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The map label for this gene is cidA2 [H]

Identifier: 49479308

GI number: 49479308

Start: 4862435

End: 4862803

Strand: Reverse

Name: cidA2 [H]

Synonym: BT9727_4812

Alternate gene names: 49479308

Gene position: 4862803-4862435 (Counterclockwise)

Preceding gene: 49481799

Following gene: 49479337

Centisome position: 92.84

GC content: 36.04

Gene sequence:

>369_bases
ATGAAATTCACAAAAATTCTTGTCCAAATTGCTGCTCTTTACGTTTTTTATATGGTTGGAACGTGGGTACAAGAAATGCT
AAACATTCCAATCCCAGGAAGTTTGATTGGAATGTTCCTCTTACTTGTTTTACTTAGCCTAAAAGTTCTTCCAGTGAAAT
GGTTCGATTTAGGAGCAGAAACACTCGTTGCTATTATGCCGTTTTTATTAATTCCGCCAACGCTTGGCCTAATGAATTAC
GGTGCTTTTTTTATGAGTAAAGGAATTTCTCTTTTCATTACAGTTGTAGCGAGTACATTTTTAATTATTATTGTCGCAGG
ACATACAGGACAATATCTTGCGAATAGAAAGGAAAGAGAGTCGCGATGA

Upstream 100 bases:

>100_bases
GGCGTTTTTTGCTGTCAAGTTGATAAATTGCAGCTTTTTACAATTTATACTATGATAAAGATATTAACAGAAGATCGTAT
AAACAAGAGGGATGATGAAC

Downstream 100 bases:

>100_bases
GTCAAATATTAATCGGAATTGGTTGGGTTCTTTTTACGGTGCTATTATATCAATTATCTAAAAAAATCTATAAATTATTT
CCAACACCATTCACCATTCC

Product: holin-like protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 122; Mature: 122

Protein sequence:

>122_residues
MKFTKILVQIAALYVFYMVGTWVQEMLNIPIPGSLIGMFLLLVLLSLKVLPVKWFDLGAETLVAIMPFLLIPPTLGLMNY
GAFFMSKGISLFITVVASTFLIIIVAGHTGQYLANRKERESR

Sequences:

>Translated_122_residues
MKFTKILVQIAALYVFYMVGTWVQEMLNIPIPGSLIGMFLLLVLLSLKVLPVKWFDLGAETLVAIMPFLLIPPTLGLMNY
GAFFMSKGISLFITVVASTFLIIIVAGHTGQYLANRKERESR
>Mature_122_residues
MKFTKILVQIAALYVFYMVGTWVQEMLNIPIPGSLIGMFLLLVLLSLKVLPVKWFDLGAETLVAIMPFLLIPPTLGLMNY
GAFFMSKGISLFITVVASTFLIIIVAGHTGQYLANRKERESR

Specific function: Increases the activity of extracellular murein hydrolases possibly by mediating their export via hole formation. Inhibited by the antiholin-like proteins LrgAB. In an unstressed cell, the LrgAB products probably inhibit the function of the CidA protein. W

COG id: COG1380

COG function: function code R; Putative effector of murein hydrolase LrgA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CidA/LrgA family. CidA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788463, Length=106, Percent_Identity=29.2452830188679, Blast_Score=62, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005538 [H]

Pfam domain/function: PF03788 LrgA [H]

EC number: NA

Molecular weight: Translated: 13626; Mature: 13626

Theoretical pI: Translated: 10.10; Mature: 10.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.7 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.7 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFTKILVQIAALYVFYMVGTWVQEMLNIPIPGSLIGMFLLLVLLSLKVLPVKWFDLGAE
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHH
TLVAIMPFLLIPPTLGLMNYGAFFMSKGISLFITVVASTFLIIIVAGHTGQYLANRKERE
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHCC
SR
CC
>Mature Secondary Structure
MKFTKILVQIAALYVFYMVGTWVQEMLNIPIPGSLIGMFLLLVLLSLKVLPVKWFDLGAE
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHH
TLVAIMPFLLIPPTLGLMNYGAFFMSKGISLFITVVASTFLIIIVAGHTGQYLANRKERE
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHCC
SR
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12721629 [H]