATTTTGATTTGAAGAAAGTAGAAAATGGCGAAGCTA
CACAAGAGGAAATAGATAAGAAAAATAAAGAGCAAGATGATGAATAA

Upstream 100 bases:

>100_bases
TGTTTTATGCTAGAATAGAAAAAGATGTAAGACAGCAGTGAGGACACCTGTATGAAGGTGTCCCTTTCACATTACATAGC
TGTTGGTAGAGGGGGTTTGT

Downstream 100 bases:

>100_bases
AGAAGTTGTAAAAAAAGCACACTATTTGAAAAGATAGTGTGCTTTTTTTTATGGTTCATGCATACGTTTTAATAAAGTGG
ACAAGCATATCATATCGGGA

Product: penicillin-binding protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 708; Mature: 707

Protein sequence:

>708_residues
MSKKQKQQKKKTHVPFRLNVLFFCVFLMFSAVIVRLGYVQIVRGEEYKNEVERKENSTISNPVPRGKIFDRYGRAVVDNA
AVRTITFTKMKGSTAEARLETAKKLADLIEVPTDKLTDRDKKDYWLAIHKEEAKEKITNKDRQEFKDKKIDDKELDERQR
NRVTEEEVNQLSAKDLEVLAIKSKMDGGYAMTPQVIKKDATDEEYAIISENLAQLPGVDTSVDWERKYAYDGDLFRSVLG
GVTTSDEGLPRERLDYYLVRDYNRNDRVGKSYLEQQYEDSLHGNKAEVRNVTDKNGNILETINVSKGQSGNDLNLTIDME
LQKRVEEIITKSLLKYKGGQPLLDRAFVVMMNPKNGEVLSMAGKQLVNENGETKVQDFALGTMTSSYPMGSTVKGATILT
GYQTGAIQPGSVQLDEPIVLKGPLKKSSWKTMGYINDLTALKMSSNVYMFKTAMNIAGVPYVRGGTLDIKQKSYDTMRYY
FGQFGLGVKTGIDLPNETAGQRGRTDHMPGFLLDLSIGQYDTYTPLQLAQYVSTIANGGYRMQPQVVKEIRQPAAKQDEV
GKVVHSMEPKVLNRVDMPESQIKRVQEGFKQVFNSPGGTALSYFSTAKYTAAGKTGTAQTVYGGDKEIGRNAKGERKETY
NLTLVGYAPAEDPEVAFSVVVPWVDDKSGINGYISRDILDAYFDLKKVENGEATQEEIDKKNKEQDDE

Sequences:

>Translated_708_residues
MSKKQKQQKKKTHVPFRLNVLFFCVFLMFSAVIVRLGYVQIVRGEEYKNEVERKENSTISNPVPRGKIFDRYGRAVVDNA
AVRTITFTKMKGSTAEARLETAKKLADLIEVPTDKLTDRDKKDYWLAIHKEEAKEKITNKDRQEFKDKKIDDKELDERQR
NRVTEEEVNQLSAKDLEVLAIKSKMDGGYAMTPQVIKKDATDEEYAIISENLAQLPGVDTSVDWERKYAYDGDLFRSVLG
GVTTSDEGLPRERLDYYLVRDYNRNDRVGKSYLEQQYEDSLHGNKAEVRNVTDKNGNILETINVSKGQSGNDLNLTIDME
LQKRVEEIITKSLLKYKGGQPLLDRAFVVMMNPKNGEVLSMAGKQLVNENGETKVQDFALGTMTSSYPMGSTVKGATILT
GYQTGAIQPGSVQLDEPIVLKGPLKKSSWKTMGYINDLTALKMSSNVYMFKTAMNIAGVPYVRGGTLDIKQKSYDTMRYY
FGQFGLGVKTGIDLPNETAGQRGRTDHMPGFLLDLSIGQYDTYTPLQLAQYVSTIANGGYRMQPQVVKEIRQPAAKQDEV
GKVVHSMEPKVLNRVDMPESQIKRVQEGFKQVFNSPGGTALSYFSTAKYTAAGKTGTAQTVYGGDKEIGRNAKGERKETY
NLTLVGYAPAEDPEVAFSVVVPWVDDKSGINGYISRDILDAYFDLKKVENGEATQEEIDKKNKEQDDE
>Mature_707_residues
SKKQKQQKKKTHVPFRLNVLFFCVFLMFSAVIVRLGYVQIVRGEEYKNEVERKENSTISNPVPRGKIFDRYGRAVVDNAA
VRTITFTKMKGSTAEARLETAKKLADLIEVPTDKLTDRDKKDYWLAIHKEEAKEKITNKDRQEFKDKKIDDKELDERQRN
RVTEEEVNQLSAKDLEVLAIKSKMDGGYAMTPQVIKKDATDEEYAIISENLAQLPGVDTSVDWERKYAYDGDLFRSVLGG
VTTSDEGLPRERLDYYLVRDYNRNDRVGKSYLEQQYEDSLHGNKAEVRNVTDKNGNILETINVSKGQSGNDLNLTIDMEL
QKRVEEIITKSLLKYKGGQPLLDRAFVVMMNPKNGEVLSMAGKQLVNENGETKVQDFALGTMTSSYPMGSTVKGATILTG
YQTGAIQPGSVQLDEPIVLKGPLKKSSWKTMGYINDLTALKMSSNVYMFKTAMNIAGVPYVRGGTLDIKQKSYDTMRYYF
GQFGLGVKTGIDLPNETAGQRGRTDHMPGFLLDLSIGQYDTYTPLQLAQYVSTIANGGYRMQPQVVKEIRQPAAKQDEVG
KVVHSMEPKVLNRVDMPESQIKRVQEGFKQVFNSPGGTALSYFSTAKYTAAGKTGTAQTVYGGDKEIGRNAKGERKETYN
LTLVGYAPAEDPEVAFSVVVPWVDDKSGINGYISRDILDAYFDLKKVENGEATQEEIDKKNKEQDDE

Specific function: Cell Wall Formation; Pbp-2 Is Responsible For The Determination Of The Rod Shape Of The Cell. Its Synthesize Cross- Linked Peptidoglycan From The Lipid Intermediates. [C]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=522, Percent_Identity=25.2873563218391, Blast_Score=127, Evalue=3e-30,
Organism=Escherichia coli, GI1786272, Length=404, Percent_Identity=26.980198019802, Blast_Score=76, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 79567; Mature: 79436

Theoretical pI: Translated: 8.16; Mature: 8.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKKQKQQKKKTHVPFRLNVLFFCVFLMFSAVIVRLGYVQIVRGEEYKNEVERKENSTIS
CCCHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHCCCCC
NPVPRGKIFDRYGRAVVDNAAVRTITFTKMKGSTAEARLETAKKLADLIEVPTDKLTDRD
CCCCCCHHHHHHCHHHHCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCHHHCCCC
KKDYWLAIHKEEAKEKITNKDRQEFKDKKIDDKELDERQRNRVTEEEVNQLSAKDLEVLA
CCCEEEEEEHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHCCCCEEEEE
IKSKMDGGYAMTPQVIKKDATDEEYAIISENLAQLPGVDTSVDWERKYAYDGDLFRSVLG
EEECCCCCEECCHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHCCCCHHHHHHHHC
GVTTSDEGLPRERLDYYLVRDYNRNDRVGKSYLEQQYEDSLHGNKAEVRNVTDKNGNILE
CCCCCCCCCCHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCEEE
TINVSKGQSGNDLNLTIDMELQKRVEEIITKSLLKYKGGQPLLDRAFVVMMNPKNGEVLS
EEECCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCHH
MAGKQLVNENGETKVQDFALGTMTSSYPMGSTVKGATILTGYQTGAIQPGSVQLDEPIVL
HHHHHHHCCCCCCCHHHHEECCCCCCCCCCCCCCCCEEEEECCCCCCCCCCEECCCCEEE
KGPLKKSSWKTMGYINDLTALKMSSNVYMFKTAMNIAGVPYVRGGTLDIKQKSYDTMRYY
ECCCCCCCCCHHHHHHHHHHEEECCCEEEEEEHHHHCCCCEEECCEEEECCCHHHHHHHH
FGQFGLGVKTGIDLPNETAGQRGRTDHMPGFLLDLSIGQYDTYTPLQLAQYVSTIANGGY
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCE
RMQPQVVKEIRQPAAKQDEVGKVVHSMEPKVLNRVDMPESQIKRVQEGFKQVFNSPGGTA
EECHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCE
LSYFSTAKYTAAGKTGTAQTVYGGDKEIGRNAKGERKETYNLTLVGYAPAEDPEVAFSVV
EHHHHCCEEEECCCCCCCEEEECCCHHHCCCCCCCCCEEEEEEEEEECCCCCCCEEEEEE
VPWVDDKSGINGYISRDILDAYFDLKKVENGEATQEEIDKKNKEQDDE
EECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SKKQKQQKKKTHVPFRLNVLFFCVFLMFSAVIVRLGYVQIVRGEEYKNEVERKENSTIS
CCHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHCCCCC
NPVPRGKIFDRYGRAVVDNAAVRTITFTKMKGSTAEARLETAKKLADLIEVPTDKLTDRD
CCCCCCHHHHHHCHHHHCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCHHHCCCC
KKDYWLAIHKEEAKEKITNKDRQEFKDKKIDDKELDERQRNRVTEEEVNQLSAKDLEVLA
CCCEEEEEEHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHCCCCEEEEE
IKSKMDGGYAMTPQVIKKDATDEEYAIISENLAQLPGVDTSVDWERKYAYDGDLFRSVLG
EEECCCCCEECCHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHCCCCHHHHHHHHC
GVTTSDEGLPRERLDYYLVRDYNRNDRVGKSYLEQQYEDSLHGNKAEVRNVTDKNGNILE
CCCCCCCCCCHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCEEE
TINVSKGQSGNDLNLTIDMELQKRVEEIITKSLLKYKGGQPLLDRAFVVMMNPKNGEVLS
EEECCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCHH
MAGKQLVNENGETKVQDFALGTMTSSYPMGSTVKGATILTGYQTGAIQPGSVQLDEPIVL
HHHHHHHCCCCCCCHHHHEECCCCCCCCCCCCCCCCEEEEECCCCCCCCCCEECCCCEEE
KGPLKKSSWKTMGYINDLTALKMSSNVYMFKTAMNIAGVPYVRGGTLDIKQKSYDTMRYY
ECCCCCCCCCHHHHHHHHHHEEECCCEEEEEEHHHHCCCCEEECCEEEECCCHHHHHHHH
FGQFGLGVKTGIDLPNETAGQRGRTDHMPGFLLDLSIGQYDTYTPLQLAQYVSTIANGGY
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCE
RMQPQVVKEIRQPAAKQDEVGKVVHSMEPKVLNRVDMPESQIKRVQEGFKQVFNSPGGTA
EECHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCE
LSYFSTAKYTAAGKTGTAQTVYGGDKEIGRNAKGERKETYNLTLVGYAPAEDPEVAFSVV
EHHHHCCEEEECCCCCCCEEEECCCHHHCCCCCCCCCEEEEEEEEEECCCCCCCEEEEEE
VPWVDDKSGINGYISRDILDAYFDLKKVENGEATQEEIDKKNKEQDDE
EECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]