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The map label for this gene is hemN [H]

Identifier: 49474877

GI number: 49474877

Start: 76229

End: 77428

Strand: Reverse

Name: hemN [H]

Synonym: BH00530

Alternate gene names: 49474877

Gene position: 77428-76229 (Counterclockwise)

Preceding gene: 49474878

Following gene: 49474873

Centisome position: 4.01

GC content: 42.42

Gene sequence:

>1200_bases
ATGAATGAACCTTTTGGCATCTACATCCATTGGCCCTTTTGCGCTGCCAAATGTCCTTATTGTGACTTTAATTCGCATGT
TCGCCTTCATGGTGTTGATCAACCACGTTTCGTAACCGCCTTTGAACGTGAAATAGAAACACAATATCATAAAATAGGTC
CACGTTGTATTAAGAGTATTTTTATTGGTGGGGGAACCCCATCGCTTATGACACCTCAAACTGTTGATGCCTTGTTGCAG
ATATTGGCAAGAACGTGGAACATCGATGATAAAGCTGAAATTACAATGGAAGCGAACCCATCCAGTGTAGAAGCAGAGCG
TTTTCGTGGATACCGTGTAGCAGGGGTGAACCGCTTGTCTCTTGGTGTACAAGCACTCAATGACAAAGCACTACGACAAC
TTGGACGTCTCCATGATGTCAAACAAGCTCTCCATGCTATTGCTTTAGCACGGAAAATTTTCCCCCGTTTATCCTTTGAT
CTTATCTATGCCCGCCCCGGACAAACACTCGAACAATGGAAATGTGAACTTTTTCAAGCCATTGATTTAGCAGCAGACCA
TCTTTCTCTTTACCAACTAACTATCGAAGAAGGAACAGCATTTAAACGGCTCCATGCCGCAGGAAGACTGTTTCTCCCCG
AATCAGAACTTGCAGCAGATCTCTATCAACTCACACAAGAAATAACCGCACTACACGGGCTTCCAGCTTATGAAATCTCC
AATCATGCAATTTCTGGTGCGGAATCAGTGCATAATCTTCTCTATTGGCGTTATCACGAATATGCGGGTTTTGGTCCAGG
AGCTCATGGACGCTTTATTGAGCACTCACAAAATCATTCTTCTGCCTCTTCAAAAGCAGATCCTTCTCAAATCGAAAACC
GTGAACGTTCTGTCACAATCAATGAAAAATATCCAGAACATTGGCTCGAATTGGTAGAAAAGACAGGACATGGCTGTATT
GAGACAGAACAATTGACGACAGAACAACAAGCAAACGAAATGCTCCTTATGGGTTTGCGTCTTTGCGAAGGTTTGGATCT
TATACGCTACAAAAGCTTAAGCTCTAAAAACTTGCCCATGGAAAAACTTATCGATTTACAACAACAAGGGCTGGTAGAAA
TGGTAGAAAACCAACGCTTAAAAGCGACAAACAAAGGACGCATTCTGCTTGACTATATTATCAATCAATTGGCACACTAA

Upstream 100 bases:

>100_bases
CAACGGAGCAAAAACATGGTTGGAAACTCAATGATCAAACACCGCTCTCTCATCGTGCATGTGCCTTCAAACTTTTAGCA
GAAAACCTTTTAAAACTCTC

Downstream 100 bases:

>100_bases
AATCTTGATGGTTTCAACCTGTCACCTTTTGTTACATTAGTTGTGAGAGAACAATCACATACCCTTTTTCGACAGAATTA
CGCCTTATCTTTTCCATTCA

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 399; Mature: 399

Protein sequence:

>399_residues
MNEPFGIYIHWPFCAAKCPYCDFNSHVRLHGVDQPRFVTAFEREIETQYHKIGPRCIKSIFIGGGTPSLMTPQTVDALLQ
ILARTWNIDDKAEITMEANPSSVEAERFRGYRVAGVNRLSLGVQALNDKALRQLGRLHDVKQALHAIALARKIFPRLSFD
LIYARPGQTLEQWKCELFQAIDLAADHLSLYQLTIEEGTAFKRLHAAGRLFLPESELAADLYQLTQEITALHGLPAYEIS
NHAISGAESVHNLLYWRYHEYAGFGPGAHGRFIEHSQNHSSASSKADPSQIENRERSVTINEKYPEHWLELVEKTGHGCI
ETEQLTTEQQANEMLLMGLRLCEGLDLIRYKSLSSKNLPMEKLIDLQQQGLVEMVENQRLKATNKGRILLDYIINQLAH

Sequences:

>Translated_399_residues
MNEPFGIYIHWPFCAAKCPYCDFNSHVRLHGVDQPRFVTAFEREIETQYHKIGPRCIKSIFIGGGTPSLMTPQTVDALLQ
ILARTWNIDDKAEITMEANPSSVEAERFRGYRVAGVNRLSLGVQALNDKALRQLGRLHDVKQALHAIALARKIFPRLSFD
LIYARPGQTLEQWKCELFQAIDLAADHLSLYQLTIEEGTAFKRLHAAGRLFLPESELAADLYQLTQEITALHGLPAYEIS
NHAISGAESVHNLLYWRYHEYAGFGPGAHGRFIEHSQNHSSASSKADPSQIENRERSVTINEKYPEHWLELVEKTGHGCI
ETEQLTTEQQANEMLLMGLRLCEGLDLIRYKSLSSKNLPMEKLIDLQQQGLVEMVENQRLKATNKGRILLDYIINQLAH
>Mature_399_residues
MNEPFGIYIHWPFCAAKCPYCDFNSHVRLHGVDQPRFVTAFEREIETQYHKIGPRCIKSIFIGGGTPSLMTPQTVDALLQ
ILARTWNIDDKAEITMEANPSSVEAERFRGYRVAGVNRLSLGVQALNDKALRQLGRLHDVKQALHAIALARKIFPRLSFD
LIYARPGQTLEQWKCELFQAIDLAADHLSLYQLTIEEGTAFKRLHAAGRLFLPESELAADLYQLTQEITALHGLPAYEIS
NHAISGAESVHNLLYWRYHEYAGFGPGAHGRFIEHSQNHSSASSKADPSQIENRERSVTINEKYPEHWLELVEKTGHGCI
ETEQLTTEQQANEMLLMGLRLCEGLDLIRYKSLSSKNLPMEKLIDLQQQGLVEMVENQRLKATNKGRILLDYIINQLAH

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=321, Percent_Identity=38.6292834890966, Blast_Score=226, Evalue=3e-59,
Organism=Escherichia coli, GI1789325, Length=269, Percent_Identity=40.8921933085502, Blast_Score=202, Evalue=4e-53,
Organism=Escherichia coli, GI87082341, Length=191, Percent_Identity=31.9371727748691, Blast_Score=102, Evalue=5e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 45282; Mature: 45282

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEPFGIYIHWPFCAAKCPYCDFNSHVRLHGVDQPRFVTAFEREIETQYHKIGPRCIKSI
CCCCEEEEEECCHHHCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCHHHHHHH
FIGGGTPSLMTPQTVDALLQILARTWNIDDKAEITMEANPSSVEAERFRGYRVAGVNRLS
HCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHCCEEEECCCHHH
LGVQALNDKALRQLGRLHDVKQALHAIALARKIFPRLSFDLIYARPGQTLEQWKCELFQA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHH
IDLAADHLSLYQLTIEEGTAFKRLHAAGRLFLPESELAADLYQLTQEITALHGLPAYEIS
HHHHHHHHEEEEEEECCCHHHHHHHHCCCEECCHHHHHHHHHHHHHHHHHHHCCCCHHHC
NHAISGAESVHNLLYWRYHEYAGFGPGAHGRFIEHSQNHSSASSKADPSQIENRERSVTI
CCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCEEEE
NEKYPEHWLELVEKTGHGCIETEQLTTEQQANEMLLMGLRLCEGLDLIRYKSLSSKNLPM
CCCCHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCH
EKLIDLQQQGLVEMVENQRLKATNKGRILLDYIINQLAH
HHHHHHHHHHHHHHHHCCCCCCCCCCCEEHHHHHHHHCC
>Mature Secondary Structure
MNEPFGIYIHWPFCAAKCPYCDFNSHVRLHGVDQPRFVTAFEREIETQYHKIGPRCIKSI
CCCCEEEEEECCHHHCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCHHHHHHH
FIGGGTPSLMTPQTVDALLQILARTWNIDDKAEITMEANPSSVEAERFRGYRVAGVNRLS
HCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHCCEEEECCCHHH
LGVQALNDKALRQLGRLHDVKQALHAIALARKIFPRLSFDLIYARPGQTLEQWKCELFQA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHH
IDLAADHLSLYQLTIEEGTAFKRLHAAGRLFLPESELAADLYQLTQEITALHGLPAYEIS
HHHHHHHHEEEEEEECCCHHHHHHHHCCCEECCHHHHHHHHHHHHHHHHHHHCCCCHHHC
NHAISGAESVHNLLYWRYHEYAGFGPGAHGRFIEHSQNHSSASSKADPSQIENRERSVTI
CCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCEEEE
NEKYPEHWLELVEKTGHGCIETEQLTTEQQANEMLLMGLRLCEGLDLIRYKSLSSKNLPM
CCCCHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCH
EKLIDLQQQGLVEMVENQRLKATNKGRILLDYIINQLAH
HHHHHHHHHHHHHHHHCCCCCCCCCCCEEHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8757728; 8969508; 9384377; 1339421 [H]