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The map label for this gene is murB

Identifier: 49479405

GI number: 49479405

Start: 3749468

End: 3750373

Strand: Reverse

Name: murB

Synonym: BT9727_3651

Alternate gene names: 49479405

Gene position: 3750373-3749468 (Counterclockwise)

Preceding gene: 161761253

Following gene: 49479399

Centisome position: 71.6

GC content: 38.85

Gene sequence:

>906_bases
ATGGAGCAATTAGTAAATGAGCTTATAGAAGCAAATGTTGGTCGCGTGTTAGTGGATGAACCGTTAGCACGTTATACCAC
TATGAAAATAGGTGGGCCAGCTGATATTTTAATTGTGCCAAAGCATGTTGCTGGTATTGAAAAAACGTTACAGTTAGTAA
AGAAATATAAAACAAAGTGGACTGTAATTGGTCGTGGTTCGAACCTTCTTGTATCTGATCTAGGTATAGAAGGTGTCGTT
ATTCGTTTAGGAGAAGGATTAGACCACTTAGAAGTCGAAAAACATAGAGTAAGAGTTGGTGGTGGGTATCCCCTAATTAA
ATTATCAACTTTACTTAGTCGTCAAGGGTTAGCCGGTCTGGAGTTCGCAAGTGGTATTCCGGGAAGTGTTGGCGGTGCAG
TGTATATGAATGCAGGAGCACATAAATCGGATATATCAAACATATTATCAAAAGCTCTTATTTTGTTTGAAGACGGAACA
ATTGACTGGTTAACGCATGGAGAAATGGGGTTTTCCTATCGTACATCTGTATTGCAAACGAAACGTCCTGGTATTGTTTT
GGAGGCTGAGTTTCAATTACAGATAGGTGAGCGTGAGAGAATTGTAAGTGTTATGCAAAAGAATAAAGATTACCGTCGTG
AGACACAGCCATGGAATCATCCGTGTGCAGGAAGTGTGTTTCGGAATCCAACTCCATACTTTGCAGGAGATTTAATAGAA
AAGGCAGGGCTTCGTGGTTATCAAATAGGTGGGGCTCAAATTTCTGAAATGCATGGAAATTTTATTATTAATACTGGGGG
AGCCAGCGCGCAAGATGTCTTATCTTTAATTGCATTAATAAAACAAACAATTAAGGATAAATTTGGCGTAGAAATGCATA
CAGAAGTAGAAATCATTGGAAGATAA

Upstream 100 bases:

>100_bases
AAGCTGTATGAAGTCATGAATAAGCTTGTAAAAAAATAACGTTAGGTGAACGCCCTGCATACTACTGTAATAAGGATGCT
GAGTATGGGGGAGATTGTTT

Downstream 100 bases:

>100_bases
CGGTTATTCGTTCCGCTCATTATCATTTATGTTATAATAAGAAGATAAGAACGGCATGAGGAACATGCCGTTCTTTATGT
TACGTAGGGGGATCGTACAT

Product: UDP-N-acetylenolpyruvoylglucosamine reductase

Products: NA

Alternate protein names: UDP-N-acetylmuramate dehydrogenase 1 [H]

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MEQLVNELIEANVGRVLVDEPLARYTTMKIGGPADILIVPKHVAGIEKTLQLVKKYKTKWTVIGRGSNLLVSDLGIEGVV
IRLGEGLDHLEVEKHRVRVGGGYPLIKLSTLLSRQGLAGLEFASGIPGSVGGAVYMNAGAHKSDISNILSKALILFEDGT
IDWLTHGEMGFSYRTSVLQTKRPGIVLEAEFQLQIGERERIVSVMQKNKDYRRETQPWNHPCAGSVFRNPTPYFAGDLIE
KAGLRGYQIGGAQISEMHGNFIINTGGASAQDVLSLIALIKQTIKDKFGVEMHTEVEIIGR

Sequences:

