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The map label for this gene is gcvT [H]

Identifier: 49475981

GI number: 49475981

Start: 1434620

End: 1435738

Strand: Reverse

Name: gcvT [H]

Synonym: BH12840

Alternate gene names: 49475981

Gene position: 1435738-1434620 (Counterclockwise)

Preceding gene: 49475986

Following gene: 49475980

Centisome position: 74.35

GC content: 44.59

Gene sequence:

>1119_bases
ATGGGTACATCACAAGAATTTGAAACATCTTCTTTAAAAACACTTCCTTTATATGAATTGCATGAAAAAGCCGGAGCAAA
ATTTGGTGCTTTTGCCGGTTGGCGAATGCCTTTGACTTATCCTCTTGGGGTTTTGAAAGAGCATCTTCATACGCGTGCGC
ATGCAGGCCTTTTTGATATTTCTCATATGAAATTGATTGCTGTTGAGGGGCCGAAAGCAGTGGAATTTTTATCTTATGCT
CTTCCTGTTGATGCGGCACTGTTAAAGATTGGTCAATCGCGCTATAGCTATTTGCTTAATGAGCGGGCTGGCATTCTTGA
TGATCTTATCCTTACTCGTTTGGCAGAGTGCCGCTTTATGCTGGTCGCTAATGCTGGTAATGCACAAGCCGACTTTGCTG
AACTTGAAAAACGTGCTTTTGGCTTTGAATGTCAAGTGATTGCTCTTGAAAGGGTCTTACTTGCTCTTCAAGGGCCACAA
GCGGCTGCTGTTCTAGCTGATGCTGGTTTGCCGGGAAATGAACTGTTGTTTATGCAAGGATTTGAACCACAACAAGATTG
GTTTATCACCCGTTCTGGTTATACAGGAGAAGATGGTTTTGAAATTGCTCTTCCTATAGGTTGTGCACGCGCATTGGCTG
AAAAGCTGCTCGGCGATTCTCGTGTTGAGTGGGTTGGTCTTGCAGCGCGTGACAGTCTTCGATTGGAGGCAGGGTTATGC
TTGCATGGCAATGATATTACCCCTGATACTACGCCCATTGATGCTGCACTGACATGGGCTGTTCCCAAAAATGTTCGAGA
AAAAGCGCAATTTTATGGAGCAAAGGCTTTTCTGGAATCTCTTCAGAAAGGTCCCTCTCGTTGTCGTGTTGGTTTAAAAC
CACAAACACGCCAACCTATTCGTGCTGGTGCTGTGCTTTTCGATAATGAAGGCAATCGGATTGGGGTGGTAACGTCAGGT
GGTTTTGGCCCTTCTTTTGATGGTCCTGTCGCGATGGGGTATGTTCCTGTTGCTTGGAAAGTGGAAGGAACAGAAGTATT
TACAGAGCTGCGTGGCAAAAAGATTGCACTGTCTGTTCATTCACTCCCTTTTGTTGAACAACGTTATTTTAAAGGATAA

Upstream 100 bases:

>100_bases
GGTGTAAGCGAAAACTTTTTTCGCGAGTCTCTCAGGTTTGTAACAGAGGGGTGCAGAGACGAACACATTGTGTGAGTGTT
GGCGCGACTTTGGAGATATT

Downstream 100 bases:

>100_bases
TTTTTTTATGTCTAAAACTTATTTTACACAAGATCATGAATGGCTTAGCGTTGAAGGACAAGTGGTTACTGTTGGGATCA
CAGATTATGCTCAAGAGCAA

Product: glycine cleavage system aminomethyltransferase T

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 372; Mature: 371

Protein sequence:

>372_residues
MGTSQEFETSSLKTLPLYELHEKAGAKFGAFAGWRMPLTYPLGVLKEHLHTRAHAGLFDISHMKLIAVEGPKAVEFLSYA
LPVDAALLKIGQSRYSYLLNERAGILDDLILTRLAECRFMLVANAGNAQADFAELEKRAFGFECQVIALERVLLALQGPQ
AAAVLADAGLPGNELLFMQGFEPQQDWFITRSGYTGEDGFEIALPIGCARALAEKLLGDSRVEWVGLAARDSLRLEAGLC
LHGNDITPDTTPIDAALTWAVPKNVREKAQFYGAKAFLESLQKGPSRCRVGLKPQTRQPIRAGAVLFDNEGNRIGVVTSG
GFGPSFDGPVAMGYVPVAWKVEGTEVFTELRGKKIALSVHSLPFVEQRYFKG

Sequences:

>Translated_372_residues
MGTSQEFETSSLKTLPLYELHEKAGAKFGAFAGWRMPLTYPLGVLKEHLHTRAHAGLFDISHMKLIAVEGPKAVEFLSYA
LPVDAALLKIGQSRYSYLLNERAGILDDLILTRLAECRFMLVANAGNAQADFAELEKRAFGFECQVIALERVLLALQGPQ
AAAVLADAGLPGNELLFMQGFEPQQDWFITRSGYTGEDGFEIALPIGCARALAEKLLGDSRVEWVGLAARDSLRLEAGLC
LHGNDITPDTTPIDAALTWAVPKNVREKAQFYGAKAFLESLQKGPSRCRVGLKPQTRQPIRAGAVLFDNEGNRIGVVTSG
GFGPSFDGPVAMGYVPVAWKVEGTEVFTELRGKKIALSVHSLPFVEQRYFKG
>Mature_371_residues
GTSQEFETSSLKTLPLYELHEKAGAKFGAFAGWRMPLTYPLGVLKEHLHTRAHAGLFDISHMKLIAVEGPKAVEFLSYAL
PVDAALLKIGQSRYSYLLNERAGILDDLILTRLAECRFMLVANAGNAQADFAELEKRAFGFECQVIALERVLLALQGPQA
AAVLADAGLPGNELLFMQGFEPQQDWFITRSGYTGEDGFEIALPIGCARALAEKLLGDSRVEWVGLAARDSLRLEAGLCL
HGNDITPDTTPIDAALTWAVPKNVREKAQFYGAKAFLESLQKGPSRCRVGLKPQTRQPIRAGAVLFDNEGNRIGVVTSGG
FGPSFDGPVAMGYVPVAWKVEGTEVFTELRGKKIALSVHSLPFVEQRYFKG

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI44662838, Length=370, Percent_Identity=41.0810810810811, Blast_Score=255, Evalue=5e-68,
Organism=Homo sapiens, GI257796258, Length=350, Percent_Identity=41.7142857142857, Blast_Score=242, Evalue=3e-64,
Organism=Homo sapiens, GI257796254, Length=365, Percent_Identity=37.8082191780822, Blast_Score=215, Evalue=6e-56,
Organism=Homo sapiens, GI257796256, Length=312, Percent_Identity=40.3846153846154, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI24797151, Length=338, Percent_Identity=25.4437869822485, Blast_Score=81, Evalue=1e-15,
Organism=Escherichia coli, GI1789272, Length=362, Percent_Identity=33.4254143646409, Blast_Score=168, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI17560118, Length=381, Percent_Identity=37.2703412073491, Blast_Score=201, Evalue=5e-52,
Organism=Caenorhabditis elegans, GI71994052, Length=357, Percent_Identity=22.4089635854342, Blast_Score=65, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI71994045, Length=357, Percent_Identity=22.4089635854342, Blast_Score=65, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6320222, Length=388, Percent_Identity=37.1134020618557, Blast_Score=211, Evalue=1e-55,
Organism=Drosophila melanogaster, GI20129441, Length=374, Percent_Identity=37.1657754010695, Blast_Score=218, Evalue=4e-57,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 40555; Mature: 40424

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGTSQEFETSSLKTLPLYELHEKAGAKFGAFAGWRMPLTYPLGVLKEHLHTRAHAGLFDI
CCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCEEEE
SHMKLIAVEGPKAVEFLSYALPVDAALLKIGQSRYSYLLNERAGILDDLILTRLAECRFM
CCEEEEEECCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCEEE
LVANAGNAQADFAELEKRAFGFECQVIALERVLLALQGPQAAAVLADAGLPGNELLFMQG
EEECCCCCCHHHHHHHHHHCCCEEEHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEEEEC
FEPQQDWFITRSGYTGEDGFEIALPIGCARALAEKLLGDSRVEWVGLAARDSLRLEAGLC
CCCCCCEEEEECCCCCCCCCEEEECHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEEEEE
LHGNDITPDTTPIDAALTWAVPKNVREKAQFYGAKAFLESLQKGPSRCRVGLKPQTRQPI
EECCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCHHHCEECCCCCCCCCC
RAGAVLFDNEGNRIGVVTSGGFGPSFDGPVAMGYVPVAWKVEGTEVFTELRGKKIALSVH
CCCEEEECCCCCEEEEEEECCCCCCCCCCEEEEEEEEEEEECHHHHHHHHCCCEEEEEEC
SLPFVEQRYFKG
CCCHHHHHHCCC
>Mature Secondary Structure 
GTSQEFETSSLKTLPLYELHEKAGAKFGAFAGWRMPLTYPLGVLKEHLHTRAHAGLFDI
CCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCEEEE
SHMKLIAVEGPKAVEFLSYALPVDAALLKIGQSRYSYLLNERAGILDDLILTRLAECRFM
CCEEEEEECCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCEEE
LVANAGNAQADFAELEKRAFGFECQVIALERVLLALQGPQAAAVLADAGLPGNELLFMQG
EEECCCCCCHHHHHHHHHHCCCEEEHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEEEEC
FEPQQDWFITRSGYTGEDGFEIALPIGCARALAEKLLGDSRVEWVGLAARDSLRLEAGLC
CCCCCCEEEEECCCCCCCCCEEEECHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEEEEE
LHGNDITPDTTPIDAALTWAVPKNVREKAQFYGAKAFLESLQKGPSRCRVGLKPQTRQPI
EECCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCHHHCEECCCCCCCCCC
RAGAVLFDNEGNRIGVVTSGGFGPSFDGPVAMGYVPVAWKVEGTEVFTELRGKKIALSVH
CCCEEEECCCCCEEEEEEECCCCCCCCCCEEEEEEEEEEEECHHHHHHHHCCCEEEEEEC
SLPFVEQRYFKG
CCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA