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The map label for this gene is ydhC [H]

Identifier: 49475966

GI number: 49475966

Start: 1399045

End: 1400241

Strand: Reverse

Name: ydhC [H]

Synonym: BH12560

Alternate gene names: 49475966

Gene position: 1400241-1399045 (Counterclockwise)

Preceding gene: 49475972

Following gene: 49475965

Centisome position: 72.51

GC content: 37.68

Gene sequence:

>1197_bases
ATGCAACATAAATATACATTACCATTCATTATACTTATTGTTTTTTTATCGACAGGAGGTCTGATTTCTACAGATATTTT
TCTGCCAGCACTTGGAGAAATGCGCCAATACTATCAAGTTACTGAATCTCAGATTCAAAGTGCGGTGGCAGTTTTTCTAT
TTGCATTGGCTATCGGACAGCTAATTTATGGGCCACTCAGTGATAATTTTGGGCGTAAAAAAACACTGCTCTTTGGCTTA
TTTTTATGGCTATTTACCACGTTAAGTGTGATTTATACAGTTCATATTCAAGCTTTTCTTGCATTACGTTTCTTACAAGG
TCTTGGAGCTTGTGCGGGAATTGTTTTAAGTCGTGCTATTATCAATGATTTGTTAGATAAAAAAGCAGCAGGAAAACTTT
ATTTGATTGTTTTTCCCTTTATTGGAATGTCACCAGCGTTTGCTCCTTTAGTTGGAGGCATGCTGTTACAAGCTTTCAGT
TGGTATGCTACTTTTATTTTTTTAAGTCTTTTTATATTCTTAACTATTTTGCTCTGTTGTTTTGTCTTAACGGAAACATT
GCCTCTTCAAAAGCGTCAGCATTTTTCTTTTGTGGGATTTATGAAGGCGTGTTTGGGAGTTCTCAGAAATAAACAATTTA
TTTTTTATGCACTTATTCCCTGCTTTTCTTACGCCGCCTATTTTGCGTATATTGTAGAATCGCCTTTTTTACTTACAATC
TTAGGTTTGCCACCAATCTATATTGGCTATAGCTACATTGGTGTTTCGTTACCCTATATTTTGGGAAATCTGATGGCACG
ATGGCTTTTTAAACGAGAATCTATGGAAAAAACTGTCTGGCGCGGGTATATTATTTTTGTGATAGGAGGGGTATTATTTG
CCTTGCAAATGTATGTTAGTCCATGGCCACTTGTAACGAGTTTTATAGCTATCGCTGTTCTTACTTTTGGTAATGGTTTT
TTATTGCCATTAGGGACAGCCTTGGCTATTTCCTCACATCCGCAAGCTGCTGGGGCAGCCTCTGGTGTTATGGGGGCCTT
ACAATTAGGCAGTGCTGCGTTAAGTGCTTCCGTTATTGGAAAGACGTCTGGGCACAATCCAAAGACTATGGCAGTTTTAT
TGGCTGTGTGTTGTTTGCTCGGATTTATGATTTATGTCCGCAAAGCATATGATTTTATGCGTGTGGAAATGGATTGA

Upstream 100 bases:

>100_bases
CTTAAAAAGTAAAAGTAAAAATTATATATTTATTATAAATAAAAAATAATTATTCAAATAAATAACATTTATTTTTAAAT
TATAAAGTGTGCCTTTGTTC

Downstream 100 bases:

>100_bases
ATGATAATAAAGAGAGCATCATGCTTTTGATGCTTTTTGTATGAATGAGACGTATCGGGTAGGTTGGAGTGAATTTTAAT
GACATGATTTCATCAAACAT

Product: transport protein

Products: Proton [Cytoplasm]; drug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MQHKYTLPFIILIVFLSTGGLISTDIFLPALGEMRQYYQVTESQIQSAVAVFLFALAIGQLIYGPLSDNFGRKKTLLFGL
FLWLFTTLSVIYTVHIQAFLALRFLQGLGACAGIVLSRAIINDLLDKKAAGKLYLIVFPFIGMSPAFAPLVGGMLLQAFS
WYATFIFLSLFIFLTILLCCFVLTETLPLQKRQHFSFVGFMKACLGVLRNKQFIFYALIPCFSYAAYFAYIVESPFLLTI
LGLPPIYIGYSYIGVSLPYILGNLMARWLFKRESMEKTVWRGYIIFVIGGVLFALQMYVSPWPLVTSFIAIAVLTFGNGF
LLPLGTALAISSHPQAAGAASGVMGALQLGSAALSASVIGKTSGHNPKTMAVLLAVCCLLGFMIYVRKAYDFMRVEMD

Sequences:

>Translated_398_residues
MQHKYTLPFIILIVFLSTGGLISTDIFLPALGEMRQYYQVTESQIQSAVAVFLFALAIGQLIYGPLSDNFGRKKTLLFGL
FLWLFTTLSVIYTVHIQAFLALRFLQGLGACAGIVLSRAIINDLLDKKAAGKLYLIVFPFIGMSPAFAPLVGGMLLQAFS
WYATFIFLSLFIFLTILLCCFVLTETLPLQKRQHFSFVGFMKACLGVLRNKQFIFYALIPCFSYAAYFAYIVESPFLLTI
LGLPPIYIGYSYIGVSLPYILGNLMARWLFKRESMEKTVWRGYIIFVIGGVLFALQMYVSPWPLVTSFIAIAVLTFGNGF
LLPLGTALAISSHPQAAGAASGVMGALQLGSAALSASVIGKTSGHNPKTMAVLLAVCCLLGFMIYVRKAYDFMRVEMD
>Mature_398_residues
MQHKYTLPFIILIVFLSTGGLISTDIFLPALGEMRQYYQVTESQIQSAVAVFLFALAIGQLIYGPLSDNFGRKKTLLFGL
FLWLFTTLSVIYTVHIQAFLALRFLQGLGACAGIVLSRAIINDLLDKKAAGKLYLIVFPFIGMSPAFAPLVGGMLLQAFS
WYATFIFLSLFIFLTILLCCFVLTETLPLQKRQHFSFVGFMKACLGVLRNKQFIFYALIPCFSYAAYFAYIVESPFLLTI
LGLPPIYIGYSYIGVSLPYILGNLMARWLFKRESMEKTVWRGYIIFVIGGVLFALQMYVSPWPLVTSFIAIAVLTFGNGF
LLPLGTALAISSHPQAAGAASGVMGALQLGSAALSASVIGKTSGHNPKTMAVLLAVCCLLGFMIYVRKAYDFMRVEMD

Specific function: Unknown

COG id: COG0477

COG function: function code GEPR; Permeases of the major facilitator superfamily

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Bcr/CmlA family [H]

Homologues:

Organism=Escherichia coli, GI48994889, Length=389, Percent_Identity=31.8766066838046, Blast_Score=166, Evalue=3e-42,
Organism=Escherichia coli, GI1788509, Length=364, Percent_Identity=25.5494505494505, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI87082312, Length=348, Percent_Identity=26.7241379310345, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1790794, Length=325, Percent_Identity=22.7692307692308, Blast_Score=85, Evalue=8e-18,
Organism=Escherichia coli, GI1790146, Length=344, Percent_Identity=25.8720930232558, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI1787065, Length=330, Percent_Identity=23.030303030303, Blast_Score=75, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6319657, Length=170, Percent_Identity=31.1764705882353, Blast_Score=71, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6324264, Length=161, Percent_Identity=25.4658385093168, Blast_Score=68, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004812
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 43948; Mature: 43948

Theoretical pI: Translated: 9.53; Mature: 9.53

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECC
>Mature Secondary Structure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CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; drug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + drug [Cytoplasm] = Proton [Cytoplasm] + drug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9097039; 9278503 [H]