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The map label for this gene is hutA [H]

Identifier: 49475292

GI number: 49475292

Start: 580571

End: 582748

Strand: Reverse

Name: hutA [H]

Synonym: BH04970

Alternate gene names: 49475292

Gene position: 582748-580571 (Counterclockwise)

Preceding gene: 49475294

Following gene: 49475291

Centisome position: 30.18

GC content: 36.73

Gene sequence:

>2178_bases
ATGCGAATAAGACAAAAAAATATCTATAAAGGTTGTGCGATTTTAAGTGCACTATCGGTTTCTATACCTTCATTTGTTTT
TGCACAAAGCAACAATTTAGGTAGTGTAACTGAACTCAAACCCATCATTATTAAAGAAAAAAACATAGAGAATGTCTCGG
ATTCGATAACCATTTTGACTAATCGTAAAACTGCTAAGGACATTGATGAAAAACAAATAAGTGATGTCCATGATGTTAGT
CGTCTTAATCCTTCCGTAAACTACAACTCAAGAAATAATAGTTTTGTGATTCGTGGTTTAGATGCAAACCGTGTTCTCAC
AACAATGGATGGTATTGCTCTTCCATGGTTTGATGATATAGTACGTGGGAGAGGTGGAAATACAACTTTTGATTTTAATG
CACTTTCTACATTTGATGTTATTCAAGGATCTGATTCCAGTCTTTATGGATCCGGTGCACTAGGGGGCGTTGTTGCTTTA
CGTACCCTTAATCCTGAGGACCTTATTACTGAAAACAAGAATTGGGGTAGTCTTATAAAAGGTGGTTATCATTCTGTTGA
TAACAGTTGGCATATAGATCAAGCTATTGCATTGCGGAATAAGCAAACATTCGTGCTTTTTCAAGGATCTCATGTGGAAG
GGCATGAACGTAAGAATATGGGAACTGTAGAAGGCTATGAAGAGCGTACACGTAAAAACCCTGCTCAGTTTGACAAAAAT
AATTTGCTTTTTAAAATTCATCAATATTTCAATGGCAATCACCGTTTTGGTTTAACCGCAGAACGTTTTAATTACAATAT
CAATACGCATTCATTGAATGCATCTACAAGGTATGCTCCAGGTTCTGTTTATGATCAGGATAACAAGCGTCGTGAGCGTT
TTTCTTTGTCTTATAATTATAATGGCAATGAAGACGCACTTTTTGATGCATTTTCTGGGCAGCTTTATTGGCAAAAACAA
ATCAGTCGTCATATCATGAATGGATTTCGTGTTAAAGCGCCTGAAGGGGATTATTTAAGAGATAATTTCTTACGTGATAC
CAGTTACGGTTTCAATACTCATGCTCTCAAAAAAATGAATATTGGTACAGTAAGTCATACATTAAAGCTTGCTACTAATG
TTTCATCGTCTCAATTTCATCACTATCTATTAGGTAAAGACAATTGTCATTTGAAAGAATATGCACAGGGATGTGCCTTT
TTGCCTGCTAATCGATCAGATTCACCGGATACAAACAGCTACAATTTTGGTTTTGCTTTGGAAAATCAAATTGGCTTTGC
CGATGATCATTTCCGCGTGACACCTGGGGTTCGTTATGATTGGTATAAGCACATTCCTCAAAAAACATCCTCTTATGAAA
AAGCTCTCATTTCTGACAAATATCCTCCAGAAAGAAATGGTTCGCGTTTTTCTCCTAAATTACGTATGGAGTGGGATGTT
CGTGATCAAGTAACATTCTATGTACAATGGGCACAAGCTTTTCGCGCTCCACGTGTTTCAGAACTCTACCTCTCCTATGT
CAAACCTCCCCTTTATTATGTAAAAGGAAACCCTGACCTTAAGTCAGAAACAAGTAATGGATATGATATCGGTATACGAT
ATGGAAATGCAAATTTTGGTGGTTCATTTAATGCTTTTACCAACCGATATAAGAATTTTATAACTACTGAGGATAAGGGA
TCATCAGAAGAATTCCGGTTTGGACGTCGACACTATGTAAATCTTTCAAACGTGCGTATTTTTGGTGTTGAAACAAAAAT
GCATTGGGTTCTTAATAATGGTTTCCATAGCAATTTTGCCCTTGCTTATTCACAAGGGAAAGACCTTGACAAAAATGAGT
ATCTTAACTCAATTCCAGCTTTAAAAGCGATTATTGGAGTAGGATATGCAAAAGACACTTGGGGGGCGGATGTTGTGGTT
ACTTCGTCTGCTAAACGTGATAAAGTTGCTAAAGGTTCTGATTATCAAAAAATTCCGGGCTACAAGGTTGTTGATGTATC
TGGTTGGTGGAAACCATTCGATAAAAAAGGCCTTGTTGTAAGAGCTGGTATTTATAATCTTTTCAATGAAAAATATTGGA
ATGTATCAGACCTTCCTGATGGAAAAAGTTCAACACCAAAGGATTATTACAGCCAGCCTGGTCGTAACTTTAAGGTGTCA
TTCGTGCAAAGGTTTTAG

Upstream 100 bases:

>100_bases
CTTGCTTGGCTGGCTAGTTTTGATTGGTGAGTCAAGCGTTTTTATTATATGTAATTTTCAAAAGTTAGAGGGGATGTTTA
ACAAAAGGTTATGATGTGTT

Downstream 100 bases:

>100_bases
TCACTTCTGTTAACCATTGGATCAATATAAAGTTATATCGATAAAAGGGTAAATTATTATGTTGCTCCTCAACCTACAAA
GACTTGAAAGAGGGGTTTTA

Product: Heme receptor precursor

Products: NA

Alternate protein names: Hemoglobin-haptoglobin utilization protein A [H]

Number of amino acids: Translated: 725; Mature: 725

Protein sequence:

>725_residues
MRIRQKNIYKGCAILSALSVSIPSFVFAQSNNLGSVTELKPIIIKEKNIENVSDSITILTNRKTAKDIDEKQISDVHDVS
RLNPSVNYNSRNNSFVIRGLDANRVLTTMDGIALPWFDDIVRGRGGNTTFDFNALSTFDVIQGSDSSLYGSGALGGVVAL
RTLNPEDLITENKNWGSLIKGGYHSVDNSWHIDQAIALRNKQTFVLFQGSHVEGHERKNMGTVEGYEERTRKNPAQFDKN
NLLFKIHQYFNGNHRFGLTAERFNYNINTHSLNASTRYAPGSVYDQDNKRRERFSLSYNYNGNEDALFDAFSGQLYWQKQ
ISRHIMNGFRVKAPEGDYLRDNFLRDTSYGFNTHALKKMNIGTVSHTLKLATNVSSSQFHHYLLGKDNCHLKEYAQGCAF
LPANRSDSPDTNSYNFGFALENQIGFADDHFRVTPGVRYDWYKHIPQKTSSYEKALISDKYPPERNGSRFSPKLRMEWDV
RDQVTFYVQWAQAFRAPRVSELYLSYVKPPLYYVKGNPDLKSETSNGYDIGIRYGNANFGGSFNAFTNRYKNFITTEDKG
SSEEFRFGRRHYVNLSNVRIFGVETKMHWVLNNGFHSNFALAYSQGKDLDKNEYLNSIPALKAIIGVGYAKDTWGADVVV
TSSAKRDKVAKGSDYQKIPGYKVVDVSGWWKPFDKKGLVVRAGIYNLFNEKYWNVSDLPDGKSSTPKDYYSQPGRNFKVS
FVQRF

Sequences:

>Translated_725_residues
MRIRQKNIYKGCAILSALSVSIPSFVFAQSNNLGSVTELKPIIIKEKNIENVSDSITILTNRKTAKDIDEKQISDVHDVS
RLNPSVNYNSRNNSFVIRGLDANRVLTTMDGIALPWFDDIVRGRGGNTTFDFNALSTFDVIQGSDSSLYGSGALGGVVAL
RTLNPEDLITENKNWGSLIKGGYHSVDNSWHIDQAIALRNKQTFVLFQGSHVEGHERKNMGTVEGYEERTRKNPAQFDKN
NLLFKIHQYFNGNHRFGLTAERFNYNINTHSLNASTRYAPGSVYDQDNKRRERFSLSYNYNGNEDALFDAFSGQLYWQKQ
ISRHIMNGFRVKAPEGDYLRDNFLRDTSYGFNTHALKKMNIGTVSHTLKLATNVSSSQFHHYLLGKDNCHLKEYAQGCAF
LPANRSDSPDTNSYNFGFALENQIGFADDHFRVTPGVRYDWYKHIPQKTSSYEKALISDKYPPERNGSRFSPKLRMEWDV
RDQVTFYVQWAQAFRAPRVSELYLSYVKPPLYYVKGNPDLKSETSNGYDIGIRYGNANFGGSFNAFTNRYKNFITTEDKG
SSEEFRFGRRHYVNLSNVRIFGVETKMHWVLNNGFHSNFALAYSQGKDLDKNEYLNSIPALKAIIGVGYAKDTWGADVVV
TSSAKRDKVAKGSDYQKIPGYKVVDVSGWWKPFDKKGLVVRAGIYNLFNEKYWNVSDLPDGKSSTPKDYYSQPGRNFKVS
FVQRF
>Mature_725_residues
MRIRQKNIYKGCAILSALSVSIPSFVFAQSNNLGSVTELKPIIIKEKNIENVSDSITILTNRKTAKDIDEKQISDVHDVS
RLNPSVNYNSRNNSFVIRGLDANRVLTTMDGIALPWFDDIVRGRGGNTTFDFNALSTFDVIQGSDSSLYGSGALGGVVAL
RTLNPEDLITENKNWGSLIKGGYHSVDNSWHIDQAIALRNKQTFVLFQGSHVEGHERKNMGTVEGYEERTRKNPAQFDKN
NLLFKIHQYFNGNHRFGLTAERFNYNINTHSLNASTRYAPGSVYDQDNKRRERFSLSYNYNGNEDALFDAFSGQLYWQKQ
ISRHIMNGFRVKAPEGDYLRDNFLRDTSYGFNTHALKKMNIGTVSHTLKLATNVSSSQFHHYLLGKDNCHLKEYAQGCAF
LPANRSDSPDTNSYNFGFALENQIGFADDHFRVTPGVRYDWYKHIPQKTSSYEKALISDKYPPERNGSRFSPKLRMEWDV
RDQVTFYVQWAQAFRAPRVSELYLSYVKPPLYYVKGNPDLKSETSNGYDIGIRYGNANFGGSFNAFTNRYKNFITTEDKG
SSEEFRFGRRHYVNLSNVRIFGVETKMHWVLNNGFHSNFALAYSQGKDLDKNEYLNSIPALKAIIGVGYAKDTWGADVVV
TSSAKRDKVAKGSDYQKIPGYKVVDVSGWWKPFDKKGLVVRAGIYNLFNEKYWNVSDLPDGKSSTPKDYYSQPGRNFKVS
FVQRF

Specific function: Acts as a receptor for the hemoglobin/haptoglobin complex of the human host and is required for heme uptake. Does not bind hemoglobin alone [H]

COG id: COG1629

COG function: function code P; Outer membrane receptor proteins, mostly Fe transport

Gene ontology:

Cell location: Cell outer membrane [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tonB-dependent receptor family. Hemoglobin/haptoglobin binding protein subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: 100 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012910
- InterPro:   IPR006970
- InterPro:   IPR000531
- InterPro:   IPR010949
- InterPro:   IPR010917 [H]

Pfam domain/function: PF07715 Plug; PF04886 PT; PF00593 TonB_dep_Rec [H]