>Translated_301_residues
MEQLVNELIEANVGRVLVDEPLARYTTMKIGGPADILIVPKHVAGIEKTLQLVKKYKTKWTVIGRGSNLLVSDLGIEGVV
IRLGEGLDHLEVEKHRVRVGGGYPLIKLSTLLSRQGLAGLEFASGIPGSVGGAVYMNAGAHKSDISNILSKALILFEDGT
IDWLTHGEMGFSYRTSVLQTKRPGIVLEAEFQLQIGERERIVSVMQKNKDYRRETQPWNHPCAGSVFRNPTPYFAGDLIE
KAGLRGYQIGGAQISEMHGNFIINTGGASAQDVLSLIALIKQTIKDKFGVEMHTEVEIIGR
>Mature_301_residues
MEQLVNELIEANVGRVLVDEPLARYTTMKIGGPADILIVPKHVAGIEKTLQLVKKYKTKWTVIGRGSNLLVSDLGIEGVV
IRLGEGLDHLEVEKHRVRVGGGYPLIKLSTLLSRQGLAGLEFASGIPGSVGGAVYMNAGAHKSDISNILSKALILFEDGT
IDWLTHGEMGFSYRTSVLQTKRPGIVLEAEFQLQIGERERIVSVMQKNKDYRRETQPWNHPCAGSVFRNPTPYFAGDLIE
KAGLRGYQIGGAQISEMHGNFIINTGGASAQDVLSLIALIKQTIKDKFGVEMHTEVEIIGR

Specific function: Cell wall formation [H]

COG id: COG0812

COG function: function code M; UDP-N-acetylmuramate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Escherichia coli, GI1790407, Length=313, Percent_Identity=25.5591054313099, Blast_Score=75, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016169
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR003170
- InterPro:   IPR011601
- InterPro:   IPR006094 [H]

Pfam domain/function: PF01565 FAD_binding_4; PF02873 MurB_C [H]

EC number: =1.1.1.158 [H]

Molecular weight: Translated: 32927; Mature: 32927

Theoretical pI: Translated: 8.43; Mature: 8.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQLVNELIEANVGRVLVDEPLARYTTMKIGGPADILIVPKHVAGIEKTLQLVKKYKTKW
CHHHHHHHHHCCCCEEEECCCHHHHEEEEECCCEEEEEECHHHHHHHHHHHHHHHHCCEE
TVIGRGSNLLVSDLGIEGVVIRLGEGLDHLEVEKHRVRVGGGYPLIKLSTLLSRQGLAGL
EEEECCCCEEEECCCCCEEEEEECCCCCCCEEEEEEEEECCCCCHHHHHHHHHHCCCCCC
EFASGIPGSVGGAVYMNAGAHKSDISNILSKALILFEDGTIDWLTHGEMGFSYRTSVLQT
HHHCCCCCCCCCEEEEECCCCHHHHHHHHHHHEEEEECCCEEEEECCCCCCHHHHHHHHC
KRPGIVLEAEFQLQIGERERIVSVMQKNKDYRRETQPWNHPCAGSVFRNPTPYFAGDLIE
CCCCEEEEEEEEEEECCHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHH
KAGLRGYQIGGAQISEMHGNFIINTGGASAQDVLSLIALIKQTIKDKFGVEMHTEVEIIG
HCCCCEEEECCCEEEECCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEEEEEC
R
C
>Mature Secondary Structure
MEQLVNELIEANVGRVLVDEPLARYTTMKIGGPADILIVPKHVAGIEKTLQLVKKYKTKW
CHHHHHHHHHCCCCEEEECCCHHHHEEEEECCCEEEEEECHHHHHHHHHHHHHHHHCCEE
TVIGRGSNLLVSDLGIEGVVIRLGEGLDHLEVEKHRVRVGGGYPLIKLSTLLSRQGLAGL
EEEECCCCEEEECCCCCEEEEEECCCCCCCEEEEEEEEECCCCCHHHHHHHHHHCCCCCC
EFASGIPGSVGGAVYMNAGAHKSDISNILSKALILFEDGTIDWLTHGEMGFSYRTSVLQT
HHHCCCCCCCCCEEEEECCCCHHHHHHHHHHHEEEEECCCEEEEECCCCCCHHHHHHHHC
KRPGIVLEAEFQLQIGERERIVSVMQKNKDYRRETQPWNHPCAGSVFRNPTPYFAGDLIE
CCCCEEEEEEEEEEECCHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHH
KAGLRGYQIGGAQISEMHGNFIINTGGASAQDVLSLIALIKQTIKDKFGVEMHTEVEIIG
HCCCCEEEECCCEEEECCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEEEEEC
R
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12721629 [H]