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The map label for this gene is serA

Identifier: 49480110

GI number: 49480110

Start: 3104953

End: 3106125

Strand: Reverse

Name: serA

Synonym: BT9727_3022

Alternate gene names: 49480110

Gene position: 3106125-3104953 (Counterclockwise)

Preceding gene: 49480113

Following gene: 49478102

Centisome position: 59.3

GC content: 38.96

Gene sequence:

>1173_bases
ATGTTTCGTGTTCAAACGTTAAATCAAATTGCAGAAAAAGGTTTGCAAGTGCTTGGCGGAGAGCGCTATGAAGTAGGGGA
GAGAATGGACCACCCAGACGGCATTTTACTTCGCAGTTATTCTTTACATCAAGAAGAATTTTCAAAAGACTTAAAGGCCA
TTGCAAGAGCTGGTGCAGGGGTAAATAATATTCCTGTCGAGCGATGTACAGAAAAAGGGATTGTAGTATTTAATACGCCA
GGAGCGAATGCCAATGCAGTAAAGGAACTTATTATCGCCAGTCTTATTATGTCTTCACGTAACATTATTAATGGCGTAAG
CTGGACGAAAAATTTAGAGGGTGAGGAAGTACCGCAGCTTGTTGAATCAGGAAAAAAACAATTTGTTGGATCTGAAATTG
CGGGAAAACGTCTAGGAGTTATCGGACTTGGTGCGATTGGAGCTTTAGTTGCGAACGATGCGTTAGCTTTAGGGATGGAC
GTTGTCGGATATGACCCTTACATTTCAGTTGAAACAGCTTGGCGCCTTTCTACACATGTGCAAAGAGCATTTAGTTTAGA
TGAAATTTTTGCAACGTGTGATTATATTACCCTTCATATTCCTCTTACGAATCAAACGAAGGGAATGATTGGTGAACACG
CTGTAGAGAAGATGAAAAAAGGTATGCGTCTATTCAATTTCTCTAGAGGAGAACTTGTAGATGAAAAGGTTCTTCAAAAA
GCGTTAGAAGAAGAGATTATTGCACATTACGTAACGGACTTCCCGAATGAAAATGTGATAAAGATGAAAAATGTAACAGC
GACGCCTCACCTTGGTGCATCTACGTCTGAATCAGAAGAAAATTGTGCAGTCATGGCAGCGCGCCAATTACGTGAATATT
TAGAGACAGGAAATATTCGTAATTCAGTCAACTATCCAAATGTTGAGCTGCCGTATATCGGAAAGAAACGTATTACAATC
ATGCATCAAAACGTACCGAACATGGTAGGACAAATTACAGGGTGTTTAGCAGAGCATCATATTAATATTGCAGATATGAT
TAATCGTAGTAAACATTCTTGGGCGTACACAATGATTGATATCGATAACGGAATTGATGATATAATAAAAGAGAACATTG
TGGAAAATATAAGCAAAATTACAGGTGTTGTAGCCGTTCGAATGATTGTGTAA

Upstream 100 bases:

>100_bases
GCGCGCTAGTATTTACAATGCGATGCCAGCACACGGCGTACAGCAATTAGTAAATTATATGAAGGAATTTGAGCTTGAGA
ATAGATAGGGAGATGGGGAT

Downstream 100 bases:

>100_bases
AGGAGAGAGGGAATTGGCAAAAATCCGACCGTTTCGGGCCATTCGTCCAGTAGAAGAAAAAGCAGCACAAGTTGCAGCTT
TACCGTATGACGTTTTAAAT

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MFRVQTLNQIAEKGLQVLGGERYEVGERMDHPDGILLRSYSLHQEEFSKDLKAIARAGAGVNNIPVERCTEKGIVVFNTP
GANANAVKELIIASLIMSSRNIINGVSWTKNLEGEEVPQLVESGKKQFVGSEIAGKRLGVIGLGAIGALVANDALALGMD
VVGYDPYISVETAWRLSTHVQRAFSLDEIFATCDYITLHIPLTNQTKGMIGEHAVEKMKKGMRLFNFSRGELVDEKVLQK
ALEEEIIAHYVTDFPNENVIKMKNVTATPHLGASTSESEENCAVMAARQLREYLETGNIRNSVNYPNVELPYIGKKRITI
MHQNVPNMVGQITGCLAEHHINIADMINRSKHSWAYTMIDIDNGIDDIIKENIVENISKITGVVAVRMIV

Sequences:

>Translated_390_residues
MFRVQTLNQIAEKGLQVLGGERYEVGERMDHPDGILLRSYSLHQEEFSKDLKAIARAGAGVNNIPVERCTEKGIVVFNTP
GANANAVKELIIASLIMSSRNIINGVSWTKNLEGEEVPQLVESGKKQFVGSEIAGKRLGVIGLGAIGALVANDALALGMD
VVGYDPYISVETAWRLSTHVQRAFSLDEIFATCDYITLHIPLTNQTKGMIGEHAVEKMKKGMRLFNFSRGELVDEKVLQK
ALEEEIIAHYVTDFPNENVIKMKNVTATPHLGASTSESEENCAVMAARQLREYLETGNIRNSVNYPNVELPYIGKKRITI
MHQNVPNMVGQITGCLAEHHINIADMINRSKHSWAYTMIDIDNGIDDIIKENIVENISKITGVVAVRMIV
>Mature_390_residues
MFRVQTLNQIAEKGLQVLGGERYEVGERMDHPDGILLRSYSLHQEEFSKDLKAIARAGAGVNNIPVERCTEKGIVVFNTP
GANANAVKELIIASLIMSSRNIINGVSWTKNLEGEEVPQLVESGKKQFVGSEIAGKRLGVIGLGAIGALVANDALALGMD
VVGYDPYISVETAWRLSTHVQRAFSLDEIFATCDYITLHIPLTNQTKGMIGEHAVEKMKKGMRLFNFSRGELVDEKVLQK
ALEEEIIAHYVTDFPNENVIKMKNVTATPHLGASTSESEENCAVMAARQLREYLETGNIRNSVNYPNVELPYIGKKRITI
MHQNVPNMVGQITGCLAEHHINIADMINRSKHSWAYTMIDIDNGIDDIIKENIVENISKITGVVAVRMIV

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=307, Percent_Identity=32.8990228013029, Blast_Score=161, Evalue=8e-40,
Organism=Homo sapiens, GI61743967, Length=286, Percent_Identity=31.1188811188811, Blast_Score=112, Evalue=6e-25,
Organism=Homo sapiens, GI4557497, Length=272, Percent_Identity=32.7205882352941, Blast_Score=112, Evalue=7e-25,
Organism=Homo sapiens, GI145580578, Length=275, Percent_Identity=31.2727272727273, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI4557499, Length=275, Percent_Identity=31.2727272727273, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI145580575, Length=275, Percent_Identity=31.2727272727273, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI6912396, Length=249, Percent_Identity=25.7028112449799, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1789279, Length=361, Percent_Identity=30.4709141274238, Blast_Score=152, Evalue=3e-38,
Organism=Escherichia coli, GI87082289, Length=272, Percent_Identity=27.2058823529412, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1787645, Length=219, Percent_Identity=31.9634703196347, Blast_Score=87, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17532191, Length=277, Percent_Identity=33.9350180505415, Blast_Score=135, Evalue=3e-32,
Organism=Caenorhabditis elegans, GI25147481, Length=275, Percent_Identity=27.6363636363636, Blast_Score=95, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6320925, Length=373, Percent_Identity=29.4906166219839, Blast_Score=152, Evalue=6e-38,
Organism=Saccharomyces cerevisiae, GI6322116, Length=398, Percent_Identity=28.894472361809, Blast_Score=147, Evalue=3e-36,
Organism=Saccharomyces cerevisiae, GI6324055, Length=273, Percent_Identity=24.1758241758242, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI19921140, Length=280, Percent_Identity=34.2857142857143, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24646446, Length=283, Percent_Identity=32.1554770318021, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24646448, Length=283, Percent_Identity=32.1554770318021, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24646452, Length=283, Percent_Identity=32.1554770318021, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24646450, Length=283, Percent_Identity=32.1554770318021, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI62472511, Length=283, Percent_Identity=32.1554770318021, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI45552429, Length=282, Percent_Identity=26.241134751773, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24585514, Length=282, Percent_Identity=26.241134751773, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI28574282, Length=282, Percent_Identity=26.241134751773, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI45551003, Length=282, Percent_Identity=26.241134751773, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI28574284, Length=282, Percent_Identity=26.241134751773, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI28574286, Length=258, Percent_Identity=25.5813953488372, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI28571528, Length=257, Percent_Identity=27.6264591439689, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24585516, Length=253, Percent_Identity=23.7154150197628, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 43112; Mature: 43112

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFRVQTLNQIAEKGLQVLGGERYEVGERMDHPDGILLRSYSLHQEEFSKDLKAIARAGAG
CCCHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCEEEEECHHHHHHHHHHHHHHHHHCCC
VNNIPVERCTEKGIVVFNTPGANANAVKELIIASLIMSSRNIINGVSWTKNLEGEEVPQL
CCCCCHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCHHHHHHH
VESGKKQFVGSEIAGKRLGVIGLGAIGALVANDALALGMDVVGYDPYISVETAWRLSTHV
HHHHHHHHCCHHHCCCCCCEEEHHHHHHHHHCCHHHHCCCEECCCCEEEHHHHHHHHHHH
QRAFSLDEIFATCDYITLHIPLTNQTKGMIGEHAVEKMKKGMRLFNFSRGELVDEKVLQK
HHHHHHHHHHHHCCEEEEEEEECCCCCCHHHHHHHHHHHCCHHHHCCCCCCHHHHHHHHH
ALEEEIIAHYVTDFPNENVIKMKNVTATPHLGASTSESEENCAVMAARQLREYLETGNIR
HHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCC
NSVNYPNVELPYIGKKRITIMHQNVPNMVGQITGCLAEHHINIADMINRSKHSWAYTMID
CCCCCCCEECCCCCCCEEEEEECCHHHHHHHHHHHHHHHCCCHHHHHCCCCCCEEEEEEE
IDNGIDDIIKENIVENISKITGVVAVRMIV
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MFRVQTLNQIAEKGLQVLGGERYEVGERMDHPDGILLRSYSLHQEEFSKDLKAIARAGAG
CCCHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCEEEEECHHHHHHHHHHHHHHHHHCCC
VNNIPVERCTEKGIVVFNTPGANANAVKELIIASLIMSSRNIINGVSWTKNLEGEEVPQL
CCCCCHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCHHHHHHH
VESGKKQFVGSEIAGKRLGVIGLGAIGALVANDALALGMDVVGYDPYISVETAWRLSTHV
HHHHHHHHCCHHHCCCCCCEEEHHHHHHHHHCCHHHHCCCEECCCCEEEHHHHHHHHHHH
QRAFSLDEIFATCDYITLHIPLTNQTKGMIGEHAVEKMKKGMRLFNFSRGELVDEKVLQK
HHHHHHHHHHHHCCEEEEEEEECCCCCCHHHHHHHHHHHCCHHHHCCCCCCHHHHHHHHH
ALEEEIIAHYVTDFPNENVIKMKNVTATPHLGASTSESEENCAVMAARQLREYLETGNIR
HHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCC
NSVNYPNVELPYIGKKRITIMHQNVPNMVGQITGCLAEHHINIADMINRSKHSWAYTMID
CCCCCCCEECCCCCCCEEEEEECCHHHHHHHHHHHHHHHCCCHHHHHCCCCCCEEEEEEE
IDNGIDDIIKENIVENISKITGVVAVRMIV
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]