EC number: NA

Molecular weight: Translated: 82613; Mature: 82613

Theoretical pI: Translated: 9.72; Mature: 9.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIRQKNIYKGCAILSALSVSIPSFVFAQSNNLGSVTELKPIIIKEKNIENVSDSITILT
CCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHCCEEEEECCCCCCCCCCEEEEE
NRKTAKDIDEKQISDVHDVSRLNPSVNYNSRNNSFVIRGLDANRVLTTMDGIALPWFDDI
CCCHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCEEEECCCCCCCCHHHH
VRGRGGNTTFDFNALSTFDVIQGSDSSLYGSGALGGVVALRTLNPEDLITENKNWGSLIK
HHCCCCCCEEECCCCCEEEEEECCCCCEECCCCCCCEEEEEECCHHHHHCCCCCCHHHHC
GGYHSVDNSWHIDQAIALRNKQTFVLFQGSHVEGHERKNMGTVEGYEERTRKNPAQFDKN
CCCCCCCCCCCCCHHHEECCCEEEEEEECCCCCCHHHCCCCCCCCHHHHHCCCCCCCCCC
NLLFKIHQYFNGNHRFGLTAERFNYNINTHSLNASTRYAPGSVYDQDNKRRERFSLSYNY
CEEEEEEEHHCCCEEECEEHHHEEEEEEEEEECCCCCCCCCCCCCCCCCCCEEEEEEECC
NGNEDALFDAFSGQLYWQKQISRHIMNGFRVKAPEGDYLRDNFLRDTSYGFNTHALKKMN
CCCCCCEEEHHCCCEEEHHHHHHHHHCCEEEECCCCCCHHHHHHCCCCCCCCCCEEEEEC
IGTVSHTLKLATNVSSSQFHHYLLGKDNCHLKEYAQGCAFLPANRSDSPDTNSYNFGFAL
CCCHHEEEEEEECCCCHHCEEEEECCCCCCHHHHHCCCEECCCCCCCCCCCCCEEEEEEE
ENQIGFADDHFRVTPGVRYDWYKHIPQKTSSYEKALISDKYPPERNGSRFSPKLRMEWDV
CCCCCCCCCCEEECCCCCCHHHHHCCCCCCHHHHHHHCCCCCCCCCCCCCCCEEEEEECC
RDQVTFYVQWAQAFRAPRVSELYLSYVKPPLYYVKGNPDLKSETSNGYDIGIRYGNANFG
CCCEEEEEEEHHHHCCCCHHHHHHHHCCCCEEEEECCCCCCCCCCCCEEEEEEECCCCCC
GSFNAFTNRYKNFITTEDKGSSEEFRFGRRHYVNLSNVRIFGVETKMHWVLNNGFHSNFA
CCHHHHHHHHHHCEECCCCCCCHHHHCCCEEEEEECCEEEEEEEEEEEEEEECCCCCCEE
LAYSQGKDLDKNEYLNSIPALKAIIGVGYAKDTWGADVVVTSSAKRDKVAKGSDYQKIPG
EEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCC
YKVVDVSGWWKPFDKKGLVVRAGIYNLFNEKYWNVSDLPDGKSSTPKDYYSQPGRNFKVS
EEEEECCCCCCCCCCCCCEEEEHHHHHHHCCCCCCCCCCCCCCCCCHHHHHCCCCCEEEE
FVQRF
EEECC
>Mature Secondary Structure
MRIRQKNIYKGCAILSALSVSIPSFVFAQSNNLGSVTELKPIIIKEKNIENVSDSITILT
CCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHCCEEEEECCCCCCCCCCEEEEE
NRKTAKDIDEKQISDVHDVSRLNPSVNYNSRNNSFVIRGLDANRVLTTMDGIALPWFDDI
CCCHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCEEEECCCCCCCCHHHH
VRGRGGNTTFDFNALSTFDVIQGSDSSLYGSGALGGVVALRTLNPEDLITENKNWGSLIK
HHCCCCCCEEECCCCCEEEEEECCCCCEECCCCCCCEEEEEECCHHHHHCCCCCCHHHHC
GGYHSVDNSWHIDQAIALRNKQTFVLFQGSHVEGHERKNMGTVEGYEERTRKNPAQFDKN
CCCCCCCCCCCCCHHHEECCCEEEEEEECCCCCCHHHCCCCCCCCHHHHHCCCCCCCCCC
NLLFKIHQYFNGNHRFGLTAERFNYNINTHSLNASTRYAPGSVYDQDNKRRERFSLSYNY
CEEEEEEEHHCCCEEECEEHHHEEEEEEEEEECCCCCCCCCCCCCCCCCCCEEEEEEECC
NGNEDALFDAFSGQLYWQKQISRHIMNGFRVKAPEGDYLRDNFLRDTSYGFNTHALKKMN
CCCCCCEEEHHCCCEEEHHHHHHHHHCCEEEECCCCCCHHHHHHCCCCCCCCCCEEEEEC
IGTVSHTLKLATNVSSSQFHHYLLGKDNCHLKEYAQGCAFLPANRSDSPDTNSYNFGFAL
CCCHHEEEEEEECCCCHHCEEEEECCCCCCHHHHHCCCEECCCCCCCCCCCCCEEEEEEE
ENQIGFADDHFRVTPGVRYDWYKHIPQKTSSYEKALISDKYPPERNGSRFSPKLRMEWDV
CCCCCCCCCCEEECCCCCCHHHHHCCCCCCHHHHHHHCCCCCCCCCCCCCCCEEEEEECC
RDQVTFYVQWAQAFRAPRVSELYLSYVKPPLYYVKGNPDLKSETSNGYDIGIRYGNANFG
CCCEEEEEEEHHHHCCCCHHHHHHHHCCCCEEEEECCCCCCCCCCCCEEEEEEECCCCCC
GSFNAFTNRYKNFITTEDKGSSEEFRFGRRHYVNLSNVRIFGVETKMHWVLNNGFHSNFA
CCHHHHHHHHHHCEECCCCCCCHHHHCCCEEEEEECCEEEEEEEEEEEEEEECCCCCCEE
LAYSQGKDLDKNEYLNSIPALKAIIGVGYAKDTWGADVVVTSSAKRDKVAKGSDYQKIPG
EEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCC
YKVVDVSGWWKPFDKKGLVVRAGIYNLFNEKYWNVSDLPDGKSSTPKDYYSQPGRNFKVS
EEEEECCCCCCCCCCCCCEEEEHHHHHHHCCCCCCCCCCCCCCCCCHHHHHCCCCCEEEE
FVQRF
EEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8751920 [H]