Click here to switch to the map view.

The map label for this gene is htrA2 [H]

Identifier: 49475768

GI number: 49475768

Start: 1140670

End: 1142061

Strand: Reverse

Name: htrA2 [H]

Synonym: BH10250

Alternate gene names: 49475768

Gene position: 1142061-1140670 (Counterclockwise)

Preceding gene: 49475769

Following gene: 49475767

Centisome position: 59.14

GC content: 38.51

Gene sequence:

>1392_bases
ATGAGGTATTCTTTTGTAGGGTGGTTTTTTTGGGCGATTATGGCACAGATATCATTTCATTGTGCTTATGCTGAAATTCC
ACAAACACAAAAAGAAATCACTCTTTCATTTGCTCCTTTAGTTAAAAAGACTATTCCATCTGTTGTGAATATTTATGCAG
CTCGACAAATTAGAGCACGTTCCCCTTTTGAAGGTGATCCATTTTTTGAGCAATTTTTTAGTCGTTTTCAAAATAATTTG
CCTGTACGTAAGCAATCTTCATTAGGGTCTGGAGTGATTGTAGATAAGCGTGGTTTAGTTGTTACGAATTACCATGTCAT
TAAGGATGCAAACGAAATTAAAGTTGCTCTTTCTGATGGGAGGGAATTTGAAAGTAAGGTTATGCTAAAAGATGAGGCAA
CCGATATTGCTGTGCTGGAAATAGATGCCAAGGAGGCGCAGTTTCCTGTTCTTCCTTTGGGAGATTCTGATGCAGTTAAA
GTGGGCGATCTTGTTTTAGCAATTGGTAATCCTTTTGGTGTTGGTCAAACGGTTACAAGTGGTATTGTTTCAGCACAAGC
GCGTACACGTGTTGGTATTTCTGATTTTGACTTTTTTATTCAAACAGATGCGGCCATTAATCCAGGGAATTCCGGTGGGG
CTTTGATTGATATGAAAGGACAGTTAATTGGAATTAATACGGCTATTTATTCGCGTTCAGGTGGTTCGGTAGGGATTGGC
TTTGCTATTCCAGCAAATCTTGTAAAAGTGATGCTTGATACTGTTAGACGTGGTGGAAAATATTTTGTGCCCCCTTATAT
TGGGGCGTCTTTTCAAAATGTTACCCCTGATATTGCTGGTGGCTTAGGCTTAGAACGCCCTTATGGTGCTCTTGTCATCG
AAGTTATAAAAGATAGTCCTGCTAAAAAAGCTGGTTTAAGAGTAGGTGATGTTATTTTAAGTGTGCAAGGGATACGGGTT
GATAGCCCAGATAGTCTTGGATATCGTTTGATGACAGCTGGTATTGGAGATAGCCTTGTTTTAGAATATTTAAGAAGTGG
AAAAACTTTTCAGACGAAAATAACTATTTCATCAATACCGGATGCATTTTCAAAATCTGAAAAAATTATTGATGAAGGTC
CTCTTTCTGGTGCTGAAGTGTTAGATTTAACACCGCAAAATAGTCGACGTTTTCATCTTTCTACATCTGCAAAAGGTGTT
GTGATTAGCAATCTTGATGAAATGAGCAATGCTGCTGGGATTTTTCGTACTGGGGATATTTTGCGGGTTATTAATGGTCA
TAAGATTCAAACGGTCAGTCAGTTGAAAAAGATTCTTATGCAAGATCGTCCGCGGGTTTGGCAATTGGAATATGAACGTG
ATGGTATGTATATTCGCCAATTTATTCGCTGA

Upstream 100 bases:

>100_bases
TATTAATGAATGTTTTTAGCTTATGCAATATGAGAGGTTTTCTTATATCCTATTAATGTTAAAGAGTAGGCTAGTTGTTA
GTTTTTTTAAGGAGAAAGTC

Downstream 100 bases:

>100_bases
GGTTTTTTTTGAATAAAGATCTTTTTATTTCGTCTTTTGATCATCGGGTTTATAAAAAGCAGCCGCTTGCAGAAAGGATG
CGTCCTCACTCCCTTAATGA

Product: Serine protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 463; Mature: 463

Protein sequence:

>463_residues
MRYSFVGWFFWAIMAQISFHCAYAEIPQTQKEITLSFAPLVKKTIPSVVNIYAARQIRARSPFEGDPFFEQFFSRFQNNL
PVRKQSSLGSGVIVDKRGLVVTNYHVIKDANEIKVALSDGREFESKVMLKDEATDIAVLEIDAKEAQFPVLPLGDSDAVK
VGDLVLAIGNPFGVGQTVTSGIVSAQARTRVGISDFDFFIQTDAAINPGNSGGALIDMKGQLIGINTAIYSRSGGSVGIG
FAIPANLVKVMLDTVRRGGKYFVPPYIGASFQNVTPDIAGGLGLERPYGALVIEVIKDSPAKKAGLRVGDVILSVQGIRV
DSPDSLGYRLMTAGIGDSLVLEYLRSGKTFQTKITISSIPDAFSKSEKIIDEGPLSGAEVLDLTPQNSRRFHLSTSAKGV
VISNLDEMSNAAGIFRTGDILRVINGHKIQTVSQLKKILMQDRPRVWQLEYERDGMYIRQFIR

Sequences:

>Translated_463_residues
MRYSFVGWFFWAIMAQISFHCAYAEIPQTQKEITLSFAPLVKKTIPSVVNIYAARQIRARSPFEGDPFFEQFFSRFQNNL
PVRKQSSLGSGVIVDKRGLVVTNYHVIKDANEIKVALSDGREFESKVMLKDEATDIAVLEIDAKEAQFPVLPLGDSDAVK
VGDLVLAIGNPFGVGQTVTSGIVSAQARTRVGISDFDFFIQTDAAINPGNSGGALIDMKGQLIGINTAIYSRSGGSVGIG
FAIPANLVKVMLDTVRRGGKYFVPPYIGASFQNVTPDIAGGLGLERPYGALVIEVIKDSPAKKAGLRVGDVILSVQGIRV
DSPDSLGYRLMTAGIGDSLVLEYLRSGKTFQTKITISSIPDAFSKSEKIIDEGPLSGAEVLDLTPQNSRRFHLSTSAKGV
VISNLDEMSNAAGIFRTGDILRVINGHKIQTVSQLKKILMQDRPRVWQLEYERDGMYIRQFIR
>Mature_463_residues
MRYSFVGWFFWAIMAQISFHCAYAEIPQTQKEITLSFAPLVKKTIPSVVNIYAARQIRARSPFEGDPFFEQFFSRFQNNL
PVRKQSSLGSGVIVDKRGLVVTNYHVIKDANEIKVALSDGREFESKVMLKDEATDIAVLEIDAKEAQFPVLPLGDSDAVK
VGDLVLAIGNPFGVGQTVTSGIVSAQARTRVGISDFDFFIQTDAAINPGNSGGALIDMKGQLIGINTAIYSRSGGSVGIG
FAIPANLVKVMLDTVRRGGKYFVPPYIGASFQNVTPDIAGGLGLERPYGALVIEVIKDSPAKKAGLRVGDVILSVQGIRV
DSPDSLGYRLMTAGIGDSLVLEYLRSGKTFQTKITISSIPDAFSKSEKIIDEGPLSGAEVLDLTPQNSRRFHLSTSAKGV
VISNLDEMSNAAGIFRTGDILRVINGHKIQTVSQLKKILMQDRPRVWQLEYERDGMYIRQFIR

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=294, Percent_Identity=38.0952380952381, Blast_Score=160, Evalue=3e-39,
Organism=Homo sapiens, GI7019477, Length=296, Percent_Identity=38.5135135135135, Blast_Score=146, Evalue=4e-35,
Organism=Homo sapiens, GI22129776, Length=297, Percent_Identity=34.6801346801347, Blast_Score=142, Evalue=5e-34,
Organism=Homo sapiens, GI24308541, Length=289, Percent_Identity=32.5259515570934, Blast_Score=137, Evalue=3e-32,
Organism=Escherichia coli, GI1786356, Length=473, Percent_Identity=35.5179704016913, Blast_Score=244, Evalue=7e-66,
Organism=Escherichia coli, GI1789629, Length=459, Percent_Identity=35.7298474945534, Blast_Score=238, Evalue=6e-64,
Organism=Escherichia coli, GI1789630, Length=294, Percent_Identity=41.156462585034, Blast_Score=192, Evalue=4e-50,
Organism=Drosophila melanogaster, GI24646839, Length=251, Percent_Identity=35.4581673306773, Blast_Score=138, Evalue=8e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 50563; Mature: 50563

Theoretical pI: Translated: 9.44; Mature: 9.44

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYSFVGWFFWAIMAQISFHCAYAEIPQTQKEITLSFAPLVKKTIPSVVNIYAARQIRAR
CCCCHHHHHHHHHHHHHHHHEEECCCCCCCHHEEEHHHHHHHHHHHHHHHHHHHHHHHCC
SPFEGDPFFEQFFSRFQNNLPVRKQSSLGSGVIVDKRGLVVTNYHVIKDANEIKVALSDG
CCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCEEEEEEEEEECCCEEEEEECCC
REFESKVMLKDEATDIAVLEIDAKEAQFPVLPLGDSDAVKVGDLVLAIGNPFGVGQTVTS
CCCCCEEEEEECCCEEEEEEECCCCCCCCEEECCCCCCEEECEEEEEECCCCCCCHHHHH
GIVSAQARTRVGISDFDFFIQTDAAINPGNSGGALIDMKGQLIGINTAIYSRSGGSVGIG
HHHHHHHHHCCCCCCCEEEEEECCEECCCCCCCEEEEECCEEEEEEEEEEECCCCCEEEE
FAIPANLVKVMLDTVRRGGKYFVPPYIGASFQNVTPDIAGGLGLERPYGALVIEVIKDSP
EHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCHHHCCCCCCCCCHHEEEEEECCCC
AKKAGLRVGDVILSVQGIRVDSPDSLGYRLMTAGIGDSLVLEYLRSGKTFQTKITISSIP
CHHHCCEEEEEEEEEECEEECCCCCCCEEEEECCCCHHHHHHHHHCCCEEEEEEEECCCC
DAFSKSEKIIDEGPLSGAEVLDLTPQNSRRFHLSTSAKGVVISNLDEMSNAAGIFRTGDI
CHHHHCCHHHHCCCCCCCEEEEECCCCCCEEEEECCCCCEEEECHHHHHCCCCEEECCCE
LRVINGHKIQTVSQLKKILMQDRPRVWQLEYERDGMYIRQFIR
EEECCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHCC
>Mature Secondary Structure
MRYSFVGWFFWAIMAQISFHCAYAEIPQTQKEITLSFAPLVKKTIPSVVNIYAARQIRAR
CCCCHHHHHHHHHHHHHHHHEEECCCCCCCHHEEEHHHHHHHHHHHHHHHHHHHHHHHCC
SPFEGDPFFEQFFSRFQNNLPVRKQSSLGSGVIVDKRGLVVTNYHVIKDANEIKVALSDG
CCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCEEEEEEEEEECCCEEEEEECCC
REFESKVMLKDEATDIAVLEIDAKEAQFPVLPLGDSDAVKVGDLVLAIGNPFGVGQTVTS
CCCCCEEEEEECCCEEEEEEECCCCCCCCEEECCCCCCEEECEEEEEECCCCCCCHHHHH
GIVSAQARTRVGISDFDFFIQTDAAINPGNSGGALIDMKGQLIGINTAIYSRSGGSVGIG
HHHHHHHHHCCCCCCCEEEEEECCEECCCCCCCEEEEECCEEEEEEEEEEECCCCCEEEE
FAIPANLVKVMLDTVRRGGKYFVPPYIGASFQNVTPDIAGGLGLERPYGALVIEVIKDSP
EHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCHHHCCCCCCCCCHHEEEEEECCCC
AKKAGLRVGDVILSVQGIRVDSPDSLGYRLMTAGIGDSLVLEYLRSGKTFQTKITISSIP
CHHHCCEEEEEEEEEECEEECCCCCCCEEEEECCCCHHHHHHHHHCCCEEEEEEEECCCC
DAFSKSEKIIDEGPLSGAEVLDLTPQNSRRFHLSTSAKGVVISNLDEMSNAAGIFRTGDI
CHHHHCCHHHHCCCCCCCEEEEECCCCCCEEEEECCCCCEEEECHHHHHCCCCEEECCCE
LRVINGHKIQTVSQLKKILMQDRPRVWQLEYERDGMYIRQFIR
EEECCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362 [H]