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The map label for this gene is moeA

Identifier: 49478738

GI number: 49478738

Start: 4508805

End: 4510094

Strand: Reverse

Name: moeA

Synonym: BT9727_4454

Alternate gene names: 49478738

Gene position: 4510094-4508805 (Counterclockwise)

Preceding gene: 49481370

Following gene: 49481544

Centisome position: 86.11

GC content: 41.32

Gene sequence:

>1290_bases
ATGGTAGAAAAACGAATTCCGATTCAAGTTGCTGAGGCAGTAGAGAGAGTAATGGAATATGCGAAAATTGGTGAAGTAGA
AGAGGTTTCTATTACGGAAAGTTACGGGAAAATTCTTGGGGAGGATGTTGTCTCTGATCATGACGTTCCTCATTTTGATC
GTTCTCCTTACGATGGTTTCGCAATTCGAGCAGAAGATACGAAAGAAGCAAATCAAGAGAATGCAATTGAGTTTGAAGTA
ATAGGAGAAATCGGGGCTGGATCTGTTTTTACAGAAGAAGTAGGATCTTTTCAGGCGGTTCGTATTATGACAGGAGCAGC
TATTCCAGCAGATTGTAATGCAGTCGTAATGCTAGAATTGACGGAAGGTTTTGAGAAGAACGGAAAAACATATATGAAGT
TAAAGCGTCCTTTTCATAGTGGCGACAATGTGTCATTTAAAGGAGAGGATATAAAACAAAATCAAGTTCTCGTTAAGAAA
GGTGCTGTAATCAATCCAGGTGTTGCGGCCTTATTAGCGACGTTTGGATACAGTAATGTGAAGGTTGTAAAACAGCCAGT
TGTTGGTATTGTGACGACAGGAAGTGAATTGTTAGAAGTACATGAGTCATTACAGCCGGGGAAAATTAGAAATAGTAACT
CTTATATGATTGCCGCCCAAATTATGAAAGCTGGGGGTAAAGTCCGTTATTATGGTCAACTTGCCGACGAGTTAGATGCA
TGTTTTACAGCCGTTCAATCGGCGATAGAAGAGGTGGATATTTTAATTACGACAGGCGGTGTGTCGGTAGGAGATTATGA
CTACTTACCGGCTATTTATGAAAGGTTACAGGCGAATGTACTCTTTAATAAAATAGCGATGAGACCGGGCAGTGTAACGA
CAGTAGCTGAAGTGGATGGAAAGTTACTTTTCGGTTTATCAGGGAATCCGTCAGCTTGTTATGTGGGATTTGAGTTATTT
GTGCATCCGGTTATAAAAACTTATTTGTATGCGAAGGAACCACACGTATATAGAGCAGATGCTATTTTACAAAAAGATTT
TCCAAAACCAAATCCGTTTACTCGTTTTGTAAGAGCAAAGGTGACAATCGTGGACGGGGCATTACACGCGATGCCAGTCG
GTTTAGATAAATCGAGTGCGGTATCTTCACTTGCAGATGCGAATGCTTTTATTGTGTTGCCTGGAGGAACCAGAGGGTTT
GAGGCAGGGATGAAAGTGTCTGTATTATTGTTAGAGCACGCTGAGGGATGTGATTGGCCATGGGCAAAGCCCCTTCGCTC
TTACAAATAG

Upstream 100 bases:

>100_bases
TGTGTGAATGAAGACATGGAATTCCTCCTTGAAGTAATTTCTATTCAATATATAAAGTTTAATCGAGATAAAAAAAATTG
CAAATATGGGGTGAGAAACG

Downstream 100 bases:

>100_bases
TAGGGTATCAAAATAGCGGGAAAACAACACTTGTAGAGAAAATTGTGCATGCATTAGCTGAACGAAAAATGAAAGTTGCT
ACGATTAAACATCACGGGCA

Product: molybdopterin biosynthesis protein

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 429; Mature: 429

Protein sequence:

>429_residues
MVEKRIPIQVAEAVERVMEYAKIGEVEEVSITESYGKILGEDVVSDHDVPHFDRSPYDGFAIRAEDTKEANQENAIEFEV
IGEIGAGSVFTEEVGSFQAVRIMTGAAIPADCNAVVMLELTEGFEKNGKTYMKLKRPFHSGDNVSFKGEDIKQNQVLVKK
GAVINPGVAALLATFGYSNVKVVKQPVVGIVTTGSELLEVHESLQPGKIRNSNSYMIAAQIMKAGGKVRYYGQLADELDA
CFTAVQSAIEEVDILITTGGVSVGDYDYLPAIYERLQANVLFNKIAMRPGSVTTVAEVDGKLLFGLSGNPSACYVGFELF
VHPVIKTYLYAKEPHVYRADAILQKDFPKPNPFTRFVRAKVTIVDGALHAMPVGLDKSSAVSSLADANAFIVLPGGTRGF
EAGMKVSVLLLEHAEGCDWPWAKPLRSYK

Sequences:

>Translated_429_residues
MVEKRIPIQVAEAVERVMEYAKIGEVEEVSITESYGKILGEDVVSDHDVPHFDRSPYDGFAIRAEDTKEANQENAIEFEV
IGEIGAGSVFTEEVGSFQAVRIMTGAAIPADCNAVVMLELTEGFEKNGKTYMKLKRPFHSGDNVSFKGEDIKQNQVLVKK
GAVINPGVAALLATFGYSNVKVVKQPVVGIVTTGSELLEVHESLQPGKIRNSNSYMIAAQIMKAGGKVRYYGQLADELDA
CFTAVQSAIEEVDILITTGGVSVGDYDYLPAIYERLQANVLFNKIAMRPGSVTTVAEVDGKLLFGLSGNPSACYVGFELF
VHPVIKTYLYAKEPHVYRADAILQKDFPKPNPFTRFVRAKVTIVDGALHAMPVGLDKSSAVSSLADANAFIVLPGGTRGF
EAGMKVSVLLLEHAEGCDWPWAKPLRSYK
>Mature_429_residues
MVEKRIPIQVAEAVERVMEYAKIGEVEEVSITESYGKILGEDVVSDHDVPHFDRSPYDGFAIRAEDTKEANQENAIEFEV
IGEIGAGSVFTEEVGSFQAVRIMTGAAIPADCNAVVMLELTEGFEKNGKTYMKLKRPFHSGDNVSFKGEDIKQNQVLVKK
GAVINPGVAALLATFGYSNVKVVKQPVVGIVTTGSELLEVHESLQPGKIRNSNSYMIAAQIMKAGGKVRYYGQLADELDA
CFTAVQSAIEEVDILITTGGVSVGDYDYLPAIYERLQANVLFNKIAMRPGSVTTVAEVDGKLLFGLSGNPSACYVGFELF
VHPVIKTYLYAKEPHVYRADAILQKDFPKPNPFTRFVRAKVTIVDGALHAMPVGLDKSSAVSSLADANAFIVLPGGTRGF
EAGMKVSVLLLEHAEGCDWPWAKPLRSYK

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=398, Percent_Identity=32.6633165829146, Blast_Score=181, Evalue=2e-45,
Organism=Homo sapiens, GI10880983, Length=398, Percent_Identity=32.6633165829146, Blast_Score=180, Evalue=2e-45,
Organism=Escherichia coli, GI1787049, Length=374, Percent_Identity=31.5508021390374, Blast_Score=156, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI25147659, Length=390, Percent_Identity=27.4358974358974, Blast_Score=143, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI17562606, Length=366, Percent_Identity=24.0437158469945, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI17136978, Length=379, Percent_Identity=30.3430079155673, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24638841, Length=379, Percent_Identity=30.3430079155673, Blast_Score=129, Evalue=3e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 46651; Mature: 46651

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVEKRIPIQVAEAVERVMEYAKIGEVEEVSITESYGKILGEDVVSDHDVPHFDRSPYDGF
CCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCE
AIRAEDTKEANQENAIEFEVIGEIGAGSVFTEEVGSFQAVRIMTGAAIPADCNAVVMLEL
EEEECCCCCCCCCCCEEEEEEECCCCCCEEHHHHCCEEEEEEEECCCCCCCCCEEEEEEE
TEGFEKNGKTYMKLKRPFHSGDNVSFKGEDIKQNQVLVKKGAVINPGVAALLATFGYSNV
ECCCCCCCCEEEEEECCCCCCCCEEECCCCCCCCEEEEECCCEECCCHHHHHHHHCCCCE
KVVKQPVVGIVTTGSELLEVHESLQPGKIRNSNSYMIAAQIMKAGGKVRYYGQLADELDA
EEEECCCEEEEECCHHHHHHHHCCCCCCEECCCCEEEEEHHHHCCCCEEEEHHHHHHHHH
CFTAVQSAIEEVDILITTGGVSVGDYDYLPAIYERLQANVLFNKIAMRPGSVTTVAEVDG
HHHHHHHHHHHEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCC
KLLFGLSGNPSACYVGFELFVHPVIKTYLYAKEPHVYRADAILQKDFPKPNPFTRFVRAK
EEEEEECCCCCEEEEHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHCCCCCCHHHHHHEEE
VTIVDGALHAMPVGLDKSSAVSSLADANAFIVLPGGTRGFEAGMKVSVLLLEHAEGCDWP
EEEEECCHHHEECCCCCHHHHHHHHCCCEEEEECCCCCCCCCCCEEEEEEEECCCCCCCC
WAKPLRSYK
CCCHHHCCC
>Mature Secondary Structure
MVEKRIPIQVAEAVERVMEYAKIGEVEEVSITESYGKILGEDVVSDHDVPHFDRSPYDGF
CCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCE
AIRAEDTKEANQENAIEFEVIGEIGAGSVFTEEVGSFQAVRIMTGAAIPADCNAVVMLEL
EEEECCCCCCCCCCCEEEEEEECCCCCCEEHHHHCCEEEEEEEECCCCCCCCCEEEEEEE
TEGFEKNGKTYMKLKRPFHSGDNVSFKGEDIKQNQVLVKKGAVINPGVAALLATFGYSNV
ECCCCCCCCEEEEEECCCCCCCCEEECCCCCCCCEEEEECCCEECCCHHHHHHHHCCCCE
KVVKQPVVGIVTTGSELLEVHESLQPGKIRNSNSYMIAAQIMKAGGKVRYYGQLADELDA
EEEECCCEEEEECCHHHHHHHHCCCCCCEECCCCEEEEEHHHHCCCCEEEEHHHHHHHHH
CFTAVQSAIEEVDILITTGGVSVGDYDYLPAIYERLQANVLFNKIAMRPGSVTTVAEVDG
HHHHHHHHHHHEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCC
KLLFGLSGNPSACYVGFELFVHPVIKTYLYAKEPHVYRADAILQKDFPKPNPFTRFVRAK
EEEEEECCCCCEEEEHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHCCCCCCHHHHHHEEE
VTIVDGALHAMPVGLDKSSAVSSLADANAFIVLPGGTRGFEAGMKVSVLLLEHAEGCDWP
EEEEECCHHHEECCCCCHHHHHHHHCCCEEEEECCCCCCCCCCCEEEEEEEECCCCCCCC
WAKPLRSYK
CCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]