Click here to switch to the map view.

The map label for this gene is csgA [H]

Identifier: 49478220

GI number: 49478220

Start: 3266355

End: 3267059

Strand: Reverse

Name: csgA [H]

Synonym: BT9727_3196

Alternate gene names: 49478220

Gene position: 3267059-3266355 (Counterclockwise)

Preceding gene: 49478221

Following gene: 49478219

Centisome position: 62.38

GC content: 36.17

Gene sequence:

>705_bases
ATGAGAGTTCTAATTACAGGTGGAAATCGCGGATTAGGGTTGCAGTTAGTAAAAGTATTTCATGAAAATGGGCATATTAT
TTATCCGTTAGTTAGAACTGAGGTTGCGGTAACGCAATTGAAGCAAATGTTTAGTTGTAGATGTTTTCCTATATTAGCAG
ACTTAGCAGCTGATGAGAGTACAGAGCAAATTAAGAAACAGCTTGAGGAATATACAGAGTATATTGATCTAGTTATAAAT
AACGCTGGAATTACTGGAAAGGAGACTGAGGTTTTACATACGAATTCAGAAGAGTTAACGGACTTATTTAATATTCATTG
CTTAGGTGTAATTCGAGCTGTAAAAGGTACATATGTGGCTTTAGCTAAATCGGATCATCCGAGAATAATAAATGTGTCCT
CTCGGTTAGGTTCATTGCATAAAATGGCCAACAAAGAGTTTCCGCAAGGCCATTTCTCATATTCATATCGAATTGCTAAA
GCTGCACAAAATATGCTAACACTCTGCTTACAACAAGAGTTTGAGAATAAAGGAATAAGTGTAACTGCCATTCATCCTGG
AAAATTAAAGACTGAAATTGGTGCTTTTGATGCGAATATGACCCCGGCTGAAGGAGCAAAAAATATATATGATTGGGTAA
TAGATTCAAATGAGGATGTTTCAGGAAAGTTTATTGAGCCAGGTGTAGGTGAAATAAAGTGGTGA

Upstream 100 bases:

>100_bases
GAGCAGGTTTTTCTTTTGAATGCAAGAGAGAGGCGTTTTCTTTGGAGAATGGTGAGTGGATGGATTTTCTTATTTATTTT
AAAAATAAGGAGATGGATAT

Downstream 100 bases:

>100_bases
TATACGATCTTGCAATCATTCAGAATTTGTTTGGCCCTTCTAAAAAAGTATTAAATGGCTTACCCAATGCAGTGACCATT
GAAGAAATAGAAGAAGACGT

Product: short chain dehydrogenase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: C signal [H]

Number of amino acids: Translated: 234; Mature: 234

Protein sequence:

>234_residues
MRVLITGGNRGLGLQLVKVFHENGHIIYPLVRTEVAVTQLKQMFSCRCFPILADLAADESTEQIKKQLEEYTEYIDLVIN
NAGITGKETEVLHTNSEELTDLFNIHCLGVIRAVKGTYVALAKSDHPRIINVSSRLGSLHKMANKEFPQGHFSYSYRIAK
AAQNMLTLCLQQEFENKGISVTAIHPGKLKTEIGAFDANMTPAEGAKNIYDWVIDSNEDVSGKFIEPGVGEIKW

Sequences:

>Translated_234_residues
MRVLITGGNRGLGLQLVKVFHENGHIIYPLVRTEVAVTQLKQMFSCRCFPILADLAADESTEQIKKQLEEYTEYIDLVIN
NAGITGKETEVLHTNSEELTDLFNIHCLGVIRAVKGTYVALAKSDHPRIINVSSRLGSLHKMANKEFPQGHFSYSYRIAK
AAQNMLTLCLQQEFENKGISVTAIHPGKLKTEIGAFDANMTPAEGAKNIYDWVIDSNEDVSGKFIEPGVGEIKW
>Mature_234_residues
MRVLITGGNRGLGLQLVKVFHENGHIIYPLVRTEVAVTQLKQMFSCRCFPILADLAADESTEQIKKQLEEYTEYIDLVIN
NAGITGKETEVLHTNSEELTDLFNIHCLGVIRAVKGTYVALAKSDHPRIINVSSRLGSLHKMANKEFPQGHFSYSYRIAK
AAQNMLTLCLQQEFENKGISVTAIHPGKLKTEIGAFDANMTPAEGAKNIYDWVIDSNEDVSGKFIEPGVGEIKW

Specific function: Cell-cell signaling protein required for fruiting body morphogenesis. Necessary for cellular aggregation, for spore differentiation, and for gene expression that is initiated after 6 hour of starvation [H]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: To yeast YKL071W [H]

Homologues:

Organism=Escherichia coli, GI1787335, Length=190, Percent_Identity=23.1578947368421, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17558006, Length=227, Percent_Identity=29.5154185022026, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17558990, Length=216, Percent_Identity=27.3148148148148, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI115534660, Length=198, Percent_Identity=28.7878787878788, Blast_Score=67, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17558994, Length=217, Percent_Identity=27.1889400921659, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17542178, Length=230, Percent_Identity=26.5217391304348, Blast_Score=64, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6322779, Length=243, Percent_Identity=24.2798353909465, Blast_Score=63, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24640547, Length=250, Percent_Identity=24.8, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 26050; Mature: 26050

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVLITGGNRGLGLQLVKVFHENGHIIYPLVRTEVAVTQLKQMFSCRCFPILADLAADES
CEEEEECCCCCCHHHHHEEHHCCCCEEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCC
TEQIKKQLEEYTEYIDLVINNAGITGKETEVLHTNSEELTDLFNIHCLGVIRAVKGTYVA
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCEEE
LAKSDHPRIINVSSRLGSLHKMANKEFPQGHFSYSYRIAKAAQNMLTLCLQQEFENKGIS
EEECCCCCEEEHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCE
VTAIHPGKLKTEIGAFDANMTPAEGAKNIYDWVIDSNEDVSGKFIEPGVGEIKW
EEEECCCCCCHHHCCCCCCCCCCCCCCHHHHHEECCCCCCCCEEECCCCCCCCC
>Mature Secondary Structure
MRVLITGGNRGLGLQLVKVFHENGHIIYPLVRTEVAVTQLKQMFSCRCFPILADLAADES
CEEEEECCCCCCHHHHHEEHHCCCCEEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCC
TEQIKKQLEEYTEYIDLVINNAGITGKETEVLHTNSEELTDLFNIHCLGVIRAVKGTYVA
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCEEE
LAKSDHPRIINVSSRLGSLHKMANKEFPQGHFSYSYRIAKAAQNMLTLCLQQEFENKGIS
EEECCCCCEEEHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCE
VTAIHPGKLKTEIGAFDANMTPAEGAKNIYDWVIDSNEDVSGKFIEPGVGEIKW
EEEECCCCCCHHHCCCCCCCCCCCCCCHHHHHEECCCCCCCCEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2152896; 2107980; 2118510; 1372277 [H]