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The map label for this gene is ldc [H]

Identifier: 49475973

GI number: 49475973

Start: 1420457

End: 1421590

Strand: Reverse

Name: ldc [H]

Synonym: BH12730

Alternate gene names: 49475973

Gene position: 1421590-1420457 (Counterclockwise)

Preceding gene: 49475974

Following gene: 49475972

Centisome position: 73.62

GC content: 42.5

Gene sequence:

>1134_bases
ATGGCGACGCAACGTATTCGCGATTTTCTTGCAAAACATCGTTCTGAAGGTCCCTGCTTAATTGTTGACCTTGATATTAT
TCGTGAAAATTATTTAAACTTTGAAAAAGCTCTTCCGCAGTCCCGGATCTTTTACGCGATAAAGGCGAATCCAGCTCCTG
AAATTTTAAATTTGCTTGCCTCTTTAGGGTCTTCTTTTGATGCTGCTTCTGTTGCGGAAATTGAAATGGCTTTAAAGGCA
GGAGCAACCTCTGATCGTATTTCTTTTGGTAATACTATTAAAAAAGAGCGTGATATTGCACAGGCGTACGCATTGGGTAT
TTCGCTTTATGCGGTTGATTGTGTTGAAGAAGTGGAAAAGATTGCTCGAGCTGCTCCAGGAGTTCGCGTGTTTTGTCGGG
TTCTTACGGATGGAAAGGGTGCAGAATGGCCATTGTCACGTAAGTTTGGTTGTGTTCCTGCTATGGCGGTTGATGTGTTG
CGTCGCGCACATCAATTAGGTTTGCAAGCATATGGTGTTTCCTTTCATGTTGGTTCTCAGCAGACAGATCTTAGTGCATG
GGATCGCGCTTTGTCAGATGCGGCTACGGTTTTTCGGCACTTGGAGCATGAAGGAATTTCGTTGAAATTAGTGAATATGG
GGGGTGGTTTTCCAACCCGTTATTTGAAAGATGTTCCTACAACACAAGCTTATGGCACAGTTGTCTTTGATTCATTAAAA
AAATATTTTGGTAATCGTATTCCTGAAACGATCATTGAGCCAGGGCGCGGGATGGTTGGCAATGCTGGTGTTATTCGTAC
AGAGGTTGTTCTTATATCCAAAAAAGCAGACAATGATAATATCCGATGGGTTTATCTGGATGTTGGCAAATTTAACGGTC
TTACCGAGACCATGGATGAAGCTATTCGTTATCCCATTGAGACCCCTCATGATGATAAGGCAATGGAGCCTTGTATTTTA
GCTGGGCCAACTTGTGATTCGGCAGATGTTCTCTATGAAAAAACACCTTATCTGTTACCTTTATCCCTCACAGTAGGGGA
TGAGTTATTAATTCATGGGACTGGTGCTTATACGGCGACTTACGCGTCTGTTGCATTTAATGGTTTTGAGCCTTTACCAT
CCTATGTGATTTGA

Upstream 100 bases:

>100_bases
CAGGGTGTAGAGCGTTTTTGTGTGTGTTTTGTCCTTTGGCTATAAGCAGCTTTGTGCTGTCCAGTCGTAGGGTGGGTTTA
TCCCCTGGGAGAATTGACAG

Downstream 100 bases:

>100_bases
ATTTTTCCTTTATAAGATGGTATAAAGAGCTACAAGTGGGGGTGGTGACAAACATGAATATGATTTATTTTCAAACAAAA
GATGATGCATTTTTTACACT

Product: ornithine decarboxylase

Products: NA

Alternate protein names: LDC [H]

Number of amino acids: Translated: 377; Mature: 376

Protein sequence:

>377_residues
MATQRIRDFLAKHRSEGPCLIVDLDIIRENYLNFEKALPQSRIFYAIKANPAPEILNLLASLGSSFDAASVAEIEMALKA
GATSDRISFGNTIKKERDIAQAYALGISLYAVDCVEEVEKIARAAPGVRVFCRVLTDGKGAEWPLSRKFGCVPAMAVDVL
RRAHQLGLQAYGVSFHVGSQQTDLSAWDRALSDAATVFRHLEHEGISLKLVNMGGGFPTRYLKDVPTTQAYGTVVFDSLK
KYFGNRIPETIIEPGRGMVGNAGVIRTEVVLISKKADNDNIRWVYLDVGKFNGLTETMDEAIRYPIETPHDDKAMEPCIL
AGPTCDSADVLYEKTPYLLPLSLTVGDELLIHGTGAYTATYASVAFNGFEPLPSYVI

Sequences:

>Translated_377_residues
MATQRIRDFLAKHRSEGPCLIVDLDIIRENYLNFEKALPQSRIFYAIKANPAPEILNLLASLGSSFDAASVAEIEMALKA
GATSDRISFGNTIKKERDIAQAYALGISLYAVDCVEEVEKIARAAPGVRVFCRVLTDGKGAEWPLSRKFGCVPAMAVDVL
RRAHQLGLQAYGVSFHVGSQQTDLSAWDRALSDAATVFRHLEHEGISLKLVNMGGGFPTRYLKDVPTTQAYGTVVFDSLK
KYFGNRIPETIIEPGRGMVGNAGVIRTEVVLISKKADNDNIRWVYLDVGKFNGLTETMDEAIRYPIETPHDDKAMEPCIL
AGPTCDSADVLYEKTPYLLPLSLTVGDELLIHGTGAYTATYASVAFNGFEPLPSYVI
>Mature_376_residues
ATQRIRDFLAKHRSEGPCLIVDLDIIRENYLNFEKALPQSRIFYAIKANPAPEILNLLASLGSSFDAASVAEIEMALKAG
ATSDRISFGNTIKKERDIAQAYALGISLYAVDCVEEVEKIARAAPGVRVFCRVLTDGKGAEWPLSRKFGCVPAMAVDVLR
RAHQLGLQAYGVSFHVGSQQTDLSAWDRALSDAATVFRHLEHEGISLKLVNMGGGFPTRYLKDVPTTQAYGTVVFDSLKK
YFGNRIPETIIEPGRGMVGNAGVIRTEVVLISKKADNDNIRWVYLDVGKFNGLTETMDEAIRYPIETPHDDKAMEPCILA
GPTCDSADVLYEKTPYLLPLSLTVGDELLIHGTGAYTATYASVAFNGFEPLPSYVI

Specific function: Decarboxylates both L-lysine and L-ornithine with similar catalytic efficiency [H]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=376, Percent_Identity=34.0425531914894, Blast_Score=164, Evalue=1e-40,
Organism=Homo sapiens, GI16506287, Length=359, Percent_Identity=29.2479108635098, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI22538418, Length=384, Percent_Identity=26.3020833333333, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI21361583, Length=384, Percent_Identity=26.3020833333333, Blast_Score=119, Evalue=5e-27,
Organism=Escherichia coli, GI1789203, Length=386, Percent_Identity=26.6839378238342, Blast_Score=91, Evalue=9e-20,
Organism=Caenorhabditis elegans, GI17562780, Length=393, Percent_Identity=32.0610687022901, Blast_Score=164, Evalue=5e-41,
Organism=Caenorhabditis elegans, GI25141365, Length=375, Percent_Identity=24, Blast_Score=68, Evalue=9e-12,
Organism=Saccharomyces cerevisiae, GI6322664, Length=394, Percent_Identity=31.9796954314721, Blast_Score=160, Evalue=3e-40,
Organism=Drosophila melanogaster, GI24586472, Length=359, Percent_Identity=31.7548746518106, Blast_Score=144, Evalue=8e-35,
Organism=Drosophila melanogaster, GI24586474, Length=358, Percent_Identity=30.4469273743017, Blast_Score=121, Evalue=8e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183
- InterPro:   IPR002433 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.17; =4.1.1.18 [H]

Molecular weight: Translated: 41301; Mature: 41170

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATQRIRDFLAKHRSEGPCLIVDLDIIRENYLNFEKALPQSRIFYAIKANPAPEILNLLA
CCHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHH
SLGSSFDAASVAEIEMALKAGATSDRISFGNTIKKERDIAQAYALGISLYAVDCVEEVEK
HHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IARAAPGVRVFCRVLTDGKGAEWPLSRKFGCVPAMAVDVLRRAHQLGLQAYGVSFHVGSQ
HHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEECEEEEECCC
QTDLSAWDRALSDAATVFRHLEHEGISLKLVNMGGGFPTRYLKDVPTTQAYGTVVFDSLK
CCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHCCCCCHHHHHHHHHHHH
KYFGNRIPETIIEPGRGMVGNAGVIRTEVVLISKKADNDNIRWVYLDVGKFNGLTETMDE
HHHCCCCCHHHHCCCCCCCCCCCEEEEEEEEEEECCCCCCEEEEEEECCCCCCHHHHHHH
AIRYPIETPHDDKAMEPCILAGPTCDSADVLYEKTPYLLPLSLTVGDELLIHGTGAYTAT
HHCCCCCCCCCCCCCCCEEEECCCCCCCCHHCCCCCCEEEEEEECCCEEEEEECCCHHHH
YASVAFNGFEPLPSYVI
HHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
ATQRIRDFLAKHRSEGPCLIVDLDIIRENYLNFEKALPQSRIFYAIKANPAPEILNLLA
CHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHH
SLGSSFDAASVAEIEMALKAGATSDRISFGNTIKKERDIAQAYALGISLYAVDCVEEVEK
HHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IARAAPGVRVFCRVLTDGKGAEWPLSRKFGCVPAMAVDVLRRAHQLGLQAYGVSFHVGSQ
HHHHCCCHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEECEEEEECCC
QTDLSAWDRALSDAATVFRHLEHEGISLKLVNMGGGFPTRYLKDVPTTQAYGTVVFDSLK
CCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHCCCCCHHHHHHHHHHHH
KYFGNRIPETIIEPGRGMVGNAGVIRTEVVLISKKADNDNIRWVYLDVGKFNGLTETMDE
HHHCCCCCHHHHCCCCCCCCCCCEEEEEEEEEEECCCCCCEEEEEEECCCCCCHHHHHHH
AIRYPIETPHDDKAMEPCILAGPTCDSADVLYEKTPYLLPLSLTVGDELLIHGTGAYTAT
HHCCCCCCCCCCCCCCCEEEECCCCCCCCHHCCCCCCEEEEEEECCCEEEEEECCCHHHH
YASVAFNGFEPLPSYVI
HHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11073919 [H]