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The map label for this gene is gp18 [H]

Identifier: 49475134

GI number: 49475134

Start: 401366

End: 402475

Strand: Reverse

Name: gp18 [H]

Synonym: BH03320

Alternate gene names: 49475134

Gene position: 402475-401366 (Counterclockwise)

Preceding gene: 49475135

Following gene: 49475133

Centisome position: 20.84

GC content: 45.59

Gene sequence:

>1110_bases
TTGATACCACAGATTCAGACCCTTCAGAGACTTATGAAAGCAACCAAGGCAGCGAGGCACACAAAAATGGTGAATAATCT
CGACATGCCGTTTTTGGCATCACGGCTTTTTGTGGTTCCACACATGCTTGCCTCCACAAAGCTTGATATCATCCTTAATG
CTCTTGCACCACGCCTTTTTGCAGGTGAAAAGTTTCCCATTGAAGCTTATTCGCAAGGTAATACAGAAGCTTTCAGACCA
CCAGAAACTTACGTGGTCCAAAACAATATTGCCATCATACCGGTTCATGGCACACTTGTACGCCGTAGCGCATGGCTTGG
AGCTTTATCGGGCTTGACTTCTTATGAAGGTTTAAGGGCTTCTTTTCGTGAAGCCATTGCACAGCCTGATGTGAATGCTG
TCTTACTTGATATTGATAGTGGTGGTGGAGAAGCCGGTGGCATCTTTGATTTGGTTGAAGAGTTTCAAACCCTTTCAAAA
CAATATGCCAAGCCCATTTGGGCGCATGCCAATGAATTTGCTTGTTCGGCAGCTTATGCCATTGCTTGTGCAGCTTCTCA
AATATGGATTGCACGCACAGGTGTTGTGGGTTCCATTGGGGTTGTTTGCGCCCATCTTGACCAATCTCTTGCAGATGAGA
AACAGGGACTTAAATGGACCTTTGTTTTTGAAGGTGATCACAAAACGCATGGCAATTCTCACGAACCCTTGAGCGATACA
GCACAGATAAAAATGCAAGCCGATTGTGCCCTGCTCTACGAGATGTTTGTCGATTGGGTTGCAAAAAACAGACCTCTGAG
TGCGGACGCAATTCGTGACACAAAAGCAGAAACTTTTATAGGCATCCAAGCTTTAGAGCTTGGATTAGCAGATGCGCAGG
GCACCCTTGCGCAAGCTTTGGAAGCCTTAACGGATTCCATATCACAAACCCCAACAGCAACAAAAGAAGGACAAAACACA
TGGCACGCACACAATACCGCGCCGAAGAAGATGATGATGAAAAAGTTGTCGACGTCATCAACGAAGACGAAGAGGACGAA
AACAAGAGCGACATTGATGAAGACTTCGACGAAGACGAAGATGAGGACGAAGATAAACAGGAAAGCGTAA

Upstream 100 bases:

>100_bases
AGCATTCATGCCGAACTTGAGGAAGAACACACAGATGCTCGTGCACGCGGTTTATCTTTTGATACGGATATGGCGGCATC
CTCTGGTGACAATCAAATAA

Downstream 100 bases:

>100_bases
AAGCTGCTCTTGAAAAGGAAAGAAAACGTGGCGAGGCACTGACAAACCTTGAAAGGCAAGCAAAGCGCTTAGGCGTTTCT
TTTGATGCAGCAAAAGCCAT

Product: Phage protein gp18

Products: NA

Alternate protein names: Endopeptidase IV; Protease IV homolog; Signal peptide peptidase [H]

Number of amino acids: Translated: 369; Mature: 369

Protein sequence:

>369_residues
MIPQIQTLQRLMKATKAARHTKMVNNLDMPFLASRLFVVPHMLASTKLDIILNALAPRLFAGEKFPIEAYSQGNTEAFRP
PETYVVQNNIAIIPVHGTLVRRSAWLGALSGLTSYEGLRASFREAIAQPDVNAVLLDIDSGGGEAGGIFDLVEEFQTLSK
QYAKPIWAHANEFACSAAYAIACAASQIWIARTGVVGSIGVVCAHLDQSLADEKQGLKWTFVFEGDHKTHGNSHEPLSDT
AQIKMQADCALLYEMFVDWVAKNRPLSADAIRDTKAETFIGIQALELGLADAQGTLAQALEALTDSISQTPTATKEGQNT
WHAHNTAPKKMMMKKLSTSSTKTKRTKTRATLMKTSTKTKMRTKINRKA

Sequences:

>Translated_369_residues
MIPQIQTLQRLMKATKAARHTKMVNNLDMPFLASRLFVVPHMLASTKLDIILNALAPRLFAGEKFPIEAYSQGNTEAFRP
PETYVVQNNIAIIPVHGTLVRRSAWLGALSGLTSYEGLRASFREAIAQPDVNAVLLDIDSGGGEAGGIFDLVEEFQTLSK
QYAKPIWAHANEFACSAAYAIACAASQIWIARTGVVGSIGVVCAHLDQSLADEKQGLKWTFVFEGDHKTHGNSHEPLSDT
AQIKMQADCALLYEMFVDWVAKNRPLSADAIRDTKAETFIGIQALELGLADAQGTLAQALEALTDSISQTPTATKEGQNT
WHAHNTAPKKMMMKKLSTSSTKTKRTKTRATLMKTSTKTKMRTKINRKA
>Mature_369_residues
MIPQIQTLQRLMKATKAARHTKMVNNLDMPFLASRLFVVPHMLASTKLDIILNALAPRLFAGEKFPIEAYSQGNTEAFRP
PETYVVQNNIAIIPVHGTLVRRSAWLGALSGLTSYEGLRASFREAIAQPDVNAVLLDIDSGGGEAGGIFDLVEEFQTLSK
QYAKPIWAHANEFACSAAYAIACAASQIWIARTGVVGSIGVVCAHLDQSLADEKQGLKWTFVFEGDHKTHGNSHEPLSDT
AQIKMQADCALLYEMFVDWVAKNRPLSADAIRDTKAETFIGIQALELGLADAQGTLAQALEALTDSISQTPTATKEGQNT
WHAHNTAPKKMMMKKLSTSSTKTKRTKTRATLMKTSTKTKMRTKINRKA

Specific function: Digestion of the cleaved signal peptides. This activity is necessary to maintain proper secretion of mature proteins across the membrane [H]

COG id: COG0616

COG function: function code OU; Periplasmic serine proteases (ClpP class)

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S49 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004634
- InterPro:   IPR004635
- InterPro:   IPR002142 [H]

Pfam domain/function: PF01343 Peptidase_S49 [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 40387; Mature: 40387

Theoretical pI: Translated: 9.65; Mature: 9.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPQIQTLQRLMKATKAARHTKMVNNLDMPFLASRLFVVPHMLASTKLDIILNALAPRLF
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGEKFPIEAYSQGNTEAFRPPETYVVQNNIAIIPVHGTLVRRSAWLGALSGLTSYEGLRA
CCCCCCCHHCCCCCCCCCCCCCCEEEECCEEEEEECHHHHHHHHHHHHHHCCHHHHHHHH
SFREAIAQPDVNAVLLDIDSGGGEAGGIFDLVEEFQTLSKQYAKPIWAHANEFACSAAYA
HHHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHH
IACAASQIWIARTGVVGSIGVVCAHLDQSLADEKQGLKWTFVFEGDHKTHGNSHEPLSDT
HHHHHHHHEEEECCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCC
AQIKMQADCALLYEMFVDWVAKNRPLSADAIRDTKAETFIGIQALELGLADAQGTLAQAL
HHEEEHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCHHHHHHHHHHHHCCCCCCCHHHHHH
EALTDSISQTPTATKEGQNTWHAHNTAPKKMMMKKLSTSSTKTKRTKTRATLMKTSTKTK
HHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCHHHH
MRTKINRKA
HHHHHCCCC
>Mature Secondary Structure
MIPQIQTLQRLMKATKAARHTKMVNNLDMPFLASRLFVVPHMLASTKLDIILNALAPRLF
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGEKFPIEAYSQGNTEAFRPPETYVVQNNIAIIPVHGTLVRRSAWLGALSGLTSYEGLRA
CCCCCCCHHCCCCCCCCCCCCCCEEEECCEEEEEECHHHHHHHHHHHHHHCCHHHHHHHH
SFREAIAQPDVNAVLLDIDSGGGEAGGIFDLVEEFQTLSKQYAKPIWAHANEFACSAAYA
HHHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCHHHHCCCHHHHHHHHH
IACAASQIWIARTGVVGSIGVVCAHLDQSLADEKQGLKWTFVFEGDHKTHGNSHEPLSDT
HHHHHHHHEEEECCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCC
AQIKMQADCALLYEMFVDWVAKNRPLSADAIRDTKAETFIGIQALELGLADAQGTLAQAL
HHEEEHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCHHHHHHHHHHHHCCCCCCCHHHHHH
EALTDSISQTPTATKEGQNTWHAHNTAPKKMMMKKLSTSSTKTKRTKTRATLMKTSTKTK
HHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCHHHH
MRTKINRKA
HHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]