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The map label for this gene is fhuB

Identifier: 49478980

GI number: 49478980

Start: 5126219

End: 5127274

Strand: Reverse

Name: fhuB

Synonym: BT9727_5063

Alternate gene names: 49478980

Gene position: 5127274-5126219 (Counterclockwise)

Preceding gene: 49480807

Following gene: 49481655

Centisome position: 97.89

GC content: 42.23

Gene sequence:

>1056_bases
ATGGAAGCGAGCGCAAGGAGTATAGAACAGCAAGATGTGAATGTTAAAGAGATTAAGAGCAGGCCGCTCATTGCTTCTAT
TATTTTAGTAGCAGGTACAATTTTGTTAGCTTTAAGCATGGCATTGTCTATTTCGTTTGGTGCTGCAGATATTAGTTTAA
AGACGGTATGGCAAGCTGTATTTCAGTTTGATGGGTCGTTGACGCATCATAACGTAATTCAAGAACTTCGCATGCCTAGA
GCAATAGGGGGCGTAGTTGCAGGTGCCTTTTTAGCGGTATCAGGGGCAATTATGCAAGGGATGACGCGAAATCCACTTGC
TTCTCCATCATTAATGGGTATTACAGATGGGGCTGTATTTGGAATTGCAATTATGTATGCCTTCTTCCCTAATTCACCTT
ATTTAATGTTCGTTATCGCATCTTTTATTGGTGCAGCGTTTGGAGCGAGCATTGTATATGGAATTGGGTCTTCTTCACCA
GGTGGATTAACGCCTGTGAAATTAGCTTTAGCAGGAGCAGCAATTAGTGCTTTATTAGGGGCCATTTCATCTGGAATTGC
ACTGTATTTCAATCTTGCCCAAGAGGTGAGTATGTGGAATGCGGGCGGAGTTGCTGGAGTGAAATGGGAAAGCATCAATA
TGCTAGTGCCAATCGGTCTAGTTTGTCTCTTTATCGCGATTATGATGTCGAGGTATATTACGATTTTGAGCTTCGGTGAA
GAGATTGCGATTGGACTTGGTCAAAATACGACATTAATTAAATTTATCGGAACAGTACTTGTTCTTGTGTTAACTGGTTC
TGCAGTTTCTATGGCAGGGTCGGTTGGATTTGTTGGTCTTGTAATCCCGCATATGACTCGTTTCCTTGTAGGCTCAGACT
ATAGATGGGTTATCCCATGTTCTGCAGTTTTAGGTGGGCTGTTAATTGAATGTGCAGATATGTTATCTCGCGTTATTAAT
CCGCCGTTTGAAACGCCAATTGGAGCAATTACAGCGCTAATTGGAGTTCCATTCTTCCTCTACTTAGCACGTAACGAAGG
GAGAGGGAAAATGTGA

Upstream 100 bases:

>100_bases
AATCATTATCAGAGAAAATGATTCATCTAATTTTTTTATTTCTATTTGAGAATAAATTTCATTTCATTAAATATATGTTG
TTGGTTAGGATGGTTGAGGG

Downstream 100 bases:

>100_bases
GGACAAGTGTCTTAACAAAAAAGAACGTTTCTGTTTTAACAATTTTAGTAGGATTAATCGTTACTGTATTTTTAGTGAGT
TTAAATACAGGGACATTTAA

Product: ferrichrome ABC transporter permease

Products: ADP; phosphate; ferric enterobactin [Cytoplasm] [C]

Alternate protein names: Ferric hydroxamate uptake protein B; Ferrichrome transport system permease protein fhuB; Iron(III)-hydroxamate import system permease protein fhuB [H]

Number of amino acids: Translated: 351; Mature: 351

Protein sequence:

>351_residues
MEASARSIEQQDVNVKEIKSRPLIASIILVAGTILLALSMALSISFGAADISLKTVWQAVFQFDGSLTHHNVIQELRMPR
AIGGVVAGAFLAVSGAIMQGMTRNPLASPSLMGITDGAVFGIAIMYAFFPNSPYLMFVIASFIGAAFGASIVYGIGSSSP
GGLTPVKLALAGAAISALLGAISSGIALYFNLAQEVSMWNAGGVAGVKWESINMLVPIGLVCLFIAIMMSRYITILSFGE
EIAIGLGQNTTLIKFIGTVLVLVLTGSAVSMAGSVGFVGLVIPHMTRFLVGSDYRWVIPCSAVLGGLLIECADMLSRVIN
PPFETPIGAITALIGVPFFLYLARNEGRGKM

Sequences:

>Translated_351_residues
MEASARSIEQQDVNVKEIKSRPLIASIILVAGTILLALSMALSISFGAADISLKTVWQAVFQFDGSLTHHNVIQELRMPR
AIGGVVAGAFLAVSGAIMQGMTRNPLASPSLMGITDGAVFGIAIMYAFFPNSPYLMFVIASFIGAAFGASIVYGIGSSSP
GGLTPVKLALAGAAISALLGAISSGIALYFNLAQEVSMWNAGGVAGVKWESINMLVPIGLVCLFIAIMMSRYITILSFGE
EIAIGLGQNTTLIKFIGTVLVLVLTGSAVSMAGSVGFVGLVIPHMTRFLVGSDYRWVIPCSAVLGGLLIECADMLSRVIN
PPFETPIGAITALIGVPFFLYLARNEGRGKM
>Mature_351_residues
MEASARSIEQQDVNVKEIKSRPLIASIILVAGTILLALSMALSISFGAADISLKTVWQAVFQFDGSLTHHNVIQELRMPR
AIGGVVAGAFLAVSGAIMQGMTRNPLASPSLMGITDGAVFGIAIMYAFFPNSPYLMFVIASFIGAAFGASIVYGIGSSSP
GGLTPVKLALAGAAISALLGAISSGIALYFNLAQEVSMWNAGGVAGVKWESINMLVPIGLVCLFIAIMMSRYITILSFGE
EIAIGLGQNTTLIKFIGTVLVLVLTGSAVSMAGSVGFVGLVIPHMTRFLVGSDYRWVIPCSAVLGGLLIECADMLSRVIN
PPFETPIGAITALIGVPFFLYLARNEGRGKM

Specific function: Part of the ABC transporter complex fhuBGCD involved in iron(3+)-hydroxamate import. Responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786805, Length=311, Percent_Identity=35.3697749196142, Blast_Score=159, Evalue=2e-40,
Organism=Escherichia coli, GI1790740, Length=317, Percent_Identity=32.1766561514196, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI1790741, Length=281, Percent_Identity=37.0106761565836, Blast_Score=154, Evalue=9e-39,
Organism=Escherichia coli, GI1786347, Length=350, Percent_Identity=30, Blast_Score=118, Evalue=5e-28,
Organism=Escherichia coli, GI1788004, Length=282, Percent_Identity=30.8510638297872, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1786804, Length=335, Percent_Identity=27.4626865671642, Blast_Score=103, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 36699; Mature: 36699

Theoretical pI: Translated: 8.05; Mature: 8.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEASARSIEQQDVNVKEIKSRPLIASIILVAGTILLALSMALSISFGAADISLKTVWQAV
CCCCHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
FQFDGSLTHHNVIQELRMPRAIGGVVAGAFLAVSGAIMQGMTRNPLASPSLMGITDGAVF
HHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHH
GIAIMYAFFPNSPYLMFVIASFIGAAFGASIVYGIGSSSPGGLTPVKLALAGAAISALLG
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHHHHHHH
AISSGIALYFNLAQEVSMWNAGGVAGVKWESINMLVPIGLVCLFIAIMMSRYITILSFGE
HHHCCHHHHHHHHHHHHHCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
EIAIGLGQNTTLIKFIGTVLVLVLTGSAVSMAGSVGFVGLVIPHMTRFLVGSDYRWVIPC
HHEEECCCCCHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHHCCCCEEEEEH
SAVLGGLLIECADMLSRVINPPFETPIGAITALIGVPFFLYLARNEGRGKM
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MEASARSIEQQDVNVKEIKSRPLIASIILVAGTILLALSMALSISFGAADISLKTVWQAV
CCCCHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
FQFDGSLTHHNVIQELRMPRAIGGVVAGAFLAVSGAIMQGMTRNPLASPSLMGITDGAVF
HHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHH
GIAIMYAFFPNSPYLMFVIASFIGAAFGASIVYGIGSSSPGGLTPVKLALAGAAISALLG
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHHHHHHH
AISSGIALYFNLAQEVSMWNAGGVAGVKWESINMLVPIGLVCLFIAIMMSRYITILSFGE
HHHCCHHHHHHHHHHHHHCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
EIAIGLGQNTTLIKFIGTVLVLVLTGSAVSMAGSVGFVGLVIPHMTRFLVGSDYRWVIPC
HHEEECCCCCHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHHCCCCEEEEEH
SAVLGGLLIECADMLSRVINPPFETPIGAITALIGVPFFLYLARNEGRGKM
HHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; ferric enterobactin [Periplasm]; H2O [C]

Specific reaction: ATP + ferric enterobactin [Periplasm] + H2O = ADP + phosphate + ferric enterobactin [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9639930; 9384377; 8388528 [H]