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The map label for this gene is ilvA [H]

Identifier: 49475814

GI number: 49475814

Start: 1178217

End: 1179482

Strand: Reverse

Name: ilvA [H]

Synonym: BH10760

Alternate gene names: 49475814

Gene position: 1179482-1178217 (Counterclockwise)

Preceding gene: 49475815

Following gene: 49475813

Centisome position: 61.08

GC content: 38.39

Gene sequence:

>1266_bases
ATGAGTAAATTTATTCAAGATGTAAACAAGGCTATGGTGGCTTTGCATAATGTATTTGCTGAAACACCTCTTCAAAGAAA
TGATTTTCTTAGTCAAAAATATGATGCAGAAATTTATTTGAAACGTGAAGATTTAACTCCGGTGCGATCTTATAAAATTC
GCGGTGCTTTTAATTTTGTTTCAGAAATGCTTAGTAAGATATCTCAAAATGCAGCATTTGTTTGTGCGTCAGCGGGGAAT
CACGCGCAAGGGGTTTCATTTGTTTGTCGCTATTTTAAACGTAAAGGCGTGATTTTTATGCCTGTGACGACTCCGCAACA
GAAAATTGATAAGACGCGCGTTTTTGGCAAAGAGTTTGTTGATATCCGTTTAATTGGTGAAACGTTTGACCAATGTTATG
CGGCAGCACAATCTTTTGCTACGGAGAGTGGTGGTGTTATGGCACCGCCTTTTGACGATACTCGCATTATTACGGGGCAG
GCGACAGTTTTGTGTGAGGCTGTTTTGCAATGGAAAAAACTCAATGGTGAAAGCGAGCCAGATTTGATTCTTGTTCCTGT
AGGTGGAGGTGGTTTGGCCAGTGGTGTGAGCAAGTTTTTACATGAATATGGTTGGAAAACCGAGCTTCGCTTTGTTGAGC
CGAAGAGAGCTGCAAGCTTGTTCGCTTGTTTGAAGAGTGGAAAACGTGTCAAACTTGAAAATATCGATACATTTGTAGAT
GGAGCTGCTGTAGCGGAAATTGGTGCATTAAATTACACAATGCTGAAGAATTTTTCACCAGATTCTGTTATTACAGTTCC
TGAGAACCGTGTGTGCTCTACAATGGTTGAAATGCTCAATGTTGAAGGTGTGGTCCTTGAACCAGCTGGTGCTTTATCGA
TTGATGCTCTTAATAGTCTTCCTCCTCAAGAGTTAAAAGGCAAAAAAATTCTTCTTGTTATTTCAGGTGGTAATTTTGAT
TTTGAGCGTTTGCCAGATATTAAAGAACGTTCTCTCCGTTTTCAGGGATTGAGAAAATATTTTATTTTTAGTTTTCCGCA
ACATCCTGGTGCGTTGCGTAGTTTTCTTGCTCAACTTTCTCCCGATGATGATATCGTACGTTTTGAATATCTTAAGAAAT
CATCTAGAAGTTTTGGCTCTGTGTTGATTGCAATTGAGACAAAAAAATATGATAATTTTTGTCTTTTAGAGAAAAAATTT
CAAGAGTTAGGTTGGCGCTATCGTGATATTACCGATGATCAAACGTTATTTGATTTTGTTATCTGA

Upstream 100 bases:

>100_bases
AAACTTTTCATTCTTCGTTCAATTTTTAACTGACAATGGCCGCTTTTATAGCTAGAAGGGGCCTGTATAGTATTAATTGA
AGCATGAAATGACTGCTGTT

Downstream 100 bases:

>100_bases
CGACCAATTCTTGCTGAAAAAAAAATATAAAAATCAGATCTCTTTTTTTGATTTTGTGCTGGAATTGTCTTTTTAAATAT
TACTACTCAACACAGTTTAA

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 421; Mature: 420

Protein sequence:

>421_residues
MSKFIQDVNKAMVALHNVFAETPLQRNDFLSQKYDAEIYLKREDLTPVRSYKIRGAFNFVSEMLSKISQNAAFVCASAGN
HAQGVSFVCRYFKRKGVIFMPVTTPQQKIDKTRVFGKEFVDIRLIGETFDQCYAAAQSFATESGGVMAPPFDDTRIITGQ
ATVLCEAVLQWKKLNGESEPDLILVPVGGGGLASGVSKFLHEYGWKTELRFVEPKRAASLFACLKSGKRVKLENIDTFVD
GAAVAEIGALNYTMLKNFSPDSVITVPENRVCSTMVEMLNVEGVVLEPAGALSIDALNSLPPQELKGKKILLVISGGNFD
FERLPDIKERSLRFQGLRKYFIFSFPQHPGALRSFLAQLSPDDDIVRFEYLKKSSRSFGSVLIAIETKKYDNFCLLEKKF
QELGWRYRDITDDQTLFDFVI

Sequences:

>Translated_421_residues
MSKFIQDVNKAMVALHNVFAETPLQRNDFLSQKYDAEIYLKREDLTPVRSYKIRGAFNFVSEMLSKISQNAAFVCASAGN
HAQGVSFVCRYFKRKGVIFMPVTTPQQKIDKTRVFGKEFVDIRLIGETFDQCYAAAQSFATESGGVMAPPFDDTRIITGQ
ATVLCEAVLQWKKLNGESEPDLILVPVGGGGLASGVSKFLHEYGWKTELRFVEPKRAASLFACLKSGKRVKLENIDTFVD
GAAVAEIGALNYTMLKNFSPDSVITVPENRVCSTMVEMLNVEGVVLEPAGALSIDALNSLPPQELKGKKILLVISGGNFD
FERLPDIKERSLRFQGLRKYFIFSFPQHPGALRSFLAQLSPDDDIVRFEYLKKSSRSFGSVLIAIETKKYDNFCLLEKKF
QELGWRYRDITDDQTLFDFVI
>Mature_420_residues
SKFIQDVNKAMVALHNVFAETPLQRNDFLSQKYDAEIYLKREDLTPVRSYKIRGAFNFVSEMLSKISQNAAFVCASAGNH
AQGVSFVCRYFKRKGVIFMPVTTPQQKIDKTRVFGKEFVDIRLIGETFDQCYAAAQSFATESGGVMAPPFDDTRIITGQA
TVLCEAVLQWKKLNGESEPDLILVPVGGGGLASGVSKFLHEYGWKTELRFVEPKRAASLFACLKSGKRVKLENIDTFVDG
AAVAEIGALNYTMLKNFSPDSVITVPENRVCSTMVEMLNVEGVVLEPAGALSIDALNSLPPQELKGKKILLVISGGNFDF
ERLPDIKERSLRFQGLRKYFIFSFPQHPGALRSFLAQLSPDDDIVRFEYLKKSSRSFGSVLIAIETKKYDNFCLLEKKFQ
ELGWRYRDITDDQTLFDFVI

Specific function: Catalyzes the formation of alpha-ketobutyrate from threonine in a two-step reaction. The first step is a dehydration of threonine, followed by rehydration and liberation of ammonia [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=321, Percent_Identity=26.1682242990654, Blast_Score=99, Evalue=8e-21,
Organism=Homo sapiens, GI33469958, Length=333, Percent_Identity=27.6276276276276, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI19923959, Length=334, Percent_Identity=27.5449101796407, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI1790207, Length=399, Percent_Identity=30.3258145363409, Blast_Score=159, Evalue=4e-40,
Organism=Escherichia coli, GI1789505, Length=324, Percent_Identity=30.8641975308642, Blast_Score=124, Evalue=8e-30,
Organism=Caenorhabditis elegans, GI71991565, Length=354, Percent_Identity=29.0960451977401, Blast_Score=112, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17537387, Length=402, Percent_Identity=29.8507462686567, Blast_Score=106, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17508781, Length=284, Percent_Identity=26.056338028169, Blast_Score=91, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6320930, Length=415, Percent_Identity=29.6385542168675, Blast_Score=176, Evalue=9e-45,
Organism=Saccharomyces cerevisiae, GI6322631, Length=317, Percent_Identity=28.7066246056782, Blast_Score=110, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6319788, Length=282, Percent_Identity=23.4042553191489, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21355833, Length=358, Percent_Identity=27.9329608938547, Blast_Score=88, Evalue=1e-17,

Paralogues:

None

Copy number: 1344 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR001721
- InterPro:   IPR011820 [H]

Pfam domain/function: PF00291 PALP; PF00585 Thr_dehydrat_C [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 47228; Mature: 47097

Theoretical pI: Translated: 8.25; Mature: 8.25

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKFIQDVNKAMVALHNVFAETPLQRNDFLSQKYDAEIYLKREDLTPVRSYKIRGAFNFV
CCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCEEEEEECCCCCCHHEEECHHHHHH
SEMLSKISQNAAFVCASAGNHAQGVSFVCRYFKRKGVIFMPVTTPQQKIDKTRVFGKEFV
HHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHCCHHE
DIRLIGETFDQCYAAAQSFATESGGVMAPPFDDTRIITGQATVLCEAVLQWKKLNGESEP
EEEEHHHHHHHHHHHHHHHCCCCCCEECCCCCCCEEEECHHHHHHHHHHHHHHCCCCCCC
DLILVPVGGGGLASGVSKFLHEYGWKTELRFVEPKRAASLFACLKSGKRVKLENIDTFVD
CEEEEECCCCHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHCCCEEEECCCHHHHC
GAAVAEIGALNYTMLKNFSPDSVITVPENRVCSTMVEMLNVEGVVLEPAGALSIDALNSL
CHHHHHHCCCCHHHHCCCCCCCEEECCCCHHHHHHHHHHCCCCEEECCCCCEEHHHHCCC
PPQELKGKKILLVISGGNFDFERLPDIKERSLRFQGLRKYFIFSFPQHPGALRSFLAQLS
CCHHHCCCEEEEEEECCCCCHHHCCCHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHCC
PDDDIVRFEYLKKSSRSFGSVLIAIETKKYDNFCLLEKKFQELGWRYRDITDDQTLFDFV
CCCCHHHHHHHHHHCCCCCEEEEEEEECCCCCEEHHHHHHHHCCCEECCCCCCCHHHHHC
I
C
>Mature Secondary Structure 
SKFIQDVNKAMVALHNVFAETPLQRNDFLSQKYDAEIYLKREDLTPVRSYKIRGAFNFV
CHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCEEEEEECCCCCCHHEEECHHHHHH
SEMLSKISQNAAFVCASAGNHAQGVSFVCRYFKRKGVIFMPVTTPQQKIDKTRVFGKEFV
HHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHCCHHE
DIRLIGETFDQCYAAAQSFATESGGVMAPPFDDTRIITGQATVLCEAVLQWKKLNGESEP
EEEEHHHHHHHHHHHHHHHCCCCCCEECCCCCCCEEEECHHHHHHHHHHHHHHCCCCCCC
DLILVPVGGGGLASGVSKFLHEYGWKTELRFVEPKRAASLFACLKSGKRVKLENIDTFVD
CEEEEECCCCHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHCCCEEEECCCHHHHC
GAAVAEIGALNYTMLKNFSPDSVITVPENRVCSTMVEMLNVEGVVLEPAGALSIDALNSL
CHHHHHHCCCCHHHHCCCCCCCEEECCCCHHHHHHHHHHCCCCEEECCCCCEEHHHHCCC
PPQELKGKKILLVISGGNFDFERLPDIKERSLRFQGLRKYFIFSFPQHPGALRSFLAQLS
CCHHHCCCEEEEEEECCCCCHHHCCCHHHHHHHHHHHHHHEEEECCCCCHHHHHHHHHCC
PDDDIVRFEYLKKSSRSFGSVLIAIETKKYDNFCLLEKKFQELGWRYRDITDDQTLFDFV
CCCCHHHHHHHHHHCCCCCEEEEEEEECCCCCEEHHHHHHHHCCCEECCCCCCCHHHHHC
I
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA