Click here to switch to the map view.

The map label for this gene is mutL

Identifier: 49475080

GI number: 49475080

Start: 353376

End: 355214

Strand: Reverse

Name: mutL

Synonym: BH02690

Alternate gene names: 49475080

Gene position: 355214-353376 (Counterclockwise)

Preceding gene: 49475084

Following gene: 49475079

Centisome position: 18.39

GC content: 40.95

Gene sequence:

>1839_bases
ATGATCATACGCCATCTCAGCGAAAATATTATTAATCAAATTGCCGCCGGTGAAGTTATTGAACGGCCAGCAAATGTTGT
CAAAGAACTTGTTGAAAATGCCATTGATGCTGAAGCAACTCGCATTGAAATTGTTACAACAAATGGTGGAAAAAATTTTA
TAAGGGTGAGTGATAATGGCTGTGGTATTCCTGCCGATCAGTTAACTCTAGCTGTTTCTCGCCATTGTACCTCAAAAATT
ACCGATGATGTGCACAATATCTGCTTTCTAGGATTTAGAGGAGAAGCTTTACCCTCTATTGGTTCTGTTGCTAAACTTAA
ATTAACCTCACGAACACAAAATGCTGAAAGTGCTGCTGAAATTATCGTTACAGCAGGAAAAATTGTCGGTCCCAAACCGG
CTGCCGCAAATCCTGGAACAATCGTTGAAGTTCGTGATCTCTTTTTTGTCACGCCAGCACGGCTAAAATTTATGAAAACT
GACCGCGCTGAAACGAATTCCATTACCGATATGATTAAACGAATTGCTATTGCATTTCCACATATACACTTTTCTCTTTC
AGGTTCAGACAGAACTTCTCTGGAACTCCCCGCTACAGCAAATAATACTCAAGGACAATTACAACGTATTACACAAATCA
TGGGTAAAGAATTTGCTCCCAACAGTATCGTATTGAATGCTGAACGCGAATCAGTTCGTTTGACTGGATTTGCTTGTTTG
CCATCTTTCAACCGTAGTAACAGCCTGCATCAATTTGCTTATGTTAATGGGCGTCCAGTACGTGATAAATTTCTCTGGGG
AGCAATCCGAGGAGCCTATGCTGACGTCATGACACGAGATCGTTATCCTGTATCCATTCTTTTTATTGATCTGCCACCTG
CTGATGTAGACGTTAACGTGCATCCAACCAAAGCCGATGTCCGTTTCCGTGACCCAGGGTTCATTCGTGGTTTAATCGTT
GGAGCAATTCGTGAAGCATTGCACCATACTGGTGTTCGCTCTACTTCAACGCGTTCTGAAGCAATGTTAGCTGCATTTCA
AACACAAAAACCATTGAAAACTTTTAAAAGTACTTATAAGCCTTCTTCTTACAGCCCACAGCCTTATCATGTTGAATCAG
CATCAATGGTAAACAAACCATTGGATATTATCAGCCCTGTTGGTTTAAAAGAAGATGCACCTCCTCTTATGGAAGGCTTA
GATATACCAAGCGGTGATGCCTACACTCCAAACACTCCAGCTGCATCAGAAGAATGCTCTTATCCATTAGGAGCTGCTAG
AGCACAAATCCATAAAAATTACATTATCGCTCAAACCCAAGATAGCTTGATCATTGTCGATCAGCATGCTGCTCATGAAC
GATTGGTCTATGAAGCACTCAAGAATGCCCTTTATTCTAAACCACTGCCTTCACAATTATTGCTTATCCCTGAAATTGTA
GAACTCTCTGAAGAAGATGCAACATGCCTTCTCACACACAAAGATGCTTTGCAAAAATTTGGCTTAGGAATAGAAGCATT
TGGACCTGGTGCAATCGTTGTGCGCGAAACACCCTCTCTACTAGGAGAAATAAACGTAGAAGCACTTATTAAGGATCTCG
CAGATGAAGCTGCTGAATATGATACGACAGATAATTTAAAAACAATGCTTGATTATGTTGCAGCAACTATGGCTTGTCAT
GGCTCAATACGGTCAGGACGCCTTTTACACCCTGAAGAAATGAATGCCCTCTTACGGCAAATAGAAGCAACACCCAATAC
AGGTACGTGTAATCACGGTCGTCCTACTTATATTGAACTCAAATTGGCTGATATAGAGAGACTTTTTGGTAGAAAATAA

Upstream 100 bases:

>100_bases
ATAAGACCTTTCACACACTCTCATTCTTGAATGTTGCACAAATAATGCTATCATATGTCAAAACTTCTATAGAATCCTTA
GGAATCTTGTTAGATTTATT

Downstream 100 bases:

>100_bases
GTGTCCTTCACCATTTTGGTAAGAAAGAAATACTTTTTTAATTTACTCTCGACTTTATAAGGCAGCTTATGGCACTGTCT
TCGGATTATCTCTCATACAA

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 612; Mature: 612

Protein sequence:

>612_residues
MIIRHLSENIINQIAAGEVIERPANVVKELVENAIDAEATRIEIVTTNGGKNFIRVSDNGCGIPADQLTLAVSRHCTSKI
TDDVHNICFLGFRGEALPSIGSVAKLKLTSRTQNAESAAEIIVTAGKIVGPKPAAANPGTIVEVRDLFFVTPARLKFMKT
DRAETNSITDMIKRIAIAFPHIHFSLSGSDRTSLELPATANNTQGQLQRITQIMGKEFAPNSIVLNAERESVRLTGFACL
PSFNRSNSLHQFAYVNGRPVRDKFLWGAIRGAYADVMTRDRYPVSILFIDLPPADVDVNVHPTKADVRFRDPGFIRGLIV
GAIREALHHTGVRSTSTRSEAMLAAFQTQKPLKTFKSTYKPSSYSPQPYHVESASMVNKPLDIISPVGLKEDAPPLMEGL
DIPSGDAYTPNTPAASEECSYPLGAARAQIHKNYIIAQTQDSLIIVDQHAAHERLVYEALKNALYSKPLPSQLLLIPEIV
ELSEEDATCLLTHKDALQKFGLGIEAFGPGAIVVRETPSLLGEINVEALIKDLADEAAEYDTTDNLKTMLDYVAATMACH
GSIRSGRLLHPEEMNALLRQIEATPNTGTCNHGRPTYIELKLADIERLFGRK

Sequences:

>Translated_612_residues
MIIRHLSENIINQIAAGEVIERPANVVKELVENAIDAEATRIEIVTTNGGKNFIRVSDNGCGIPADQLTLAVSRHCTSKI
TDDVHNICFLGFRGEALPSIGSVAKLKLTSRTQNAESAAEIIVTAGKIVGPKPAAANPGTIVEVRDLFFVTPARLKFMKT
DRAETNSITDMIKRIAIAFPHIHFSLSGSDRTSLELPATANNTQGQLQRITQIMGKEFAPNSIVLNAERESVRLTGFACL
PSFNRSNSLHQFAYVNGRPVRDKFLWGAIRGAYADVMTRDRYPVSILFIDLPPADVDVNVHPTKADVRFRDPGFIRGLIV
GAIREALHHTGVRSTSTRSEAMLAAFQTQKPLKTFKSTYKPSSYSPQPYHVESASMVNKPLDIISPVGLKEDAPPLMEGL
DIPSGDAYTPNTPAASEECSYPLGAARAQIHKNYIIAQTQDSLIIVDQHAAHERLVYEALKNALYSKPLPSQLLLIPEIV
ELSEEDATCLLTHKDALQKFGLGIEAFGPGAIVVRETPSLLGEINVEALIKDLADEAAEYDTTDNLKTMLDYVAATMACH
GSIRSGRLLHPEEMNALLRQIEATPNTGTCNHGRPTYIELKLADIERLFGRK
>Mature_612_residues
MIIRHLSENIINQIAAGEVIERPANVVKELVENAIDAEATRIEIVTTNGGKNFIRVSDNGCGIPADQLTLAVSRHCTSKI
TDDVHNICFLGFRGEALPSIGSVAKLKLTSRTQNAESAAEIIVTAGKIVGPKPAAANPGTIVEVRDLFFVTPARLKFMKT
DRAETNSITDMIKRIAIAFPHIHFSLSGSDRTSLELPATANNTQGQLQRITQIMGKEFAPNSIVLNAERESVRLTGFACL
PSFNRSNSLHQFAYVNGRPVRDKFLWGAIRGAYADVMTRDRYPVSILFIDLPPADVDVNVHPTKADVRFRDPGFIRGLIV
GAIREALHHTGVRSTSTRSEAMLAAFQTQKPLKTFKSTYKPSSYSPQPYHVESASMVNKPLDIISPVGLKEDAPPLMEGL
DIPSGDAYTPNTPAASEECSYPLGAARAQIHKNYIIAQTQDSLIIVDQHAAHERLVYEALKNALYSKPLPSQLLLIPEIV
ELSEEDATCLLTHKDALQKFGLGIEAFGPGAIVVRETPSLLGEINVEALIKDLADEAAEYDTTDNLKTMLDYVAATMACH
GSIRSGRLLHPEEMNALLRQIEATPNTGTCNHGRPTYIELKLADIERLFGRK

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family

Homologues:

Organism=Homo sapiens, GI4557757, Length=313, Percent_Identity=33.5463258785943, Blast_Score=183, Evalue=5e-46,
Organism=Homo sapiens, GI4505911, Length=327, Percent_Identity=29.0519877675841, Blast_Score=129, Evalue=8e-30,
Organism=Homo sapiens, GI189458898, Length=327, Percent_Identity=29.0519877675841, Blast_Score=129, Evalue=1e-29,
Organism=Homo sapiens, GI189458896, Length=325, Percent_Identity=28.9230769230769, Blast_Score=118, Evalue=2e-26,
Organism=Homo sapiens, GI4505913, Length=342, Percent_Identity=26.0233918128655, Blast_Score=110, Evalue=4e-24,
Organism=Homo sapiens, GI310128478, Length=342, Percent_Identity=26.0233918128655, Blast_Score=110, Evalue=4e-24,
Organism=Homo sapiens, GI263191589, Length=218, Percent_Identity=28.4403669724771, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI91992162, Length=267, Percent_Identity=29.9625468164794, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI91992160, Length=267, Percent_Identity=29.9625468164794, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI310128480, Length=295, Percent_Identity=24.406779661017, Blast_Score=79, Evalue=9e-15,
Organism=Escherichia coli, GI1790612, Length=551, Percent_Identity=33.5753176043557, Blast_Score=250, Evalue=2e-67,
Organism=Caenorhabditis elegans, GI71991825, Length=322, Percent_Identity=33.5403726708075, Blast_Score=155, Evalue=8e-38,
Organism=Caenorhabditis elegans, GI17562796, Length=371, Percent_Identity=25.3369272237197, Blast_Score=123, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6323819, Length=379, Percent_Identity=33.7730870712401, Blast_Score=181, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6324247, Length=332, Percent_Identity=29.5180722891566, Blast_Score=112, Evalue=1e-25,
Organism=Saccharomyces cerevisiae, GI6325093, Length=721, Percent_Identity=20.8044382801664, Blast_Score=90, Evalue=9e-19,
Organism=Drosophila melanogaster, GI17136968, Length=344, Percent_Identity=31.9767441860465, Blast_Score=190, Evalue=3e-48,
Organism=Drosophila melanogaster, GI17136970, Length=347, Percent_Identity=26.2247838616715, Blast_Score=93, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MUTL_BARHE (Q6G4R4)

Other databases:

- EMBL:   BX897699
- RefSeq:   YP_033121.1
- HSSP:   P23367
- ProteinModelPortal:   Q6G4R4
- SMR:   Q6G4R4
- GeneID:   2865369
- GenomeReviews:   BX897699_GR
- KEGG:   bhe:BH02690
- NMPDR:   fig|283166.1.peg.249
- HOGENOM:   HBG520262
- OMA:   KIFFAPP
- PhylomeDB:   Q6G4R4
- ProtClustDB:   PRK00095
- BioCyc:   BHEN283166:BH02690-MONOMER
- HAMAP:   MF_00149
- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.565.10
- Gene3D:   G3DSA:3.30.230.10
- PANTHER:   PTHR10073
- SMART:   SM00387
- SMART:   SM00853
- TIGRFAMs:   TIGR00585

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C; SSF55874 ATP_bd_ATPase; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: NA

Molecular weight: Translated: 66926; Mature: 66926

Theoretical pI: Translated: 6.66; Mature: 6.66

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIRHLSENIINQIAAGEVIERPANVVKELVENAIDAEATRIEIVTTNGGKNFIRVSDNG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCEEEEECCCC
CGIPADQLTLAVSRHCTSKITDDVHNICFLGFRGEALPSIGSVAKLKLTSRTQNAESAAE
CCCCHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCEEEEEEECCCCCHHHHHH
IIVTAGKIVGPKPAAANPGTIVEVRDLFFVTPARLKFMKTDRAETNSITDMIKRIAIAFP
EEEECCCEECCCCCCCCCCCEEEEEHEEEECHHHHEEEECCCCCHHHHHHHHHHHHHHCC
HIHFSLSGSDRTSLELPATANNTQGQLQRITQIMGKEFAPNSIVLNAERESVRLTGFACL
CEEEEECCCCCCEEECCCCCCCCHHHHHHHHHHHCCCCCCCCEEEECCCCEEEEEEEEEC
PSFNRSNSLHQFAYVNGRPVRDKFLWGAIRGAYADVMTRDRYPVSILFIDLPPADVDVNV
CCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCEEEEE
HPTKADVRFRDPGFIRGLIVGAIREALHHTGVRSTSTRSEAMLAAFQTQKPLKTFKSTYK
CCCCCCEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCHHHHHHHHHCC
PSSYSPQPYHVESASMVNKPLDIISPVGLKEDAPPLMEGLDIPSGDAYTPNTPAASEECS
CCCCCCCCEEECHHHHHCCCHHHHCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCC
YPLGAARAQIHKNYIIAQTQDSLIIVDQHAAHERLVYEALKNALYSKPLPSQLLLIPEIV
CCCHHHHHHHHCCEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHCCCCCHHHEEHHHHH
ELSEEDATCLLTHKDALQKFGLGIEAFGPGAIVVRETPSLLGEINVEALIKDLADEAAEY
HCCCCCCEEEEECHHHHHHHCCCEEEECCCEEEEECCHHHHHHCCHHHHHHHHHHHHHCC
DTTDNLKTMLDYVAATMACHGSIRSGRLLHPEEMNALLRQIEATPNTGTCNHGRPTYIEL
CCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEE
KLADIERLFGRK
EHHHHHHHHCCC
>Mature Secondary Structure
MIIRHLSENIINQIAAGEVIERPANVVKELVENAIDAEATRIEIVTTNGGKNFIRVSDNG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCEEEEECCCC
CGIPADQLTLAVSRHCTSKITDDVHNICFLGFRGEALPSIGSVAKLKLTSRTQNAESAAE
CCCCHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCEEEEEEECCCCCHHHHHH
IIVTAGKIVGPKPAAANPGTIVEVRDLFFVTPARLKFMKTDRAETNSITDMIKRIAIAFP
EEEECCCEECCCCCCCCCCCEEEEEHEEEECHHHHEEEECCCCCHHHHHHHHHHHHHHCC
HIHFSLSGSDRTSLELPATANNTQGQLQRITQIMGKEFAPNSIVLNAERESVRLTGFACL
CEEEEECCCCCCEEECCCCCCCCHHHHHHHHHHHCCCCCCCCEEEECCCCEEEEEEEEEC
PSFNRSNSLHQFAYVNGRPVRDKFLWGAIRGAYADVMTRDRYPVSILFIDLPPADVDVNV
CCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCEEEEE
HPTKADVRFRDPGFIRGLIVGAIREALHHTGVRSTSTRSEAMLAAFQTQKPLKTFKSTYK
CCCCCCEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCHHHHHHHHHCC
PSSYSPQPYHVESASMVNKPLDIISPVGLKEDAPPLMEGLDIPSGDAYTPNTPAASEECS
CCCCCCCCEEECHHHHHCCCHHHHCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCC
YPLGAARAQIHKNYIIAQTQDSLIIVDQHAAHERLVYEALKNALYSKPLPSQLLLIPEIV
CCCHHHHHHHHCCEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHCCCCCHHHEEHHHHH
ELSEEDATCLLTHKDALQKFGLGIEAFGPGAIVVRETPSLLGEINVEALIKDLADEAAEY
HCCCCCCEEEEECHHHHHHHCCCEEEECCCEEEEECCHHHHHHCCHHHHHHHHHHHHHCC
DTTDNLKTMLDYVAATMACHGSIRSGRLLHPEEMNALLRQIEATPNTGTCNHGRPTYIEL
CCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEE
KLADIERLFGRK
EHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA