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The map label for this gene is pyrC

Identifier: 49478433

GI number: 49478433

Start: 3728990

End: 3730276

Strand: Reverse

Name: pyrC

Synonym: BT9727_3630

Alternate gene names: 49478433

Gene position: 3730276-3728990 (Counterclockwise)

Preceding gene: 49478434

Following gene: 49479098

Centisome position: 71.22

GC content: 40.02

Gene sequence:

>1287_bases
ATGAATTATTTGTTTAAAAATGGTCGTTATATGAATGAAGAAGGAAAAATCGTAGCAACGGATCTTCTCGTACAAGACGG
TAAAATCGCTAAAGTAGCAGAAAATATTACGGCAGATAATGCTGAAGTAATCGATGTGAACGGAAAGTTAATCGCACCTG
GATTAGTAGATGTACACGTACACCTTCGTGAACCAGGTGGTGAACATAAAGAAACAATTGAAACAGGTACATTAGCAGCG
GCAAAAGGTGGATTCACTACAATTTGTGCAATGCCAAATACACGCCCAGTACCAGATTGCAGAGAACATATGGAAGACTT
GCAAAATCGTATTAAAGAAAAAGCACATGTTAACGTACTACCATATGGAGCAATTACAGTACGTCAAGCGGGTTCTGAAA
TGACAGATTTCGAAACATTAAAAGAGCTTGGAGCATTTGCTTTCACTGATGACGGTGTAGGCGTACAAGATGCTAGCATG
ATGTTAGCTGCTATGAAGCGTGCAGCGAAATTAAATATGGCAGTAGTTGCGCACTGTGAAGAGAATACTCTTATTAATAA
AGGTTGTGTACATGAAGGGAAGTTTTCTGAGAAACACGGATTAAACGGTATCCCATCAGTATGTGAATCTGTACATATTG
CAAGGGATATACTGCTTGCTGAAGCAGCAGATTGTCACTATCACGTATGTCACGTAAGTACGAAAGGCTCTGTACGCGTA
ATTCGTGATGCAAAGCGCGCTGGAATTAAAGTAACAGCAGAGGTAACGCCTCATCACTTAGTGTTATGTGAAGATGATAT
CCCATCAGCTGATCCTAATTTTAAAATGAACCCACCGCTTCGTGGAAAAGAAGACCACGCAGCATTAATTGAAGGTTTAT
TAGATGGAACAATCGATATGATCGCAACTGACCATGCACCGCATACAGCAGAAGAGAAAGCGCAAGGAATTGAAAGAGCA
CCATTCGGGATTACTGGTTTTGAAACTGCATTCCCACTTCTATACACAAACCTTGTGAAAAAAGGAATTATTACACTAGA
GCAGTTAATTCAATTCTTAACAGAAAAGCCAGCTGATACATTCGGCTTAGAAGCAGGTCGCCTGAAAGAAGGTAGAACAG
CTGATATTACAATCATTGATTTAGAACAAGAAGAAGAGATTGACCCAACAACATTCTTATCAAAAGGAAAAAATACACCA
TTCGTAGGTTGGAAATGCCAAGGATGGCCGGTAATGACAATCGTTGGTGGTAAGATCGCATGGCAAAAGGAGAGTGCATT
AGTATGA

Upstream 100 bases:

>100_bases
TGTGAGCGTTCACGCATATTTAAACAAATGGAAAATGGAGTTTACGTAAGAATGGCTGTACTAAAACGCGCCTTACCAAA
TGTATTAGGAGGAATGAAAC

Downstream 100 bases:

>100_bases
AAAGACAACTTATCTTAGAAGATGGAACAGTATTAATTGGAACAGGTTTCGGAGGAGAAATCGAAAAGTCAGGTGAGGTT
GTATTTACAACAGGAATGAC

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MNYLFKNGRYMNEEGKIVATDLLVQDGKIAKVAENITADNAEVIDVNGKLIAPGLVDVHVHLREPGGEHKETIETGTLAA
AKGGFTTICAMPNTRPVPDCREHMEDLQNRIKEKAHVNVLPYGAITVRQAGSEMTDFETLKELGAFAFTDDGVGVQDASM
MLAAMKRAAKLNMAVVAHCEENTLINKGCVHEGKFSEKHGLNGIPSVCESVHIARDILLAEAADCHYHVCHVSTKGSVRV
IRDAKRAGIKVTAEVTPHHLVLCEDDIPSADPNFKMNPPLRGKEDHAALIEGLLDGTIDMIATDHAPHTAEEKAQGIERA
PFGITGFETAFPLLYTNLVKKGIITLEQLIQFLTEKPADTFGLEAGRLKEGRTADITIIDLEQEEEIDPTTFLSKGKNTP
FVGWKCQGWPVMTIVGGKIAWQKESALV

Sequences:

>Translated_428_residues
MNYLFKNGRYMNEEGKIVATDLLVQDGKIAKVAENITADNAEVIDVNGKLIAPGLVDVHVHLREPGGEHKETIETGTLAA
AKGGFTTICAMPNTRPVPDCREHMEDLQNRIKEKAHVNVLPYGAITVRQAGSEMTDFETLKELGAFAFTDDGVGVQDASM
MLAAMKRAAKLNMAVVAHCEENTLINKGCVHEGKFSEKHGLNGIPSVCESVHIARDILLAEAADCHYHVCHVSTKGSVRV
IRDAKRAGIKVTAEVTPHHLVLCEDDIPSADPNFKMNPPLRGKEDHAALIEGLLDGTIDMIATDHAPHTAEEKAQGIERA
PFGITGFETAFPLLYTNLVKKGIITLEQLIQFLTEKPADTFGLEAGRLKEGRTADITIIDLEQEEEIDPTTFLSKGKNTP
FVGWKCQGWPVMTIVGGKIAWQKESALV
>Mature_428_residues
MNYLFKNGRYMNEEGKIVATDLLVQDGKIAKVAENITADNAEVIDVNGKLIAPGLVDVHVHLREPGGEHKETIETGTLAA
AKGGFTTICAMPNTRPVPDCREHMEDLQNRIKEKAHVNVLPYGAITVRQAGSEMTDFETLKELGAFAFTDDGVGVQDASM
MLAAMKRAAKLNMAVVAHCEENTLINKGCVHEGKFSEKHGLNGIPSVCESVHIARDILLAEAADCHYHVCHVSTKGSVRV
IRDAKRAGIKVTAEVTPHHLVLCEDDIPSADPNFKMNPPLRGKEDHAALIEGLLDGTIDMIATDHAPHTAEEKAQGIERA
PFGITGFETAFPLLYTNLVKKGIITLEQLIQFLTEKPADTFGLEAGRLKEGRTADITIIDLEQEEEIDPTTFLSKGKNTP
FVGWKCQGWPVMTIVGGKIAWQKESALV

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=389, Percent_Identity=32.6478149100257, Blast_Score=162, Evalue=5e-40,
Organism=Homo sapiens, GI4503375, Length=452, Percent_Identity=25.2212389380531, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI4503051, Length=444, Percent_Identity=24.5495495495495, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI62422571, Length=444, Percent_Identity=24.5495495495495, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI19923821, Length=444, Percent_Identity=25.2252252252252, Blast_Score=94, Evalue=2e-19,
Organism=Escherichia coli, GI1786722, Length=446, Percent_Identity=30.4932735426009, Blast_Score=184, Evalue=8e-48,
Organism=Escherichia coli, GI87082175, Length=435, Percent_Identity=28.735632183908, Blast_Score=139, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI193204318, Length=359, Percent_Identity=32.5905292479109, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI71989490, Length=448, Percent_Identity=29.0178571428571, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17539558, Length=448, Percent_Identity=26.7857142857143, Blast_Score=111, Evalue=8e-25,
Organism=Caenorhabditis elegans, GI86575075, Length=443, Percent_Identity=25.7336343115124, Blast_Score=103, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6322218, Length=436, Percent_Identity=25.4587155963303, Blast_Score=108, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24642586, Length=384, Percent_Identity=32.8125, Blast_Score=162, Evalue=3e-40,
Organism=Drosophila melanogaster, GI18859883, Length=413, Percent_Identity=26.1501210653753, Blast_Score=107, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 46627; Mature: 46627

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: PS00482 DIHYDROOROTASE_1 ; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNYLFKNGRYMNEEGKIVATDLLVQDGKIAKVAENITADNAEVIDVNGKLIAPGLVDVHV
CCCEECCCCEECCCCCEEEEEEEECCCCHHHHHHHCCCCCCEEEEECCEEECCCEEEEEE
HLREPGGEHKETIETGTLAAAKGGFTTICAMPNTRPVPDCREHMEDLQNRIKEKAHVNVL
EEECCCCCHHHHHHHCCEEECCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHEEEEE
PYGAITVRQAGSEMTDFETLKELGAFAFTDDGVGVQDASMMLAAMKRAAKLNMAVVAHCE
CCCEEEEECCCCCCHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHHCCEEEEEECC
ENTLINKGCVHEGKFSEKHGLNGIPSVCESVHIARDILLAEAADCHYHVCHVSTKGSVRV
CCCEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEE
IRDAKRAGIKVTAEVTPHHLVLCEDDIPSADPNFKMNPPLRGKEDHAALIEGLLDGTIDM
EEHHHHCCEEEEEEECCCEEEEECCCCCCCCCCCEECCCCCCCCHHHHHHHHHHCCCEEE
IATDHAPHTAEEKAQGIERAPFGITGFETAFPLLYTNLVKKGIITLEQLIQFLTEKPADT
EEECCCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
FGLEAGRLKEGRTADITIIDLEQEEEIDPTTFLSKGKNTPFVGWKCQGWPVMTIVGGKIA
HCCCCCCCCCCCEEEEEEEECCCCCCCCHHHHHHCCCCCCEEEEEECCCEEEEEECCEEE
WQKESALV
ECCCCCCC
>Mature Secondary Structure
MNYLFKNGRYMNEEGKIVATDLLVQDGKIAKVAENITADNAEVIDVNGKLIAPGLVDVHV
CCCEECCCCEECCCCCEEEEEEEECCCCHHHHHHHCCCCCCEEEEECCEEECCCEEEEEE
HLREPGGEHKETIETGTLAAAKGGFTTICAMPNTRPVPDCREHMEDLQNRIKEKAHVNVL
EEECCCCCHHHHHHHCCEEECCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHEEEEE
PYGAITVRQAGSEMTDFETLKELGAFAFTDDGVGVQDASMMLAAMKRAAKLNMAVVAHCE
CCCEEEEECCCCCCHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHHCCEEEEEECC
ENTLINKGCVHEGKFSEKHGLNGIPSVCESVHIARDILLAEAADCHYHVCHVSTKGSVRV
CCCEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEE
IRDAKRAGIKVTAEVTPHHLVLCEDDIPSADPNFKMNPPLRGKEDHAALIEGLLDGTIDM
EEHHHHCCEEEEEEECCCEEEEECCCCCCCCCCCEECCCCCCCCHHHHHHHHHHCCCEEE
IATDHAPHTAEEKAQGIERAPFGITGFETAFPLLYTNLVKKGIITLEQLIQFLTEKPADT
EEECCCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
FGLEAGRLKEGRTADITIIDLEQEEEIDPTTFLSKGKNTPFVGWKCQGWPVMTIVGGKIA
HCCCCCCCCCCCEEEEEEEECCCCCCCCHHHHHHCCCCCCEEEEEECCCEEEEEECCEEE
WQKESALV
ECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA