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The map label for this gene is yhaU [H]

Identifier: 49479342

GI number: 49479342

Start: 4805508

End: 4806707

Strand: Reverse

Name: yhaU [H]

Synonym: BT9727_4756

Alternate gene names: 49479342

Gene position: 4806707-4805508 (Counterclockwise)

Preceding gene: 49479319

Following gene: 49479341

Centisome position: 91.77

GC content: 35.67

Gene sequence:

>1200_bases
ATGGATACGTTAATTTTTGAAGTTGGTACAGCTTTAGTTTTAGTTGCAATTGCAGCAGTAATTGCTGGAAAGTTTAAATT
CTCAGTCATTCCATTTCTAATTGTTCTTGGGATGCTAGTGGGGCCACATGCGCCGACAATAGGTGTGATCGATTTCAAAT
TTATTGAAAGTGCAAATGTAATTTCGTTTCTTGGACGGATTGGCGTTCTGTTTCTTCTGTTCTATCTAGGACTAGAGTTT
TCAATGAAAAAACTAATTAAATCTGGACGTTCTATTGCGATTGGTGGAACAATCTATATTTTAATTAACTTTTCACTTGG
GTTATTATACGGATTTATCATGGGATTCCCTTTACTAGAAATTTTAATTATTGCGGGTATTATTACGATTTCTTCTAGCG
CTATCGTTGCAAAGGTGTTAGTGGACTTAAGAAGAACTGGTAATAATGAGACCGAATTAATTTTAGGAATTATCATGTTC
GAAGATATATTCCTTGCTGTATATTTATCAGTTGTTTCTGGTTTAGTTCTAGGGGATCATGCTTCCTTTTTAGGTGCCCT
TACTTCAATTGGAATTGCTTTAGGATATATGCTTCTATTCTTTATTGTAGCTAGAAAGGCGACGCCGTTATTAAATAAAT
TGCTTAATATTAGTTCAGATGAAATTTTCATTATTGTAGTATTTGCTTCGTTATTCTTTATTGCAGGCTTCTCAGAAACA
ATTCACGTTGCCGAAGCAATTGGAGCACTTCTTTTAGGGTTAGTTTTCTCTGAGACAGAGCATAGTGACAGAATGGAACA
TCTCGTCGTTCCATTTAGAGACTTTTTCGGAGCTATTTTCTTCTTCAGTTTCGGATTAAGTATTGATCCGTTTTCATTAG
GAGGGGCAATATGGTTAACGTTAGGTGCTGTCCTTCTTACAATCATCGGAAACTTTGTAGCAGGGATGATTGCTGGGAGA
CAAGCGGGATTATCGCATAAAGCATCAACAAATATTGGATTAACAATCGTTTCAAGAGGAGAATTCTCTATCATTATGGC
CAATATTGGTATCGCGGGTGGTTTAATGTCAGTACTGAAACCATTCTCAGCATTATACGTGCTTATACTGTCGATCTTAG
GTCCACTTCTGACGAAAGAGTCAAAGAATGTATATAAATTGTTAAATAAAATCTTTAAGTGGGATATGAAGAAGAGCTAA

Upstream 100 bases:

>100_bases
TGCGGTAATTGAAGAAGGCGATATGCTTGTAGTTTCTGGTGAGAGAGAAGAAATTAAAAAAATCATTAATGAGTTACTTT
CGAATAGGGGGACTGACTAG

Downstream 100 bases:

>100_bases
ATTTTTAAAAATCAAAGTACAAAATATGTATGAAAAAGGGATCTATGTCGACATAGATCCCTTTTTTTATTGGCATTTTT
TTTAGGATGAAAGAATACGT

Product: Na+/H+ antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 399; Mature: 399

Protein sequence:

>399_residues
MDTLIFEVGTALVLVAIAAVIAGKFKFSVIPFLIVLGMLVGPHAPTIGVIDFKFIESANVISFLGRIGVLFLLFYLGLEF
SMKKLIKSGRSIAIGGTIYILINFSLGLLYGFIMGFPLLEILIIAGIITISSSAIVAKVLVDLRRTGNNETELILGIIMF
EDIFLAVYLSVVSGLVLGDHASFLGALTSIGIALGYMLLFFIVARKATPLLNKLLNISSDEIFIIVVFASLFFIAGFSET
IHVAEAIGALLLGLVFSETEHSDRMEHLVVPFRDFFGAIFFFSFGLSIDPFSLGGAIWLTLGAVLLTIIGNFVAGMIAGR
QAGLSHKASTNIGLTIVSRGEFSIIMANIGIAGGLMSVLKPFSALYVLILSILGPLLTKESKNVYKLLNKIFKWDMKKS

Sequences:

>Translated_399_residues
MDTLIFEVGTALVLVAIAAVIAGKFKFSVIPFLIVLGMLVGPHAPTIGVIDFKFIESANVISFLGRIGVLFLLFYLGLEF
SMKKLIKSGRSIAIGGTIYILINFSLGLLYGFIMGFPLLEILIIAGIITISSSAIVAKVLVDLRRTGNNETELILGIIMF
EDIFLAVYLSVVSGLVLGDHASFLGALTSIGIALGYMLLFFIVARKATPLLNKLLNISSDEIFIIVVFASLFFIAGFSET
IHVAEAIGALLLGLVFSETEHSDRMEHLVVPFRDFFGAIFFFSFGLSIDPFSLGGAIWLTLGAVLLTIIGNFVAGMIAGR
QAGLSHKASTNIGLTIVSRGEFSIIMANIGIAGGLMSVLKPFSALYVLILSILGPLLTKESKNVYKLLNKIFKWDMKKS
>Mature_399_residues
MDTLIFEVGTALVLVAIAAVIAGKFKFSVIPFLIVLGMLVGPHAPTIGVIDFKFIESANVISFLGRIGVLFLLFYLGLEF
SMKKLIKSGRSIAIGGTIYILINFSLGLLYGFIMGFPLLEILIIAGIITISSSAIVAKVLVDLRRTGNNETELILGIIMF
EDIFLAVYLSVVSGLVLGDHASFLGALTSIGIALGYMLLFFIVARKATPLLNKLLNISSDEIFIIVVFASLFFIAGFSET
IHVAEAIGALLLGLVFSETEHSDRMEHLVVPFRDFFGAIFFFSFGLSIDPFSLGGAIWLTLGAVLLTIIGNFVAGMIAGR
QAGLSHKASTNIGLTIVSRGEFSIIMANIGIAGGLMSVLKPFSALYVLILSILGPLLTKESKNVYKLLNKIFKWDMKKS

Specific function: Potassium/proton antiporter that mediates the efflux of potassium ions from the cell. Potassium antiport activity requires the presence of khtT. Has higher activity at alkaline pH. Can also mediate rubidium/proton antiport. Has no permeability for sodium

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell membrane [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 2 (CPA2) transporter (TC 2.A.37) family [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=351, Percent_Identity=27.9202279202279, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI1786685, Length=377, Percent_Identity=27.3209549071618, Blast_Score=105, Evalue=6e-24,
Organism=Escherichia coli, GI1786232, Length=268, Percent_Identity=24.6268656716418, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 42990; Mature: 42990

Theoretical pI: Translated: 9.20; Mature: 9.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTLIFEVGTALVLVAIAAVIAGKFKFSVIPFLIVLGMLVGPHAPTIGVIDFKFIESANV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHCCCHH
ISFLGRIGVLFLLFYLGLEFSMKKLIKSGRSIAIGGTIYILINFSLGLLYGFIMGFPLLE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCEEEEEHHHHHHHHHHHHHHHHHHH
ILIIAGIITISSSAIVAKVLVDLRRTGNNETELILGIIMFEDIFLAVYLSVVSGLVLGDH
HHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
ASFLGALTSIGIALGYMLLFFIVARKATPLLNKLLNISSDEIFIIVVFASLFFIAGFSET
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCEEHHHHHHHHHHHHCCHHH
IHVAEAIGALLLGLVFSETEHSDRMEHLVVPFRDFFGAIFFFSFGLSIDPFSLGGAIWLT
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCHHHHHH
LGAVLLTIIGNFVAGMIAGRQAGLSHKASTNIGLTIVSRGEFSIIMANIGIAGGLMSVLK
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCEEEEEECCCHHHHHHHHHH
PFSALYVLILSILGPLLTKESKNVYKLLNKIFKWDMKKS
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MDTLIFEVGTALVLVAIAAVIAGKFKFSVIPFLIVLGMLVGPHAPTIGVIDFKFIESANV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHCCCHH
ISFLGRIGVLFLLFYLGLEFSMKKLIKSGRSIAIGGTIYILINFSLGLLYGFIMGFPLLE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCEEEEEHHHHHHHHHHHHHHHHHHH
ILIIAGIITISSSAIVAKVLVDLRRTGNNETELILGIIMFEDIFLAVYLSVVSGLVLGDH
HHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH
ASFLGALTSIGIALGYMLLFFIVARKATPLLNKLLNISSDEIFIIVVFASLFFIAGFSET
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCEEHHHHHHHHHHHHCCHHH
IHVAEAIGALLLGLVFSETEHSDRMEHLVVPFRDFFGAIFFFSFGLSIDPFSLGGAIWLT
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCHHHHHH
LGAVLLTIIGNFVAGMIAGRQAGLSHKASTNIGLTIVSRGEFSIIMANIGIAGGLMSVLK
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCEEEEEECCCHHHHHHHHHH
PFSALYVLILSILGPLLTKESKNVYKLLNKIFKWDMKKS
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]