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The map label for this gene is adk

Identifier: 49475773

GI number: 49475773

Start: 1144995

End: 1145573

Strand: Reverse

Name: adk

Synonym: BH10300

Alternate gene names: 49475773

Gene position: 1145573-1144995 (Counterclockwise)

Preceding gene: 49475774

Following gene: 49475772

Centisome position: 59.32

GC content: 39.72

Gene sequence:

>579_bases
ATGAGGATTGTTCTTTTAGGTCCTCCTGGAGCTGGAAAAGGTACACAAGCTAAGATGTTGTGTGAGGAATATCACATCCC
TCAGTTATCAACAGGCGATATGTTGCGTGAAGTTATTCGCAGAGAAACGGAAATTGGCAAGAAAGCTAAAGCTATGATCA
ATGCTGGTACTTTGGTCTCTGATAGTATTGTTAATCAAATTGTATCCGATCGCATTGACGAATCTGATTGTATAAACGGT
TTTGTTTTGGATGGATATCCGCGCACTGTAGGACAGGCAGAAGTTTTGCAACAGGTTTTACAGTCAAAAAATATGCAGCT
TGATGCCGTTATTGAGTTAATTGTTGATGAAGATGCATTGCTTGAACGAATGAAGAAGCGTGTTCAGGAAACAATAATTG
CCGGTGGACAGGTCCGTTCGGATGATAATCCTGTTGCTTTTGCAAAACGATTAGTGGAATATCGTGAGAAGACAGCTCCT
TTGTCGGAATTTTATTTGCAAAGGAGATTATTGAAGCTAGTTGATGGAATGATTGGTGTTACTGAGGTATCACGCAAAAT
TAGAGAGGTTCTTAAATAG

Upstream 100 bases:

>100_bases
TTACGCTTGATACAGTTGCCCAAATTCAGGGACATCTTGTGGCACACCAATATGAAGGATTGATTAAAAAGTCAAAACTT
CGTGGAGGCAGAAGGAATCG

Downstream 100 bases:

>100_bases
GGATTTTTTTAGAAATAAATGAAAAGAGTTGACTTTTTGGGTGAAATCTATCAAAAACTGCTTTAATCTATTTCATTAAA
ATGATTAGGATTCGGAAAAT

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 192; Mature: 192

Protein sequence:

>192_residues
MRIVLLGPPGAGKGTQAKMLCEEYHIPQLSTGDMLREVIRRETEIGKKAKAMINAGTLVSDSIVNQIVSDRIDESDCING
FVLDGYPRTVGQAEVLQQVLQSKNMQLDAVIELIVDEDALLERMKKRVQETIIAGGQVRSDDNPVAFAKRLVEYREKTAP
LSEFYLQRRLLKLVDGMIGVTEVSRKIREVLK

Sequences:

>Translated_192_residues
MRIVLLGPPGAGKGTQAKMLCEEYHIPQLSTGDMLREVIRRETEIGKKAKAMINAGTLVSDSIVNQIVSDRIDESDCING
FVLDGYPRTVGQAEVLQQVLQSKNMQLDAVIELIVDEDALLERMKKRVQETIIAGGQVRSDDNPVAFAKRLVEYREKTAP
LSEFYLQRRLLKLVDGMIGVTEVSRKIREVLK
>Mature_192_residues
MRIVLLGPPGAGKGTQAKMLCEEYHIPQLSTGDMLREVIRRETEIGKKAKAMINAGTLVSDSIVNQIVSDRIDESDCING
FVLDGYPRTVGQAEVLQQVLQSKNMQLDAVIELIVDEDALLERMKKRVQETIIAGGQVRSDDNPVAFAKRLVEYREKTAP
LSEFYLQRRLLKLVDGMIGVTEVSRKIREVLK

Specific function: This small ubiquitous enzyme is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI7524346, Length=197, Percent_Identity=40.1015228426396, Blast_Score=141, Evalue=3e-34,
Organism=Homo sapiens, GI4502013, Length=197, Percent_Identity=40.1015228426396, Blast_Score=141, Evalue=3e-34,
Organism=Homo sapiens, GI310110345, Length=199, Percent_Identity=31.1557788944724, Blast_Score=98, Evalue=4e-21,
Organism=Homo sapiens, GI53832003, Length=199, Percent_Identity=31.1557788944724, Blast_Score=98, Evalue=4e-21,
Organism=Homo sapiens, GI8051579, Length=199, Percent_Identity=31.1557788944724, Blast_Score=98, Evalue=4e-21,
Organism=Homo sapiens, GI53832001, Length=199, Percent_Identity=31.1557788944724, Blast_Score=98, Evalue=4e-21,
Organism=Homo sapiens, GI19923437, Length=199, Percent_Identity=31.1557788944724, Blast_Score=97, Evalue=7e-21,
Organism=Homo sapiens, GI4502011, Length=174, Percent_Identity=31.0344827586207, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI22749187, Length=127, Percent_Identity=33.8582677165354, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI28144899, Length=175, Percent_Identity=30.2857142857143, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI28144897, Length=164, Percent_Identity=31.7073170731707, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI7706497, Length=196, Percent_Identity=28.5714285714286, Blast_Score=73, Evalue=1e-13,
Organism=Escherichia coli, GI1786680, Length=217, Percent_Identity=38.2488479262673, Blast_Score=140, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI17552384, Length=214, Percent_Identity=35.5140186915888, Blast_Score=143, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI17567503, Length=165, Percent_Identity=30.3030303030303, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17550688, Length=191, Percent_Identity=30.3664921465969, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17533833, Length=175, Percent_Identity=29.7142857142857, Blast_Score=77, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17537943, Length=131, Percent_Identity=33.587786259542, Blast_Score=74, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6320432, Length=197, Percent_Identity=40.6091370558376, Blast_Score=140, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6321018, Length=199, Percent_Identity=31.6582914572864, Blast_Score=102, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6322828, Length=167, Percent_Identity=32.3353293413174, Blast_Score=78, Evalue=9e-16,
Organism=Drosophila melanogaster, GI22026816, Length=210, Percent_Identity=38.0952380952381, Blast_Score=140, Evalue=6e-34,
Organism=Drosophila melanogaster, GI17737899, Length=199, Percent_Identity=34.6733668341709, Blast_Score=108, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24645822, Length=199, Percent_Identity=34.6733668341709, Blast_Score=108, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24663208, Length=164, Percent_Identity=29.8780487804878, Blast_Score=83, Evalue=8e-17,
Organism=Drosophila melanogaster, GI17647141, Length=169, Percent_Identity=29.585798816568, Blast_Score=83, Evalue=9e-17,
Organism=Drosophila melanogaster, GI221459597, Length=190, Percent_Identity=26.8421052631579, Blast_Score=74, Evalue=5e-14,
Organism=Drosophila melanogaster, GI21356893, Length=190, Percent_Identity=26.8421052631579, Blast_Score=74, Evalue=5e-14,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_BARHE (Q6G2Y6)

Other databases:

- EMBL:   BX897699
- RefSeq:   YP_033814.1
- ProteinModelPortal:   Q6G2Y6
- SMR:   Q6G2Y6
- GeneID:   2866065
- GenomeReviews:   BX897699_GR
- KEGG:   bhe:BH10300
- NMPDR:   fig|283166.1.peg.942
- HOGENOM:   HBG630208
- OMA:   YPRNTSQ
- ProtClustDB:   PRK00279
- BioCyc:   BHEN283166:BH10300-MONOMER
- BRENDA:   2.7.4.3
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK

EC number: =2.7.4.3

Molecular weight: Translated: 21481; Mature: 21481

Theoretical pI: Translated: 7.27; Mature: 7.27

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIVLLGPPGAGKGTQAKMLCEEYHIPQLSTGDMLREVIRRETEIGKKAKAMINAGTLVS
CEEEEECCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
DSIVNQIVSDRIDESDCINGFVLDGYPRTVGQAEVLQQVLQSKNMQLDAVIELIVDEDAL
HHHHHHHHHHCCCHHHHCCCEEECCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCHHH
LERMKKRVQETIIAGGQVRSDDNPVAFAKRLVEYREKTAPLSEFYLQRRLLKLVDGMIGV
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
TEVSRKIREVLK
HHHHHHHHHHHC
>Mature Secondary Structure
MRIVLLGPPGAGKGTQAKMLCEEYHIPQLSTGDMLREVIRRETEIGKKAKAMINAGTLVS
CEEEEECCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
DSIVNQIVSDRIDESDCINGFVLDGYPRTVGQAEVLQQVLQSKNMQLDAVIELIVDEDAL
HHHHHHHHHHCCCHHHHCCCEEECCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHCCHHH
LERMKKRVQETIIAGGQVRSDDNPVAFAKRLVEYREKTAPLSEFYLQRRLLKLVDGMIGV
HHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
TEVSRKIREVLK
HHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA