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The map label for this gene is accC [H]

Identifier: 49475570

GI number: 49475570

Start: 906090

End: 907448

Strand: Reverse

Name: accC [H]

Synonym: BH08050

Alternate gene names: 49475570

Gene position: 907448-906090 (Counterclockwise)

Preceding gene: 49475571

Following gene: 49475560

Centisome position: 46.99

GC content: 40.62

Gene sequence:

>1359_bases
ATGATTCGAAAAATCCTCATTGCTAATCGGGGAGAAATTGCTCTTCGCGTTTTGCGAGCCTGCAAAGAACTTGGAATAAA
AACCGTAGCCGTTCACTCAACTGCTGACGCTGATGCAATGCACGTTCGTCTTGCTGACGAAAGTGTCTGTATTGGACCTC
CCCCAGTTCGCGATTCTTATTTAAGTATTCAACAAATTATTGCTGCCTGTGAGATCACAGGTGCTGATGCGGTTCATCCG
GGCTATGGTTTTCTTTCTGAGAATGCAAAATTTGCAGATGTTCTAGAAGCCCATAAGATTACATTCATTGGCCCAACGGC
TGCGCATATTCGCATCATGGGTGATAAAATTGAAGCAAAAAAAACCGCTAAAAAACTTGGAATTCCTGTAGTCCCTGGTT
CAGATGGGGCAATTACTGAAGAAGCAGAGGCTCTGCGTATTGCCCATGAAATTGGTTATCCCGTTATTATTAAAGCTTCT
GCCGGCGGTGGCGGACGCGGTATGAAAGTGGTTCGTTCTGAACAAGAGTTTGCTATAGCTCTTGAAACAACACGTTCAGA
AGCAGCAGCAGCTTTTGGTGATGATGCAGTTTATATCGAAAAATATTTAGAAAAGCCACGTCATATTGAAATTCAAGTTA
TAGGTGATGGAGCTGGGAATGCTATTCACTTAGGGGAACGCGATTGTTCACTTCAACGGCGTCATCAAAAAATATGGGAA
GAAGCAACTTCACCTGCACTTAATGAAATTGAACGGAAAAAAATTGGCGATATTGTCGCAAATGCTTGTGCACAACTAGG
ATATCGTGGAGCGGGTACTATTGAATTTCTTTATGAAAATGGCAAATTCTATTTTATTGAAATGAATACGCGTTTACAAG
TTGAACACCCTGTAACTGAAGCGATTACGGGCATAGATTTAGTCCATGAGCAAATTCATATTGCATCAGGTTGTAGGCTT
TCAGTTGTACAAGAGGATATCTGCTTCTCTGGTCATGCTATTGAATGTCGTATTAATGCGGAAGATCCTATTAACTTTAC
ACCATCACCGGGAACTATTACACATTTTCATACACCTGGAGGTTTAGGAATACGTGTCGATTCAGGTGCTTATTCAGGTT
ACTGTATTCCTCCTTATTACGATAGTATGATTGGAAAGCTTATTGTTCATGGACGTACCCGTTTAGAATGCATGATGCGT
TTACGGCGTGCTTTAGATGAGTTTGTAGTTGATGGGATAAAAACTACATTACCTCTCTTTCGCGATCTCATTAACAATCA
AGATATTGCAGATGGTAATTATAATATTCATTGGCTAGAAAAATATCTTTCTAGCCAATCAACTTCTTCAGACTCGTGA

Upstream 100 bases:

>100_bases
CCCCACGTTCAGGCAAAGTGACTACTATTTTTGTTAAAGATGGCCAACCCGTTGAGTTTGGTGAACCGCTTATTGTTGTT
GAATAAAGTGAGAAGTAGCT

Downstream 100 bases:

>100_bases
TTCAGTAACAAAATGATGTGCTTTCATCAGCGGCTTCTATGAAGTGGTAATGTGGAAATAATATAAAACGTTGCTGTAAA
AAATAGTAAGAAAGATGATT

Product: acetyl-CoA carboxylase biotin carboxylase subunit

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 452; Mature: 452

Protein sequence:

>452_residues
MIRKILIANRGEIALRVLRACKELGIKTVAVHSTADADAMHVRLADESVCIGPPPVRDSYLSIQQIIAACEITGADAVHP
GYGFLSENAKFADVLEAHKITFIGPTAAHIRIMGDKIEAKKTAKKLGIPVVPGSDGAITEEAEALRIAHEIGYPVIIKAS
AGGGGRGMKVVRSEQEFAIALETTRSEAAAAFGDDAVYIEKYLEKPRHIEIQVIGDGAGNAIHLGERDCSLQRRHQKIWE
EATSPALNEIERKKIGDIVANACAQLGYRGAGTIEFLYENGKFYFIEMNTRLQVEHPVTEAITGIDLVHEQIHIASGCRL
SVVQEDICFSGHAIECRINAEDPINFTPSPGTITHFHTPGGLGIRVDSGAYSGYCIPPYYDSMIGKLIVHGRTRLECMMR
LRRALDEFVVDGIKTTLPLFRDLINNQDIADGNYNIHWLEKYLSSQSTSSDS

Sequences:

>Translated_452_residues
MIRKILIANRGEIALRVLRACKELGIKTVAVHSTADADAMHVRLADESVCIGPPPVRDSYLSIQQIIAACEITGADAVHP
GYGFLSENAKFADVLEAHKITFIGPTAAHIRIMGDKIEAKKTAKKLGIPVVPGSDGAITEEAEALRIAHEIGYPVIIKAS
AGGGGRGMKVVRSEQEFAIALETTRSEAAAAFGDDAVYIEKYLEKPRHIEIQVIGDGAGNAIHLGERDCSLQRRHQKIWE
EATSPALNEIERKKIGDIVANACAQLGYRGAGTIEFLYENGKFYFIEMNTRLQVEHPVTEAITGIDLVHEQIHIASGCRL
SVVQEDICFSGHAIECRINAEDPINFTPSPGTITHFHTPGGLGIRVDSGAYSGYCIPPYYDSMIGKLIVHGRTRLECMMR
LRRALDEFVVDGIKTTLPLFRDLINNQDIADGNYNIHWLEKYLSSQSTSSDS
>Mature_452_residues
MIRKILIANRGEIALRVLRACKELGIKTVAVHSTADADAMHVRLADESVCIGPPPVRDSYLSIQQIIAACEITGADAVHP
GYGFLSENAKFADVLEAHKITFIGPTAAHIRIMGDKIEAKKTAKKLGIPVVPGSDGAITEEAEALRIAHEIGYPVIIKAS
AGGGGRGMKVVRSEQEFAIALETTRSEAAAAFGDDAVYIEKYLEKPRHIEIQVIGDGAGNAIHLGERDCSLQRRHQKIWE
EATSPALNEIERKKIGDIVANACAQLGYRGAGTIEFLYENGKFYFIEMNTRLQVEHPVTEAITGIDLVHEQIHIASGCRL
SVVQEDICFSGHAIECRINAEDPINFTPSPGTITHFHTPGGLGIRVDSGAYSGYCIPPYYDSMIGKLIVHGRTRLECMMR
LRRALDEFVVDGIKTTLPLFRDLINNQDIADGNYNIHWLEKYLSSQSTSSDS

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI65506442, Length=440, Percent_Identity=50.9090909090909, Blast_Score=429, Evalue=1e-120,
Organism=Homo sapiens, GI189095269, Length=440, Percent_Identity=50.9090909090909, Blast_Score=429, Evalue=1e-120,
Organism=Homo sapiens, GI295821183, Length=440, Percent_Identity=50.9090909090909, Blast_Score=429, Evalue=1e-120,
Organism=Homo sapiens, GI116805327, Length=444, Percent_Identity=47.0720720720721, Blast_Score=410, Evalue=1e-114,
Organism=Homo sapiens, GI106049528, Length=448, Percent_Identity=47.3214285714286, Blast_Score=391, Evalue=1e-109,
Organism=Homo sapiens, GI106049295, Length=448, Percent_Identity=47.3214285714286, Blast_Score=391, Evalue=1e-109,
Organism=Homo sapiens, GI106049292, Length=448, Percent_Identity=47.3214285714286, Blast_Score=391, Evalue=1e-109,
Organism=Homo sapiens, GI38679977, Length=514, Percent_Identity=28.988326848249, Blast_Score=223, Evalue=4e-58,
Organism=Homo sapiens, GI38679967, Length=514, Percent_Identity=28.988326848249, Blast_Score=223, Evalue=4e-58,
Organism=Homo sapiens, GI38679960, Length=514, Percent_Identity=28.988326848249, Blast_Score=223, Evalue=4e-58,
Organism=Homo sapiens, GI38679974, Length=514, Percent_Identity=28.988326848249, Blast_Score=223, Evalue=4e-58,
Organism=Homo sapiens, GI38679971, Length=514, Percent_Identity=28.988326848249, Blast_Score=223, Evalue=4e-58,
Organism=Homo sapiens, GI134142062, Length=524, Percent_Identity=29.5801526717557, Blast_Score=218, Evalue=1e-56,
Organism=Escherichia coli, GI1789654, Length=447, Percent_Identity=61.744966442953, Blast_Score=545, Evalue=1e-156,
Organism=Escherichia coli, GI1786216, Length=244, Percent_Identity=22.9508196721311, Blast_Score=64, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17567343, Length=440, Percent_Identity=46.5909090909091, Blast_Score=402, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI71987519, Length=435, Percent_Identity=45.7471264367816, Blast_Score=372, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI17562816, Length=449, Percent_Identity=44.543429844098, Blast_Score=362, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI71997168, Length=514, Percent_Identity=28.5992217898833, Blast_Score=204, Evalue=5e-53,
Organism=Caenorhabditis elegans, GI71997163, Length=514, Percent_Identity=28.5992217898833, Blast_Score=204, Evalue=7e-53,
Organism=Caenorhabditis elegans, GI133931226, Length=493, Percent_Identity=29.6146044624746, Blast_Score=199, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6319685, Length=445, Percent_Identity=42.4719101123596, Blast_Score=352, Evalue=6e-98,
Organism=Saccharomyces cerevisiae, GI6319695, Length=441, Percent_Identity=45.3514739229025, Blast_Score=344, Evalue=2e-95,
Organism=Saccharomyces cerevisiae, GI6321376, Length=441, Percent_Identity=45.578231292517, Blast_Score=337, Evalue=2e-93,
Organism=Saccharomyces cerevisiae, GI6324343, Length=532, Percent_Identity=31.015037593985, Blast_Score=224, Evalue=3e-59,
Organism=Saccharomyces cerevisiae, GI6323863, Length=491, Percent_Identity=32.7902240325866, Blast_Score=216, Evalue=8e-57,
Organism=Drosophila melanogaster, GI281363050, Length=449, Percent_Identity=47.8841870824053, Blast_Score=393, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24652224, Length=449, Percent_Identity=47.8841870824053, Blast_Score=393, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24652222, Length=449, Percent_Identity=47.8841870824053, Blast_Score=393, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24652220, Length=449, Percent_Identity=47.8841870824053, Blast_Score=393, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24652218, Length=449, Percent_Identity=47.8841870824053, Blast_Score=393, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24652212, Length=449, Percent_Identity=47.8841870824053, Blast_Score=393, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24652210, Length=449, Percent_Identity=47.8841870824053, Blast_Score=393, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24652214, Length=449, Percent_Identity=47.8841870824053, Blast_Score=393, Evalue=1e-109,
Organism=Drosophila melanogaster, GI19921944, Length=449, Percent_Identity=47.8841870824053, Blast_Score=393, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24652216, Length=449, Percent_Identity=47.8841870824053, Blast_Score=393, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24651757, Length=448, Percent_Identity=42.6339285714286, Blast_Score=370, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24651759, Length=410, Percent_Identity=41.219512195122, Blast_Score=327, Evalue=9e-90,
Organism=Drosophila melanogaster, GI161076407, Length=517, Percent_Identity=29.4003868471954, Blast_Score=210, Evalue=1e-54,
Organism=Drosophila melanogaster, GI24586460, Length=517, Percent_Identity=29.4003868471954, Blast_Score=210, Evalue=1e-54,
Organism=Drosophila melanogaster, GI24586458, Length=517, Percent_Identity=29.4003868471954, Blast_Score=210, Evalue=2e-54,
Organism=Drosophila melanogaster, GI161076409, Length=517, Percent_Identity=29.4003868471954, Blast_Score=210, Evalue=2e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 49428; Mature: 49428

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRKILIANRGEIALRVLRACKELGIKTVAVHSTADADAMHVRLADESVCIGPPPVRDSY
CCCEEEEECCCHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEECCCCEECCCCCCCCHH
LSIQQIIAACEITGADAVHPGYGFLSENAKFADVLEAHKITFIGPTAAHIRIMGDKIEAK
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCEEEEECCCCEEEEEECCHHHHH
KTAKKLGIPVVPGSDGAITEEAEALRIAHEIGYPVIIKASAGGGGRGMKVVRSEQEFAIA
HHHHHCCCEECCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEECCCCEEEE
LETTRSEAAAAFGDDAVYIEKYLEKPRHIEIQVIGDGAGNAIHLGERDCSLQRRHQKIWE
EECCCCHHHHHCCCCHHHHHHHHCCCCEEEEEEEECCCCCEEEECCCCHHHHHHHHHHHH
EATSPALNEIERKKIGDIVANACAQLGYRGAGTIEFLYENGKFYFIEMNTRLQVEHPVTE
HHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCEEEEEEECCEEEECCCHHH
AITGIDLVHEQIHIASGCRLSVVQEDICFSGHAIECRINAEDPINFTPSPGTITHFHTPG
HHHHHHHHHHHHHHCCCCEEEEEHHHHCCCCCEEEEEECCCCCCCCCCCCCCEEEEECCC
GLGIRVDSGAYSGYCIPPYYDSMIGKLIVHGRTRLECMMRLRRALDEFVVDGIKTTLPLF
CEEEEECCCCCCCEECCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RDLINNQDIADGNYNIHWLEKYLSSQSTSSDS
HHHHCCCCCCCCCCCHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MIRKILIANRGEIALRVLRACKELGIKTVAVHSTADADAMHVRLADESVCIGPPPVRDSY
CCCEEEEECCCHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEECCCCEECCCCCCCCHH
LSIQQIIAACEITGADAVHPGYGFLSENAKFADVLEAHKITFIGPTAAHIRIMGDKIEAK
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHCEEEEECCCCEEEEEECCHHHHH
KTAKKLGIPVVPGSDGAITEEAEALRIAHEIGYPVIIKASAGGGGRGMKVVRSEQEFAIA
HHHHHCCCEECCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEECCCCEEEE
LETTRSEAAAAFGDDAVYIEKYLEKPRHIEIQVIGDGAGNAIHLGERDCSLQRRHQKIWE
EECCCCHHHHHCCCCHHHHHHHHCCCCEEEEEEEECCCCCEEEECCCCHHHHHHHHHHHH
EATSPALNEIERKKIGDIVANACAQLGYRGAGTIEFLYENGKFYFIEMNTRLQVEHPVTE
HHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCEEEEEEECCEEEECCCHHH
AITGIDLVHEQIHIASGCRLSVVQEDICFSGHAIECRINAEDPINFTPSPGTITHFHTPG
HHHHHHHHHHHHHHCCCCEEEEEHHHHCCCCCEEEEEECCCCCCCCCCCCCCEEEEECCC
GLGIRVDSGAYSGYCIPPYYDSMIGKLIVHGRTRLECMMRLRRALDEFVVDGIKTTLPLF
CEEEEECCCCCCCEECCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RDLINNQDIADGNYNIHWLEKYLSSQSTSSDS
HHHHCCCCCCCCCCCHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7693652; 10984043 [H]